公开(公告)号：US12104209B2

公开(公告)日：2024-10-01

申请号：US16089835

申请日：2017-03-30

Applicant: Genfit

Inventor： Raphaël Darteil ,  Geneviève Cordonnier ,  John Brozek ,  Emilie Praca ,  Fouad Ben Sudrik

IPC: C12Q1/6883 ,  A61K31/216 ,  C12Q1/54 ,  C12Q1/6827 ,  G06F17/18 ,  G16B5/20 ,  G16B25/00 ,  G16B40/10 ,  G16H50/30

CPC classification number: C12Q1/6883 ,  A61K31/216 ,  C12Q1/54 ,  C12Q1/6827 ,  G06F17/18 ,  G16B5/20 ,  G16B25/00 ,  G16B40/10 ,  G16H50/30 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N2800/085

Abstract: The invention relates to a novel method for the diagnosis of non-alcoholic steatohepatitis (NASH), and for classifying a subject as a potential receiver of a treatment for NASH.

公开(公告)号：US20240307359A1

公开(公告)日：2024-09-19

申请号：US18418112

申请日：2024-01-19

Applicant: Minerva Biotechnologies Corporation

Inventor： Cynthia Bamdad ,  Scott Moe

IPC: A61K31/437 ,  A61K31/4045 ,  A61K31/444 ,  A61P29/00 ,  A61P35/04 ,  C12Q1/686 ,  C12Q1/6886 ,  G01N33/50 ,  G01N33/574

CPC classification number: A61K31/437 ,  A61K31/4045 ,  A61K31/444 ,  A61P29/00 ,  A61P35/04 ,  C12Q1/686 ,  C12Q1/6886 ,  G01N33/5073 ,  G01N33/574 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2800/7028

Abstract: The present application discloses a method for identifying an agent for the treatment or prevention of cancer or metastatic cancer comprising the steps of contacting stem cell with a potential agent, and identifying an agent that induces differentiation, or inhibits stem cell pluripotency or growth of the stem cell, wherein such agent is determined to be an anti-cancer agent.

公开(公告)号：US20240301493A1

公开(公告)日：2024-09-12

申请号：US18277358

申请日：2022-02-17

Applicant: Insitro, Inc.

Inventor： Max R. SALICK ,  Eric LUBECK ,  Srinivasan SIVANANDAN ,  Ajamete KAYKAS

IPC: C12Q1/6881 ,  C12Q1/6841 ,  C12Q1/6874

CPC classification number: C12Q1/6881 ,  C12Q1/6841 ,  C12Q1/6874 ,  C12Q2600/136 ,  C12Q2600/16

Abstract: Provided herein are methods of pooled screening of cells from different genetic backgrounds. Also provided herein are computer-implemented methods for aligning between a first plurality of images and a second plurality of images of biological samples.

公开(公告)号：US12060619B2

公开(公告)日：2024-08-13

申请号：US17140409

申请日：2021-01-04

Applicant: The Rockefeller University

Inventor： Sohail Tavazoie ,  Nils Halberg ,  Kim Png

IPC: C12N15/113 ,  A61K38/17 ,  A61K39/395 ,  A61K45/06 ,  C07K16/18 ,  C12Q1/6886 ,  A61K39/00

CPC classification number: C12Q1/6886 ,  A61K38/1709 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/18 ,  C12N15/113 ,  C12N15/1135 ,  A61K2039/505 ,  A61K2300/00 ,  C07K2317/73 ,  C07K2317/76 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2320/11 ,  C12N2320/12 ,  C12N2330/31 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178 ,  A61K38/1709 ,  A61K2300/00

Abstract: This invention concerns pathological angiogenesis and cancer, related treatment methods, and related compositions. Also disclosed are related diagnosis kits and methods.

公开(公告)号：US20240185956A1

公开(公告)日：2024-06-06

申请号：US18347922

申请日：2023-07-06

Applicant: Cofactor Genomics, Inc.

Inventor： Ian SCHILLEBEECKX ,  Jon R. ARMSTRONG ,  Jeffrey HIKEN

IPC: G16B40/00 ,  G06F18/213 ,  G06F18/214 ,  G06F18/24 ,  G06N3/086 ,  G06N3/126 ,  G06N5/047 ,  G06N20/00 ,  G06V10/764 ,  G06V20/69 ,  G16B25/10

CPC classification number: G16B40/00 ,  G06F18/213 ,  G06F18/214 ,  G06F18/24 ,  G06N3/086 ,  G06N3/126 ,  G06N5/047 ,  G06N20/00 ,  G06V10/764 ,  G06V20/695 ,  G16B25/10 ,  C12Q2600/136

Abstract: Disclosed herein, are systems and methods for analyzing complex data signals using artificial intelligence and/or deconvolution algorithms to determine output pertaining to the state or status of one or more parameters. Data sets may include signals from various sources that can confound or distort the signals of interest. Accordingly, disclosed herein are deconvolution algorithms that enable the determination of the status of sources that correspond to the signals of interest.

公开(公告)号：US20240117436A1

公开(公告)日：2024-04-11

申请号：US18516241

申请日：2023-11-21

Applicant: MAGI EUREGIO SCS

Inventor： Matteo BERTELLI ,  Elena MANARA ,  Paolo Enrico MALTESE ,  Sandro MICHELINI ,  Serena MICHELINI ,  Maria Rachele CECCARINI ,  Pietro CHIURAZZI ,  Karen Louise HERBST ,  Jurgen KAFTALLI ,  Kevin DONATO ,  Andrea BERNINI

IPC: C12Q1/6883 ,  A61K31/5517 ,  G01N33/74

CPC classification number: C12Q1/6883 ,  A61K31/5517 ,  G01N33/743 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2800/52

Abstract: The present invention identifies further to AKR1C1 also AKR1C2 as a lipedema-associated gene. The invention provides methods for diagnosing or assessing an individual's susceptibility to lipedema by the analysis of the AKR1C genes, in particular of the AKR1C2 gene, or the expression levels of its product and related metabolites. Also provided are therapeutic methods for treating a patient or methods for prophylactically treating an individual susceptible to lipedema.

公开(公告)号：US20240094208A1

公开(公告)日：2024-03-21

申请号：US18461820

申请日：2023-09-06

Applicant: Dana-Farber Cancer Institute, Inc.

Inventor： Levi A. Garraway ,  Caroline Emery ,  Nikhil Wagle

IPC: G01N33/574 ,  A61K38/00 ,  A61P35/00 ,  C12N9/12 ,  C12N15/10 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/686 ,  C12Q1/6886

CPC classification number: G01N33/5743 ,  A61K38/005 ,  A61P35/00 ,  C12N9/1205 ,  C12N15/1003 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/686 ,  C12Q1/6886 ,  C12Y207/12002 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  G01N2333/91205 ,  G01N2500/10 ,  G01N2500/20

Abstract: An isolated nucleic acid molecule encoding a mutant MEK1 protein having MEK1 activity is disclosed. The mutant MEK1 protein comprises an amino acid substitution at position 121 of wild-type MEK1 shown in SEQ ID NO: 2. The amino acid substitution confers resistance to one or more RAF or MEK inhibitors on a cell expressing the mutant MEK1 protein.

公开(公告)号：US20240093309A1

公开(公告)日：2024-03-21

申请号：US18387292

申请日：2023-11-06

Applicant: ISCAFF PHARMA AB

Inventor： Göran Landberg ,  Anders Ståhlberg ,  Joakim Håkansson

IPC: C12Q1/6886 ,  C12M1/12 ,  C12N5/071 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12M25/14 ,  C12N5/0631 ,  G01N33/57415 ,  C12N2502/30 ,  C12N2533/90 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: A method for determining one or more tumour properties in a subject with a tumour, the method comprising: —seeding a cell-free scaffold obtained from the tumour with cancer cells; —culturing the cancer cells in the scaffold; —assaying the cultured cancer cells for the presence of target molecules indicative of the expression of one or more genes in the cells; and —determining one or more tumour properties based on the results of the assay.

公开(公告)号：US11931347B2

公开(公告)日：2024-03-19

申请号：US15762897

申请日：2016-09-23

Applicant: MINERVA BIOTECHNOLOGIES CORPORATION

Inventor： Cynthia Bamdad ,  Scott Moe

IPC: A61P29/00 ,  A61K31/4045 ,  A61K31/437 ,  A61K31/444 ,  A61P35/04 ,  C12Q1/686 ,  C12Q1/6886 ,  G01N33/50 ,  G01N33/574

CPC classification number: A61K31/437 ,  A61K31/4045 ,  A61K31/444 ,  A61P29/00 ,  A61P35/04 ,  C12Q1/686 ,  C12Q1/6886 ,  G01N33/5073 ,  G01N33/574 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2800/7028

Abstract: The present application discloses a method for identifying an agent for the treatment or prevention of cancer or metastatic cancer comprising the steps of contacting stem cell with a potential agent, and identifying an agent that induces differentiation, or inhibits stem cell pluripotency or growth of the stem cell, wherein such agent is determined to be an anti-cancer agent.

公开(公告)号：US20240026452A1

公开(公告)日：2024-01-25

申请号：US18206133

申请日：2023-06-06

Applicant: Loma Linda University Health

Inventor： Salvador Soriano ,  Michael Castello

IPC: C12Q1/6883 ,  G01N33/50 ,  G01N33/68 ,  A61B5/00

CPC classification number: C12Q1/6883 ,  G01N33/5023 ,  G01N33/6896 ,  A61B5/00 ,  C12Q2600/118 ,  C12Q2600/136 ,  G01N2800/2821 ,  G01N2800/50 ,  G01N2800/52 ,  C12Q2600/158 ,  G01N2500/10

Abstract: In one aspect, methods of diagnosing a subject as having Alzheimer's disease and prognosing a subject as being at risk of progressing to Alzheimer's disease are provided. In some embodiments, the method comprises determining one or more of the level of expression of rhotekin 2 (RTKN2), the level of expression of microtubule-associated Ser/Thr kinase 4 (MAST4), the level of binding of forkhead box O1 (FOXO1) to the RTKN2 promoter, and the level of binding of amyloid precursor protein (APP) to the MAST4 promoter in a sample from the subject.