公开(公告)号：US20190300960A1

公开(公告)日：2019-10-03

申请号：US16467783

申请日：2017-12-08

Applicant: Loma Linda University Health

Inventor： Salvador Soriano ,  Michael Castello

IPC: C12Q1/6883 ,  G01N33/68 ,  G01N33/50

Abstract: In one aspect, methods of diagnosing a subject as having Alzheimer's disease and prognosing a subject as being at risk of progressing to Alzheimer's disease are provided. In some embodiments, the method comprises determining one or more of the level of expression of rhotekin 2 (RTKN2), the level of expression of microtubule-associated Ser/Thr kinase 4 (MAST4), the level of binding of forkhead box O1 (FOXO1) to the RTKN2 promoter, and the level of binding of amyloid precursor protein (APP) to the MAST4 promoter in a sample from the subject.

公开(公告)号：US20250009583A1

公开(公告)日：2025-01-09

申请号：US18762867

申请日：2024-07-03

Applicant: Loma Linda University Health ,  The Regents of the University of California ,  University of Notre Dame

Inventor： Christopher G. Wilson ,  Nosang V. Myung ,  Thomas F. Stahovich

IPC: A61G11/00 ,  A61B5/00 ,  A61B5/0205 ,  A61B7/04 ,  G16H40/67 ,  G16H50/70

Abstract: Provided herein are methods, systems, and devices for integrated monitoring of patients, such as infants, within incubators. In an embodiment, an integrated monitoring system may include an integrated monitoring device communicatively coupled to a plurality of sensors. The integrated monitoring device may include a processor that executes machine-readable instructions to receive an environmental condition of an incubator and a clinical variable of the infant from the plurality of sensors. The processor may generate a predicted outcome based on application of the environmental condition and the clinical variable to a model configured to associate sensor data with clinical outcomes. In response to the predicted outcome being outside a threshold, the processor may output a notification to a user device communicatively coupled to the integrated monitoring device.

公开(公告)号：US20240026452A1

公开(公告)日：2024-01-25

申请号：US18206133

申请日：2023-06-06

Applicant: Loma Linda University Health

Inventor： Salvador Soriano ,  Michael Castello

IPC: C12Q1/6883 ,  G01N33/50 ,  G01N33/68 ,  A61B5/00

CPC classification number: C12Q1/6883 ,  G01N33/5023 ,  G01N33/6896 ,  A61B5/00 ,  C12Q2600/118 ,  C12Q2600/136 ,  G01N2800/2821 ,  G01N2800/50 ,  G01N2800/52 ,  C12Q2600/158 ,  G01N2500/10

Abstract: In one aspect, methods of diagnosing a subject as having Alzheimer's disease and prognosing a subject as being at risk of progressing to Alzheimer's disease are provided. In some embodiments, the method comprises determining one or more of the level of expression of rhotekin 2 (RTKN2), the level of expression of microtubule-associated Ser/Thr kinase 4 (MAST4), the level of binding of forkhead box O1 (FOXO1) to the RTKN2 promoter, and the level of binding of amyloid precursor protein (APP) to the MAST4 promoter in a sample from the subject.

公开(公告)号：US20230165749A1

公开(公告)日：2023-06-01

申请号：US17997303

申请日：2021-04-27

Applicant: LOMA LINDA UNIVERSITY HEALTH

Inventor： Erin Hoch ,  Janel Duggins

IPC: A61H23/00 ,  A41B13/06 ,  A61F7/03 ,  A61N5/06 ,  A61H23/02

CPC classification number: A61H23/006 ,  A41B13/06 ,  A61F7/03 ,  A61N5/0625 ,  A61H23/02 ,  A41B2400/32 ,  A61N2005/0659 ,  A61N2005/0645 ,  A61H2201/1647 ,  A61H2205/081 ,  A61H2205/086 ,  A61H2201/0107 ,  A61H2201/0207 ,  A61H2201/0214 ,  A61H2201/0278 ,  A61H2201/0221 ,  A61H2205/083 ,  A61H2205/12 ,  A61H2201/10 ,  A61H2201/165

Abstract: Described herein are devices and methods used for providing comfort to an infant, and in particular, to devices and methods for introducing a therapy protocol to an infant in, for example, a neonatal intensive care unit.

公开(公告)号：US20240050455A1

公开(公告)日：2024-02-15

申请号：US17928972

申请日：2021-06-01

Applicant: Loma Linda University Health

Inventor： David J. Baylink ,  Xiaolei Tang ,  Amir Abdipour ,  Samiksha Wasnik

IPC: A61K31/69 ,  A61K38/30 ,  A61K31/277 ,  A61K31/415 ,  A61K31/375 ,  A61P37/06

CPC classification number: A61K31/69 ,  A61K38/30 ,  A61K31/277 ,  A61K31/415 ,  A61K31/375 ,  A61P37/06

Abstract: Provided here are methods for treating a cytokine storm in a subject. One such method includes the administration of a therapeutically effective amount of an Insulin-like Growth Factor (IGF-1), a Ca2+-release-activated Ca2+(CRAC) channel inhibitor, or combinations thereof. Methods include treatment of acute lung injury or acute kidney injury with a therapeutically effective amount of 3,5-bis(trifluoromethyl) pyrazole derivative or teriflunomide, either individually or in combination with IGF-1.

公开(公告)号：US11708609B2

公开(公告)日：2023-07-25

申请号：US16467783

申请日：2017-12-08

Applicant: Loma Linda University Health

Inventor： Salvador Soriano ,  Michael Castello

IPC: C12Q1/6883 ,  G01N33/68 ,  A61B5/00 ,  G01N33/50

CPC classification number: C12Q1/6883 ,  A61B5/00 ,  G01N33/5023 ,  G01N33/6896 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2500/10 ,  G01N2800/2821 ,  G01N2800/50 ,  G01N2800/52

Abstract: In one aspect, methods of diagnosing a subject as having Alzheimer's disease and prognosing a subject as being at risk of progressing to Alzheimer's disease are provided. In some embodiments, the method comprises determining one or more of the level of expression of rhotekin 2 (RTKN2), the level of expression of microtubule-associated Ser/Thr kinase 4 (MAST4), the level of binding of forkhead box O1 (FOXO1) to the RTKN2 promoter, and the level of binding of amyloid precursor protein (APP) to the MAST4 promoter in a sample from the subject.

公开(公告)号：US20230338169A1

公开(公告)日：2023-10-26

申请号：US18041250

申请日：2021-08-10

Applicant: LOMA LINDA UNIVERSITY HEALTH

Inventor： Chelsie K. Rodgers ,  Abraham Castillo ,  Michael Davidson

IPC: A61F2/70 ,  A61F2/66

CPC classification number: A61F2/70 ,  A61F2/66 ,  A61F2002/708

Abstract: A device for harvesting electrical energy from movement of a prosthetic limb. The device including a generator and a controller. The generator adapted to attach to a prosthetic limb. The generator comprising a magnetic linear motor that is configured to generate electrical energy in response to movement of a portion of the prosthetic limb. The controller is electrically connected to the generator and configured to provide electrical energy to a power supply of the prosthetic limb.

公开(公告)号：US20230301805A1

公开(公告)日：2023-09-28

申请号：US18040946

申请日：2021-08-06

Applicant: LOMA LINDA UNIVERSITY HEALTH

Inventor： Spencer Cutting ,  Michael Moor

IPC: A61F2/66 ,  A61F2/70

CPC classification number: A61F2/6607 ,  A61F2/70 ,  A61F5/0111

Abstract: The present disclosure relates to an orthotic (or brace) and/or prosthetic ankle joint and associated methods adapted to enable adjustment of a talus section or ankle portion or brace with respect to a tibial section of the orthotic (or brace) and/or prosthetic ankle joint. The talus section or ankle portion of the orthotic (or brace) and/or prosthetic ankle joint is movably coupled to the tibial section with the alignment between the talus section and tibial section being adjustable between various positions by disengagement or engagement of a lock of an adjustment mechanism. As the lock is disengaged, the talus section is enabled to pivot with respect to the tibial section in at least one direction as the user moves along a slope.

公开(公告)号：US20200009289A1

公开(公告)日：2020-01-09

申请号：US16490657

申请日：2018-03-02

Applicant: LOMA LINDA UNIVERSITY HEALTH

Inventor： Mahmoud TORABINEJAD ,  Richard MASKIEWICZ

IPC: A61L15/42 ,  A61L15/44 ,  A61L15/26 ,  C08J9/40 ,  A61L15/18

Abstract: In one aspect, compositions for promoting hemostasis are provided. In some embodiments, the composition comprises a porous non-fibrous substrate impregnated with a hemostatic agent, wherein the porous non-fibrous substrate comprises a hydrophilic polyurethane foam. Methods of promoting hemostasis in a subject using such compositions, and methods of manufacturing such compositions, are also provided.