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公开(公告)号：US20240339218A1
公开(公告)日：2024-10-10
申请号：US18681425
申请日：2022-08-03
IPC分类号： G16H50/20 , C12Q1/18 , C12Q1/686 , C12Q1/689 , G01N21/65 , G16B25/20 , G16B40/10 , G16H10/60 , G16H20/10
CPC分类号： G16H50/20 , C12Q1/18 , C12Q1/686 , C12Q1/689 , G01N21/65 , G16B25/20 , G16B40/10 , G16H10/60 , G16H20/10
摘要： A sepsis detection system includes a first subsystem configured to detect a presence of an infection in a patient, a second subsystem configured to detect a presence of a dysregulated host response in the patient, a third subsystem configured to detect organ dysfunction in the patient, a fourth subsystem configured to detect antimicrobial resistance (AMR) of a pathogen in the patient, and a processing device. The first, second, third, and fourth subsystems and the processing device are communicatively coupled together via a network. The processing device is configured to determine a presence of sepsis in the patient based on the presence of the infection, the presence of the dysregulated host response, and clinical data indicative of the organ dysfunction in the patient. The subsystems utilize at least one of polymerase chain reaction (PCR) processing. Raman spectroscopy, clinical data, electronic health record (EHR) data, and antimicrobial susceptibility testing (AST).
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公开(公告)号：US20240312569A1
公开(公告)日：2024-09-19
申请号：US18605589
申请日：2024-03-14
发明人： MIE OKANO , ICHIRO HARADA , YOJI YAMAMOTO , YASUO SAKURAI
CPC分类号： G16B40/10 , C12N5/0696 , G01N21/6486
摘要： Provided is a method of stably reprogramming a cell. Provided is an information processing method for reprogramming of a blood cell, the information processing method including an autofluorescence information acquisition step of acquiring autofluorescence information on a subject blood cell and an analysis step of performing analysis based on the autofluorescence information and cell information on the subject blood cell, in which the cell information includes identification information on the blood cell.
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公开(公告)号：US12091702B2
公开(公告)日：2024-09-17
申请号：US16708417
申请日：2019-12-09
申请人： BIOMERIEUX, INC.
IPC分类号： C12Q1/04 , C12Q1/6872 , G01N33/483 , G01N33/68 , G06F18/2411 , G06F18/2413 , G06F18/2415 , G06V20/69 , G16B40/00 , G16B40/10 , G16B40/20 , H01J49/00 , H01J49/26
CPC分类号： C12Q1/04 , C12Q1/6872 , G01N33/483 , G01N33/6848 , G06F18/2411 , G06F18/2413 , G06F18/24155 , G06V20/698 , G16B40/00 , G16B40/10 , G16B40/20 , H01J49/0036 , H01J49/26
摘要： An identification by mass spectrometry of a microorganism from among reference microorganisms represented by reference data sets includes: determining a set of data of the microorganism according to a spectrum; for each reference microorganism, calculating a distance between the determined and reference sets; and calculating a probability ƒ(m) according to relation
f
(
m
)
=
pN
(
m
|
μ
,
σ
)
pN
(
m
|
μ
,
σ
)
+
(
1
-
p
)
N
(
m
|
μ
_
,
σ
_
)
where: m is the distance calculated for the reference microorganism; N(m|μ,σ) is the value, for m, of a random variable modeling the distance between a reference microorganism to be identified and the reference microorganism, when the microorganism is the reference microorganism; N(m|μ,σ) is the value, for m, of a random variable modeling the distance between a microorganism to be identified and the reference microorganism, when the microorganism is not the reference microorganism; and p is a scalar in the range from 0 to 1.-
公开(公告)号：US20240294978A1
公开(公告)日：2024-09-05
申请号：US18441809
申请日：2024-02-14
发明人： Stuart Lindsay
IPC分类号： C12Q1/6869 , C12Q1/00 , G01N27/12 , G01N33/487 , G16B30/20 , G16B40/10
CPC分类号： C12Q1/6869 , C12Q1/005 , G01N33/48721 , G16B30/20 , G16B40/10 , G01N27/125
摘要： The present disclosure provides devices, systems, and methods related to sequencing a biopolymer. In particular, the present disclosure provides methods of obtaining a bioelectronic signature based on current fluctuations that correspond to the activity of an enzyme-of-interest. As described herein, certain aspects of the bioelectronic signature can be used to determine the sequence of a biopolymer.
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公开(公告)号：US12065696B2
公开(公告)日：2024-08-20
申请号：US18104727
申请日：2023-02-01
发明人： Darrell Orlyn Ricke , James Harper , Brian S. Helfer , Joseph Isaacson , Adam M. Michaleas , Martha S. Petrovick , Eric Schwoebel , Anna Shcherbina , Philip Fremont-Smith , James G. Watkins , Edward C. Wack
IPC分类号： C12Q1/68 , C12Q1/6858 , C12Q1/6869 , C12Q1/6886 , G16B20/00 , G16B40/10
CPC分类号： C12Q1/6858 , C12Q1/6869 , C12Q1/6886 , G16B20/00 , G16B40/10 , C12Q2600/156
摘要： The disclosure provides various systems and methods for identifying individuals from one or more samples. In particular, improved systems and methods of analysis are provided for handling multiple contributors, as well as systems and methods that model not only individual error rates per locus but factor in amplification of errors induced through PCR cycles. In some embodiments, modeling of error rates can be applied in multi-contributor settings to more accurately establish real alleles from artifacts. Other aspects involve application of sequencing in error modeling. Further, methods are provided for determining the presence of common individual DNA profiles in one or more complex DNA mixtures and for deconvolution of multiple complex DNA mixtures into shared individual components. The methods of the disclosure do not require any prior knowledge of individual DNA profiles or contributors to the complex DNA mixtures. Moreover, the methods of the disclosure may use any SNP panel, including those panels already existing and those panels specifically designed to maximize performance characteristics of the methods described herein.
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公开(公告)号：US20240272169A1
公开(公告)日：2024-08-15
申请号：US18598736
申请日：2024-03-07
发明人： Brian Reed , Jeremy Lackey , Haidong Huang
IPC分类号： G01N33/58 , C07K14/47 , C07K19/00 , C12Q1/6806 , G01N1/28 , G01N21/64 , G01N33/68 , G16B25/10 , G16B30/00 , G16B40/00 , G16B40/10 , G16B50/00 , G16B50/30
CPC分类号： G01N33/581 , C07K14/47 , C07K19/00 , C12Q1/6806 , G01N1/28 , G01N21/6428 , G01N33/58 , G01N33/582 , G01N33/6821 , G01N33/6824 , G16B25/10 , G16B40/00 , G16B40/10 , G16B50/30 , G01N2021/6439 , G01N2458/00 , G16B30/00 , G16B50/00
摘要： Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
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公开(公告)号：US12061204B2
公开(公告)日：2024-08-13
申请号：US17231977
申请日：2021-04-15
发明人： Joshua Coon , Harald Marx
CPC分类号： G01N33/6848 , G01N33/6824 , G01N33/6842 , G16B30/00 , G16B30/20 , G16B40/00 , G16B40/10 , G16B40/30 , H01J49/0036 , H01J49/004 , G01N2570/00
摘要： In shotgun proteomics, generally only a fraction of peptides from a parent protein are actually detected. Because a large portion of the protein sequence is not detected, it is often impossible to determine whether the expressed protein is present in a modified, spliced, or truncated form. Provided herein are methods and systems for analyzing polypeptides which allow for the increase of the mean sequence coverage of a protein concomitant with bioinformatics analysis in order to distinguish putative proteoforms with improved amino acid resolution. Aspects of the invention include (1) a deep sequencing strategy to provide more protein sequence coverage than is typically achieved, and (2) a computational approach to view protein expression across its full length and identify regions of the protein that are potentially subject to such regulation. This technology has global utility in proteomics and will be of particular use for the analysis of biosimilar protein drug therapeutics.
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公开(公告)号：US12055548B2
公开(公告)日：2024-08-06
申请号：US16709077
申请日：2019-12-10
发明人： Brian Reed , Jeremy Lackey , Haidong Huang
IPC分类号： A61K38/00 , C07K14/47 , C07K19/00 , C12Q1/6806 , G01N1/28 , G01N21/64 , G01N33/58 , G01N33/68 , G16B25/10 , G16B40/00 , G16B40/10 , G16B50/30 , G16B30/00 , G16B50/00
CPC分类号： G01N33/581 , C07K14/47 , C07K19/00 , C12Q1/6806 , G01N1/28 , G01N21/6428 , G01N33/58 , G01N33/582 , G01N33/6821 , G01N33/6824 , G16B25/10 , G16B40/00 , G16B40/10 , G16B50/30 , G01N2021/6439 , G01N2458/00 , G16B30/00 , G16B50/00
摘要： Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
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公开(公告)号：US20240254561A1
公开(公告)日：2024-08-01
申请号：US18527076
申请日：2023-12-01
发明人： Felix J. Kim , Halley Oyer , John Vaillancourt
IPC分类号： C12Q1/6886 , A61K31/155 , A61K31/4745 , A61K45/06 , A61P35/00 , G16B40/10 , G16H50/20
CPC分类号： C12Q1/6886 , A61K31/155 , A61K31/4745 , A61P35/00 , G16B40/10 , G16H50/20 , A61K45/06
摘要： Methods and uses of using Sigma1 inhibitors are provide herein, including diagnostic methods for predicting or identifying quantitatively whether a human tumor is responsive or non-responsive to treatment with Sigma1 inhibition are also provided.
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公开(公告)号：US20240242780A1
公开(公告)日：2024-07-18
申请号：US18619978
申请日：2024-03-28
申请人： FUJIFILM Corporation
发明人： Ryo SHIMURA , Kengo GOTO , Masahiro SATO
摘要： The present disclosure enables to accurately extract a signal derived from a tumor cell from data in which a signal derived from a non-tumor cell is mixed. According to an aspect of the present invention, there is provided a data processing method executed by a data processing apparatus including a processor. The data processing method including causing the processor to execute: an input step of inputting first DNA profile data obtained by measuring a sample including a tumor cell and a plurality of known non-tumor cells; a signal removal step of removing a signal derived from the non-tumor cell, which is mixed in the input first DNA profile data, to acquire only a signal derived from the tumor cell; and an output step of outputting the signal derived from the tumor cell as a DNA profile feature amount of the sample.
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