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公开(公告)号：US10546735B2
公开(公告)日：2020-01-28
申请号：US14361885
申请日：2012-11-30
申请人： bioMerieux, Inc.
IPC分类号： H01J49/00 , G01N33/483 , H01J49/26
摘要： An identification by mass spectrometry of a microorganism from among reference microorganisms represented by reference data sets includes: determining a set of data of the microorganism according to a spectrum; for each reference microorganism, calculating a distance between the determined and reference sets; and calculating a probability f(m) according to relation f ( m ) = pN ( m ❘ μ , σ ) pN ( m ❘ μ , σ ) + ( 1 - p ) N ( m ❘ μ _ , σ _ ) where: m is the distance calculated for the reference microorganism; N(m|μ,σ) is the value, for m, of a random variable modeling the distance between a reference microorganism to be identified and the reference microorganism, when the microorganism is the reference microorganism; N(m|μ,σ) is the value, for m, of a random variable modeling the distance between a microorganism to be identified and the reference microorganism, when the microorganism is not the reference microorganism; and p is a scalar in the range from 0 to 1.
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公开(公告)号：US10541119B2
公开(公告)日：2020-01-21
申请号：US14361794
申请日：2012-11-30
申请人： Biomerieux, Inc.
摘要： A method of identifying a microorganism by mass spectrometry, including acquiring at least one mass spectrum of said microorganism; for each acquired mass spectrum: detecting peaks of the spectrum in a predetermined mass range; generating a list of peaks identifying at most one peak in each interval of a predetermined subdivision of the range of mass-to-charge ratios, the width of the intervals of the subdivision logarithmically increasing along with the mass-to-charge ratio, and analyzing the list(s) of peaks obtained according to a knowledge base of previously-identified microorganisms and/or types of microorganisms.
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3.发明申请METHOD FOR IDENTIFYING MICROORGANISMS VIA MASS SPECTROMETRY AND SCORE NORMALIZATION 审中-公开通过质谱分析和分辨率正常化识别微生物的方法公开(公告)号：US20140343864A1
公开(公告)日：2014-11-20
申请号：US14361885
申请日：2012-11-30
申请人： bioMerieux, Inc.
IPC分类号： H01J49/00 , G01N33/483
CPC分类号： H01J49/0036 , C12Q1/04 , G01N33/483 , G01N33/6848 , G06K9/00147 , G06K9/6269 , G06K9/627 , G06K9/6278 , H01J49/26
摘要： An identification by mass spectrometry of a microorganism from among reference microorganisms represented by reference data sets includes: determining a set of data of the microorganism according to a spectrum; for each reference microorganism, calculating a distance between the determined and reference sets; and calculating a probability f(m) according to relation f ( m ) = pN ( m μ , σ ) pN ( m μ , σ ) + ( 1 - p ) N ( m μ _ , σ _ ) where: m is the distance calculated for the reference microorganism; N(m|μ,σ) is the value, for m, of a random variable modeling the distance between a reference microorganism to be identified and the reference microorganism, when the microorganism is the reference microorganism; N(m| μ, σ) is the value, for m, of a random variable modeling the distance between a microorganism to be identified and the reference microorganism, when the microorganism is not the reference microorganism; and p is a scalar in the range from 0 to 1.
摘要翻译： 通过参考数据组所表示的参考微生物中的微生物的质谱鉴定包括：根据光谱确定微生物的一组数据; 对于每个参考微生物，计算所确定的和参考组之间的距离; 并且根据关系式（m）= pN（mμ，＆sgr;）pN（mμ，＆sgr）+（1-p）N（mμ）计算概率f（m） _，＆sgr; _）其中：m是参考微生物计算的距离; 当微生物是参照微生物时，N（m |μ，＆sgr;）是m的值，用于建立待鉴定的参考微生物与参照微生物之间的距离的随机变量; N（m |μ，＆sgr;）是当微生物不是参照微生物时，随机变量建模待鉴定微生物与参照微生物之间的距离的m值; p是0到1范围内的标量。
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公开(公告)号：US12091702B2
公开(公告)日：2024-09-17
申请号：US16708417
申请日：2019-12-09
申请人： BIOMERIEUX, INC.
IPC分类号： C12Q1/04 , C12Q1/6872 , G01N33/483 , G01N33/68 , G06F18/2411 , G06F18/2413 , G06F18/2415 , G06V20/69 , G16B40/00 , G16B40/10 , G16B40/20 , H01J49/00 , H01J49/26
CPC分类号： C12Q1/04 , C12Q1/6872 , G01N33/483 , G01N33/6848 , G06F18/2411 , G06F18/2413 , G06F18/24155 , G06V20/698 , G16B40/00 , G16B40/10 , G16B40/20 , H01J49/0036 , H01J49/26
摘要： An identification by mass spectrometry of a microorganism from among reference microorganisms represented by reference data sets includes: determining a set of data of the microorganism according to a spectrum; for each reference microorganism, calculating a distance between the determined and reference sets; and calculating a probability ƒ(m) according to relation
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where: m is the distance calculated for the reference microorganism; N(m|μ,σ) is the value, for m, of a random variable modeling the distance between a reference microorganism to be identified and the reference microorganism, when the microorganism is the reference microorganism; N(m|μ,σ) is the value, for m, of a random variable modeling the distance between a microorganism to be identified and the reference microorganism, when the microorganism is not the reference microorganism; and p is a scalar in the range from 0 to 1.-
公开(公告)号：US20140358449A1
公开(公告)日：2014-12-04
申请号：US14361794
申请日：2012-11-30
申请人： BIOMERIEUX, INC.
摘要： A method of identifying a microorganism by mass spectrometry, including acquiring at least one mass spectrum of said microorganism; for each acquired mass spectrum: detecting peaks of the spectrum in a predetermined mass range; generating a list of peaks identifying at most one peak in each interval of a predetermined subdivision of the range of mass-to-charge ratios, the width of the intervals of the subdivision logarithmically increasing along with the mass-to-charge ratio, and analyzing the list(s) of peaks obtained according to a knowledge base of previously-identified microorganisms and/or types of microorganisms.
摘要翻译： 一种通过质谱鉴定微生物的方法，包括获取所述微生物的至少一个质谱; 对于每个获得的质谱：检测在预定质量范围内的光谱的峰值; 产生在质量 - 电荷比范围的预定细分的每个间隔中至多标识一个峰的峰列表，细分间隔的宽度与质荷比对数增加，并分析 根据先前确定的微生物和/或微生物类型的知识库获得的峰的列表。
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