公开(公告)号：US10311205B2

公开(公告)日：2019-06-04

申请号：US14107668

申请日：2013-12-16

Applicant: Roche Molecular Systems, Inc.

Inventor： Paul Frank ,  Sascha Roehrig ,  Stephan Schweighauser

IPC: G01N33/48 ,  G06F19/10 ,  G16H40/40 ,  G16H10/40 ,  G06G7/58

Abstract: An analysis system for biological samples is disclosed that includes at least one analyzer with an analytical unit for analyzing the biological samples and an analyzer controller. The analysis system further includes an analyzer data management system (ADMS) operable for receiving a selection of an operating environment chosen from multiple operating environments. In some embodiments, an analytical system is provided which offers a switch between sample testing and software validation on the same hardware, thereby offering efficiency and flexibility. For example, if sample testing is typically restricted to a particular time of the day (e.g., blood banks often get their samples in the evening and conduct the sample testing at night), the daytime hours can be used to validate new software. In such a case, additional instruments for software validation are not required and expensive idle times of analytical systems are reduced.

公开(公告)号：US20190056380A1

公开(公告)日：2019-02-21

申请号：US15981798

申请日：2018-05-16

Applicant: UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK

Inventor： Louise Kenny ,  Philip Newton Baker ,  David Broadhurst

IPC: G01N33/493 ,  G06F19/10 ,  G01N33/68 ,  G06F19/24

CPC classification number: G01N33/493 ,  G01N33/689 ,  G01N2800/368 ,  G01N2800/50 ,  G16B40/00 ,  G16B99/00

Abstract: A method for the early prediction of risk of hypertensive disorders in pregnant women, including for example eclampsia, mild pre-eclampsia, chronic hypertension, EPH gestosis, gestational hypertension, superimposed pre-eclampsia, HELLP syndrome, or nephropathy.

公开(公告)号：US10141073B2

公开(公告)日：2018-11-27

申请号：US13720593

申请日：2012-12-19

Applicant: Elwha LLC

Inventor： Hon Wah Chin ,  Roderick A. Hyde ,  Robert C. Petroski ,  Lowell L. Wood, Jr.

IPC: G06F19/10 ,  G16H40/63 ,  G06F19/00

Abstract: Systems and methods are described for controlling acquisition of sensor information, including: one or more physiological sensors and a computing device including a processor programmed to query the physiological sensors to measure one or more physiological parameters of an individual in response to at least one flag indicating a need to measure the one or more physiological parameters; receive a set of sensor values from the physiological sensors; assign a quality value to the set of sensor values received from the physiological sensors; retain the set of sensor values if the assigned quality value of the set of sensor values meets or exceeds a minimum quality value threshold; and update the at least one flag if the assigned quality value of the set of sensor values meets or exceeds the minimum quality value threshold.

公开(公告)号：US20180298435A1

公开(公告)日：2018-10-18

申请号：US15755957

申请日：2016-07-05

Applicant: Hitachi, Ltd.

Inventor： Junko TANAKA ,  Yoshinobu KOHARA ,  Kunio HARADA ,  Yu ISHIGE

IPC: C12Q1/6869 ,  C12M1/00 ,  G06F19/10 ,  B01J19/00

Abstract: The present invention was made to provide novel methods for detecting DNA and devices therefor. Specifically, the present invention is a method of detecting DNA including the steps of: adding, to an oil, a fluorescently-labeled probe, a DNA intercalator, and a DNA solution containing a target DNA to produce droplets; performing PCR on the droplets; and measuring fluorescence from the fluorescently-labeled probe and fluorescence from the DNA intercalator, wherein the DNA solution has a concentration at which each droplet is produced so as to contain one or less target DNA molecule. In addition, the present invention is a DNA detection device including a droplet production unit, a thermal cycler unit, and a fluorescence detection unit which perform these steps.

公开(公告)号：US10083275B2

公开(公告)日：2018-09-25

申请号：US13713970

申请日：2012-12-13

Applicant: International Business Machines Corporation

Inventor： Niina S. Haiminen ,  Laxmi P. Parida

IPC: G06F19/10 ,  G06F19/22

CPC classification number: G16B30/00

Abstract: Various embodiments perform stable gene analysis of transcriptome sequencing data. In one embodiment, a plurality of datasets each including transcriptome sequencing data are received by a processor. Each of the plurality of datasets includes a plurality of genes and a respective ranking value for each of the plurality of genes. A plurality of rank normalized input datasets is generated based on assigning, for each of the plurality of datasets, a rank to each of the plurality of genes. One or more longest increasing subsequence (LIS) of ranks are identified between each pair of the plurality of rank normalized input datasets. A set of stable genes from the plurality of genes is identified based on each of the one or more LIS of ranks across the plurality of rank normalized input datasets.

公开(公告)号：US10061887B2

公开(公告)日：2018-08-28

申请号：US13607587

申请日：2012-09-07

Applicant: Vivek K. Vishnudas ,  Rangaprasad Sarangarajan ,  Niven Rajin Narain ,  Min Du ,  Tony Walshe

Inventor： Vivek K. Vishnudas ,  Rangaprasad Sarangarajan ,  Niven Rajin Narain ,  Min Du ,  Tony Walshe

IPC: G06F19/10 ,  G06F19/12 ,  C12Q1/02 ,  G01N33/50 ,  G01N33/68

CPC classification number: G16B5/00 ,  C12Q1/025 ,  G01N33/5008 ,  G01N33/68

Abstract: Described herein are methods for identifying a modulator of a biological system. Some methods include establishing a model for the biological system comprising cells, obtaining a first data set representing global proteomic in the cells, and obtaining a second data set representing one or more functional activities or cellular responses of the cells including global enzymatic activity and/or an effect of the global enzyme activity on the enzyme metabolites or substrates in the cells. The method also includes generating a consensus causal relationship network among the global proteomic changes and the one or more functional activities or cellular responses based solely on the first and second data sets using a programmed computing device, and identifying a causal relationship unique in the biological system from the consensus causal relationship network, wherein at least one enzyme associated with the unique causal relationship is identified as a modulator of the biological system.

公开(公告)号：US10055539B2

公开(公告)日：2018-08-21

申请号：US14798686

申请日：2015-07-14

Applicant: Seven Bridges Genomics Inc.

Inventor： Deniz Kural ,  Nathan Meyvis

IPC: G06F19/10 ,  G06F19/22 ,  G06F19/28

CPC classification number: G16B30/00 ,  G16B50/00 ,  G16H50/00

Abstract: Methods of analyzing a transcriptome that involves obtaining at least one pair of paired-end reads from a transcriptome from an organism, finding an alignment with an optimal score between a first read of the pair and a node in a directed acyclic data structure (the data structure has nodes representing RNA sequences such as exons or transcripts and edges connecting pairs of nodes), identifying candidate paths that include the node connected to a downstream node by a path having a length substantially similar to an insert length of the pair of paired-end reads, and aligning the paired-end rends to the candidate paths to determine an optimal-scoring alignment.

公开(公告)号：US10045720B2

公开(公告)日：2018-08-14

申请号：US15294683

申请日：2016-10-15

Applicant: Abbott Diabetes Care Inc.

Inventor： Gary Alan Hayter ,  Geoffrey V. McGarraugh

IPC: A61B5/145 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/00 ,  G06F19/10 ,  A61M5/172 ,  G16H40/63

Abstract: Methods and apparatus for providing data processing and control for use in a medical communication system are provided.

公开(公告)号：US10006148B2

公开(公告)日：2018-06-26

申请号：US14444973

申请日：2014-07-28

Applicant: QIAGEN Redwood City, Inc.

Inventor： Richard O. Chen ,  Raymond J. Cho ,  Ramon M. Felciano ,  Bret Holley ,  Viresh Patel ,  Daniel R. Richards ,  Sushma Selvarajan ,  Keith Steward ,  Sara Tanenbaum Schneider

IPC: G06F19/10 ,  C40B30/02 ,  G06F19/12 ,  G06F19/22 ,  G06F19/20

CPC classification number: G16B35/00 ,  G16B5/00 ,  G16B25/00 ,  G16B30/00 ,  G16C20/60

Abstract: Methods for identifying disease-related pathways that can be used to identify drug discovery targets, to identify new uses for known drugs, to identify markers for drug response, and related purposes.

公开(公告)号：US20180128735A1

公开(公告)日：2018-05-10

申请号：US15868025

申请日：2018-01-11

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Dino Di Carlo ,  Daniel R. Gossett ,  Henry T.K. Tse

IPC: G01N15/14 ,  G06F19/10 ,  B01L3/00 ,  C12Q1/02 ,  G01N33/487 ,  G01N33/574 ,  G01N15/10 ,  G01N15/00

CPC classification number: G01N15/1463 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502776 ,  B01L2200/0605 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2300/0654 ,  B01L2300/0864 ,  C12Q1/02 ,  G01N15/1404 ,  G01N15/1459 ,  G01N15/1484 ,  G01N33/487 ,  G01N33/574 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1415 ,  G01N2015/149 ,  G01N2015/1495 ,  G01N2015/1497 ,  G01N2800/7028 ,  G16B99/00

Abstract: A system is disclosed that enables the automated measurement of cellular mechanical parameters at high throughputs. The microfluidic device uses intersecting flows to create an extensional flow region where the cells undergo controlled stretching. Cells are focused into streamlines prior to entering the extensional flow region. In the extensional region, each cell's deformation is measured with an imaging device. Automated image analysis extracts a range of independent biomechanical parameters from the images. These may include cell size, deformability, and circularity. The single cell data that is obtained may then be used to in a variety of ways. Scatter density plots of deformability and circularity may be developed and displayed for the user. Mechanical parameters such as deformability and circularity may be gated or thresholded to identify certain cells of interest or sub-populations of interest. Similarly, the mechanical data obtained using the device may be used as cell signatures.