公开(公告)号：US20150219637A1

公开(公告)日：2015-08-06

申请号：US14615283

申请日：2015-02-05

Applicant: Roche Molecular Systems, Inc.

Inventor： Roman Egli ,  Alan Furlan ,  Sascha Roehrig

IPC: G01N33/543 ,  C12Q1/68

CPC classification number: G01N33/5434 ,  C12Q1/6834 ,  C12Q1/6837

Abstract: An analytical processing and detection device is described which comprises a rack capable of holding at least one reaction receptacle, at least one magnetic unit for exerting a magnetic field on at least one reaction receptacle comprising magnetic particles in a fluid, wherein said at least one magnetic unit is reversibly or irreversibly connected to said rack, and wherein said magnetic field causes the magnetic particles to be sequestered to the side walls of said at least one reaction receptacle, and a detection unit for detecting a signal in the fluid in said reaction receptacle.

Abstract translation: 描述了一种分析处理和检测装置，其包括能够保持至少一个反应容器的架，至少一个磁性单元，用于在包含流体中的磁性颗粒的至少一个反应容器上施加磁场，其中所述至少一个磁 单元可逆地或不可逆地连接到所述机架，并且其中所述磁场使得磁性颗粒被隔离到所述至少一个反应容器的侧壁，以及检测单元，用于检测所述反应容器中的流体中的信号。

公开(公告)号：US20130302786A1

公开(公告)日：2013-11-14

申请号：US13873507

申请日：2013-04-30

Applicant: Roche Molecular Systems, Inc.

Inventor： Leif Kuehler ,  Vijay Namasivayam ,  Michael Riedling ,  Sascha Roehrig ,  Christian Simon ,  Dirk Zimmermann

IPC: C12Q1/68 ,  C12Q1/70

CPC classification number: C12Q1/6846 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q1/70 ,  C12Q2531/113 ,  C12Q2537/143 ,  C12Q2545/113

Abstract: Methods and kits are provided for detecting or quantitating at least two different target nucleic acids using a single positive control stock solution comprising a mixture of positive control nucleic acids for the different target nucleic acids to be detected or quantitated.

Abstract translation: 提供了用于使用包含用于待检测或定量的不同靶核酸的阳性对照核酸的混合物的单一阳性对照储备溶液来检测或定量至少两种不同靶核酸的方法和试剂盒。

公开(公告)号：US20140370609A1

公开(公告)日：2014-12-18

申请号：US14244059

申请日：2014-04-03

Applicant: Roche Molecular Systems, Inc.

Inventor： Paul Frank ,  Christopher Newhouse ,  Sascha Roehrig

IPC: G01N35/00

Abstract: The invention provides for an analysis system (100, 300, 400) for analyzing a biological sample (108) comprising an analyzer (102) with an analytical unit (106) for analyzing the biological sample to obtain an analysis result (140). The analyzer is configured for receiving a cartridge (110) comprising an identifier (114) and containing at least one reagent for analyzing the biological sample. The analyzer comprises an identification unit (116) for reading the identifier. The analyzer accepts the cartridge if the identifier is valid. The analysis system further comprises a protocol creation system (150, 104). Instructions cause the protocol creation system to: receive (200) analysis protocol parameters (164) from a user interface (158); generate (202) a custom analysis protocol (138) using the analysis protocol parameters; link (204) the custom analysis protocol to an invalid identifier which changes the invalid identifier into a valid identifier, and transfer (206) the user created analysis protocol associated with the now valid identifier to the analyzer controller.

Abstract translation: 本发明提供一种分析系统（100,300,400），用于使用分析单元（106）分析包含分析器（102）的生物样品（108），用于分析生物样品以获得分析结果（140）。 分析器被配置为用于接收包括标识符（114）并且包含用于分析生物样品的至少一种试剂的盒（110）。 分析器包括用于读取标识符的识别单元（116）。 如果标识符有效，则分析仪接受墨盒。 分析系统还包括协议创建系统（150,104）。 指令使协议创建系统从用户接口（158）接收（200）分析协议参数（164）; 使用分析协议参数生成（202）定制分析协议（138）; 将定制分析协议链接（204）到将无效标识符变为有效标识符的无效标识符，并将与现有有效标识符相关联的用户创建的分析协议（206）传送（206）到分析器控制器。

公开(公告)号：US20140180601A1

公开(公告)日：2014-06-26

申请号：US14107668

申请日：2013-12-16

Applicant: Roche Molecular Systems, Inc.

Inventor： Paul Frank ,  Sascha Roehrig ,  Stephan Schweighauser

IPC: G06F19/10

CPC classification number: G06F19/10 ,  G06F19/00 ,  G16H10/40 ,  G16H40/40

Abstract: An analysis system for biological samples is disclosed that includes at least one analyzer with an analytical unit for analyzing the biological samples and an analyzer controller. The analysis system further includes an analyzer data management system (ADMS) operable for receiving a selection of an operating environment chosen from multiple operating environments. In some embodiments, an analytical system is provided which offers a switch between sample testing and software validation on the same hardware, thereby offering efficiency and flexibility. For example, if sample testing is typically restricted to a particular time of the day (e.g., blood banks often get their samples in the evening and conduct the sample testing at night), the daytime hours can be used to validate new software. In such a case, additional instruments for software validation are not required and expensive idle times of analytical systems are reduced.

Abstract translation: 公开了一种用于生物样品的分析系统，其包括至少一个具有用于分析生物样品的分析单元的分析器和分析仪控制器。 分析系统还包括分析器数据管理系统（ADMS），其可操作用于接收从多个操作环境中选择的操作环境的选择。 在一些实施例中，提供了一种分析系统，其提供在相同硬件上的样本测试和软件验证之间的切换，从而提供效率和灵活性。 例如，如果样品测试通常限于一天的特定时间（例如，血库经常在晚上获取样品并在晚上进行样品测试），则可以使用白天时间来验证新的软件。 在这种情况下，不需要用于软件验证的附加工具，并且降低了分析系统的昂贵的空闲时间。

公开(公告)号：US10416177B2

公开(公告)日：2019-09-17

申请号：US14244059

申请日：2014-04-03

Applicant: Roche Molecular Systems, Inc.

Inventor： Paul Frank ,  Christopher Newhouse ,  Sascha Roehrig

IPC: G01N35/00 ,  G16H10/40

Abstract: The invention provides for an analysis system (100, 300, 400) for analyzing a biological sample (108) comprising an analyzer (102) with an analytical unit (106) for analyzing the biological sample to obtain an analysis result (140). The analyzer is configured for receiving a cartridge (110) comprising an identifier (114) and containing at least one reagent for analyzing the biological sample. The analyzer comprises an identification unit (116) for reading the identifier. The analyzer accepts the cartridge if the identifier is valid. The analysis system further comprises a protocol creation system (150, 104). Instructions cause the protocol creation system to: receive (200) analysis protocol parameters (164) from a user interface (158); generate (202) a custom analysis protocol (138) using the analysis protocol parameters; link (204) the custom analysis protocol to an invalid identifier which changes the invalid identifier into a valid identifier, and transfer (206) the user created analysis protocol associated with the now valid identifier to the analyzer controller.

公开(公告)号：US10311205B2

公开(公告)日：2019-06-04

申请号：US14107668

申请日：2013-12-16

Applicant: Roche Molecular Systems, Inc.

Inventor： Paul Frank ,  Sascha Roehrig ,  Stephan Schweighauser

IPC: G01N33/48 ,  G06F19/10 ,  G16H40/40 ,  G16H10/40 ,  G06G7/58

Abstract: An analysis system for biological samples is disclosed that includes at least one analyzer with an analytical unit for analyzing the biological samples and an analyzer controller. The analysis system further includes an analyzer data management system (ADMS) operable for receiving a selection of an operating environment chosen from multiple operating environments. In some embodiments, an analytical system is provided which offers a switch between sample testing and software validation on the same hardware, thereby offering efficiency and flexibility. For example, if sample testing is typically restricted to a particular time of the day (e.g., blood banks often get their samples in the evening and conduct the sample testing at night), the daytime hours can be used to validate new software. In such a case, additional instruments for software validation are not required and expensive idle times of analytical systems are reduced.

公开(公告)号：US20130157273A1

公开(公告)日：2013-06-20

申请号：US13714243

申请日：2012-12-13

Applicant: Roche Molecular Systems, Inc.

Inventor： Paul Frank ,  Andreas Gisler ,  Alfred Moertlseder ,  Sascha Roehrig

IPC: C12Q1/68

CPC classification number: C12Q1/6806 ,  G01N35/0092 ,  G16B99/00 ,  G16H10/40

Abstract: A Method for nucleic acid analysis involving the steps of receiving sample tubes which contain samples, receiving a test request for each sample (the test request specifying one or more assays to be conducted for said sample), obtaining one or more sample aliquots of each sample depending on if one or more assays are to be conducted, assigning each of the sample aliquots to one or more test classes according to the assay which is to be conducted for that sample aliquot and combining sample aliquots belonging to the same test class into the same batch, while the batch includes samples for which a first and samples for which a second assay is to be conducted.

Abstract translation: 一种用于核酸分析的方法，其包括以下步骤：接收含有样品的样品管，接收每个样品的测试要求（指定针对所述样品进行一个或多个测定的测试要求），获得每个样品的一个或多个样品等分试样 取决于是否进行一个或多个测定，根据将要对该样品等分试样进行的测定将样品等分试样分配到一个或多个测试类别，并将属于相同测试类的样品等分试样合并到同一试样中 批次，而批次包括样品，其中将进行第一次测定和第二次测定的样品。