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公开(公告)号：US11373760B2
公开(公告)日：2022-06-28
申请号：US16600479
申请日：2019-10-12
IPC分类号： G06G7/58 , G16H50/70 , G06K9/62 , G06N20/00 , G06F16/245 , G06F30/20 , G16H10/20 , G06N3/00 , G16B40/00 , G16B50/00 , G06F111/14
摘要： A machine learning system receives a witness function that is determined based on an initial sample of a dataset comprising multiple pairs of stimuli and responses. Each stimulus includes multiple features. The system receives a holdout sample of the dataset comprising one or more pairs of stimuli and responses that are not used to determine the witness function. The system generates a simulated sample based on the holdout sample. Values of a particular feature of the stimuli of the simulated sample are predicted based on values of features other than the particular feature of the stimuli of the simulated sample. The system applies the holdout sample to the witness function to obtain a first result. The system applies the simulated sample to the witness function to obtain a second result. The system determines whether to select the particular feature based on a comparison between the first result and the second result.
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公开(公告)号：US11354582B1
公开(公告)日：2022-06-07
申请号：US17540142
申请日：2021-12-01
申请人： Ro5 Inc.
IPC分类号： G06G7/48 , G06G7/58 , G06N5/02 , G06F16/951 , G06K9/62 , G06N3/08 , G16B15/00 , G16B40/00 , G16B45/00 , G16B50/10
摘要： A system and method for automated retrosynthesis which can reliably identify valid and practical precursors and reaction pathways. The methodology involves a k-beam recursive process wherein at each stage of recursion, retrosynthesis is performed using a library of molecule disconnection rules to identify possible precursor sets, validation of the top k precursor sets is performed using a transformer-based forward reaction prediction scoring system, the best candidate of the top k precursor sets is selected, and a database is searched to determine whether the precursors are commercially available. The recursion process is repeated until a valid chain of chemical reactions is found wherein all precursors necessary to synthesize the target molecule are found to be commercially available.
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公开(公告)号：US11273008B2
公开(公告)日：2022-03-15
申请号：US16703375
申请日：2019-12-04
申请人： Oxilio Ltd
摘要： A methods and processors for generating a 3D-representation of a tooth-specific dental appliance are disclosed. The appliance has a grooved body and a pair of holding arms. The method includes acquiring a 3D-platform representation, acquiring a 3D-grooved body representation, and positioning the 3D-grooved body representation relative to the 3D-platform representation. The method also includes acquiring a first and second 3D-arm representations, each having a respective pair of platform anchor points and a respective adjustment anchor point. The method also includes individually positioning the first and second 3D-arm representations relative to the 3D-platform representation using the respective pairs of platform anchor points, thereby defining preliminary positions of the first and second 3D-arm representations. The method includes individually adjusting the respective preliminary positions relative to the 3D-grooved body representation using the respective adjustment anchor points, thereby defining adjusted positions of the first and second 3D-arm representations.
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公开(公告)号：US11031102B2
公开(公告)日：2021-06-08
申请号：US14941080
申请日：2015-11-13
发明人： Leonard Bell , Camille Bedrosian
摘要： This invention provides, inter alia, a complement-inhibitor-based treatment plan coupled with a risk evaluation and management strategy (“REMS”) and a safety support program (“SSP”) for reinforcing the REMS. The REMS and SPP are implemented using one or more computer devices with software tools programmed to enforce conditions of the REMS and/or prompt follow-ups by registered nurses enrolled in the SSP. The software tool(s) determines whether a prescriber requesting the complement inhibitor has agreed to abide by the REMS, and can prompt a provider of the complement inhibitor to provide updated educational materials to the prescriber at predetermined times or intervals, to monitor the prescriber for compliance with the REMS, and/or to monitor patients for signs of adverse events. Using exemplary embodiments described herein, a risk of adverse events (especially, but not limited to, meningococcal infections) can be managed and an incidence of the adverse events can be reduced.
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公开(公告)号：US10910086B2
公开(公告)日：2021-02-02
申请号：US15504299
申请日：2015-08-14
发明人： Harrison Leong , Edgar Schreiber
摘要： A computer-implemented method for determining minor variants. The method includes receiving electropherogram sequence data from a test sample, identifying any non-primary peaks in the electropherogram, and characterizing identified non-primary peaks using at least one signal feature. The method may further include analyzing the at least one signal feature across identified non-primary peaks to identify variant candidates, evaluating at least one peak characteristic of each of the identified variant candidates, and classifying variant candidates as bona fide variants based on the evaluation of peak characteristics.
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公开(公告)号：US10809246B2
公开(公告)日：2020-10-20
申请号：US15305356
申请日：2014-05-23
发明人： Michael Cafferty
IPC分类号： G01N33/48 , G01N33/49 , G01N27/06 , G01N27/327 , G06G7/58
摘要： A hemolysis detection method and system includes measuring a conductance of a blood sample in a sample test module at a plurality of multiple-frequency AC inputs provided by a sine-wave generator module, calculating an immittance value for each of the plurality of multiple-frequency AC inputs received from a multichannel A/D converter module using a computer processing module, and subjecting each immittance value calculated to a function that maps immittance values to either lysed blood levels or hematocrit levels residing in the processing module and applying further processing residing in a memory module to produce respective percent-lysed value or hematocrit value of the blood sample.
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公开(公告)号：US10796786B2
公开(公告)日：2020-10-06
申请号：US15655587
申请日：2017-07-20
申请人： PSOMAGEN, INC.
发明人： Zachary Apte , Daniel Almonacid , Jessica Richman
IPC分类号： G01N33/48 , G16B30/00 , C12Q1/689 , G06F19/00 , G16B5/00 , G16B40/00 , G16B50/00 , G16H50/20 , G06G7/58
摘要： A method for at least one of characterizing, diagnosing, and treating an endocrine system condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the endocrine system condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the endocrine system condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
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公开(公告)号：US10796784B2
公开(公告)日：2020-10-06
申请号：US14471825
申请日：2014-08-28
申请人： SHIMADZU CORPORATION
发明人： Jingwen Yao
摘要： A tag database establishment section converts, based on information such as an amino acid sequence of an identified peptide and m/z of a peak, a sequence tag indicating a partial sequence and information related to the tag into a database and creates a tag database. When MS2 spectrum information is obtained by measuring a target peptide, a sequence tag acquisition section executes, on the tag database, a search based on coincidence of the m/z of the peak and the like and extracts a sequence tag with high reliability. A peptide identification section performs, based on an amino acid sequence of the sequence tag, m/z of a precursor ion, and the like, a search by a sequence tag search method taking into account a post-translational modification or a variation and identifies a peptide.
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公开(公告)号：US10790060B2
公开(公告)日：2020-09-29
申请号：US15668620
申请日：2017-08-03
申请人： PSOMAGEN, INC.
发明人： Zachary Apte , Daniel Almonacid , Jessica Richman
IPC分类号： G01N33/48 , G16H50/20 , G06F19/00 , G16B50/00 , G16H50/70 , C12Q1/04 , C12Q1/24 , G01N33/569 , G16B40/00 , G16H50/50 , G16H10/40 , G16H20/70 , G06G7/58 , C12Q1/00
摘要： A method for at least one of characterizing, diagnosing, and treating a mental health associated condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the mental health associated condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the mental health associated condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
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公开(公告)号：US10789334B2
公开(公告)日：2020-09-29
申请号：US15649497
申请日：2017-07-13
申请人： PSOMAGEN, INC.
发明人： Zachary Apte , Jessica Richman , Daniel Almonacid , Inti Pedroso , Juan Ugalde , Rodrigo Ortiz
IPC分类号： G01N33/48 , G06F19/00 , G16B50/00 , C12Q1/6883 , C12Q1/689 , G16H40/63 , G16H40/67 , G16H50/50 , G16H50/20 , G16H10/40 , G16H20/40 , G16H20/10 , G16B20/00 , G16B50/30 , G06G7/58 , G16B40/20 , G16B50/20 , G16B30/10
摘要： Embodiments of a method and system for microbial pharmacogenomics can include: a sample handling system operable to collect containers including biological samples from a set of users, the handling system including a sequencing system operable to determine microorganism sequences from the biological samples; a microbiome characterization system operable to: determine microbiome pharmacogenomics data based on the microorganism sequences, collect supplementary data associated with the antibiotics-associated condition for the set of users, and transform the supplementary data and features extracted from the microbiome pharmacogenomics data into a characterization model associated with the antibiotics-associated condition; and a treatment system operable to promote a treatment to the user for the antibiotics-associated condition based on characterizing user biological material with the characterization model in relation to the antibiotics-associated condition.
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