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    METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS
    3.
    发明申请
    METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS 审中-公开

    公开(公告)号：US20170286619A1

    公开(公告)日：2017-10-05

    申请号：US15621144

    申请日：2017-06-13

    Applicant: uBiome, Inc.

    Inventor： Zachary Apte ,  Jessica Richman ,  Daniel Almonacid

    IPC: G06F19/28 ,  G06F19/00

    CPC classification number: G06F19/3418 ,  C12Q1/68 ,  C12Q1/6883 ,  C12Q1/689 ,  C12Q2600/118 ,  G06F19/00 ,  G06F19/10 ,  G06F19/12 ,  G06F19/28 ,  G06F19/30 ,  G16H20/10 ,  G16H50/20 ,  Y02A90/26

    Abstract: A method for diagnosing and treating an immune microbial dysfunction in a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the immune microbial dysfunction based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset, wherein the characterization is diagnostic of at least one of Crohn's disease, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), ulcerative colitis, and celiac disease; based upon the characterization, generating a therapy model configured to correct the immune microbial dysfunction; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

    Methods for mass spectrometric biopolymer analysis using optimized weighted oligomer scheduling
    4.
    发明授权
    Methods for mass spectrometric biopolymer analysis using optimized weighted oligomer scheduling 有权

    公开(公告)号：US09720001B2

    公开(公告)日：2017-08-01

    申请号：US14283582

    申请日：2014-05-21

    Applicant: Thermo Finnigan LLC

    Inventor： Robert A. Grothe, Jr. ,  Iman Mohtashemi

    IPC: G01N33/68 ,  G06F19/10

    CPC classification number: G01N33/6848 ,  G06F19/10

    Abstract: A method for detecting a list of known biopolymer molecules comprises: calculating, for each biopolymer, a respective list of oligomer molecules predicted to be produced by chemical processing; calculating, for each oligomer molecule, a respective predicted chromatographic elution time period; assigning, for each biopolymer molecule, one or more selected oligomer molecules to be detected, wherein the selecting is performed using weighted selection probabilities determined from the predicted elution times; scheduling a plurality of oligomer detection events of a detection system, wherein each oligomer detection event corresponds to a respective one of the predicted elution time periods; performing the chemical reaction or processing of the sample to generate a processed sample; introducing the processed sample into a chromatographic system; introducing any eluting oligomers into the detection system; and operating the detection system so as to search for each of the selected oligomer molecules in accordance with the scheduled detection events.

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