公开(公告)号：US11929151B2

公开(公告)日：2024-03-12

申请号：US17158940

申请日：2021-01-26

Applicant: Immunocore Limited ,  Adaptimmune Limited

Inventor： Brian John Cameron ,  Annelise Brigitte Vuidepot ,  Bent Karsten Jakobsen

IPC: G01N33/50 ,  G01N33/68 ,  G16B35/00 ,  G16B35/20 ,  G16C20/60

CPC classification number: G16B35/20 ,  G01N33/505 ,  G01N33/6866 ,  G01N33/6878 ,  G16B35/00 ,  G16C20/60 ,  G01N2333/57 ,  G01N2333/70539 ,  G01N2500/04

Abstract: The invention provides a method for predicting whether a binding peptide, which binds to a target peptide presented by a Major Histocompatibility Complex (MHC) and is for administration to a subject, has the potential to cross react with another peptide in the subject in vivo. The method comprises the steps of identifying at least one binding motif in the target peptide to which the binding peptide binds; and searching for peptides that are present in the subject that comprise the at least one binding motif and that are not the target peptide. The presence of one or more such peptides indicates that the binding peptide has the potential to cross react in vivo.

公开(公告)号：US20240055071A1

公开(公告)日：2024-02-15

申请号：US18494372

申请日：2023-10-25

Applicant: TENCENT TECHNOLOGY (SHENZHEN) COMPANY LIMITED ,  ZHEJIANG UNIVERSITY

Inventor： Xujun ZHANG ,  Benben LIAO ,  Shengyu ZHANG ,  Tingjun HOU

IPC: G16B15/30 ,  G16B40/20 ,  G16C20/30 ,  G16C20/50 ,  G16C20/60 ,  G06N3/0455 ,  G06N3/063

CPC classification number: G16B15/30 ,  G16B40/20 ,  G16C20/30 ,  G16C20/50 ,  G16C20/60 ,  G06N3/0455 ,  G06N3/063

Abstract: An artificial intelligence-based compound processing method and apparatus, an electronic device, a computer-readable storage medium, and a computer program product relates to an artificial intelligence technology. The method includes obtaining an active compound for a target protein; performing compound generation processing on an attribute property of the active compound to obtain a first candidate compound; performing molecular docking processing on the active compound and the target protein to obtain molecular docking information respectively corresponding to a plurality of molecular conformations of the active compound; screening the plurality of molecular conformations based on the molecular docking information respectively to identify a second candidate compound corresponding to the active compound; and constructing a compound library for the target protein based on the first candidate compound and the second candidate compound.

公开(公告)号：US20240047005A1

公开(公告)日：2024-02-08

申请号：US18221440

申请日：2023-07-13

Applicant: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION

Inventor： Takahiro NAKAMURA ,  Yusuke Yagi ,  Keiko Kobayashi

IPC: G16B15/00 ,  G16B30/00 ,  G16B35/00 ,  G16C20/60 ,  C07K14/415 ,  C12N15/82 ,  G16B20/50 ,  G16B20/30 ,  G16B30/10 ,  C12Q1/68 ,  G01N33/53

CPC classification number: G16B15/00 ,  G16B30/00 ,  G16B35/00 ,  G16C20/60 ,  C07K14/415 ,  C12N15/8216 ,  C12N15/8289 ,  G16B20/50 ,  G16B20/30 ,  G16B30/10 ,  C12Q1/68 ,  G01N33/5308 ,  C12N15/8287 ,  G16B20/00

Abstract: A method for designing a protein capable of binding in an RNA base selective manner or RNA base sequence specific manner is provided. The protein of the present invention is a protein containing one or more of PPR motifs (preferably 2 to 14 PPR motifs) each consisting of a polypeptide of 30- to 38-amino acid length represented by the formula 1 (wherein Helix A is a moiety of 12-amino acid length capable of forming an α-helix structure, and is represented by the formula 2, wherein, in the formula 2, A1 to A12 independently represent an amino acid; X does not exist, or is a moiety of 1- to 9-amino acid length; Helix B is a moiety of 11- to 13-amino acid length capable of forming an α-helix structure; and L is a moiety of 2- to 7-amino acid length represented by the formula 3, wherein, in the formula 3, the amino acids are numbered “i” (−1), “ii” (−2), and so on from the C-terminus side, provided that Liii to Lvii may not exist), and combination of three amino acids A1, A4 and Lii, or combination of two amino acids A4, and Lii is a combination corresponding to a target RNA base or base sequence.

公开(公告)号：US11742056B2

公开(公告)日：2023-08-29

申请号：US17195449

申请日：2021-03-08

Applicant: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION

Inventor： Takahiro Nakamura ,  Yusuke Yagi ,  Keiko Kobayashi

IPC: G16B15/00 ,  G16B30/00 ,  G16B35/00 ,  G16C20/60 ,  C07K14/415 ,  C12N15/82 ,  G16B20/50 ,  G16B20/30 ,  G16B30/10 ,  C12Q1/68 ,  G01N33/53 ,  G16B20/00

CPC classification number: G16B15/00 ,  C07K14/415 ,  C12N15/8216 ,  C12N15/8287 ,  C12N15/8289 ,  C12Q1/68 ,  G01N33/5308 ,  G16B20/30 ,  G16B20/50 ,  G16B30/00 ,  G16B30/10 ,  G16B35/00 ,  G16C20/60 ,  C07K2319/85 ,  C12Q2522/101 ,  G16B20/00

Abstract: A method for designing a protein capable of binding in an RNA base selective manner or RNA base sequence specific manner is provided. The protein of the present invention is a protein containing one or more of PPR motifs (preferably 2 to 14 PPR motifs) each consisting of a polypeptide of 30- to 38-amino acid length represented by the formula 1 (wherein Helix A is a moiety of 12-amino acid length capable of forming an α-helix structure, and is represented by the formula 2, wherein, in the formula 2, A1 to A12 independently represent an amino acid; X does not exist, or is a moiety of 1- to 9-amino acid length; Helix B is a moiety of 11- to 13-amino acid length capable of forming an α-helix structure; and L is a moiety of 2- to 7-amino acid length represented by the formula 3, wherein, in the formula 3, the amino acids are numbered “i” (−1), “ii” (−2), and so on from the C-terminus side, provided that Liii to Lvii may not exist), and combination of three amino acids A1, A4 and Lii, or combination of two amino acids A4, and Lii is a combination corresponding to a target RNA base or base sequence.

公开(公告)号：US20230197187A1

公开(公告)日：2023-06-22

申请号：US17933028

申请日：2022-09-16

Applicant: BIONIZ, LLC

Inventor： Nazli Azimi ,  Yutaka Tagaya

IPC: G16B15/00 ,  G16B20/00 ,  G16B35/00 ,  G16C20/60 ,  G16B35/20 ,  G16B20/50 ,  G16B20/30 ,  G01N33/50

CPC classification number: G16B15/00 ,  G16B20/00 ,  G16B35/00 ,  G16C20/60 ,  G16B35/20 ,  G16B20/50 ,  G16B20/30 ,  G01N33/5041 ,  G16B15/30

Abstract: Methods and compositions related to the selective, specific disruption of multiple ligand-receptor signaling interactions, such as ligand-receptor interactions implicated in disease, are disclosed. These interactions may involve multiple cytokines in a single receptor family or multiple ligand receptor interactions from at least two distinct ligand-receptor families. The compositions may comprise polypeptides having composite sequences that comprise sequence fragments of two or more ligand binding sites. The methods and compositions may involve sequence fragments of two or more ligand binding sites that are arranged to conserve the secondary structure of each of the ligands from which the sequence fragments were taken.

公开(公告)号：US11649499B2

公开(公告)日：2023-05-16

申请号：US18058376

申请日：2022-11-23

Applicant: Personalis, Inc.

Inventor： Gabor T. Bartha ,  Gemma Chandratillake ,  Richard Chen ,  Sarah Garcia ,  Hugo Yu Kor Lam ,  Shujun Luo ,  Mark R. Pratt ,  John West

IPC: C12Q1/6874 ,  G16B20/00 ,  G16B30/00 ,  G16B99/00 ,  G16B20/10 ,  G16B20/20 ,  G16B35/10 ,  C12Q1/6806 ,  C12Q1/6869 ,  G16B35/00 ,  G16C20/60

CPC classification number: C12Q1/6874 ,  C12Q1/6806 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20 ,  G16B30/00 ,  G16B35/10 ,  G16B99/00 ,  C12Q1/6869 ,  G16B35/00 ,  G16C20/60

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

公开(公告)号：US20190065669A1

公开(公告)日：2019-02-28

申请号：US16113718

申请日：2018-08-27

Applicant: Purdue Research Foundation

Inventor： Marxa L. Figueiredo ,  Charles Samuel Umbaugh ,  Herman O. Sintim ,  Adriana Diaz-Quinones

IPC: G06F19/16 ,  C40B30/02 ,  A61K31/497 ,  A61P35/00 ,  A61P19/02

CPC classification number: G16B15/00 ,  A61K31/497 ,  A61P19/02 ,  A61P35/00 ,  G16B15/30 ,  G16B35/00 ,  G16C20/50 ,  G16C20/60 ,  G16C20/64

Abstract: An in silico screening method generated compounds that are against laminin receptor 37 LR and their anti-cancer functions in prostate cancer cell lines are disclosed herein. A group of derivatives based on the hit compound from the in silico screening are synthesized and tested with improved IC50 value that can have relevant clinical use for prostate cancer or osteoarthritis.

公开(公告)号：US20180218129A1

公开(公告)日：2018-08-02

申请号：US15531213

申请日：2015-11-26

Applicant: EWHA UNIVERSITY -INDUSTRY COLLABORATION FOUNDATION

Inventor： Wan Kyu Kim ,  Yea Jee Kwon ,  Hae Seung Lee

IPC: G06F19/00 ,  C40B30/02

CPC classification number: G16C20/50 ,  G16B35/00 ,  G16C20/60 ,  G16C20/70

Abstract: The present invention relates to a virtual drug screening method with high prediction accuracy based on various biological activities extracted from multiple drug screening data, without using structures or structural attribute information of target proteins or compounds; an intensive screening library constructing method; and a system therefor.

公开(公告)号：US20180009853A1

公开(公告)日：2018-01-11

申请号：US15547499

申请日：2016-01-26

Applicant: Yeda Research And Development Co. Ltd.

Inventor： Ada YONATH ,  Zohar EYAL ,  Donna MATZOV ,  Haim ROZENBERG ,  Ella ZIMMERMAN ,  Anat BASHAN

IPC: C07K14/31 ,  C07H17/08 ,  C07D211/54 ,  C07D263/20 ,  G06F19/00 ,  G06F19/16

CPC classification number: C07K14/31 ,  C07D211/54 ,  C07D263/20 ,  C07H17/08 ,  C07K2299/00 ,  G16B15/00 ,  G16B30/00 ,  G16B35/00 ,  G16C20/50 ,  G16C20/60

Abstract: A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.

公开(公告)号：US20170362306A1

公开(公告)日：2017-12-21

申请号：US15648137

申请日：2017-07-12

Applicant: EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION ,  Medicinal Bioconvergence Research Center

Inventor： Hyun Bo SHIM ,  Ji Hye KIM ,  Xuelian BAI

IPC: C07K16/00 ,  C12N15/10

CPC classification number: C07K16/005 ,  C07K16/00 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C12N15/1037 ,  C40B40/10 ,  G16B35/00 ,  G16C20/60

Abstract: The present invention relates to a method for preparing a novel antibody library and a library prepared thereby. The antibody library prepared according to the present invention contains antibodies having excellent physical properties against a plurality of antigens, thereby having functional diversity and containing a plurality of unique sequences, and thus can be favorably used as an antibody library.