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公开(公告)号：US20240344055A1
公开(公告)日：2024-10-17
申请号：US18618660
申请日：2024-03-27
申请人： The Trustees of Columbia University in the City of New York , The Broad Institute, Inc. , President and Fellows of Harvard College
CPC分类号： C12N15/102 , C12N9/1276 , C12N9/22 , C12N15/111 , A61K38/00 , C07K2319/85 , C12N2310/20 , C12Y207/07049
摘要： The present disclosure provides systems, methods, and compositions for modifying the crumbs homologue-1 gene. Particularly the present disclosure provides systems, methods, and compositions for prime editing insertion or correction of mutations in the crumbs homologue-1 gene.
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2.发明授权公开(公告)号：US11998635B2
公开(公告)日：2024-06-04
申请号：US16852894
申请日：2020-04-20
IPC分类号： A61K9/107 , A61K9/00 , A61K31/713 , A61K47/46 , C07K14/705 , C12N15/88
CPC分类号： A61K9/1075 , A61K9/0019 , A61K31/713 , A61K47/46 , C07K14/70596 , C12N15/88 , C07K2319/03 , C07K2319/06 , C07K2319/74 , C07K2319/85 , C07K2319/91 , C12N2740/16043 , C12N2810/6081
摘要： Disclosed are extracellular vesicles comprising an engineered targeting protein for targeting the extracellular vesicles to target cells. The targeting protein is a fusion protein that includes a ligand, an engineered glycosylation site, and an exosome-targeting domain. Exemplary extracellular vesicles may include but are not limited to exosomes.
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公开(公告)号：US11987822B2
公开(公告)日：2024-05-21
申请号：US17329358
申请日：2021-05-25
申请人： SOLIS BIODYNE OÜ
发明人： Olev Kahre
CPC分类号： C12N9/1276 , C12N9/22 , C12Y207/07049 , C12Y301/26004 , C07K2319/85
摘要： The present disclosure provides non-natural reverse transcriptases for conducting reverse transcription. The non-natural reverse transcriptases herein may have increased thermostability and can conduct reverse transcription more efficiently than natural reverse transcriptases.
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公开(公告)号：US20240132557A1
公开(公告)日：2024-04-25
申请号：US18454192
申请日：2023-08-23
IPC分类号： C07K14/47 , C07K14/315 , C12N9/02 , C12N9/06 , C12N9/22 , C12N9/24 , C12N15/09 , C12N15/113 , C12N15/85 , C12N15/90
CPC分类号： C07K14/4702 , C07K14/315 , C12N9/0032 , C12N9/0069 , C12N9/0071 , C12N9/22 , C12N9/2497 , C12N15/09 , C12N15/113 , C12N15/85 , C12N15/902 , C12Y114/11 , C07K2319/09 , C07K2319/85 , C07K2319/90 , C12Y113/1102 , C12Y301/21001
摘要： Provided herein are, inter alia, compositions and methods for demethylating and methylating a target DNA sequences in a mammalian cell. The compositions and methods are, inter alia, useful for modulating the expression of a target gene, or to create a gene regulatory network.
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公开(公告)号：US11939604B2
公开(公告)日：2024-03-26
申请号：US17179215
申请日：2021-02-18
IPC分类号： C12N9/22 , A61K48/00 , C07K14/245 , C07K14/47 , C12N9/16 , C12N15/62 , C12N15/66 , C12N15/70 , C12N15/74 , C12N15/81 , C12N15/82 , C12N15/86 , C12N15/90 , A61K38/00
CPC分类号： C12N9/22 , A61K48/005 , C07K14/245 , C07K14/47 , C12N9/16 , C12N15/62 , C12N15/66 , C12N15/70 , C12N15/74 , C12N15/81 , C12N15/82 , C12N15/86 , C12N15/902 , C12N15/907 , A61K38/00 , C07K2319/09 , C07K2319/22 , C07K2319/60 , C07K2319/71 , C07K2319/80 , C07K2319/85 , C12N2310/20 , C12Y301/21004
摘要： A clustered regularly interspaced short palindromic repeat (CRISPR)-associated complex for adaptive antiviral defence (Cascade); the Cascade protein complex comprising at least CRISPR-associated protein subunits Cas7, Cas5 and Cash which includes at least one subunit with an additional amino acid sequence possessing nucleic acid or chromatin modifying, visualising, transcription activating or transcription repressing activity. The Cascade complex with additional activity is combined with an RNA molecule to produce a ribonucleoprotein complex. The RNA molecule is selected to have substantial complementarity to a target sequence. Targeted ribonucleoproteins can be used as genetic engineering tools for precise cutting of nucleic acids in homologous recombination, non-homologous end joining, gene modification, gene integration, mutation repair or for their visualisation, transcriptional activation or repression. A pair of ribonucleotides fused to FokI dimers may be used to generate double-strand breakages in the DNA to facilitate these applications in a sequence-specific manner.
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6.发明公开公开(公告)号：US20240084310A1
公开(公告)日：2024-03-14
申请号：US18000381
申请日：2021-05-31
申请人： INTHERA INC.
发明人： Deog Young CHOI , Hyun Gyo JUNG
IPC分类号： C12N15/62 , A61K39/12 , C07K14/195 , C12N15/70
CPC分类号： C12N15/62 , A61K39/12 , C07K14/195 , C12N15/70 , C07K2319/85 , C12R2001/19
摘要： The present invention relates to an encapsulin protein and a fusion protein comprising the same, and more specifically to a recombinant expression vector for vaccine production, and a preparation method therefor, the vector comprising polynucleotides that encode a target protein, an encapsulin protein and an RNA interacting domain (RID) protein, so as to improve the expression efficiency of the target protein, and thus enables a water-soluble vaccine to be produced in a highly efficient manner and a large target protein to be used.
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公开(公告)号：US11912747B2
公开(公告)日：2024-02-27
申请号：US16329577
申请日：2016-12-15
发明人： Alexander Levitzki , Yael Langut
CPC分类号： C07K14/4748 , A61K47/6851 , A61P35/00 , C07K16/3069 , C12N15/117 , C12N15/62 , A61K38/00 , A61K47/68 , A61K47/6869 , C07K2317/622 , C07K2317/77 , C07K2319/60 , C07K2319/85 , C12N2310/17 , C12N2320/32
摘要： Described herein are recombinant chimeric proteins comprising a double stranded RNA (dsRNA) binding domain and a cancer-cell targeting domain for targeting of dsRNA to cancer cells. Methods of use of the described chimeric proteins are also provided herein.
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公开(公告)号：US11884925B2
公开(公告)日：2024-01-30
申请号：US17292407
申请日：2019-11-07
CPC分类号： C12N15/635 , A61K48/0008 , C07K14/4703 , C12N9/22 , C12N15/11 , C12N15/111 , C12N15/86 , C07K2319/85 , C12N2310/16 , C12N2310/20 , C12N2310/3519 , C12N2830/005 , C12N2310/20 , C12N2310/16
摘要： Provided herein are CRISPR-based synthetic repression systems as well as methods and compositions using the synthetic repression systems to treat septicemia, an adverse immune response in a subject and Waldenström macroglobulinemia.
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公开(公告)号：US20240026342A1
公开(公告)日：2024-01-25
申请号：US18478861
申请日：2023-09-29
发明人： Jia Chen , Bei Yang , Li Yang , Xingxu Huang , Lijie Wang
CPC分类号： C12N15/102 , C12N9/22 , C12N9/506 , C12N9/78 , C12N15/111 , C12N2310/20 , C07K2319/50 , C07K2319/85 , C12Y304/22044 , C12Y305/04004 , C12Y305/04005
摘要： Provided are fusion proteins and related molecules useful for conducting base editing with reduced or no off-target mutations. The fusion protein may include a first fragment comprising a nucleobase deaminase or a catalytic domain thereof, a second fragment comprising a nucleobase deaminase inhibitor, and a protease cleavage site between the first fragment and the second fragment. Also provided are improved prime editing systems, including prime editing guide RNA with improved stability.
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公开(公告)号：US11780895B2
公开(公告)日：2023-10-10
申请号：US16333134
申请日：2017-09-13
IPC分类号： C12N9/22 , C07K14/47 , C12N9/06 , C12N9/02 , C12N9/24 , C12N15/09 , C07K14/315 , C12N15/113 , C12N15/85 , C12N15/90
CPC分类号： C07K14/4702 , C07K14/315 , C12N9/0032 , C12N9/0069 , C12N9/0071 , C12N9/22 , C12N9/2497 , C12N15/09 , C12N15/113 , C12N15/85 , C12N15/902 , C12Y114/11 , C07K2319/09 , C07K2319/85 , C07K2319/90 , C12Y113/1102 , C12Y301/21001
摘要： Provided herein are, inter alia, compositions and methods for demethylating and methylating a target DNA sequences in a mammalian cell. The compositions and methods are, useful for activity modulation of a targeted gene, or to create a gene regulatory network.
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