公开(公告)号：US20250022571A1

公开(公告)日：2025-01-16

申请号：US18751631

申请日：2024-06-24

Applicant: The Jackson Laboratory

Inventor： Jacques Banchereau ,  Diogo Fernando Troggian Veiga ,  Anne Deslattes Mays

IPC: G16H20/40

Abstract: Methods and apparatus for identifying alternative splicing events. The method comprises receiving a dataset of percent spliced in (PSI) values for each of a plurality of biological samples, wherein the plurality of biological samples includes a first population of samples having a first characteristic and a second population of samples having a second characteristic different from the first characteristic, fitting, to the dataset, a probabilistic model to identify clusters of samples in the dataset, calculating cluster characteristics for each of the clusters, filtering the clusters based, at least in part, on the cluster characteristics to identify a subset of clusters, each of which is associated with an alternative splicing event, and storing on the at least one storage device, information associated with the identified alternative splicing events.

公开(公告)号：US20240399360A1

公开(公告)日：2024-12-05

申请号：US18680164

申请日：2024-05-31

Applicant: Georgia Tech Research Corporation ,  Columbia University ,  The Jackson Laboratory ,  Imperial College London ,  Duke University

Inventor： Ross Ethier ,  Simon John ,  Krishnakumar Kizhatil ,  Darryl Overby ,  Seyed Mohammad Siadat ,  W. Daniel Stamer ,  Joseph van Batenburg-Sherwood

IPC: B01L3/00 ,  C12N5/00 ,  C12N5/071

Abstract: Disclosed herein is a biochip with a plurality of endothelial cells (e.g., Schlemm's canal cells) having a plurality of pores (e.g., transcellular pores) and methods of making and using the same.

公开(公告)号：US20240392393A1

公开(公告)日：2024-11-28

申请号：US18261836

申请日：2022-01-19

Applicant: The Jackson Laboratory

Inventor： Chia-Lin Wei ,  Chew Yee NGAN ,  Chee-Hong WONG

IPC: C12Q1/70

Abstract: The invention, in part, encompasses methods to assess viral infections in cells and subjects. The invention includes methods that can be used to determine the presence or absence of a viral infection in a cell or subject; severity of a viral infection in a cell or subject, and/or risk of a severe viral infection in a cell or subject. Certain methods of the invention also include selecting and/or administration a therapeutic regimen for a subject with a viral infection, based in part on the determination of the presence and/or severity of the viral infection in the subject.

公开(公告)号：US20240288445A1

公开(公告)日：2024-08-29

申请号：US18603889

申请日：2024-03-13

Applicant: The Jackson Laboratory

Inventor： James Keck ,  Chunting Ye

IPC: G01N33/68 ,  A01K67/0278 ,  C07K16/28

CPC classification number: G01N33/6863 ,  A01K67/0278 ,  C07K16/2809 ,  C07K16/2818 ,  C07K16/2887 ,  C07K16/2893 ,  A01K2227/105 ,  A01K2267/0325

Abstract: Humanized mouse models and methods are provided for determining whether administration of an immunomodulatory drug likely elicits a severe cytokine release syndrome in a human. Humanized mouse models and methods are also provided for determining the immunotoxicity in a human of a drug candidate or of drug combinations.

公开(公告)号：US20240238616A1

公开(公告)日：2024-07-18

申请号：US18563207

申请日：2022-05-26

Applicant: THE JACKSON LABORATORY

Inventor： Roel VERHAAK

IPC: A61N5/10

CPC classification number: A61N5/1001 ,  A61N5/1077 ,  A61N2005/1024 ,  A61N2005/1098

Abstract: The invention relates, in part, to methods and compounds for radiosensitizing cells and increasing efficacy of treatments for cancers.

公开(公告)号：US20240141411A1

公开(公告)日：2024-05-02

申请号：US18280198

申请日：2022-03-03

Applicant: The Jackson Laboratory

Inventor： Albert Cheng ,  Zukai Liu

IPC: C12Q1/6816 ,  C12N9/22 ,  C12N15/115

CPC classification number: C12Q1/6816 ,  C12N9/22 ,  C12N15/115 ,  C12N2310/16 ,  C12N2310/20 ,  C12Y301/00

Abstract: Provided herein, in some aspects, is a multiplex RNA targeting system that enables live cell imaging and/or modification of multiple RNA targets. Specifically, the disclosure provides a method of live cell imaging of ribonucleic acid (RNA), or targeting RNA in a live cell, comprising: (a) delivering to a cell an RNA-editing complex that comprises a catalytically inactive Cas13 (dCas13) nuclease, a Cas 13 guide RNA (gRNA) comprising an RNA aptamer sequence, and a detectable molecule linked to an RNA-binding domain (RBD), or an RNA effector molecule linked to an RBD sequence that specifically binds to the RNA aptamer sequence; and (b) imaging the detectable molecule or RNA aptamer and RBD binding.

公开(公告)号：US20240068042A1

公开(公告)日：2024-02-29

申请号：US18272260

申请日：2022-01-10

Applicant: The Jackson Laboratory

Inventor： Edison T. Liu ,  Francesca Menghi

IPC: C12Q1/6886 ,  C12Q1/6869

CPC classification number: C12Q1/6886 ,  C12Q1/6869 ,  C12Q2600/106 ,  C12Q2600/154 ,  C12Q2600/158

Abstract: Provided herein, in some embodiments, are novel methods for predicting response to a platinum-based chemotherapeutic agent in triple negative breast cancer and ovarian carcinoma.

公开(公告)号：US20240041011A1

公开(公告)日：2024-02-08

申请号：US18265521

申请日：2021-12-06

Applicant: The Jackson Laboratory

Inventor： James Keck

IPC: A01K67/027 ,  C12N5/071 ,  C12N5/09

CPC classification number: A01K67/0271 ,  C12N5/0688 ,  C12N5/0693 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2227/105 ,  A01K2267/0337

Abstract: Provided herein are immnunodeficient mouse models engrafted with cells comprising a pathogen entry moiety, for example, for assessing pathogenic infection. The pathogen may be a virus, such as a respiratory virus.

公开(公告)号：US20240010970A1

公开(公告)日：2024-01-11

申请号：US18032845

申请日：2021-10-20

Applicant: The Jackson Laboratory

Inventor： Julia Oh

IPC: C12N1/20 ,  A61K38/17 ,  A61P31/00 ,  G01N33/569

CPC classification number: C12N1/20 ,  A61K38/1729 ,  A61P31/00 ,  G01N33/569 ,  G01N2800/26

Abstract: Provided herein are antimicrobial biosensors for skin for treating Staphylococcus aureus Type I, Type II, Type III, and/or Type IV infection. In some embodiments, the antimicrobial biosensors are expressed in Staphylococcus epidermidis cells.

公开(公告)号：US20230374608A1

公开(公告)日：2023-11-23

申请号：US18302737

申请日：2023-04-18

Applicant: The Jackson Laboratory

Inventor： Jacques Banchereau ,  Diogo Fremando Troggian Veiga ,  Anne Deslattes Mays ,  Saman Zeeshan ,  Anna Karolina Palucka

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/158

Abstract: Provided herein, in some embodiments, are methods, compositions, and systems for identifying alternatively spliced tumor-specific exon inclusion and exclusion events that can be used for survival prognosis.