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公开(公告)号：US11773407B2
公开(公告)日：2023-10-03
申请号：US16626021
申请日：2018-06-26
Inventor： Samira Kiani , Mo Reza Ebrahimkhani , Swechchha Pradhan , Farzaneh Moghadam
IPC: C12N15/86 , C12N9/22 , C12N15/113
CPC classification number: C12N15/86 , C12N9/22 , C12N15/113 , C12N2310/20 , C12N2750/14143
Abstract: Aspects of the disclosure relate to synthetic regulatory systems composed of a multifunctional Cas nuclease, at least two guide RNAs (gRNAs) configured to target distinct nucleotide sequences, and a multilayered regulatory control element comprising ribozyme-based safety switches providing spatial and temporal control over the synthetic circuit in vivo.
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公开(公告)号：US11208640B2
公开(公告)日：2021-12-28
申请号：US16632782
申请日：2018-04-27
Inventor： Radwa Ewaisha , Samira Kiani , Shayesteh Roshdi Ferdosi , Karen Anderson , Farzaneh Moghadam , Sri Krishna , Mo Reza Ebrahimkhani
IPC: C12N9/22 , G01N33/573 , A61K48/00
Abstract: Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation.
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公开(公告)号：US20240368572A1
公开(公告)日：2024-11-07
申请号：US18778083
申请日：2024-07-19
Inventor： Radwa Ewaisha , Samira Kiani , Shayesteh Roshdi Ferdosi , Karen Anderson , Farzaneh Moghadam , Sri Krishna , Mo Reza Ebrahimkhani
IPC: C12N9/22 , A61K48/00 , G01N33/573
Abstract: Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation.
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公开(公告)号：US20210154326A1
公开(公告)日：2021-05-27
申请号：US16626013
申请日：2018-06-26
Inventor： Samira Kiani , Swechchha Pradhan , Farzaneh Moghadam , Mo Reza Ebrahimkhani
IPC: A61K48/00 , C12N15/113 , C12N15/86 , C12N9/22
Abstract: Aspects of the disclosure relate to synthetic regulatory systems comprising a multifunctional Cas nuclease and at least two guide RNAs (gRNAs) including a truncated gRNA and an multilayered regulatory control element. The synthetic regulatory system modulates endogenous gene expression, including transcriptional repression and transcriptional activation of one or more endogenous genes of a mammalian inner ear cell with multiple safety switches. Also provided herein are methods for modulating hearing sensitivity in damaged cells of the organ of corti.
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Patent Agency Ranking
公开(公告)号：US20200377871A1
公开(公告)日：2020-12-03
申请号：US16632782
申请日：2018-04-27
Inventor： Radwa Ewaisha , Samira Kiani , Shayesteh Roshdi Ferdosi , Karen Anderson , Farzaneh Moghadam , Sri Krishna , Mo Reza Ebrahimkhani
IPC: C12N9/22 , G01N33/573
Abstract: Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation.
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公开(公告)号：US12084691B2
公开(公告)日：2024-09-10
申请号：US17546810
申请日：2021-12-09
Inventor： Radwa Ewaisha , Samira Kiani , Shayesteh Roshdi Ferdosi , Karen Anderson , Farzaneh Moghadam , Sri Krishna , Mo Reza Ebrahimkhani
IPC: C12N9/22 , A61K48/00 , G01N33/573
CPC classification number: C12N9/22 , G01N33/573 , A61K48/00 , C12N2310/20 , C12N2800/80 , G01N2333/922
Abstract: Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation.
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公开(公告)号：US11884925B2
公开(公告)日：2024-01-30
申请号：US17292407
申请日：2019-11-07
Inventor： Samira Kiani , Mo Reza Ebrahimkhani , Farzaneh Moghadam
CPC classification number: C12N15/635 , A61K48/0008 , C07K14/4703 , C12N9/22 , C12N15/11 , C12N15/111 , C12N15/86 , C07K2319/85 , C12N2310/16 , C12N2310/20 , C12N2310/3519 , C12N2830/005 , C12N2310/20 , C12N2310/16
Abstract: Provided herein are CRISPR-based synthetic repression systems as well as methods and compositions using the synthetic repression systems to treat septicemia, an adverse immune response in a subject and Waldenström macroglobulinemia.
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公开(公告)号：US20220162574A1
公开(公告)日：2022-05-26
申请号：US17546810
申请日：2021-12-09
Inventor： Samira Kiani , Radwa Ewaisha , Shayesteh Roshdi Ferdosi , Karen Anderson , Farzaneh Moghadam , Sri Krishna , Mohammad R Ebrahimkhani
IPC: C12N9/22 , G01N33/573
Abstract: Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation.
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公开(公告)号：US20210155954A1
公开(公告)日：2021-05-27
申请号：US16626021
申请日：2018-06-26
Inventor： Samira Kiani , Mo Reza Ebrahimkhani , Swechchha Pradhan , Farzaneh Moghadam
IPC: C12N15/86 , C12N9/22 , C12N15/113
Abstract: Aspects of the disclosure relate to synthetic regulatory systems composed of a multifunctional Cas nuclease, at least two guide RNAs (gRNAs) configured to target distinct nucleotide sequences, and a multilayered regulatory control element comprising ribozyme-based safety switches providing spatial and temporal control over the synthetic circuit in vivo.
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