- 专利标题: TARGETED DNA DEMETHYLATION AND METHYLATION
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申请号: US18454192申请日: 2023-08-23
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公开(公告)号: US20240132557A1公开(公告)日: 2024-04-25
- 发明人: Albert Cheng , Aziz Taghbalout , Nathaniel Jillette
- 申请人: The Jackson Laboratory
- 申请人地址: US ME Bar Harbor
- 专利权人: The Jackson Laboratory
- 当前专利权人: The Jackson Laboratory
- 当前专利权人地址: US ME Bar Harbor
- 主分类号: C07K14/47
- IPC分类号: C07K14/47 ; C07K14/315 ; C12N9/02 ; C12N9/06 ; C12N9/22 ; C12N9/24 ; C12N15/09 ; C12N15/113 ; C12N15/85 ; C12N15/90
摘要:
Provided herein are, inter alia, compositions and methods for demethylating and methylating a target DNA sequences in a mammalian cell. The compositions and methods are, inter alia, useful for modulating the expression of a target gene, or to create a gene regulatory network.
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