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公开(公告)号：US12129497B2
公开(公告)日：2024-10-29
申请号：US18053614
申请日：2022-11-08
申请人： Novozymes A/S
发明人： Morten Gjermansen , Klaus Gori , Henrik Marcus Geertz-Hansen , Jesper Salomon , Thomas Holberg Blicher , Nikolaj Spodsberg
CPC分类号： C12N9/22 , C11D3/2065 , C11D3/22 , C11D3/3707 , C11D3/38627 , C11D3/38636 , C11D3/38681 , C12Y301/21 , C12Y301/21001 , C11D2111/12
摘要： The present invention relates to polypeptides, nucleotides encoding the polypeptide, as well as methods of producing the polypeptides. The present invention also relates to detergent compositions comprising polypeptides, a laundering method and the use of polypeptides.
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公开(公告)号：US12060589B2
公开(公告)日：2024-08-13
申请号：US18343131
申请日：2023-06-28
申请人： Novozymes A/S
发明人： Lars Henrik Oestegaard , Gernot J. Abel , Dorte Marie Koefoed Klitgaard , Annette Helle Johansen
CPC分类号： C12N9/22 , C11D3/38636 , C12Y301/21001
摘要： The present invention relates to polypeptide variants and methods for obtaining variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
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公开(公告)号：US20240218301A1
公开(公告)日：2024-07-04
申请号：US18319681
申请日：2023-05-18
发明人： Lars Lehmann Hylling CHRISTENSEN , Annette Helle JOHANSEN , Neil Joseph LANT , Marco MALTEN , Christian Berg OEHLENSCHLAEGER , Lars Henrik OESTERGAARD
IPC分类号： C11D3/386
CPC分类号： C11D3/38681 , C11D3/38618 , C11D3/38636 , C12Y301/21001 , C11D2111/12
摘要： A detergent composition may include a DNase variant and a cleaning adjunct. Also, methods of treating surfaces such as fabrics by contacting the surface with an aqueous wash liquor having the detergent composition therein.
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公开(公告)号：US20240216483A1
公开(公告)日：2024-07-04
申请号：US18562803
申请日：2022-05-24
发明人： Moshe MIZRAHY , Dmitry GENKIN
CPC分类号： A61K38/465 , A61P15/08 , C12Y301/21001
摘要： The invention provides methods for induction of pregnancy in a couple in need thereof wherein the male subject in said couple has been diagnosed as sub-fertile, said method comprising administering systemically to said male subject a pharmaceutical composition comprising a human DNase.
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5.发明公开公开(公告)号：US20240026411A1
公开(公告)日：2024-01-25
申请号：US18343633
申请日：2023-06-28
CPC分类号： C12P21/005 , C12N1/20 , C12N9/0051 , C12N9/1051 , C12N9/16 , C12N9/88 , C12N9/93 , C12Y108/01007 , C12Y301/21001 , C12Y402/01047
摘要： Disclosed are methods, systems, components, and compositions for cell-free synthesis of proteins and glycoproteins. The methods, systems, components, and compositions may be utilized for incorporating non-standard amino acids (nsAAs) into cell-free synthesized proteins and glycosylating or otherwise modifying the cell-free synthesized proteins in vitro. The nsAAs of the cell-free synthesized protein may be modified via glycosylation or other modification.
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公开(公告)号：US20230287456A1
公开(公告)日：2023-09-14
申请号：US17931027
申请日：2022-09-09
CPC分类号： C12N15/907 , C12N9/22 , C12Y301/21001 , C12N15/11 , C12N9/78 , C12Y305/04004 , C12N2310/20
摘要： The present invention relates to compositions comprising a Cas12i polypeptide, a deaminase polypeptide, and an RNA guide, processes for characterizing the compositions, cells comprising the compositions, Cas12i fusion proteins, Cas12i complexes, and methods of using the compositions.
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公开(公告)号：US11732252B2
公开(公告)日：2023-08-22
申请号：US17531220
申请日：2021-11-19
申请人： Novozymes A/S
发明人： Lars Henrik Oestergaard , Gernot J. Abel , Dorte Marie Koefoed Klitgaard , Annette Helle Johansen
CPC分类号： C12N9/22 , C11D3/38636 , C12Y301/21001
摘要： The present invention relates to polypeptide variants and methods for obtaining variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
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公开(公告)号：US11643670B2
公开(公告)日：2023-05-09
申请号：US16260630
申请日：2019-01-29
发明人： Guoping Feng , Jonathan Wilde , Tomomi Aida , Martin Wienisch , Qiangge Zhang
IPC分类号： C12N15/90 , C12N9/22 , C12N15/113 , C12N15/10 , A01K67/027 , A61K31/136 , A61K35/54 , C12N5/073 , C12N15/877
CPC分类号： C12N15/907 , A01K67/0275 , A61K31/136 , A61K35/54 , C12N5/0603 , C12N9/22 , C12N15/102 , C12N15/113 , C12N15/8776 , C12N2310/20 , C12Q2521/301 , C12Y301/21001
摘要： Described herein are methods of enhancing chromosomal homologous recombination to stimulate a loss of heterozygosity at a gene locus of interest in a living cell. These methods are driven by an enhancer component and a target-specific endonuclease component and proceed through a mechanism whereby: exogenous donor DNA that is homologous to the gene locus of interest is not introduced into the living cell; the desired allele of the gene locus of interest remains uncleaved; and the undesired allele is either uncleaved, cleaved at a single location, or cleaved at multiple locations. These methods have numerous applications, including the repair of risk alleles for disease prevention, the correction of heterozygous mutations in dividing cells, the design of cancer therapeutics, and the design of novel gene-drive strategies.
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公开(公告)号：US09867871B2
公开(公告)日：2018-01-16
申请号：US14362589
申请日：2012-08-20
申请人： Sandeep Jain
发明人： Sandeep Jain
CPC分类号： A61K38/465 , A61K9/0048 , A61K31/465 , A61K45/05 , A61K45/06 , C12Q1/6816 , C12Y301/21001 , A61K2300/00
摘要： Provided herein is a composition and a method for treating nucleic acid-related eye disease.
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公开(公告)号：US09642822B2
公开(公告)日：2017-05-09
申请号：US14119499
申请日：2012-05-25
申请人： Denisa D. Wagner , Tobias A. Fuchs , Simon De Meyer , Kimberly Martinod , Alexander Brill , Grace M. Thomas
发明人： Denisa D. Wagner , Tobias A. Fuchs , Simon De Meyer , Kimberly Martinod , Alexander Brill , Grace M. Thomas
IPC分类号： A61K31/166 , A61K31/155 , A61K38/46 , A61K39/395 , A61K45/06 , A61K38/49 , A61M1/34
CPC分类号： A61K38/465 , A61K31/155 , A61K31/166 , A61K38/49 , A61K39/3955 , A61K45/06 , A61M1/0209 , A61M1/34 , C12Y301/21001 , A61K2300/00
摘要： Embodiments of the technology described herein are based upon the discoveries that neturophil extracellular traps (NETs) provide a stimulus for thrombus formation and that NETs are present in stored blood products. Accordingly, some embodiments relate to methods of treating and preventing toxicity of NETs and thrombosis caused by NETs. Additional embodiments are directed towards methods of treating stored blood products to prevent transfusion-related injuries.
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