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公开(公告)号：US11981941B2
公开(公告)日：2024-05-14
申请号：US18168096
申请日：2023-02-13
申请人： Novozymes A/S
发明人： Morten Gjermansen , Klaus Gori , Henrik Marcus Geertz-Hansen , Jesper Salomon , Thomas Holberg Blicher , Nikolaj Spodsberg
CPC分类号： C12N9/22 , C11D3/2065 , C11D3/22 , C11D3/3707 , C11D3/38627 , C11D3/38636 , C11D3/38681 , C12Y301/21 , C12Y301/21001 , C11D2111/12
摘要： The present invention relates to polypeptides, nucleotides encoding the polypeptide, as well as methods of producing the polypeptides. The present invention also relates to detergent composition comprising polypeptides, a laundering method and the use of polypeptides.
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公开(公告)号：US11866699B2
公开(公告)日：2024-01-09
申请号：US16476917
申请日：2018-02-12
发明人： Marc Joseph Lajoie , Elizabeth Erin Gray , Neil P. King , Daniel Brewster Stetson , David Baker , Katherine DaPron
IPC分类号： C07H21/04 , C12N15/11 , C07K14/005 , C12N9/22 , C12N15/85
CPC分类号： C12N15/11 , C07K14/005 , C12N9/22 , C12N15/111 , C12N15/85 , C12Y301/21 , C12N2310/20 , C12N2800/80 , C12Q2521/301
摘要： The application discloses multimeric assemblies packaging one or more active component and their use to carry out nucleic acid regulation or gene editing.
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公开(公告)号：US20230287307A1
公开(公告)日：2023-09-14
申请号：US18045573
申请日：2022-10-11
申请人： Novozymes A/S
CPC分类号： C11D3/38636 , C11D11/0017 , C12Y301/21 , C12Y302/01052
摘要： The present invention relates to compositions such as cleaning compositions comprising a mix of enzymes. The invention further relates, use of compositions comprising such enzymes in cleaning processes.
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公开(公告)号：US20230181698A1
公开(公告)日：2023-06-15
申请号：US17832457
申请日：2022-06-03
发明人： Kamel Khalili , Wenhui Hu
CPC分类号： A61K38/465 , C12N15/111 , A61K48/00 , A61K9/0034 , A61K35/12 , A61K45/06 , A61K48/005 , C12N7/00 , C12N9/22 , C12N2320/30 , C12N2310/20 , C12N2740/16063 , C12Y301/21
摘要： A method of preventing transmission of a retrovirus from a mother to her offspring, by administering to the mother a therapeutically effective amount of a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and the two or more different multiplex gRNAs, wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) of proviral DNA of the virus that is unique from the genome of the host cell, cleaving a double strand of the proviral DNA at a first target protospacer sequence with the CRISPR-associated endonuclease, cleaving a double strand of the proviral DNA at a second target protospacer sequence with the CRISPR-associated endonuclease, excising an entire HIV-I proviral genome, eradicating the HIV-I proviral DNA from the host cell, and preventing transmission of the proviral DNA to the offspring.
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公开(公告)号：US20190184035A1
公开(公告)日：2019-06-20
申请号：US16320280
申请日：2017-07-25
申请人： bluebird bio, Inc.
发明人： Jordan JARJOUR , Jasdeep MANN
CPC分类号： A61K48/0066 , A61K48/0058 , A61K48/0091 , A61P7/00 , C12N9/00 , C12N9/14 , C12N9/16 , C12N9/22 , C12Y301/21
摘要： The present disclosure provides improved genome editing compositions and methods for editing a BCL11A gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of a hemoglobinopathy.
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公开(公告)号：US20190000997A1
公开(公告)日：2019-01-03
申请号：US16030675
申请日：2018-07-09
发明人： Matthew ANGEL , Christopher ROHDE
IPC分类号： A61K48/00 , A61P3/10 , A61P35/00 , A61P29/00 , A61P9/00 , A61P3/00 , A61P11/00 , A61P1/16 , A61K31/7115 , C12N9/22 , C07K14/00 , A61P3/06
CPC分类号： A61K48/005 , A61K9/0019 , A61K31/7115 , A61K48/0058 , A61K48/0066 , A61P1/16 , A61P3/00 , A61P3/06 , A61P3/10 , A61P9/00 , A61P11/00 , A61P29/00 , A61P35/00 , C07K14/001 , C07K14/003 , C12N9/22 , C12N2310/20 , C12Y301/21
摘要： The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.
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公开(公告)号：US20180228876A1
公开(公告)日：2018-08-16
申请号：US15950236
申请日：2018-04-11
发明人： Kamel Khalili , Wenhui Hu
CPC分类号： A61K38/465 , A61K9/0034 , A61K35/12 , A61K45/06 , A61K48/00 , A61K48/005 , C12N7/00 , C12N9/22 , C12N15/111 , C12N2310/20 , C12N2320/30 , C12N2740/16063 , C12Y301/21
摘要： A method of preventing transmission of a retrovirus from a mother to her offspring, by administering to the mother a therapeutically effective amount of a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and the two or more different multiplex gRNAs, wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) of proviral DNA of the virus that is unique from the genome of the host cell, cleaving a double strand of the proviral DNA at a first target protospacer sequence with the CRISPR-associated endonuclease, cleaving a double strand of the proviral DNA at a second target protospacer sequence with the CRISPR-associated endonuclease, excising an entire HIV-1 proviral genome, eradicating the HIV-1 proviral DNA from the host cell, and preventing transmission of the proviral DNA to the offspring.
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公开(公告)号：US20180200343A1
公开(公告)日：2018-07-19
申请号：US15902263
申请日：2018-02-22
发明人： Kamel KHALILI , Wenhui HU
CPC分类号： A61K38/465 , A61K9/0034 , A61K35/12 , A61K45/06 , A61K48/00 , A61K48/005 , C12N7/00 , C12N9/22 , C12N15/111 , C12N2310/20 , C12N2320/30 , C12N2740/16063 , C12Y301/21
摘要： A method of treating a subject having or at risk for having a virus infection, by administering a therapeutically effective amount of a composition comprising a vector encoding a CRISPR-associated endonuclease and at least two guide RNAs that are complementary to two target sequences spanning from the 5′- to 3′-LTRs of the sequence in the virus, and completely excising a fragment of greater than 9000-bp of integrated proviral DNA that spanned from its 5′- to 3′-LTRs. A method of treating a subject having or at risk for having a genetic caused disease, by administering a therapeutically effective amount of a composition comprising a vector encoding a CRISPR-associated endonuclease and at least two guide RNAs that are complementary to two target sequences spanning from the sequence of the subjects DNA greater than 9000-bp that is chromosomally integrated and causes the genetic caused disease, and excising the chromosomally integrated sequence.
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公开(公告)号：US20180177893A1
公开(公告)日：2018-06-28
申请号：US15881721
申请日：2018-01-26
发明人： Matthew ANGEL , Christopher ROHDE
CPC分类号： A61K48/0058 , A61K31/7115 , A61P1/16 , A61P3/00 , A61P3/06 , A61P3/10 , A61P9/00 , A61P11/00 , A61P29/00 , A61P35/00 , C07K14/001 , C12N9/22 , C12N2310/20 , C12Y301/21
摘要： The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.
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公开(公告)号：US20180169193A1
公开(公告)日：2018-06-21
申请号：US15879877
申请日：2018-01-25
发明人： Kamel KHALILI , Wenhui HU
CPC分类号： A61K38/465 , A61K9/0034 , A61K35/12 , A61K45/06 , A61K48/00 , A61K48/005 , C12N7/00 , C12N9/22 , C12N15/111 , C12N2310/20 , C12N2320/30 , C12N2740/16063 , C12Y301/21
摘要： Methods of inactivating a proviral DNA genome or a DNA genome integrated into the genome of a host cell latently infected with a retrovirus, by treating the host cell with a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and two or more different multiplex guide RNAs (gRNAs), wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) of the proviral DNA that is unique from the genome of the host cell, cleaving a double strand of the proviral DNA at a first target protospacer sequence with the CRISPR-associated endonuclease, cleaving a double strand of the proviral DNA at a second target protospacer sequence with the CRISPR-associated endonuclease, excising an entire proviral genome of the proviral DNA, and eradicating the proviral DNA from the host cell.
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