公开(公告)号：US20240208971A1

公开(公告)日：2024-06-27

申请号：US18392204

申请日：2023-12-21

Applicant: Purdue Research Foundation

Inventor： Herman O. Sintim ,  Neetu Dayal ,  Clemen Opoku-Temeng

IPC: C07D471/14 ,  C07D209/08 ,  C07D231/56 ,  C07D401/14 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D491/147 ,  C07D495/14 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

CPC classification number: C07D471/14 ,  C07D209/08 ,  C07D231/56 ,  C07D401/14 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D491/147 ,  C07D495/14 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C07B2200/05

Abstract: The present invention generally relates to compounds as a dual kinase-demethylase inhibitor useful for the treatment of diseases mediated by a kinase and/or a histone demethylase, such as inflammation, cancer, viral and bacterial infections, neurological and immunological disorders. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.

公开(公告)号：US20220194957A1

公开(公告)日：2022-06-23

申请号：US17552421

申请日：2021-12-16

Applicant: Purdue Research Foundation

Inventor： Herman O. Sintim ,  George Naclerio ,  Caroline Karanja

IPC: C07D495/04

Abstract: Cyclic nucleotides, both mono- and di-nucleotides, play diverse roles in the prokaryotes and eukaryotes. Described are compounds, which inhibit phosphodiesterases that inhibit cyclic mononucleotide or dinucleotides and/or both mononucleotide and dinucleotide. These compounds have potential diverse applications as antiviral, antibacterial, anti-inflammatory and anticancer agents, including cancer immunotherapy. Pharmaceutical compositions and methods for treating those kinase related diseases are within the scope of this invention.

公开(公告)号：US11001559B2

公开(公告)日：2021-05-11

申请号：US16325022

申请日：2017-08-15

Applicant: Purdue Research Foundation

Inventor： Herman O. Sintim

IPC: C07D471/04 ,  C07D401/06 ,  C07D217/22 ,  C07D401/12 ,  C07D487/04 ,  C07D417/04 ,  C07D471/10 ,  C07D473/32 ,  C07D413/04 ,  C07D239/95 ,  C07D213/73 ,  C07D239/84 ,  C07D401/04 ,  C07D403/04 ,  C07D417/12 ,  C07D401/10 ,  C07D403/10 ,  A61P35/00 ,  C07D209/49 ,  C07D221/02 ,  C07D233/10 ,  C07D271/06 ,  C07D413/06

Abstract: This invention relates to 4-substituted isoquinoline compounds and their derivatives and uses thereof for treatment of cancer, for example, acute myeloid leukemia.

公开(公告)号：US10438688B2

公开(公告)日：2019-10-08

申请号：US16113718

申请日：2018-08-27

Applicant: Purdue Research Foundation

Inventor： Marxa L. Figueiredo ,  Charles Samuel Umbaugh ,  Herman O. Sintim ,  Adriana Diaz-Quinones

IPC: A61K31/497 ,  G16B15/00 ,  A61P19/02 ,  A61P35/00 ,  G16B35/00 ,  G16C20/60

Abstract: An in silico screening method generated compounds that are against laminin receptor 37LR and their anti-cancer functions in prostate cancer cell lines are disclosed herein. A group of derivatives based on the hit compound from the in silico screening are synthesized and tested with improved IC50 value that can have relevant clinical use for prostate cancer or osteoarthritis.

公开(公告)号：US12122786B2

公开(公告)日：2024-10-22

申请号：US17552421

申请日：2021-12-16

Applicant: Purdue Research Foundation

Inventor： Herman O. Sintim ,  George Naclerio ,  Caroline Karanja

IPC: C07D495/04

CPC classification number: C07D495/04

Abstract: The described compounds are of the class of cyclic nucleotides, both mono- and di-nucleotides, which play diverse roles in the prokaryotes and eukaryotes having the general formula




which inhibit phosphodiesterases that inhibit cyclic mononucleotide or dinucleotides and/or both mononucleotide and dinucleotide. These compounds have potential diverse applications as antiviral, antibacterial, anti-inflammatory and anticancer agents, including cancer immunotherapy. Pharmaceutical compositions and methods for treating those kinase related diseases are within the scope of this invention.

公开(公告)号：US20220249447A1

公开(公告)日：2022-08-11

申请号：US17606720

申请日：2020-04-24

Applicant: Purdue Research Foundation

Inventor： Herman O. Sintim ,  George Naclerio

IPC: A61K31/4245 ,  C07D413/04 ,  C07D417/14 ,  C07D413/14 ,  C07D271/113 ,  C07D409/04 ,  C07D271/07 ,  C07D413/12 ,  C07D277/46 ,  C07D231/40 ,  C07D257/06 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/4196 ,  A61K31/433 ,  A61K31/426 ,  A61K31/415 ,  A61K31/41 ,  A61K45/06

Abstract: The present invention generally relates to compounds as a new antibiotic to treat various infections, including infections caused by methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate and vancomycin-resistant S. aureus (VISA and VRSA respectively) vancomycin-resistant Enterococcusfaecalis (VRE), and Clostridioides difficile. Pharmaceutical compositions and methods for treating those infection diseases are within the scope of this invention.

公开(公告)号：US11731964B2

公开(公告)日：2023-08-22

申请号：US17046957

申请日：2019-03-29

Applicant: Purdue Research Foundation

Inventor： Herman O. Sintim ,  Mohamed Seleem ,  Clement Opoku-Temeng ,  Haroon Taj Mohammad ,  George Naclerio

IPC: C07D417/14 ,  A61P31/04 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

CPC classification number: C07D417/14 ,  A61P31/04 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

Abstract: The present invention generally relates to compounds as a new antibiotic to treat various infections, including infections caused by methicillin-resistant Staphylococcus aureus, vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis and Clostridioides difficile. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.

公开(公告)号：US20230219934A1

公开(公告)日：2023-07-13

申请号：US18009311

申请日：2021-06-24

Applicant: Purdue Research Foundation

Inventor： Herman O. Sintim ,  Elizabeth Anne Larocque ,  Delmis E. Hernandez ,  Neetu Dayal

IPC: C07D403/14 ,  A61P35/00

CPC classification number: C07D403/14 ,  A61P35/00

Abstract: The present invention generally relates to 2,3-Disubstituted pyrido[3,4-b]pyrazine-containing compounds as a kinase inhibitor and methods of uses thereof. Pharmaceutical compositions and methods for treating those kinase related diseases are within the scope of this invention.

公开(公告)号：US20210371420A1

公开(公告)日：2021-12-02

申请号：US17243629

申请日：2021-04-29

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Herman O. Sintim ,  Neetu Dayal ,  Clement Opoku-Temeng

IPC: C07D471/14 ,  C07D209/08 ,  C07D231/56 ,  C07D401/14 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D491/147 ,  C07D495/14 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present invention generally relates to compounds as a dual kinase-demethylase inhibitor useful for the treatment of diseases mediated by a kinase and/or a histone demethylase, such as inflammation, cancer, viral and bacterial infections, neurological and immunological disorders. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.

公开(公告)号：US11040973B2

公开(公告)日：2021-06-22

申请号：US16499133

申请日：2018-03-29

Applicant: Purdue Research Foundation

Inventor： Herman O. Sintim ,  Neetu Dayal ,  Clement Opoku-Temeng

IPC: C07D471/02 ,  A61K31/4745 ,  C07D471/14 ,  C07D209/08 ,  C07D231/56 ,  C07D401/14 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D491/147 ,  C07D495/14 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present invention generally relates to compounds as a dual kinase-demethylase inhibitor useful for the treatment of diseases mediated by a kinase and/or a histone demethylase, such as inflammation, cancer, viral and bacterial infections, neurological and immunological disorders. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.