公开(公告)号：US11731964B2

公开(公告)日：2023-08-22

申请号：US17046957

申请日：2019-03-29

Applicant: Purdue Research Foundation

Inventor： Herman O. Sintim ,  Mohamed Seleem ,  Clement Opoku-Temeng ,  Haroon Taj Mohammad ,  George Naclerio

IPC: C07D417/14 ,  A61P31/04 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

CPC classification number: C07D417/14 ,  A61P31/04 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

Abstract: The present invention generally relates to compounds as a new antibiotic to treat various infections, including infections caused by methicillin-resistant Staphylococcus aureus, vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis and Clostridioides difficile. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.

公开(公告)号：US20250002501A1

公开(公告)日：2025-01-02

申请号：US18885251

申请日：2024-09-13

Applicant: Purdue Research Foundation

Inventor： Herman O. Sintim ,  George Naclerio ,  Caroline Karanja

IPC: C07D495/04

Abstract: Cyclic nucleotides, both mono- and di-nucleotides, play diverse roles in the prokaryotes and eukaryotes. Described are compounds, which inhibit phosphodiesterases that inhibit cyclic mononucleotide or dinucleotides and/or both mononucleotide and dinucleotide. These compounds have potential diverse applications as antiviral, antibacterial, anti-inflammatory and anticancer agents, including cancer immunotherapy. Pharmaceutical compositions and methods for treating those kinase related diseases are within the scope of this invention.

公开(公告)号：US20220194957A1

公开(公告)日：2022-06-23

申请号：US17552421

申请日：2021-12-16

Applicant: Purdue Research Foundation

Inventor： Herman O. Sintim ,  George Naclerio ,  Caroline Karanja

IPC: C07D495/04

Abstract: Cyclic nucleotides, both mono- and di-nucleotides, play diverse roles in the prokaryotes and eukaryotes. Described are compounds, which inhibit phosphodiesterases that inhibit cyclic mononucleotide or dinucleotides and/or both mononucleotide and dinucleotide. These compounds have potential diverse applications as antiviral, antibacterial, anti-inflammatory and anticancer agents, including cancer immunotherapy. Pharmaceutical compositions and methods for treating those kinase related diseases are within the scope of this invention.

公开(公告)号：US12122786B2

公开(公告)日：2024-10-22

申请号：US17552421

申请日：2021-12-16

Applicant: Purdue Research Foundation

Inventor： Herman O. Sintim ,  George Naclerio ,  Caroline Karanja

IPC: C07D495/04

CPC classification number: C07D495/04

Abstract: The described compounds are of the class of cyclic nucleotides, both mono- and di-nucleotides, which play diverse roles in the prokaryotes and eukaryotes having the general formula




which inhibit phosphodiesterases that inhibit cyclic mononucleotide or dinucleotides and/or both mononucleotide and dinucleotide. These compounds have potential diverse applications as antiviral, antibacterial, anti-inflammatory and anticancer agents, including cancer immunotherapy. Pharmaceutical compositions and methods for treating those kinase related diseases are within the scope of this invention.

公开(公告)号：US20220249447A1

公开(公告)日：2022-08-11

申请号：US17606720

申请日：2020-04-24

Applicant: Purdue Research Foundation

Inventor： Herman O. Sintim ,  George Naclerio

IPC: A61K31/4245 ,  C07D413/04 ,  C07D417/14 ,  C07D413/14 ,  C07D271/113 ,  C07D409/04 ,  C07D271/07 ,  C07D413/12 ,  C07D277/46 ,  C07D231/40 ,  C07D257/06 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/4196 ,  A61K31/433 ,  A61K31/426 ,  A61K31/415 ,  A61K31/41 ,  A61K45/06

Abstract: The present invention generally relates to compounds as a new antibiotic to treat various infections, including infections caused by methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate and vancomycin-resistant S. aureus (VISA and VRSA respectively) vancomycin-resistant Enterococcusfaecalis (VRE), and Clostridioides difficile. Pharmaceutical compositions and methods for treating those infection diseases are within the scope of this invention.