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公开(公告)号：US20250002501A1
公开(公告)日：2025-01-02
申请号：US18885251
申请日：2024-09-13
Applicant: Purdue Research Foundation
Inventor： Herman O. Sintim , George Naclerio , Caroline Karanja
IPC: C07D495/04
Abstract: Cyclic nucleotides, both mono- and di-nucleotides, play diverse roles in the prokaryotes and eukaryotes. Described are compounds, which inhibit phosphodiesterases that inhibit cyclic mononucleotide or dinucleotides and/or both mononucleotide and dinucleotide. These compounds have potential diverse applications as antiviral, antibacterial, anti-inflammatory and anticancer agents, including cancer immunotherapy. Pharmaceutical compositions and methods for treating those kinase related diseases are within the scope of this invention.
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公开(公告)号：US12122786B2
公开(公告)日：2024-10-22
申请号：US17552421
申请日：2021-12-16
Applicant: Purdue Research Foundation
Inventor： Herman O. Sintim , George Naclerio , Caroline Karanja
IPC: C07D495/04
CPC classification number: C07D495/04
Abstract: The described compounds are of the class of cyclic nucleotides, both mono- and di-nucleotides, which play diverse roles in the prokaryotes and eukaryotes having the general formula
which inhibit phosphodiesterases that inhibit cyclic mononucleotide or dinucleotides and/or both mononucleotide and dinucleotide. These compounds have potential diverse applications as antiviral, antibacterial, anti-inflammatory and anticancer agents, including cancer immunotherapy. Pharmaceutical compositions and methods for treating those kinase related diseases are within the scope of this invention.
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公开(公告)号：US20220194957A1
公开(公告)日：2022-06-23
申请号：US17552421
申请日：2021-12-16
Applicant: Purdue Research Foundation
Inventor： Herman O. Sintim , George Naclerio , Caroline Karanja
IPC: C07D495/04
Abstract: Cyclic nucleotides, both mono- and di-nucleotides, play diverse roles in the prokaryotes and eukaryotes. Described are compounds, which inhibit phosphodiesterases that inhibit cyclic mononucleotide or dinucleotides and/or both mononucleotide and dinucleotide. These compounds have potential diverse applications as antiviral, antibacterial, anti-inflammatory and anticancer agents, including cancer immunotherapy. Pharmaceutical compositions and methods for treating those kinase related diseases are within the scope of this invention.
