公开(公告)号：US12116408B2

公开(公告)日：2024-10-15

申请号：US17380404

申请日：2021-07-20

Applicant: Novo Nordisk A/S

Inventor： Anette Henriksen ,  Kristian Kjaergaard ,  Vibeke Westphal Stennicke ,  Charlotte Wiberg

IPC: C07K16/28

CPC classification number: C07K16/2803 ,  C07K2299/00 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94

Abstract: Antibodies that are capable of specifically binding and preventing the activation of TREM-1, a protein expressed on monocytes, macrophages and neutrophils with both good affinity and low viscosity at clinically relevant concentrations are described. Such antibodies find utility in the treatment of individuals with an inflammatory disease, such as rheumatoid arthritis and inflammatory bowel disease.

公开(公告)号：US11906524B2

公开(公告)日：2024-02-20

申请号：US15776697

申请日：2016-11-19

Applicant: Duke University

Inventor： Homme W. Hellinga ,  Malin J. Allert

IPC: G01N33/62 ,  C12Q1/58 ,  G01N21/64 ,  G01N33/542 ,  C07K14/195 ,  C07K1/30

CPC classification number: G01N33/62 ,  C07K14/195 ,  C12Q1/58 ,  G01N21/6428 ,  G01N33/542 ,  C07K1/306 ,  C07K2299/00 ,  C07K2319/20 ,  G01N2021/6439 ,  G01N2333/195 ,  G01N2333/47

Abstract: The present subject matter provides urea biosensors as well as compositions, devices, and methods comprising such biosensors.

公开(公告)号：US11820829B2

公开(公告)日：2023-11-21

申请号：US17079075

申请日：2020-10-23

Applicant: MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT

Inventor： Felix Oden ,  Stephen Marino ,  Oliver Daumke

IPC: C07K16/28 ,  A61K47/68 ,  C12N5/10 ,  C12N15/00 ,  A61K39/00 ,  A61K39/395

CPC classification number: C07K16/2878 ,  A61K47/6849 ,  A61K47/6867 ,  A61K39/395 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2299/00 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  C12N5/10 ,  C12N15/00

Abstract: A nucleic acid molecule encoding an antibody or antibody fragment, wherein the antibody or antibody fragment binds an epitope of the extracellular domain of CD269 (BCMA), a host cell comprising the nucleic acid molecule and a composition comprising the host cell.

公开(公告)号：US20180208635A1

公开(公告)日：2018-07-26

申请号：US15745021

申请日：2016-08-25

Applicant: HISTIDE AG

Inventor： Omar F. ZOUANI

IPC: C07K14/51

CPC classification number: C07K14/51 ,  A61L27/227 ,  C07K2299/00

Abstract: The present disclosure provides peptides, or variants or analogs thereof, with between 8 and 30 amino acids, having growth factor receptor-binding capability, wherein the RMSD value of the structure coordinates of said peptide, variant or analog thereof with respect to PEPREF is 2.45A (Angstroms) or less.

公开(公告)号：US09995733B2

公开(公告)日：2018-06-12

申请号：US13483280

申请日：2012-05-30

Applicant: Frank Osterroth ,  Christoph Uherek ,  Christoph Bruecher ,  Benjamin Daelken ,  André Engling ,  Chantal Zuber ,  Niklas Czeloth ,  Holger Wallmeier ,  Kirsten Völp ,  Gregor Schulz

Inventor： Frank Osterroth ,  Christoph Uherek ,  Christoph Bruecher ,  Benjamin Daelken ,  André Engling ,  Chantal Zuber ,  Niklas Czeloth ,  Holger Wallmeier ,  Kirsten Völp ,  Gregor Schulz

IPC: G01N33/48 ,  G01N33/50 ,  C07K16/28 ,  G06G7/58

CPC classification number: G01N33/505 ,  C07K16/2812 ,  C07K2299/00 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/75 ,  G01N2333/70514

Abstract: Provided are methods of screening to identify molecules capable of binding to CD4 and capable of activating CD4+CD25+ regulatory T cells. Further provided are antibodies and antibody fragments capable of activating CD4+CD25+ regulatory T cells and methods and uses involving the antibodies and fragments thereof.

公开(公告)号：US20180057598A1

公开(公告)日：2018-03-01

申请号：US15669861

申请日：2017-08-04

Applicant: Genentech, Inc.

Inventor： Greg LAZAR ,  Yanli YANG ,  Erin H. CHRISTENSEN ,  Julie HANG ,  Jeong KIM ,  Seth HARRIS

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/2878 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2818 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/35 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/71 ,  C07K2317/75 ,  C07K2317/90 ,  C07K2317/92

Abstract: Provided herein are tetravalent antigen binding complexes having agonist activity for a cell surface receptor. In some embodiments, the complexes comprise binding specificities for multiple epitopes of the same cell surface receptor. Further provided herein are nucleic acids, vectors, host cells, pharmaceutical compositions, and methods of production related thereto.

公开(公告)号：US20180044649A1

公开(公告)日：2018-02-15

申请号：US15672091

申请日：2017-08-08

Applicant: EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL)

Inventor： Stephen CUSACK ,  Eva KOWALINSKI ,  Chloe ZUBIETA

IPC: C12N9/22 ,  C07D211/32 ,  C07D211/96 ,  G06F19/16 ,  C07H19/10 ,  C07K14/005 ,  C07K16/40 ,  A61K31/33 ,  C07D311/62

CPC classification number: C12N9/22 ,  A61K31/33 ,  A61K38/00 ,  C07D211/32 ,  C07D211/96 ,  C07D311/62 ,  C07H19/10 ,  C07K14/005 ,  C07K16/40 ,  C07K2299/00 ,  C07K2317/34 ,  C12N2760/16122 ,  G16B15/00

Abstract: The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase possessing endonuclease activity, wherein said PA subunit is from Influenza A 2009 pandemic H1N1 virus or is a variant thereof. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of said polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit said endonucleolytic activity, preferably in a high throughput setting. This invention also relates to compounds which are able to modulate, preferably to inhibit, the endonuclease activity of the PA subunit polypeptide fragment or variant thereof of the present invention and pharmaceutical compositions comprising said compounds for the treatment of disease conditions caused by viral infections with viruses of the Orthomyxoviridae family, Bunyaviridae family and/or Arenviridae family, preferably caused by viral infections with Influenza A 2009 pandemic H1N1 virus. Preferably, said compounds are identifiable by the methods disclosed herein or said pharmaceutical compositions are producible by the methods disclosed herein.

公开(公告)号：US09884913B2

公开(公告)日：2018-02-06

申请号：US15462585

申请日：2017-03-17

Applicant: Novartis AG ,  DANA-FARBER CANCER INSTITUTE, INC. ,  Children's Medical Center Corporation

Inventor： Catherine Anne Sabatos-Peyton ,  Barbara Brannetti ,  Alan S. Harris ,  Thomas Huber ,  Thomas Pietzonka ,  Jennifer Marie Mataraza ,  Walter A. Blattler ,  Daniel J. Hicklin ,  Maximiliano Vasquez ,  Rosemarie H. DeKruyff ,  Dale T. Umetsu ,  Gordon James Freeman ,  Tiancen Hu ,  John A. Taraszka ,  Fangmin Xu

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  G01N33/68

CPC classification number: C07K16/2803 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  C07K2299/00 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/6893

Abstract: Antibody molecules that specifically bind to TIM-3 are disclosed. The anti-TIM-3 antibody molecules can be used to treat, prevent and/or diagnose immune, cancerous, or infectious conditions and/or disorders.

公开(公告)号：US20180030431A1

公开(公告)日：2018-02-01

申请号：US15593395

申请日：2017-05-12

Applicant: INVISTA North America S.A.R.L.

Inventor： Eric ALTHOFF ,  Nadia KADI ,  Mihai Luchian AZOITEI ,  Yih-En A. BAN ,  Daniela GRABS-RÖTHLISBERGER ,  Alexander PISARCHIK ,  Alexandre ZANGHELLINI ,  Adriana L. BOTES

IPC: C12N9/88 ,  C08F136/06 ,  C07C11/167 ,  C07C11/18 ,  C07C11/21 ,  C07K16/40 ,  C12P5/00 ,  C08F136/08 ,  A61K38/00 ,  C08F36/22 ,  C08F36/08 ,  C08F36/06 ,  G01N33/573 ,  C12P5/02

CPC classification number: C12N9/88 ,  A61K38/00 ,  C07C11/167 ,  C07C11/18 ,  C07C11/21 ,  C07K16/40 ,  C07K2299/00 ,  C08F36/06 ,  C08F36/08 ,  C08F36/22 ,  C08F136/06 ,  C08F136/08 ,  C12P5/007 ,  C12P5/026 ,  C12Y402/01053 ,  C12Y402/01095 ,  C12Y402/01127 ,  C12Y402/01131 ,  G01N33/573

Abstract: The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.

公开(公告)号：US20180009853A1

公开(公告)日：2018-01-11

申请号：US15547499

申请日：2016-01-26

Applicant: Yeda Research And Development Co. Ltd.

Inventor： Ada YONATH ,  Zohar EYAL ,  Donna MATZOV ,  Haim ROZENBERG ,  Ella ZIMMERMAN ,  Anat BASHAN

IPC: C07K14/31 ,  C07H17/08 ,  C07D211/54 ,  C07D263/20 ,  G06F19/00 ,  G06F19/16

CPC classification number: C07K14/31 ,  C07D211/54 ,  C07D263/20 ,  C07H17/08 ,  C07K2299/00 ,  G16B15/00 ,  G16B30/00 ,  G16B35/00 ,  G16C20/50 ,  G16C20/60

Abstract: A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.