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公开(公告)号：US12085565B2
公开(公告)日：2024-09-10
申请号：US15934837
申请日：2018-03-23
发明人： Robert Siman
IPC分类号： G01N33/566 , G01N33/68
CPC分类号： G01N33/566 , G01N33/6896 , G01N2333/47 , G01N2333/4703 , G01N2800/28 , G01N2800/2871 , G01N2800/50 , G01N2800/52
摘要： The invention relates to methods for providing prognosis, diagnosis, monitoring and treatment of a mild traumatic brain injury (mTBI) in a subject, including a sports-related concussion. The invention further relates to assessing the severity of brain damage resulting from mTBI in a subject, including in a subject who has not undergone a CT scan following the injury. For example, the methods of the invention can be used to determine the suitability for someone who has suffered a sports-related injury to return to play that sport. This invention also relates to methods of predicting risk for developing brain damage and long-term dysfunction in a subject having suffered mTBI.
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公开(公告)号：US12018064B2
公开(公告)日：2024-06-25
申请号：US17396305
申请日：2021-08-06
发明人： Andrea Mahr , Toni Weinschenk , Oliver Schoor , Jens Fritsche , Harpreet Singh , Lea Stevermann
IPC分类号： A61K38/00 , A01N37/46 , A61K38/06 , A61K38/08 , A61K38/17 , A61K39/00 , A61K45/06 , C07K7/02 , C07K7/06 , C07K14/00 , C07K14/47 , C07K14/725 , C07K14/74 , C07K16/18 , C07K16/28 , C07K16/30 , C12N5/0783 , C12N9/64 , C12Q1/6886 , G01N33/50 , G01N33/566 , G01N33/569
CPC分类号： C07K14/70539 , A01N37/46 , A61K38/06 , A61K38/08 , A61K38/1774 , A61K39/0005 , A61K39/0011 , A61K45/06 , C07K7/02 , C07K7/06 , C07K14/001 , C07K14/47 , C07K14/4702 , C07K14/4748 , C07K14/7051 , C07K16/18 , C07K16/2833 , C07K16/30 , C12N5/0636 , C12N5/0638 , C12N9/6491 , C12Q1/6886 , G01N33/505 , G01N33/5088 , G01N33/566 , G01N33/56972 , G01N33/56977 , A61K38/00 , A61K2039/5158 , A61K2039/54 , A61K2039/57 , A61K2039/572 , A61K2039/585 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2319/00 , C07K2319/40 , C12N2501/998 , C12N2502/11 , C12Q2600/106 , C12Q2600/158 , C12Y304/24 , G01N2333/47 , G01N2333/70503 , G01N2333/7051 , G01N2333/70539 , G01N2500/10
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US12006349B2
公开(公告)日：2024-06-11
申请号：US17396323
申请日：2021-08-06
发明人： Andrea Mahr , Toni Weinschenk , Oliver Schoor , Jens Fritsche , Harpreet Singh , Lea Stevermann
IPC分类号： A61K38/00 , A01N37/46 , A61K38/06 , A61K38/08 , A61K38/17 , A61K39/00 , A61K45/06 , C07K7/02 , C07K7/06 , C07K14/00 , C07K14/47 , C07K14/725 , C07K14/74 , C07K16/18 , C07K16/28 , C07K16/30 , C12N5/0783 , C12N9/64 , C12Q1/6886 , G01N33/50 , G01N33/566 , G01N33/569
CPC分类号： C07K14/70539 , A01N37/46 , A61K38/06 , A61K38/08 , A61K38/1774 , A61K39/0005 , A61K39/0011 , A61K45/06 , C07K7/02 , C07K7/06 , C07K14/001 , C07K14/47 , C07K14/4702 , C07K14/4748 , C07K14/7051 , C07K16/18 , C07K16/2833 , C07K16/30 , C12N5/0636 , C12N5/0638 , C12N9/6491 , C12Q1/6886 , G01N33/505 , G01N33/5088 , G01N33/566 , G01N33/56972 , G01N33/56977 , A61K38/00 , A61K2039/5158 , A61K2039/54 , A61K2039/57 , A61K2039/572 , A61K2039/585 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2319/00 , C07K2319/40 , C12N2501/998 , C12N2502/11 , C12Q2600/106 , C12Q2600/158 , C12Y304/24 , G01N2333/47 , G01N2333/70503 , G01N2333/7051 , G01N2333/70539 , G01N2500/10
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US20240151726A1
公开(公告)日：2024-05-09
申请号：US18413155
申请日：2024-01-16
发明人： Eli N. Glezer , Anu Mathew , Martin Stengelin , Mingyue Wang
IPC分类号： G01N33/574
CPC分类号： G01N33/57438 , G01N2333/47 , G01N2333/4725 , G01N2333/70503 , G01N2400/00 , G01N2800/085 , G01N2800/56
摘要： The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a chemotherapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
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公开(公告)号：US11977084B2
公开(公告)日：2024-05-07
申请号：US17005892
申请日：2020-08-28
IPC分类号： G01N33/68 , A61K31/165 , A61K31/69 , A61K38/05 , A61K51/00 , G01N30/72 , G01N30/88 , G01N33/50
CPC分类号： G01N33/6896 , A61K31/165 , A61K31/69 , A61K38/05 , A61K51/00 , G01N30/72 , G01N33/5023 , G01N33/5058 , G01N2030/8831 , G01N2333/47 , G01N2800/2821
摘要： The inventors surprisingly found that neural stimulation caused the synthesis and degradation of proteins into peptides which were then secreted into the cell media within minutes of stimulation by a novel neural-specific and membrane bound proteasome (neuronal membrane proteasome or NMP) that is transmembrane in nature. These secreted, activity-induced, proteasomal peptides (SNAPPs) range in size from about 500 Daltons to about 3000 Daltons. Surprisingly none of the peptides appear to be those previously known to have any neuronal function. Moreover, these SNAPPs have stimulatory activity and are heretofore a new class of signaling molecules. Moreover, the NMP appears to play a highly significant role in aspects of neuronal signaling known to be critical for neuronal function. The inventors have gone on to develop all tools to study this novel mechanisms including protocols and practice for generation and purification of SNAPPs as well as a new and specific inhibitor of the NMP allowing for selective control of this process in the nervous system. The present invention provides methods of making and using these SNAPPs for both laboratory and clinical purposes, the screening for molecules which modulate NMP function in vivo and in vitro, and methods for diagnosis of NMP related diseases.
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公开(公告)号：US20240085430A1
公开(公告)日：2024-03-14
申请号：US18242804
申请日：2023-09-06
发明人： Philippe J. Goix , Robert Puskas , John Todd , Richard Livingston , Douglas Held , Allan H.B. Wu
CPC分类号： G01N33/68 , G01N21/6428 , G01N21/6486 , G01N33/582 , G01N33/6887 , G01N33/6893 , G01N2333/47 , G01N2800/32 , G01N2800/324 , G01N2800/325 , G01N2800/50
摘要： The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
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公开(公告)号：US20230258661A1
公开(公告)日：2023-08-17
申请号：US18147420
申请日：2022-12-28
申请人： Abbott Laboratories
发明人： Beth McQuiston , Saul Datwyler , Raj Chandran , Hongwei Zhang
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2800/2871 , G01N2800/60 , G01N2333/916 , G01N2333/47 , C12Y301/02015
摘要： Disclosed herein are methods and systems of determining whether a subject's levels of GFAP, UCH-L1, or GFAP and UCH-L1 are elevated in a sample collected from the subject. The methods comprise determining whether the levels of GFAP, UCH-L1, or GFAP and UCH-L1 are elevated in the sample, and communicating the determination on or from an instrument. The methods may be used to aid in the diagnosis and evaluation of a subject (e.g., a human subject) that has sustained or may have sustained an injury to the head, such as to determine whether the subject is suffering from a mild, moderate, severe, or moderate to severe traumatic brain injury (TBI).
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公开(公告)号：US20190233893A1
公开(公告)日：2019-08-01
申请号：US16208903
申请日：2018-12-04
发明人： LINDA C. GIUDICE
IPC分类号： C12Q1/6883 , C12N15/11 , A61K38/00 , G01N33/68 , A61K31/60 , A61K31/485 , A61K31/57 , C12N15/00 , C12Q1/68
CPC分类号： C12Q1/6883 , A61K31/485 , A61K31/57 , A61K31/60 , A61K38/00 , C12N15/00 , C12N15/11 , C12Q1/68 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/6893 , G01N2333/47 , G01N2333/4703 , G01N2333/4716 , G01N2333/4725 , G01N2333/575 , G01N2333/96436 , G01N2800/364
摘要： The present invention provides biomarkers for the diagnosis and prognosis of endometriosis. Generally, the methods of this invention find use in diagnosing or for providing a prognosis for endometriosis by detecting the expression levels of biomarkers, which are differentially expressed (up- or down-regulated) in endometrial cells from a patient with endometriosis. Similarly, these markers can be used to diagnose reduced fertility in a patient with endometriosis or to provide a prognosis for a fertility trial in a patient suffering from endometriosis. The present invention also provides methods of identifying a compound for treating or preventing endometriosis. Finally, the present invention provides kits for the diagnosis or prognosis of endometriosis.
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公开(公告)号：US20190233506A1
公开(公告)日：2019-08-01
申请号：US16128978
申请日：2018-09-12
发明人： Roger Nitsch , Feng Chen , Jan Grimm , Jean-Luc Baeriswyl , Christoph Hock
IPC分类号： C07K16/18 , A61K39/395 , C07K14/47 , G01N33/68
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , C07K14/47 , C07K14/4711 , C07K2317/10 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/90 , C07K2317/92 , G01N33/6896 , G01N2333/47 , G01N2800/56
摘要： Provided are novel human tau-specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for tau are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for tau targeted immunotherapy and diagnosis, respectively.
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公开(公告)号：US20190211086A1
公开(公告)日：2019-07-11
申请号：US16250733
申请日：2019-01-17
申请人： rPeptide LLC
CPC分类号： C07K16/18 , A61K49/0002 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , G01N33/6896 , G01N2333/47 , G01N2800/28
摘要： The present invention relates, in part, to isolated antibodies that specifically interact with and show measurable binding affinity to an epitope of the tau protein. Such antibodies may be used for the modulation of tau activity and/or aggregation, to study the effects of the tau protein on cell function and, in certain embodiments, for the treatment and/or prevention of a disease or condition associated with neurodegenerative tauopathy.
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