公开(公告)号：US20240094223A1

公开(公告)日：2024-03-21

申请号：US18502243

申请日：2023-11-06

申请人： BIO-RAD EUROPE GMBH ,  BIO-RAD LABORATORIES, INC.

发明人： ISABELLE BATXELLI-MOLINA ,  FLORIAN SALIPANTE ,  ROGER P. WALKER ,  JOHN FLANAGAN ,  JEANNETTE FAREH-MICHIEL

IPC分类号： G01N33/68 ,  G16B25/10

CPC分类号： G01N33/6893 ,  G01N33/6869 ,  G16B25/10 ,  G01N2333/521 ,  G01N2333/5421 ,  G01N2333/575 ,  G01N2400/40 ,  G01N2800/085

摘要： The invention provides a method of diagnosing Non-Alcoholic Steatohepatitis (NASH) and/or the hepatic fibrosis status of a subject, especially a subject afflicted with Non-alcoholic fatty liver disease (NAFLD) or NASH, based on the level of only three or more particular biomarkers. The invention further provides a kit suitable for performing said method and the use of said method and methods of treating patients diagnosed in accordance with the disclosed methods.

公开(公告)号：US20240036049A1

公开(公告)日：2024-02-01

申请号：US18265677

申请日：2021-04-08

申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  INHA-INDUSTRY PARTNERSHIP INSTITUTE

发明人： Sunghyouk PARK ,  Sunmi KANG ,  Hoonsik NAM ,  Soon Sun HONG ,  Kyung Hee JUNG

IPC分类号： G01N33/574

CPC分类号： G01N33/57438 ,  G01N2333/575

摘要： A biomarker, for diagnosing pancreatic cancer, including asprosin, and the use thereof, has been confirmed that: the survival prognosis of a pancreatic cancer patient is worse in the case of a higher expression of FBN-1 gene encoding fibrillin-1 which is the precursor of asprosin in a clinical information database; an asprosin level at a cell level is related to an occurrence of pancreatic cancer; and the asprosin level in the blood of a pancreatic cancer patient or an early stage pancreatic cancer patient is higher than that of a healthy person.

公开(公告)号：US11651866B2

公开(公告)日：2023-05-16

申请号：US16137076

申请日：2018-09-20

申请人： RELIANT IMMUNE DIAGNOSTICS, INC

发明人： Jovan Hutton Pulitzer ,  Henry Joseph Legere, III

IPC分类号： G01N33/558 ,  G16H80/00 ,  G06Q40/08 ,  G16H20/10 ,  G06Q10/10 ,  G01N33/569

CPC分类号： G16H80/00 ,  G01N33/558 ,  G01N33/56983 ,  G06Q10/10 ,  G06Q40/08 ,  G16H20/10 ,  G01N2333/575 ,  G01N2333/59 ,  G01N2333/9513

摘要： A method for initiating a telemedicine conference on a mobile device is provided. The method comprises receiving diagnostic test results in response to a diagnostic test, determining if the diagnostic test results include a positive result, storing the diagnostic test results on a server disposed on a network, presenting, if the diagnostic test results are positive, a telemedicine initiation option on a screen of the mobile device, determining whether the telemedicine initiation option is selected, sending the diagnostic test results from the server to the telemedicine provider, sending additional medical history information to the telemedicine provider, and initiating a telemedicine conference with the telemedicine provider. Some of these aspects also provide healthcare providers the ability to electronically send prescriptions and provide users the ability to use a mobile application to send prescriptions to pharmacies to be filled.

公开(公告)号：US11644410B2

公开(公告)日：2023-05-09

申请号：US17135437

申请日：2020-12-28

申请人： Labrador Diagnostics LLC

发明人： Anthony J. Nugent ,  Daniel L. Young ,  Elizabeth A. Holmes ,  Michael Siegel ,  Ryan Wistort

IPC分类号： G01N21/51 ,  G01N21/03 ,  B04B5/04 ,  G01N21/00 ,  B01L3/02 ,  G01N33/543 ,  H04N23/60 ,  C12Q1/42 ,  C12Q1/48 ,  C12Q1/6809 ,  C12Q1/689 ,  G01N21/59 ,  G01N33/569 ,  G01N33/573 ,  G01N33/74 ,  G01N33/80 ,  G06T3/40 ,  G06T7/00 ,  C12Q1/52 ,  C12Q1/6806 ,  G01N1/40 ,  G01N33/53 ,  G01N33/82 ,  G01N33/92 ,  G01N35/10 ,  G16C20/20 ,  G01N35/00

CPC分类号： G01N21/0303 ,  B01L3/0275 ,  B04B5/0421 ,  C12Q1/42 ,  C12Q1/48 ,  C12Q1/52 ,  C12Q1/6806 ,  C12Q1/689 ,  C12Q1/6809 ,  G01N1/4077 ,  G01N21/00 ,  G01N21/51 ,  G01N21/59 ,  G01N33/5308 ,  G01N33/54326 ,  G01N33/54393 ,  G01N33/56972 ,  G01N33/56983 ,  G01N33/573 ,  G01N33/74 ,  G01N33/743 ,  G01N33/80 ,  G01N33/82 ,  G01N33/92 ,  G01N35/10 ,  G06T3/4084 ,  G06T7/0002 ,  G06T7/0012 ,  H04N23/64 ,  B01L2300/168 ,  C12Q2600/158 ,  G01N2001/4083 ,  G01N2035/00495 ,  G01N2035/1018 ,  G01N2333/575 ,  G01N2333/62 ,  G01N2333/91188 ,  G01N2333/96463 ,  G06T2207/30004 ,  G06T2207/30168 ,  G16C20/20

摘要： The present invention provides systems, devices, and methods for point-of-care and/or distributed testing services. The methods and devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device can be modified to allow for more flexible and robust use with the disclosed methods for a variety of medical, laboratory, and other applications. The systems, devices, and methods of the present invention can allow for effective use of samples by improved sample preparation and analysis.

公开(公告)号：US11643688B2

公开(公告)日：2023-05-09

申请号：US16469760

申请日：2017-02-13

申请人： HUCIRCADIAN CO., LTD.

发明人： Heon-Jeong Lee ,  Chul-Hyun Cho ,  Joung-Ho Moon

IPC分类号： C12Q1/6883 ,  G01N33/74

CPC分类号： C12Q1/6883 ,  G01N33/743 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N2333/575

摘要： The present disclosure relates to a method for diagnosing mood disorder such as mania, depression and mania mixed using a circadian rhythm. According to the diagnostic method of the present disclosure, the condition of mood disorder can be diagnosed objectively and clearly based on the advance or delay of the circadian rhythm. That is to say, hypomania, mania, depression, mixed mania, etc. may be determined quickly and adequately so that appropriate therapeutic intervention can be made. In addition, according to the diagnostic method of the present disclosure, schizophrenia which is frequently confused with severe depression or bipolar disorder can be distinguished clearly. In addition, the selection of a therapeutic drug can be benefited greatly through this.

公开(公告)号：US20190233498A1

公开(公告)日：2019-08-01

申请号：US16272406

申请日：2019-02-11

申请人： ALDER BIOPHARMACEUTICALS, INC.

发明人： Maria-Cristina Loomis ,  Leon Garcia-Martinez ,  Benjamin H. Dutzar ,  Daniel S. Allison ,  Katherine Lee Hendrix ,  Ethan W. Ojala ,  Pei Fan ,  Jeffrey T.L. Smith ,  John A. Latham ,  Charlie Karasek ,  Jenny Mulligan ,  Michelle Scalley-Kim ,  Erica Stewart ,  Vanessa Lisbeth Rubin ,  Jens J. Billgren

IPC分类号： C07K14/705 ,  A61K38/22 ,  C07K16/18 ,  C12N5/07 ,  G01N33/68 ,  C07K16/42 ,  C07K16/26 ,  C07K16/28 ,  C07K14/72 ,  C07K14/47 ,  A61K38/17 ,  C12N15/09 ,  C12N15/63 ,  A61K39/395

CPC分类号： C07K14/70503 ,  A61K38/00 ,  A61K38/17 ,  A61K38/22 ,  A61K39/3955 ,  A61K48/00 ,  A61K2039/505 ,  A61P25/06 ,  C07K14/47 ,  C07K14/575 ,  C07K14/72 ,  C07K16/18 ,  C07K16/26 ,  C07K16/28 ,  C07K16/2869 ,  C07K16/4241 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12N5/06 ,  C12N15/09 ,  C12N15/63 ,  G01N33/6854 ,  G01N2333/575 ,  Y02A50/382 ,  Y02A50/383

摘要： The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated. Other embodiments of the invention contemplate using anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, photophobia, mast cell degranulation, and/or neuronal activation, would be therapeutically beneficial.

公开(公告)号：US10076528B2

公开(公告)日：2018-09-18

申请号：US15854053

申请日：2017-12-26

申请人： Pop Test Oncology LLC

发明人： Randice Lisa Altschul ,  Neil David Theise ,  Myron Rapkin ,  Rebecca O'Brien

IPC分类号： A61K31/58 ,  A61K45/06

CPC分类号： A61K31/58 ,  A61J1/10 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/10 ,  A61K9/107 ,  A61K31/337 ,  A61K38/09 ,  A61K45/06 ,  A61K47/10 ,  A61K47/26 ,  A61K47/34 ,  A61K47/42 ,  A61K47/44 ,  A61K51/00 ,  A61N5/1001 ,  B65D75/002 ,  B65D75/36 ,  B65D75/367 ,  C07J17/00 ,  G01N33/743 ,  G01N2333/575 ,  G01N2800/56 ,  A61K2300/00

摘要： This invention relates the use of cortisol blockers (glucocorticoid receptor [GR] antagonists) for the treating or preventing treatment resistant prostate cancer, treating or preventing neoplasia, and treating or preventing infection related to acute or chronic injury or disease.

公开(公告)号：US10058563B2

公开(公告)日：2018-08-28

申请号：US15478368

申请日：2017-04-04

申请人： Pop Test Oncology Limited Liability Company

发明人： Randice Lisa Altschul ,  Neil David Theise ,  Myron Rapkin ,  Rebecca O'Brien

IPC分类号： A61K31/58

CPC分类号： A61K31/58 ,  A61J1/10 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/10 ,  A61K9/107 ,  A61K31/337 ,  A61K38/09 ,  A61K45/06 ,  A61K47/10 ,  A61K47/26 ,  A61K47/34 ,  A61K47/42 ,  A61K47/44 ,  A61K51/00 ,  A61N5/1001 ,  B65D75/002 ,  B65D75/36 ,  B65D75/367 ,  C07J17/00 ,  G01N33/743 ,  G01N2333/575 ,  G01N2800/56 ,  A61K2300/00

摘要： This invention relates to a low cost rapid response diagnostic system to determine cortisol levels in patients selected as potential candidates for GCR (glucocorticoid receptor) antagonist therapy utilizing a GCR antagonist, such as ORG 34517. The rapid, sensitive, and inexpensive test can be used to determine patients who have non-normal cortisol production or disordered circadian rhythms as a method for selecting subjects for GCR antagonist therapy for whom it is likely to have beneficial and/or therapeutic effects, and can also be used to monitor changes in cortisol levels in response to treatment.

公开(公告)号：US20180238865A1

公开(公告)日：2018-08-23

申请号：US15752108

申请日：2016-08-18

申请人： Bio-Rad Laboratories, inc.

发明人： Jan Zur Megede ,  George Karlin-Neumann

IPC分类号： G01N33/542 ,  G01N33/58

CPC分类号： G01N33/542 ,  G01N33/581 ,  G01N33/582 ,  G01N2333/57 ,  G01N2333/575

摘要： Methods of detecting an analyte in a sample are provided. In one embodiment, the method comprises forming a partition comprising the sample, a binding agent capable of emitting a signal when bound to the analyte, and a marker capable of identifying the partition; allowing the binding agent to bind to the analyte, if present; and detecting the presence of the analyte in the sample by detecting the signal emitted from the binding agent in the partition.

公开(公告)号：US20180156827A1

公开(公告)日：2018-06-07

申请号：US15833702

申请日：2017-12-06

申请人： Dawn Maslar

发明人： Dawn Maslar

IPC分类号： G01N33/74 ,  G01N33/558 ,  G01N21/78

CPC分类号： G01N33/743 ,  G01N21/75 ,  G01N21/78 ,  G01N21/8483 ,  G01N33/558 ,  G01N33/5743 ,  G01N2021/752 ,  G01N2021/757 ,  G01N2333/575

摘要： A lateral flow assay format test that accepts a saliva sample that is reacted with a conjugate to indicate the level of testosterone present in the saliva sample. The concentration of testosterone is used to determine the likelihood of the saliva donors commitment to an interpersonal relationship.