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85 条记录 (耗时 0.031 秒)

    SINGLE CHANNEL CARTRIDGE DEVICE FOR COAGULATION ASSAYS IN FLUID SAMPLES
    5.
    发明申请
    SINGLE CHANNEL CARTRIDGE DEVICE FOR COAGULATION ASSAYS IN FLUID SAMPLES 审中-公开
    用于在流体样品中凝结测定的单通道盒装置

    公开(公告)号：US20160091511A1

    公开(公告)日：2016-03-31

    申请号：US14866460

    申请日：2015-09-25

    申请人： Abbott Point of Care Inc.

    发明人： Katrina Petronilla Di Tullio ,  Jay Kendall Taylor ,  Niko Daniel Lee-Yow ,  Sheila Diane Ball

    IPC分类号： G01N33/86 ,  G01N27/403 ,  B01L3/00 ,  G01N27/416

    CPC分类号： G01N33/86 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2300/0645 ,  B01L2300/0809 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2400/0487 ,  B01L2400/0672 ,  B01L2400/0688 ,  G01N27/403 ,  G01N27/4166 ,  G01N33/4905 ,  G01N2333/96463

    摘要： The present invention relates to analytical testing devices comprising a single channel with micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using a single channel with micro-environment sensors in a point of care test cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample and a conduit fluidically connected to the inlet chamber. The conduit includes a sensor chip including a first micro-environment sensor and a second microenvironment sensor, and a fluid lock valve. The sample analysis cartridge further includes a pump configured to push the biological sample over the first micro-environment sensor and the second microenvironment sensor to the fluidic lock valve such that the biological sample is positioned over the first micro-environment sensor and the second micro-environment sensor.

    摘要翻译： 本发明涉及分析测试装置，其包括具有微环境传感器的单通道和用于测定施加到微环境传感器的流体样品中的凝结的方法，特别涉及使用具有微环境的单通道进行凝固测定 传感器在护理测试盒中。 例如，本发明可以涉及一种样品分析盒，其包括配置成容纳生物样品的入口室和与入口室流体连接的导管。 导管包括包括第一微环境传感器和第二微环境传感器的传感器芯片和流体锁定阀。 样品分析盒还包括被配置为将生物样品推过第一微环境传感器和第二微环境传感器到泵的流体锁定阀，使得生物样品位于第一微环境传感器和第二微环境传感器之上， 环境传感器

    DETERMINATION OF THE THROMBOGENIC POWER OF HUMAN IMMUNOGLOBULINS
    7.
    发明申请
    DETERMINATION OF THE THROMBOGENIC POWER OF HUMAN IMMUNOGLOBULINS 有权
    人类免疫球蛋白的致癌力测定

    公开(公告)号：US20140295471A1

    公开(公告)日：2014-10-02

    申请号：US14343642

    申请日：2011-11-18

    申请人： Catherine Michalski

    发明人： Catherine Michalski

    IPC分类号： G01N33/86

    CPC分类号： G01N33/86 ,  G01N33/6854 ,  G01N2333/96463

    摘要： A kit for the determination of the thrombogenic power of human immunoglobulins contained in a biologically acceptable product. Also a process making it possible to determine the thrombogenic power linked to the presence of activated Factor XI and/or activated Factor IX and/or activated Factor XII, and/or activated Factor VII and/or activated Factor X in a sample capable of being administered to humans.

    摘要翻译： 用于确定生物可接受产品中所含的人免疫球蛋白的血栓形成能力的试剂盒。 还有一种方法可以确定与能够存在活化因子XI和/或活化因子IX和/或活化因子XII和/或活化因子VII和/或活化因子X的样品相关的血栓形成功能 给予人。

    Coagulation proteins, coagulation-anticoagulation protein complexes, derivatives thereof and their uses
    9.
    发明申请
    Coagulation proteins, coagulation-anticoagulation protein complexes, derivatives thereof and their uses 有权
    凝血蛋白，凝血 - 抗凝蛋白复合物，其衍生物及其用途

    公开(公告)号：US20070025979A1

    公开(公告)日：2007-02-01

    申请号：US11451959

    申请日：2006-06-13

    申请人： Edward Pryzdial

    发明人： Edward Pryzdial

    IPC分类号： A61K38/48 ,  A61K38/36

    CPC分类号： A61K31/727 ,  A61K38/166 ,  A61K38/4846 ,  A61K38/49 ,  A61K38/58 ,  A61K45/06 ,  C12Q1/37 ,  G01N33/6893 ,  G01N33/86 ,  G01N2333/96463 ,  G01N2800/224 ,  A61K2300/00

    摘要： The present invention relates to the use of coagulation proteins and complexes thereof with anticoagulation proteins for the lysis of blood clots or other applications affected by accelerated plasmin production. More specifically, the present invention provides a method for accelerating the dissolution of a blood clot through the administration of at least one coagulation protein, with or without being in complex with a serpin, comprising a basic C-terminal amino acid, wherein the coagulation protein may be a derivative of Factor X or Factor V or a combination thereof. Pharmaceutical compositions for the treatment and prophylaxis of blood clots are also provided, wherein, the methods and products of the present invention advantageously accelerate clot dissolution while potentially minimizing the adverse side-effects, such as hemorrhaging, seen with other clot dissolving agents. The present invention also provides a method for detecting a fibrinolytic potential in a subject.

    摘要翻译： 本发明涉及凝血蛋白及其与抗凝蛋白的复合物在凝血酶或其它受加速纤溶酶生成影响的应用中的应用。 更具体地，本发明提供了一种通过施用包含碱性C末端氨基酸的丝氨酸蛋白酶引起的至少一种凝血蛋白加速血块溶解的方法，其中所述凝血蛋白 可以是因子X或因子V的衍生物或其组合。 还提供了用于治疗和预防血凝块的药物组合物，其中，本发明的方法和产品有利地加速凝块溶解，同时潜在地最小化与其它凝块溶解剂一起观察到的不良副作用，例如出血。 本发明还提供了一种用于检测受试者中的纤维蛋白溶解电位的方法。