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公开(公告)号：US20230416661A1
公开(公告)日：2023-12-28
申请号：US18463248
申请日：2023-09-07
发明人： Donald E. INGBER , Dongeun HUH
IPC分类号： C12M3/06 , C12N5/071 , G01N33/50 , C12N5/0789 , C12N5/0775 , C12M1/00 , C12M1/12 , B01L3/00 , C12N5/0735 , C12N5/076 , C12N5/0797 , C12M3/00 , C12N5/077 , C12N5/074
CPC分类号： C12M23/16 , C12N5/0671 , G01N33/5091 , G01N33/5005 , G01N33/5088 , C12N5/0647 , C12N5/0662 , C12M23/58 , C12M25/02 , B01L3/50273 , C12N5/0697 , C12N5/0688 , C12N5/0606 , C12N5/061 , C12N5/0623 , C12M21/08 , C12M29/10 , C12N5/0654 , C12N5/0696 , B01L2200/0663 , B01L2400/0487 , B01L2400/0472 , B01L2400/0481 , B01L2300/163 , B01L3/5027 , B01L2300/0887 , B01L2300/0854 , B01L2300/0877
摘要： System and method includes a body having a central microchannel separated by one or more porous membranes. The membranes are configured to divide the central microchannel into a two or more parallel central microchannels, wherein one or more first fluids are applied through the first central microchannel and one or more second fluids are applied through the second or more central microchannels. The surfaces of each porous membrane can be coated with cell adhesive molecules to support the attachment of cells and promote their organization into tissues on the upper and lower surface of the membrane. The pores may be large enough to only permit exchange of gases and small chemicals, or to permit migration and transchannel passage of large proteins and whole living cells. Fluid pressure, flow and channel geometry also may be varied to apply a desired mechanical force to one or both tissue layers.
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公开(公告)号：US20180196072A1
公开(公告)日：2018-07-12
申请号：US15912967
申请日：2018-03-06
发明人： Gordon Bruce Collier , Paul Willis Johns , Smitha RK Sutrala , Dan Wang , Katrina Petronilla Di Tullio
CPC分类号： G01N33/86 , B01L3/5027 , B01L3/502715 , B01L2200/0605 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/024 , B01L2300/027 , B01L2300/0636 , B01L2300/0645 , B01L2300/069 , B01L2300/0816 , B01L2300/0867 , B01L2300/161 , B01L2400/0472 , B01L2400/0481 , B01L2400/0487 , B01L2400/0688 , G01N2333/974
摘要： The present invention relates to ellagic acid formulations for performing coagulation assays that are highly stable for long term storage and reduce assay time. Particularly, aspects of the present invention are directed to a composition and method of preparing ellagic acid in a highly soluble format for use in a coagulation assay. For example, the ellagic acid may be solubilized in one or more of sodium hydroxide, methanol, a polyether compound, particularly polyethylene glycol, polyethylene oxide, or polyoxyethylene, and a cyclodextrin guest-host complex.
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公开(公告)号：US20180164331A1
公开(公告)日：2018-06-14
申请号：US15879714
申请日：2018-01-25
发明人： Tian-Xian Zhao , Anjulia Chiu-Yuk Wong , Glenn Brian Martin , Katrina Petronilla Di Tullio , Isabelle Louisette Thibodeau , Steven Roy Breeze , Smitha RK Sutrala , Eric Hong , Sheila Diane Ball
CPC分类号： G01N33/86 , B01L3/5027 , B01L3/502715 , B01L2200/04 , B01L2200/0605 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/024 , B01L2300/027 , B01L2300/0636 , B01L2300/0645 , B01L2300/069 , B01L2300/0816 , B01L2300/0867 , B01L2300/161 , B01L2400/0472 , B01L2400/0481 , B01L2400/0487 , B01L2400/0688 , G01N2333/96463 , G01N2333/974
摘要： The present invention relates to analytical testing devices including micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, performing one or more types of coagulation assays using one or more micro-environment sensors in a single point of care combined test cartridge. For example, the present invention may be directed to test sensor including at least one transducer coated with a polymer layer. The polymer layer comprises a thrombin-cleavable peptide with a detectable moiety.
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公开(公告)号：US09983197B2
公开(公告)日：2018-05-29
申请号：US14425139
申请日：2013-09-10
发明人： Francis Lin , Jiandong Wu
CPC分类号： G01N33/5029 , B01L3/502715 , B01L2300/023 , B01L2300/027 , B01L2300/0663 , B01L2300/0864 , B01L2400/0472 , G06K9/00134 , G06K9/00147 , G06T7/0012 , G06T2207/10056 , G06T2207/20021 , G06T2207/20036 , G06T2207/30004
摘要： Low-cost and portable microfluidic systems are needed for cell migration research and Point of Care (POC) testing. This study introduces a low-cost and portable USB Microscope Microfluidic Chemotaxis Analysis System (UMCAS) for rapid analysis of cell chemotaxis studies. A standalone microfluidic gradient generator is also developed for rapid generation of chemical gradient in microfluidic device without need of any peripheral perfusion apparatus. A smart phone based application program was developed for the real-time remote monitoring of the migration data. This system is validated by observing the neutrophil migration in three different conditions: 1) medium control, 2) uniform IL-8 control, and 3) IL-8 gradient. The results show that neutrophils exhibit random migration in both medium and uniform IL-8 control experiments, while they show strong directional migration to the IL-8 gradient. These results successfully validated the developed UMCAS system.
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公开(公告)号：US09778153B2
公开(公告)日：2017-10-03
申请号：US14101928
申请日：2013-12-10
申请人： IBIDI GMBH
发明人： Roman Zantl
CPC分类号： G01N1/30 , B01F13/0059 , B01F13/0093 , B01F15/0404 , B01L3/5025 , B01L3/502707 , B01L3/502746 , B01L3/502769 , B01L2300/0816 , B01L2300/0867 , B01L2400/0406 , B01L2400/0472 , C12Q1/34
摘要： A microfluid device for producing diffusively built gradients comprising a bottom plate and a cover plate, wherein the cover plate has recesses and is connected to the bottom plate in a liquid-tight manner so that the recesses form at least two reservoirs and one observation chamber, which connects the reservoir, a reservoir can be filled particularly through an inlet/outlet through the cover plate, and the cross-sectional surface of the observation chamber is at least 5 times, preferably at least 200 times smaller at the aperture of the observation chamber into one of the reservoirs than the maximum cross-sectional surface of the reservoir in parallel to this cross-sectional surface of the observation chamber.
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公开(公告)号：US20170121758A1
公开(公告)日：2017-05-04
申请号：US15315978
申请日：2015-06-02
CPC分类号： C12Q1/689 , B01L3/502753 , B01L2200/0689 , B01L2200/0694 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/12 , B01L2300/165 , B01L2400/0472 , G01N15/06 , G01N15/1056 , G01N2015/1006 , G01N2015/1081 , G01N2015/1486
摘要： The present disclosure relates to devices and systems for separating motile pathogenic bacterial cells from samples. The disclosure also provides for methods of determining whether a sample is contaminated by pathogenic bacteria. The devices and systems disclosed herein are useful for screening water sources, environmental testing sites, food sources, and bodily fluids for the presence, absence, or quantity of bacterial cells in a sample representative of the screened sources.
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公开(公告)号：US20160091512A1
公开(公告)日：2016-03-31
申请号：US14866518
申请日：2015-09-25
发明人： Gordon Bruce Collier , Paul Willis Johns, JR. , Smitha RK Sutrala , Dan Wang , Katrina Petronilla Di Tullio
IPC分类号： G01N33/86
CPC分类号： G01N33/86 , B01L3/5027 , B01L3/502715 , B01L2200/0605 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/024 , B01L2300/027 , B01L2300/0636 , B01L2300/0645 , B01L2300/069 , B01L2300/0816 , B01L2300/0867 , B01L2300/161 , B01L2400/0472 , B01L2400/0481 , B01L2400/0487 , B01L2400/0688 , G01N2333/974
摘要： The present invention relates to ellagic acid formulations for performing coagulation assays that are highly stable for long term storage and reduce assay time. Particularly, aspects of the present invention are directed to a composition and method of preparing ellagic acid in a highly soluble format for use in a coagulation assay. For example, the ellagic acid may be solubilized in one or more of sodium hydroxide, methanol, a polyether compound, particularly polyethylene glycol, polyethylene oxide, or polyoxyethylene, and a cyclodextrin guest-host complex.
摘要翻译： 本发明涉及用于进行凝血测定的鞣花酸制剂，其对于长期储存是高度稳定的并且减少了测定时间。 特别地，本发明的方面涉及制备用于凝血试验的高度可溶性形式的鞣花酸的组合物和方法。 例如，鞣花酸可以溶解在一种或多种氢氧化钠，甲醇，聚醚化合物，特别是聚乙二醇，聚环氧乙烷或聚氧乙烯，以及环糊精客体 - 复合物中。
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8.发明申请ORGAN MIMIC DEVICE WITH MICROCHANNELS AND METHODS OF USE AND MANUFACTURING THEREOF 审中-公开具有微通道的有机MIMIC器件及其使用及制造方法公开(公告)号：US20160046897A1
公开(公告)日：2016-02-18
申请号：US14922840
申请日：2015-10-26
发明人： Donald E. INGBER , Dongeun HUH
IPC分类号： C12M3/06 , C12N5/074 , C12N5/0775 , C12M3/00 , C12N5/077 , C12N5/0797 , C12N5/076 , C12N5/0735 , C12N5/0789
CPC分类号： C12M23/16 , B01L3/5027 , B01L3/50273 , B01L2200/0663 , B01L2300/0854 , B01L2300/0877 , B01L2300/0887 , B01L2300/163 , B01L2400/0472 , B01L2400/0481 , B01L2400/0487 , C12M21/08 , C12M23/58 , C12M25/02 , C12M29/10 , C12N5/0606 , C12N5/061 , C12N5/0623 , C12N5/0647 , C12N5/0654 , C12N5/0662 , C12N5/0671 , C12N5/0688 , C12N5/0696 , C12N5/0697 , G01N33/5005 , G01N33/5088 , G01N33/5091
摘要： System and method includes a body having a central microchannel separated by one or more porous membranes. The membranes are configured to divide the central microchannel into a two or more parallel central microchannels, wherein one or more first fluids are applied through the first central microchannel and one or more second fluids are applied through the second or more central microchannels. The surfaces of each porous membrane can be coated with cell adhesive molecules to support the attachment of cells and promote their organization into tissues on the upper and lower surface of the membrane. The pores may be large enough to only permit exchange of gases and small chemicals, or to permit migration and transchannel passage of large proteins and whole living cells. Fluid pressure, flow and channel geometry also may be varied to apply a desired mechanical force to one or both tissue layers.
摘要翻译： 系统和方法包括具有由一个或多个多孔膜分离的中心微通道的主体。 膜构造成将中心微通道分成两个或更多个平行的中央微通道，其中一个或多个第一流体通过第一中心微通道施加，并且一个或多个第二流体通过第二或更多个中心微通道施加。 每个多孔膜的表面可以涂覆有细胞粘附分子以支持细胞的附着并促进它们组织在膜的上表面和下表面上的组织中。 毛孔可能足够大，仅允许气体和小化学物质的交换，或允许大蛋白质和整个活细胞的迁移和经通道通过。 流体压力，流动和通道几何形状也可以变化，以将所需的机械力施加到一个或两个组织层。
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9.发明授权公开(公告)号：US09174222B2
公开(公告)日：2015-11-03
申请号：US13232781
申请日：2011-09-14
申请人： Lotien Richard Huang , Thomas Barber , Bruce L. Carvalho , Ravi Kapur , Paul Vernucci , Mehmet Toner , Zihua Wang
发明人： Lotien Richard Huang , Thomas Barber , Bruce L. Carvalho , Ravi Kapur , Paul Vernucci , Mehmet Toner , Zihua Wang
CPC分类号： B03C1/30 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/043 , B01L2400/0472 , B01L2400/0487 , B01L2400/086 , B03C1/32 , B03C2201/18 , B33Y80/00 , C12M47/04 , C12M47/06 , G01N1/40 , G01N1/4077 , G01N33/5044 , G01N2035/00237 , Y10T137/0318 , Y10T137/8593 , Y10T436/25 , Y10T436/25375
摘要： The invention features devices and methods for the deterministic separation of particles. Exemplary methods include the enrichment of a sample in a desired particle or the alteration of a desired particle in the device. The devices and methods are advantageously employed to enrich for rare cells, e.g., fetal cells, present in a sample, e.g., maternal blood and rare cell components, e.g., fetal cell nuclei. The invention further provides a method for preferentially lysing cells of interest in a sample, e.g., to extract clinical information from a cellular component, e.g., a nucleus, of the cells of interest. In general, the method employs differential lysis between the cells of interest and other cells (e.g., other nucleated cells) in the sample.
摘要翻译： 本发明的特征在于确定性分离颗粒的装置和方法。 示例性的方法包括在所需颗粒中富集样品或改变装置中所需的颗粒。 该装置和方法有利地用于富集存在于样品中的稀有细胞，例如胎儿细胞，例如母体血液和稀有细胞成分，例如胎儿细胞核。 本发明还提供了用于优先裂解样品中感兴趣的细胞的方法，例如从目的细胞的细胞组分（例如细胞核）提取临床信息。 通常，该方法在样品中感兴趣的细胞和其他细胞（例如其他有核细胞）之间使用差异裂解。
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公开(公告)号：US09131884B2
公开(公告)日：2015-09-15
申请号：US13049813
申请日：2011-03-16
申请人： Elizabeth A. Holmes , Shaunak Roy , John Howard , Chengwang Wang
发明人： Elizabeth A. Holmes , Shaunak Roy , John Howard , Chengwang Wang
IPC分类号： C12M1/34 , A61B5/1455 , A61B5/00 , A61B5/15 , A61B5/145 , A61B5/1473 , A61B5/1477 , A61M37/00 , B01L3/00 , A61B5/1486 , A61M5/142 , A61M5/145 , A61M5/172 , G01N35/00
CPC分类号： A61B5/073 , A61B5/0024 , A61B5/0031 , A61B5/1411 , A61B5/145 , A61B5/14514 , A61B5/14532 , A61B5/14542 , A61B5/14546 , A61B5/1455 , A61B5/14556 , A61B5/1473 , A61B5/1477 , A61B5/1486 , A61B5/150022 , A61B5/150221 , A61B5/150229 , A61B5/150251 , A61B5/150282 , A61B5/150343 , A61B5/150854 , A61B5/150862 , A61B5/15087 , A61B5/150969 , A61B5/150984 , A61B5/15107 , A61B5/15117 , A61B5/15119 , A61B5/15121 , A61B5/15123 , A61B5/15125 , A61B5/1519 , A61B5/157 , A61B5/417 , A61B5/4238 , A61B5/4839 , A61B5/4848 , A61B5/6833 , A61B5/685 , A61B5/6865 , A61B5/7282 , A61B2560/0412 , A61M5/14276 , A61M37/0015 , A61M2005/14513 , A61M2005/1726 , A61M2037/0023 , A61M2205/0244 , A61M2205/3569 , A61M2205/3592 , A61M2205/50 , B01L3/5027 , B01L3/502707 , B01L3/502761 , B01L3/502776 , B01L2200/10 , B01L2300/023 , B01L2300/024 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2400/0406 , B01L2400/0415 , B01L2400/0472 , B01L2400/0487 , G01N2035/00158
摘要： The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device; and a plurality of microchips comprising a microarray scanning device capable of obtaining physical parameter data of an interaction between the disease marker biological analyte with the bioactive agent; a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile; optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs; an interface device capable of facilitating communications between the microarray scanning device, biometric recognition device and the therapeutic agent releasing device; and an energy source to power the medical device. Specifically, the invention relates to a medical device capable of detecting an analyte in a bodily fluid comprising at least one microneedle capable of obtaining a sample of a bodily fluid, a first microchannel through which the sample flows and is in fluid communication with the at least one microneedle, a second microchannel in fluid communication with the first microchannel, through which a buffer flows, wherein the second channel comprises a microarray with a bioactive agent, a microarray scanning device to detect an interaction between the bioactive agent and the analyte in the bodily fluid; and an interface device.
摘要翻译： 本发明涉及一种可摄入的，可植入的或可穿戴的医疗装置，其包括微阵列，其包含能够与疾病标记生物分析物相互作用的生物活性剂; 储存器，其包含至少一种治疗剂并能够从所述医疗装置释放所述治疗剂; 以及多个微芯片，其包括微阵列扫描装置，其能够获得疾病标记生物分析物与生物活性剂之间的相互作用的物理参数数据; 能够将物理参数数据与分析物相互作用谱进行比较的生物识别装置; 任选的能够控制治疗剂从储存器释放的治疗剂释放装置; 能够促进微阵列扫描装置，生物识别装置和治疗剂释放装置之间的通信的接口装置; 以及为医疗装置供电的能量源。 具体地说，本发明涉及一种能够检测体液中分析物的医疗装置，其包含能够获得体液样品的至少一个微针，所述样品流过的第一微通道至少与所述至少一个微流体连通 一个微针，与第一微通道流体连通的第二微通道，缓冲液流过其中，其中第二通道包含具有生物活性剂的微阵列，微阵列扫描装置，用于检测身体中生物活性剂和分析物之间的相互作用 流体; 和接口设备。
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