公开(公告)号：US12128396B2

公开(公告)日：2024-10-29

申请号：US17453107

申请日：2021-11-01

Applicant: GILSON SAS

Inventor： Nicolas Paris ,  Frédéric Sanquer ,  Frédéric De Maack

IPC: B01L3/02 ,  G01N35/00 ,  G01N35/10

CPC classification number: B01L3/0237 ,  G01N35/00871 ,  G01N35/1009 ,  B01L2200/0605 ,  B01L2200/146 ,  B01L2300/023

Abstract: A manually-operated mono-channel or multi-channel pipette for the sampling and dispensing of a liquid sample in accordance with a given protocol, comprising a control button equipped with an autonomous control device which can supply a user with information relating to a pipetting operation in real time during the pipetting operation.

公开(公告)号：US12121893B2

公开(公告)日：2024-10-22

申请号：US17739567

申请日：2022-05-09

Applicant: Weavr Health Corp.

Inventor： Brandon T. Johnson

IPC: B01L3/00 ,  A61B5/15

CPC classification number: B01L3/5023 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150755 ,  B01L3/502753 ,  B01L3/527 ,  A61B5/150343 ,  B01L2200/0605 ,  B01L2200/16 ,  B01L2300/041 ,  B01L2300/0609 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0475 ,  B01L2400/0478

Abstract: A blood sample collection and/or storage device includes a two-piece housing that encompasses a port at which a fingertip blood sample is collected. After the sample is taken, the two-piece housing is moved to a closed position to protect the sample for storage and optionally process the sample within the housing. The housing may also be opened to access the stored sample for further processing.

公开(公告)号：US20240302401A1

公开(公告)日：2024-09-12

申请号：US18559150

申请日：2022-05-04

Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Inventor： Christian FREESE ,  Peter SPANG

IPC: G01N35/10 ,  B01L3/02

CPC classification number: G01N35/1065 ,  B01L3/0282 ,  B01L3/0289 ,  G01N35/1016 ,  B01L2200/0605 ,  G01N2035/1053 ,  G01N2035/1058

Abstract: A metering head for receiving and metering at least two media, having at least two media inlets, one or multiple dispensing terminals, and fluid lines connecting the media inlets to the one or multiple dispensing terminals. The one or multiple dispensing terminals each have at least two fluidically separated media outlets. A metering system, having a metering head, at least one connecting element for fluidically connecting the metering head to a carrier substrate or to a microfluidic cartridge, and optionally a connection piece, wherein the dispensing terminal is designed to receive the connecting element directly or to receive the connecting element indirectly via the connection piece.

公开(公告)号：US12087566B2

公开(公告)日：2024-09-10

申请号：US18227417

申请日：2023-07-28

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Livia Schiavinato Eberlin ,  Thomas Milner ,  Jialing Zhang ,  John Lin ,  John Rector ,  Nitesh Katta ,  Aydin Zahedivash

IPC: H01J49/04 ,  A61B10/00 ,  B01L3/00 ,  G01N30/72 ,  G01N33/487 ,  G01N33/574 ,  G01N33/68 ,  H01J49/00 ,  B01L3/02 ,  G01N1/02 ,  G01N1/40

CPC classification number: H01J49/0431 ,  A61B10/0045 ,  B01L3/502 ,  G01N30/72 ,  G01N33/487 ,  G01N33/574 ,  G01N33/6848 ,  H01J49/0031 ,  H01J49/04 ,  B01L3/0293 ,  B01L2200/0605 ,  B01L2400/0655 ,  G01N1/02 ,  G01N2001/028 ,  G01N2001/4061 ,  G01N2560/00

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

公开(公告)号：US12013332B2

公开(公告)日：2024-06-18

申请号：US13435885

申请日：2012-03-30

Applicant: Nicholas Anderson ,  Jeffery Debad ,  Eli N. Glezer ,  Sudeep Kumar ,  Noel Lawrence ,  Kenneth Page ,  George Sigal ,  Sharon West

Inventor： Nicholas Anderson ,  Jeffery Debad ,  Eli N. Glezer ,  Sudeep Kumar ,  Noel Lawrence ,  Kenneth Page ,  George Sigal ,  Sharon West

IPC: G01N21/05 ,  B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  G01F23/02 ,  G01F23/292 ,  G01N1/10 ,  G01N21/03 ,  G01N21/69 ,  G01N21/76

CPC classification number: G01N21/05 ,  B01L3/5027 ,  G01F23/02 ,  G01F23/292 ,  G01N1/10 ,  G01N21/03 ,  G01N21/0303 ,  G01N21/69 ,  G01N21/76 ,  B01L3/502723 ,  B01L3/502746 ,  B01L3/502784 ,  B01L7/00 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/04 ,  B01L2200/0605 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2200/141 ,  B01L2200/147 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/024 ,  B01L2300/027 ,  B01L2300/044 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0809 ,  B01L2300/0874 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2300/126 ,  B01L2300/161 ,  B01L2400/0487 ,  B01L2400/0672 ,  B01L2400/0683 ,  B01L2400/0688 ,  G01N2021/0346 ,  G01N2021/054 ,  Y10T137/0396 ,  Y10T137/8593

Abstract: Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.

公开(公告)号：US11951478B2

公开(公告)日：2024-04-09

申请号：US17175021

申请日：2021-02-12

Applicant: Combinati Incorporated

Inventor： Ju-Sung Hung ,  Andrew Zayac ,  Megan Dueck

IPC: B01L3/00 ,  B01L7/00 ,  C12Q1/686 ,  C12Q1/68

CPC classification number: B01L3/50273 ,  B01L7/52 ,  C12Q1/686 ,  B01L2200/0605 ,  B01L2300/0609 ,  B01L2300/0851 ,  B01L2300/0864 ,  B01L2300/18 ,  B01L2400/0487 ,  B01L2400/049 ,  C12Q1/686 ,  C12Q2563/159 ,  C12Q2565/629

Abstract: In some aspects, the present disclose provides methods for amplifying and quantifying nucleic acids. Methods for amplifying and quantifying nucleic acids comprise isolating a sample comprising nucleic acid molecules into a plurality of microchambers, performing a polymerase chain reaction on the plurality of microchambers, and analyzing the results of the polymerase chain reaction. In some aspects, the present disclosure provides devices consistent with the methods herein.

公开(公告)号：US20240058813A1

公开(公告)日：2024-02-22

申请号：US17891636

申请日：2022-08-19

Applicant: Agilent Technologies, Inc.

Inventor： Jonathan Irribarren ,  Joel Myerson ,  Bo Curry

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0638 ,  B01L2400/0655

Abstract: A fluid delivery device is configured to create a pressure differential across a compartment in which a liquid resides, causing the liquid to flow through the compartment. After a period of time, the fluid delivery device is configured to eliminate the pressure differential and thereby equilibrate the pressure across the compartment, with the use of a pressure equilibration channel that is separate from the compartment. The compartment may contain a packed bed of solid phase particles such as beads. In such case, the pressure differential causes the liquid to flow through the packed bed. The liquid may include chemical reagents or precursors that participate in chemical reactions on or at the solid phase particles. The reactions may relate to chemical synthesis, for example the synthesis of bio-chemicals such as nucleotides.

公开(公告)号：US11904314B2

公开(公告)日：2024-02-20

申请号：US17129783

申请日：2020-12-21

Applicant: WAINAMICS, INC.

Inventor： Arturo M. Escajeda ,  Huyen Tran ,  Ming X. Tan

IPC: C12Q1/6844 ,  B01L3/00

CPC classification number: B01L3/502715 ,  C12Q1/6844 ,  B01L2200/04 ,  B01L2200/0605 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/16 ,  B01L2300/08

Abstract: The invention is directed to devices and methods for performing rapid low-cost bioassays in self-contained disposable cartridges that provide efficient mixing of sample and reactants under a layer of liquid wax. Some embodiments additionally use gravity assisted distribution of sample and assay reagents in conjunction with an appliance containing all necessary valves, pneumatic sources, heat sources and detection stations.

公开(公告)号：US11833513B2

公开(公告)日：2023-12-05

申请号：US17858309

申请日：2022-07-06

Applicant: Capitainer AB

Inventor： Gabriel Lenk ,  Anna Ohlander

IPC: B01L3/00 ,  B01L9/00

CPC classification number: B01L3/502753 ,  B01L3/50273 ,  B01L3/502738 ,  B01L9/527 ,  B01L2200/0605 ,  B01L2200/0684 ,  B01L2300/0681 ,  B01L2300/0867 ,  B01L2300/126 ,  B01L2400/0406 ,  B01L2400/0457

Abstract: A microfluidic device comprising: an inlet section, for receiving a body fluid sample, the inlet section comprising an inlet port arranged to receive a supply of body fluid; a metering function configured to receive body fluid from the inlet section and comprising a first channel; and a sequent section configured to receive the body fluid from the metering function and comprising a second channel, wherein the first channel comprises a capillary stop valve configured to interrupt or reduce flow of the body fluid therethrough, and a means for visual inspection arranged adjacent to the capillary stop valve, wherein a geometry and/or dimension of the inlet port is configured such that when the supply of body fluid to the inlet port is removed, the Laplace pressure of a body fluid meniscus at the inlet port is higher than a threshold pressure of the capillary stop valve.

公开(公告)号：US20230341300A1

公开(公告)日：2023-10-26

申请号：US18215471

申请日：2023-06-28

Applicant: Becton, Dickinson and Company

Inventor： Milan Ivosevic ,  Adam Edelhauser

IPC: G01N1/38 ,  A61B5/15 ,  G01N33/49 ,  A61B5/154 ,  G01N1/14 ,  B01L3/00

CPC classification number: G01N1/38 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150251 ,  A61B5/150351 ,  A61B5/150732 ,  A61B5/15074 ,  A61B5/150755 ,  A61B5/154 ,  B01L3/502 ,  G01N1/14 ,  G01N33/49 ,  B01L3/0296 ,  B01L2200/0605 ,  B01L2300/048 ,  B01L2300/0609 ,  B01L2300/0832 ,  B01L2300/0838 ,  B01L2400/0481 ,  B01L2400/049 ,  G01N2001/386

Abstract: A biological fluid collection device that receives a sample and provides flow-through blood stabilization technology and a precise sample dispensing function for point-of-care and near patient testing applications is disclosed. A biological fluid collection device of the present disclosure is able to effectuate distributed mixing of a sample stabilizer within a blood sample and dispense the stabilized sample in a controlled manner. In this manner, a biological fluid collection device of the present disclosure enables blood micro-sample management, e.g., passive mixing with a sample stabilizer and controlled dispensing, for point-of-care and near patient testing applications.