公开(公告)号：US12036387B2

公开(公告)日：2024-07-16

申请号：US18126599

申请日：2023-03-27

申请人： DEKA Products Limited Partnership

发明人： Dean Kamen ,  Larry B. Gray ,  Russell H. Beavis ,  John M. Kerwin ,  Derek G. Kane

IPC分类号： G01F22/00 ,  A61B5/15 ,  A61B5/151 ,  A61M5/14 ,  A61M5/142 ,  A61M5/145 ,  A61M5/148 ,  A61M5/168 ,  A61M5/32 ,  B23P15/00 ,  F04B7/00 ,  F04B43/02 ,  F04B43/09 ,  G05D7/06 ,  A61B5/00 ,  A61B5/155 ,  A61J1/20 ,  A61M5/152 ,  A61M5/158 ,  A61M5/162 ,  A61M5/172 ,  A61M5/36 ,  A61M5/50 ,  F04B43/12 ,  G05B23/02 ,  G08C17/02 ,  H04B7/26

CPC分类号： A61M5/14248 ,  A61B5/150022 ,  A61B5/150175 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/15117 ,  A61B5/15186 ,  A61M5/1413 ,  A61M5/142 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/1452 ,  A61M5/14586 ,  A61M5/148 ,  A61M5/168 ,  A61M5/16804 ,  A61M5/16809 ,  A61M5/16831 ,  A61M5/3287 ,  B23P15/00 ,  F04B7/00 ,  F04B43/02 ,  F04B43/09 ,  G01F22/00 ,  G05D7/0676 ,  A61B5/0024 ,  A61B5/1427 ,  A61B5/15107 ,  A61B5/15119 ,  A61B5/15121 ,  A61B5/15123 ,  A61B5/15125 ,  A61B5/6833 ,  A61B2560/0412 ,  A61J1/20 ,  A61M2005/1402 ,  A61M5/141 ,  A61M2005/14208 ,  A61M5/14216 ,  A61M5/14224 ,  A61M5/14244 ,  A61M2005/14252 ,  A61M2005/14268 ,  A61M2005/14506 ,  A61M5/152 ,  A61M5/158 ,  A61M2005/1581 ,  A61M2005/1583 ,  A61M2005/1585 ,  A61M2005/1586 ,  A61M5/162 ,  A61M5/16813 ,  A61M2005/16863 ,  A61M5/16886 ,  A61M5/172 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M5/365 ,  A61M5/5086 ,  A61M2205/0266 ,  A61M2205/0294 ,  A61M2205/04 ,  A61M2205/16 ,  A61M2205/18 ,  A61M2205/3303 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3337 ,  A61M2205/3341 ,  A61M2205/3368 ,  A61M2205/3375 ,  A61M2205/3379 ,  A61M2205/3389 ,  A61M2205/3523 ,  A61M2205/3546 ,  A61M2205/3569 ,  A61M2205/3576 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583 ,  A61M2205/8206 ,  A61M2205/8237 ,  A61M2206/22 ,  A61M2207/00 ,  A61M2209/045 ,  A61M2230/201 ,  F04B43/1253 ,  F04C2230/60 ,  G05B23/02 ,  G05D7/0647 ,  G08C17/02 ,  H04B7/2609 ,  Y10T29/49236 ,  Y10T29/494 ,  Y10T29/49412 ,  Y10T29/49826 ,  Y10T29/49828

摘要： An apparatus for determining the volume of fluid dispensed. The apparatus has an acoustic volume sensor that acoustically excites a reference volume and a measurement chamber with a loudspeaker and measures the acoustic response with microphones acoustically coupled to the reference and the measurement chamber. The loudspeaker and sensing microphones are connected to the measurement chamber by separate ports. A detachable dispensing chamber is coupled to the acoustic volume sensor. The volume of the fluid dispensed is determined by a processor based on the acoustic response of the microphones to acoustic excitement by the loudspeaker.

公开(公告)号：US20240148293A1

公开(公告)日：2024-05-09

申请号：US17981538

申请日：2022-11-07

申请人： Human Holding ApS

发明人： Andreas Christian TUXEN ,  Victor Leth STAALKJAER

IPC分类号： A61B5/15

CPC分类号： A61B5/150022 ,  A61B5/150412 ,  A61B5/15107

摘要： A sampling and/or injecting device (100) comprising an elongated tubular housing (101) and a sampling and/or injecting arrangement (105) comprising a piercing element (106) configured to engage a sampling and/or injecting area (103) and a sampling and/or injecting element (107) configured for automatically collecting a body fluid sample from said sampling and/or injecting area (103) and/or injecting a substance in said sampling and/or injecting area (103). A securing element (102) is disposed at a distal end of the tubular housing (101) and a sealing element (110) is disposed within or around the securing element (102). An activator (113) is configured to activate automatic movement of the piercing element (106) to and/or from the sampling and/or injecting area (103) after attachment of the securing element (102) to the sampling and/or injecting area (103). A mechanical resistor (114), controlling the automatic movement of the piercing element (106), is mechanically or pneumatically operably connected to the activator (113).

公开(公告)号：US11844926B2

公开(公告)日：2023-12-19

申请号：US17140261

申请日：2021-01-04

申请人： DEKA Products Limited Partnership

发明人： Larry B. Gray

IPC分类号： A61M5/142 ,  F04B43/02 ,  A61M5/145 ,  A61M5/168 ,  G05D7/06 ,  F04B43/09 ,  F04B7/00 ,  A61M5/32 ,  B23P15/00 ,  A61B5/15 ,  A61B5/151 ,  A61M5/148 ,  G01F22/00 ,  A61M5/14 ,  F04B43/12 ,  A61M5/152 ,  A61M5/158 ,  A61M5/172 ,  G08C17/02 ,  H04B7/26 ,  A61B5/00 ,  A61M5/50 ,  A61M5/162 ,  A61M5/36 ,  A61B5/155 ,  A61J1/20 ,  G05B23/02

CPC分类号： A61M5/14248 ,  A61B5/150022 ,  A61B5/15117 ,  A61B5/150175 ,  A61B5/15186 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150503 ,  A61M5/142 ,  A61M5/148 ,  A61M5/1413 ,  A61M5/1452 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/14586 ,  A61M5/168 ,  A61M5/16804 ,  A61M5/16809 ,  A61M5/16831 ,  A61M5/3287 ,  B23P15/00 ,  F04B7/00 ,  F04B43/02 ,  F04B43/09 ,  G01F22/00 ,  G05D7/0676 ,  A61B5/0024 ,  A61B5/1427 ,  A61B5/15107 ,  A61B5/15119 ,  A61B5/15121 ,  A61B5/15123 ,  A61B5/15125 ,  A61B5/6833 ,  A61B2560/0412 ,  A61J1/20 ,  A61M5/141 ,  A61M5/14216 ,  A61M5/14224 ,  A61M5/14244 ,  A61M5/152 ,  A61M5/158 ,  A61M5/162 ,  A61M5/16813 ,  A61M5/16886 ,  A61M5/172 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/5086 ,  A61M2005/1402 ,  A61M2005/14208 ,  A61M2005/14252 ,  A61M2005/14268 ,  A61M2005/14506 ,  A61M2005/1581 ,  A61M2005/1583 ,  A61M2005/1585 ,  A61M2005/1586 ,  A61M2005/16863 ,  A61M2005/1726 ,  A61M2205/0266 ,  A61M2205/0294 ,  A61M2205/04 ,  A61M2205/16 ,  A61M2205/18 ,  A61M2205/3303 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3337 ,  A61M2205/3341 ,  A61M2205/3368 ,  A61M2205/3375 ,  A61M2205/3379 ,  A61M2205/3389 ,  A61M2205/3523 ,  A61M2205/3546 ,  A61M2205/3569 ,  A61M2205/3576 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583 ,  A61M2205/8206 ,  A61M2205/8237 ,  A61M2206/22 ,  A61M2207/00 ,  A61M2209/045 ,  A61M2230/201 ,  F04B43/1253 ,  F04C2230/60 ,  G05B23/02 ,  G05D7/0647 ,  G08C17/02 ,  H04B7/2609 ,  Y10T29/494 ,  Y10T29/49236 ,  Y10T29/49412 ,  Y10T29/49826 ,  Y10T29/49828

摘要： A system is disclosed. The system includes a reservoir for containing a fluidic medium, the reservoir including a front surface, a resilient cylindrical flexure portion connected to the front surface, the resilient cylindrical flexure portion comprising an accordion-like structure that is able to expand and contract to change an interior volume within the resilient cylindrical flexure portion, a central passageway within the resilient cylindrical flexure, and a collection chamber connected to the central passageway. Also, a system including a reservoir, a plunger head located within the reservoir, a plunger arm connected to the plunger head, a driving shaft connected to the plunger arm, and a motor connected to the driving shaft, the motor controllable to move the drive shaft in a first motion and a second motion so as to move the advance plunger head and retract the plunger head within the reservoir.

公开(公告)号：US11786651B2

公开(公告)日：2023-10-17

申请号：US17107880

申请日：2020-11-30

申请人： DEKA Products Limited Partnership

发明人： Dean Kamen ,  Larry B. Gray ,  Russell H. Beavis

IPC分类号： A61M5/142 ,  F04B43/02 ,  A61M5/145 ,  A61M5/168 ,  G05D7/06 ,  F04B43/09 ,  F04B7/00 ,  A61M5/32 ,  B23P15/00 ,  A61B5/15 ,  A61B5/151 ,  A61M5/148 ,  G01F22/00 ,  A61M5/14 ,  F04B43/12 ,  A61M5/152 ,  A61M5/158 ,  A61M5/172 ,  G08C17/02 ,  H04B7/26 ,  G05B23/02 ,  A61B5/00 ,  A61M5/50 ,  A61M5/162 ,  A61M5/36 ,  A61B5/155 ,  A61J1/20

CPC分类号： A61M5/14248 ,  A61B5/150022 ,  A61B5/15117 ,  A61B5/150175 ,  A61B5/15186 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150503 ,  A61M5/142 ,  A61M5/148 ,  A61M5/1413 ,  A61M5/1452 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/14586 ,  A61M5/168 ,  A61M5/16804 ,  A61M5/16809 ,  A61M5/16831 ,  A61M5/3287 ,  B23P15/00 ,  F04B7/00 ,  F04B43/02 ,  F04B43/09 ,  G01F22/00 ,  G05D7/0676 ,  A61B5/0024 ,  A61B5/1427 ,  A61B5/15107 ,  A61B5/15119 ,  A61B5/15121 ,  A61B5/15123 ,  A61B5/15125 ,  A61B5/6833 ,  A61B2560/0412 ,  A61J1/20 ,  A61M5/141 ,  A61M5/14216 ,  A61M5/14224 ,  A61M5/14244 ,  A61M5/152 ,  A61M5/158 ,  A61M5/162 ,  A61M5/16813 ,  A61M5/16886 ,  A61M5/172 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/5086 ,  A61M2005/1402 ,  A61M2005/14208 ,  A61M2005/14252 ,  A61M2005/14268 ,  A61M2005/14506 ,  A61M2005/1581 ,  A61M2005/1583 ,  A61M2005/1585 ,  A61M2005/1586 ,  A61M2005/16863 ,  A61M2005/1726 ,  A61M2205/0266 ,  A61M2205/0294 ,  A61M2205/04 ,  A61M2205/16 ,  A61M2205/18 ,  A61M2205/3303 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3337 ,  A61M2205/3341 ,  A61M2205/3368 ,  A61M2205/3375 ,  A61M2205/3379 ,  A61M2205/3389 ,  A61M2205/3523 ,  A61M2205/3546 ,  A61M2205/3569 ,  A61M2205/3576 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583 ,  A61M2205/8206 ,  A61M2205/8237 ,  A61M2206/22 ,  A61M2207/00 ,  A61M2209/045 ,  A61M2230/201 ,  F04B43/1253 ,  F04C2230/60 ,  G05B23/02 ,  G05D7/0647 ,  G08C17/02 ,  H04B7/2609 ,  Y10T29/494 ,  Y10T29/49236 ,  Y10T29/49412 ,  Y10T29/49826 ,  Y10T29/49828

摘要： A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

公开(公告)号：US20230309873A1

公开(公告)日：2023-10-05

申请号：US18331376

申请日：2023-06-08

申请人： YourBio Health, Inc.

发明人： David Brancazio

IPC分类号： A61B5/15 ,  A61B5/151 ,  A61B10/00 ,  A61B10/02

CPC分类号： A61B5/150099 ,  A61B5/150022 ,  A61B5/150267 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/15105 ,  A61B5/15107 ,  A61B5/150969 ,  A61B5/1411 ,  A61B5/150343 ,  A61B5/150534 ,  A61B5/150732 ,  A61B10/0051 ,  A61B10/0064 ,  A61B10/02 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150946 ,  A61B5/15115 ,  A61B5/15142 ,  A61B5/154

摘要： The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood from subjects. In one aspect, the present invention is directed to devices and methods for receiving or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a substance transfer component (for example, one or more needles or microneedles) and a reduced pressure or vacuum chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some embodiments, the device may contain a “snap dome” or other deformable structure, which may be used, at least in part, to urge or move needles or other suitable substance transfer components into the skin of a subject. In some cases, for example, the device may contain a flexible concave member and a needle mechanically coupled to the flexible concave member such that the needle may be urged or moved into the skin using the flexible concave member. Other aspects of the present invention are directed at other devices for receiving blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

公开(公告)号：US20190216363A1

公开(公告)日：2019-07-18

申请号：US16155480

申请日：2018-10-09

申请人： Theranos IP Company, LLC

发明人： Elizabeth A. Holmes ,  Shaunak Roy ,  John Howard ,  Chengwang Wang

IPC分类号： A61B5/07 ,  A61B5/151 ,  A61B5/15 ,  A61B5/00 ,  A61B5/157 ,  A61B5/145 ,  B01L3/00 ,  A61M37/00 ,  A61B5/1477 ,  A61B5/1473 ,  A61B5/1455

CPC分类号： A61B5/073 ,  A61B5/0024 ,  A61B5/0031 ,  A61B5/1411 ,  A61B5/145 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1473 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150251 ,  A61B5/150282 ,  A61B5/150343 ,  A61B5/150854 ,  A61B5/150862 ,  A61B5/15087 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/15107 ,  A61B5/15117 ,  A61B5/15119 ,  A61B5/15121 ,  A61B5/15123 ,  A61B5/15125 ,  A61B5/1519 ,  A61B5/157 ,  A61B5/417 ,  A61B5/4238 ,  A61B5/4839 ,  A61B5/4848 ,  A61B5/6833 ,  A61B5/685 ,  A61B5/6865 ,  A61B5/7282 ,  A61B2560/0412 ,  A61M5/14276 ,  A61M37/0015 ,  A61M2005/14513 ,  A61M2005/1726 ,  A61M2037/0023 ,  A61M2205/0244 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2205/50 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/10 ,  B01L2300/023 ,  B01L2300/024 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0472 ,  B01L2400/0487 ,  G01N2035/00158

摘要： The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device; and a plurality of microchips comprising a microarray scanning device capable of obtaining physical parameter data of an interaction between the disease marker biological analyte with the bioactive agent; a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile; optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs; an interface device capable of facilitating communications between the microarray scanning device, biometric recognition device and the therapeutic agent releasing device; and an energy source to power the medical device. Specifically, the invention relates to a medical device capable of detecting an analyte in a bodily fluid comprising at least one microneedle capable of obtaining a sample of a bodily fluid, a first microchannel through which the sample flows and is in fluid communication with the at least one microneedle, a second microchannel in fluid communication with the first microchannel, through which a buffer flows, wherein the second channel comprises a microarray with a bioactive agent, a microarray scanning device to detect an interaction between the bioactive agent and the analyte in the bodily fluid; and an interface device.

公开(公告)号：US20180085041A1

公开(公告)日：2018-03-29

申请号：US15717253

申请日：2017-09-27

申请人： Roche Diabetes Care, Inc.

发明人： Wilhelm Leichner

IPC分类号： A61B5/157 ,  A61B5/145 ,  A61B5/1477 ,  A61B5/15 ,  A61B5/151

CPC分类号： A61B5/157 ,  A61B5/14532 ,  A61B5/1477 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150419 ,  A61B5/15045 ,  A61B5/150519 ,  A61B5/15107 ,  A61B5/15113 ,  A61B5/15144 ,  A61B5/15194

摘要： This disclosure concerns a sampling device and a system for collecting body fluid, comprising a metal lancing unit having a distal tip suitable for piercing skin and a capillary channel extending between the tip and a proximal section of the lancing unit for collecting body fluid; and further comprising a plastic holding unit affixed to the lancing unit for manipulating the lancing unit in order to form an incision in the skin, wherein the holding unit contains a sorbent adapted for sorption of moisture and/or volatile substances to protect the sampling device from degradation prior to use.

公开(公告)号：US20170188925A1

公开(公告)日：2017-07-06

申请号：US15154123

申请日：2016-05-13

申请人： Path Scientific, LLC

发明人： Terry O. Herndon ,  Thiruvallur R. Gowrishankar

IPC分类号： A61B5/151 ,  G01N33/49 ,  A61B5/15

CPC分类号： A61B5/15107 ,  A61B5/150022 ,  A61B5/150061 ,  A61B5/150175 ,  A61B5/150358 ,  A61B5/150396 ,  A61B5/150511 ,  A61B5/15109 ,  A61B5/15115 ,  A61B5/15194 ,  A61B5/157 ,  G01N33/49

摘要： The present invention relates to methods and devices for extraction of bodily fluids from tissue by creating microscopic openings in the outermost layers of the skin and drawing out the fluid. One embodiment of the invention is a cylindrical hollow member, made of electrically conducting material, with sharpened edges.

公开(公告)号：US09480420B2

公开(公告)日：2016-11-01

申请号：US12615563

申请日：2009-11-10

申请人： Ahmet Konya ,  Hans-Juergen Kuhr ,  Frank Deck ,  Hans List ,  Michael Keil ,  Christian Hoerauf ,  Thomas Weiss ,  Marcus Schlothauer

发明人： Ahmet Konya ,  Hans-Juergen Kuhr ,  Frank Deck ,  Hans List ,  Michael Keil ,  Christian Hoerauf ,  Thomas Weiss ,  Marcus Schlothauer

IPC分类号： A61B17/32 ,  A61B5/15 ,  A61B5/151

CPC分类号： A61B5/15169 ,  A61B5/1411 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15107 ,  A61B5/15146 ,  A61B5/15153 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/1518 ,  A61B17/32093

摘要： A puncturing system has a carrier tape carrying multiple lancets, a device housing comprising a conveying facility for moving the lancets into a usage position consecutively by moving the carrier tape in a conveying direction, a puncturing drive for accelerating one of the lancets that is positioned in the usage position in a puncturing motion, an opening in the device housing for touching against a body part in which a puncture is to be made by the puncturing motion of one of the lancets, an actuation facility for driving the conveying facility, and an unlockable interlock comprising a stop that blocks further transport of the carrier tape as soon as one of the lancets has reached the usage position.

摘要翻译： 穿刺系统具有携带多个柳叶刀的载带，一个装置壳体，包括用于通过沿输送方向移动载带将柳叶刀连续移动到使用位置的输送装置，用于加速位于 刺穿运动中的使用位置，用于与身体部分接触的装置壳体中的一个开口，其中通过其中一个刺血针的穿刺运动将产生穿刺，用于驱动输送设备的致动设备和可解锁的 互锁包括一旦其中一个刺血针已经到达使用位置就阻止载带的进一步运输的停止件。

公开(公告)号：US20160206809A1

公开(公告)日：2016-07-21

申请号：US15082578

申请日：2016-03-28

申请人： DEKA Products Limited Partnership

发明人： Dean Kamen ,  Larry B. Gray ,  Russell H. Beavis

IPC分类号： A61M5/148 ,  A61M5/142

CPC分类号： A61M5/142 ,  A61B5/1427 ,  A61B5/150022 ,  A61B5/150175 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/15107 ,  A61B5/15117 ,  A61B5/15119 ,  A61B5/15121 ,  A61B5/15123 ,  A61B5/15125 ,  A61B5/15186 ,  A61M5/14232 ,  A61M5/14244 ,  A61M5/148 ,  A61M5/158 ,  A61M2005/1581 ,  A61M2005/1583 ,  A61M2005/1585 ,  A61M2207/00

摘要： A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.