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1.发明公开公开(公告)号：US20230233537A1
公开(公告)日：2023-07-27
申请号：US18012122
申请日：2021-06-22
申请人： University of Zürich
IPC分类号： A61K31/437 , A61K31/4045 , A61K9/00 , A61P25/28
CPC分类号： A61K31/437 , A61K31/4045 , A61K9/0043 , A61K9/006 , A61P25/28
摘要： The invention relates to a kit of parts comprising N,N-dimethyltryptamine or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier; and harmine or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. Also provided is a composition comprising N,N-dimethyltryptamine fumarate and harmine hydrochloride. Further, the invention relates to a pharmaceutical composition comprising N,N-dimethyltryptamine or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier; and harmine or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
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公开(公告)号：US20210238265A1
公开(公告)日：2021-08-05
申请号：US17023814
申请日：2020-09-17
发明人： Roger Nitsch , Feng Chen , Jan Grimm , Jean-Luc Baeriswyl , Christoph Hock
IPC分类号： C07K16/18 , A61K39/395 , C07K14/47 , G01N33/68
摘要： Provided are novel human tau-specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for tau are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for tau targeted immunotherapy and diagnosis, respectively.
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公开(公告)号：US20180134773A1
公开(公告)日：2018-05-17
申请号：US15791632
申请日：2017-10-24
申请人： University of Zürich
发明人： Roger Nitsch , Christoph Hock , Christoph Esslinger , Marlen Knobloch , Kathrin Tissot , Jan Grimm
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K51/1018 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , G01N33/6854 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/52
摘要： Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which derive from native endogenous proteins but are prevalent in the body of a patient in a variant form and/or out of their normal physiological context. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of neurological disorders such as Alzheimer's disease are described.
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公开(公告)号：US09896504B2
公开(公告)日：2018-02-20
申请号：US15005948
申请日：2016-01-25
发明人： Andreas Weihofen , Jan Grimm , Roger Nitsch , Christoph Hock
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： Provided are human alpha-synuclein-specific autoantibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for α-synuclein are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for α-synuclein targeted immunotherapy and diagnosis, respectively.
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公开(公告)号：US09587014B2
公开(公告)日：2017-03-07
申请号：US14354404
申请日：2012-10-26
发明人： Roger Nitsch , Christoph Hock , Maria Grazia Barenco Montrasio , Fabio Montrasio , Jan Grimm , Jean-Luc Baeriswyl , Paul Weinreb , Janaky Coomaraswamy , Omar Quintero-Monzon
IPC分类号： C07K16/18 , A61K47/48 , A61K39/395 , A61K51/10
CPC分类号： C07K16/18 , A61K39/3955 , A61K49/16 , A61K51/1018 , A61K2039/505 , A61K2039/54 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N33/6896 , G01N2333/47 , G01N2800/2814
摘要： Provided are novel TAR DNA-binding proteins of 43 kDa (“TDP-43”)-specific binding molecules including polypeptides such as human antibodies, as well as fragments, derivatives and variants thereof. Also provided are methods related to these TDP-43 specific binding molecules. Assays, kits, and solid supports related to TDP-43-specific binding molecules, including polypeptides such as, human antibodies are also disclosed. The TDP-43-specific binding molecule, antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for TDP-43 targeted immunotherapy and diagnosis, respectively.
摘要翻译： 提供了43kDa（“TDP-43”）特异性结合分子的新型TAR DNA结合蛋白，包括多肽，例如人抗体，以及其片段，衍生物和变体。 还提供了与这些TDP-43特异性结合分子相关的方法。 还公开了与TDP-43特异性结合分子相关的测定，试剂盒和固体支持物，包括多肽，例如人抗体。 TDP-43特异性结合分子，抗体，免疫球蛋白链以及其结合片段，衍生物和变体可分别用于TDP-43靶向免疫治疗和诊断的药物和诊断组合物中。
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公开(公告)号：US20130266586A1
公开(公告)日：2013-10-10
申请号：US13841485
申请日：2013-03-15
申请人： University of Zürich
发明人： Roger NITSCH , Christoph Hock , Christoph Esslinger , Marlen Knobloch , Kathrin Tissot , Jan Grimm
IPC分类号： A61K39/395 , A61K45/06 , C07K16/18
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K51/1018 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , G01N33/6854 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/52
摘要： Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which derive from native endogenous proteins but are prevalent in the body of a patient in a variant form and/or out of their normal physiological context. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of neurological disorders such as Alzheimer's disease are described.
摘要翻译： 提供了新型特异性结合分子，特别是人抗体以及其识别疾病相关蛋白的新表型的片段，衍生物和变体，其衍生自天然内源性蛋白质，但是在变体形式和/或出口的患者体内普遍存在 的正常生理环境。 此外，描述了包含这样的结合分子的药物组合物，其抗体及其模拟物以及筛选新结合分子的方法，其可以是或可以不是抗体以及治疗神经疾病如阿尔茨海默病的靶标。
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公开(公告)号：US20200017577A1
公开(公告)日：2020-01-16
申请号：US16284602
申请日：2019-02-25
发明人： Roger Nitsch , Christoph Hock , Maria Grazia Barenco Montrasio , Fabio Montrasio , Jan Grimm , Jean-Luc Baeriswyl , Paul Weinreb , Janaky Coomaraswamy , Omar Quintero-Monzon
IPC分类号： C07K16/18 , A61K39/395 , A61K51/10 , A61K49/16 , G01N33/68
摘要： Provided are novel TDP-43-specific binding molecules including polypeptides such as human antibodies, as well as fragments, derivatives and variants thereof. Also provided are methods related to these TDP-43 specific binding molecules. Assays, kits, and solid supports related to TDP-43-specific binding molecules, including polypeptides such as, human antibodies are also disclosed. The TDP-43-specific binding molecule, antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for TDP-43 targeted immunotherapy and diagnosis, respectively.
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公开(公告)号：US20190233506A1
公开(公告)日：2019-08-01
申请号：US16128978
申请日：2018-09-12
发明人： Roger Nitsch , Feng Chen , Jan Grimm , Jean-Luc Baeriswyl , Christoph Hock
IPC分类号： C07K16/18 , A61K39/395 , C07K14/47 , G01N33/68
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , C07K14/47 , C07K14/4711 , C07K2317/10 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/90 , C07K2317/92 , G01N33/6896 , G01N2333/47 , G01N2800/56
摘要： Provided are novel human tau-specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for tau are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for tau targeted immunotherapy and diagnosis, respectively.
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公开(公告)号：US09975947B2
公开(公告)日：2018-05-22
申请号：US15410128
申请日：2017-01-19
发明人： Andreas Weihofen , Jan Grimm , Christoph Hock , Roger Nitsch , Lihe Su , Paul Weinreb
IPC分类号： A61K39/395 , C12P21/08 , C07K16/18 , G01N33/68 , A61K47/48
CPC分类号： C07K16/18 , A61K47/6849 , C07K2317/34 , C07K2317/565 , G01N33/6896 , G01N2333/47 , G01N2800/28 , G01N2800/2828 , G01N2800/2835
摘要： Provided are anti-human α-synuclein-specific binding molecules, e.g., antibodies or antiben-binding fragments, variants or derivatives thereof, as methods related thereto. Further provided are anti-human α-synuclein binding molecules which bind to specific N-terminal and C-terminal epitopes on human α-synuclein. The binding molecules described herein can be used in pharmaceutical and diagnostic compositions for α-synuclein targeted immunotherapy and diagnosis, respectively.
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公开(公告)号：US09670272B2
公开(公告)日：2017-06-06
申请号：US13717152
申请日：2012-12-17
申请人： University of Zürich
发明人： Roger Nitsch , Christoph Hock , Christoph Esslinger , Marlen Knobloch , Kathrin Tissot , Jan Grimm
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K51/1018 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , G01N33/6854 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/52
摘要： Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which derive from native endogenous proteins but are prevalent in the body of a patient in a variant form and/or out of their normal physiological context. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of neurological disorders such as Alzheimer's disease are described.
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