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    INFLUENZA A 2009 PANDEMIC H1N1 POLYPEPTIDE FRAGMENTS COMPRISING ENDONUCLEASE ACTIVITY AND THEIR USE
    1.
    发明申请
    INFLUENZA A 2009 PANDEMIC H1N1 POLYPEPTIDE FRAGMENTS COMPRISING ENDONUCLEASE ACTIVITY AND THEIR USE 审中-公开

    公开(公告)号：US20180044649A1

    公开(公告)日：2018-02-15

    申请号：US15672091

    申请日：2017-08-08

    Applicant: EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL)

    Inventor： Stephen CUSACK ,  Eva KOWALINSKI ,  Chloe ZUBIETA

    IPC: C12N9/22 ,  C07D211/32 ,  C07D211/96 ,  G06F19/16 ,  C07H19/10 ,  C07K14/005 ,  C07K16/40 ,  A61K31/33 ,  C07D311/62

    CPC classification number: C12N9/22 ,  A61K31/33 ,  A61K38/00 ,  C07D211/32 ,  C07D211/96 ,  C07D311/62 ,  C07H19/10 ,  C07K14/005 ,  C07K16/40 ,  C07K2299/00 ,  C07K2317/34 ,  C12N2760/16122 ,  G16B15/00

    Abstract: The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase possessing endonuclease activity, wherein said PA subunit is from Influenza A 2009 pandemic H1N1 virus or is a variant thereof. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of said polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit said endonucleolytic activity, preferably in a high throughput setting. This invention also relates to compounds which are able to modulate, preferably to inhibit, the endonuclease activity of the PA subunit polypeptide fragment or variant thereof of the present invention and pharmaceutical compositions comprising said compounds for the treatment of disease conditions caused by viral infections with viruses of the Orthomyxoviridae family, Bunyaviridae family and/or Arenviridae family, preferably caused by viral infections with Influenza A 2009 pandemic H1N1 virus. Preferably, said compounds are identifiable by the methods disclosed herein or said pharmaceutical compositions are producible by the methods disclosed herein.

    MICROSCOPE WITH A VIEWING DIRECTION PERPENDICULAR TO THE ILLUMINATION DIRECTION
    7.
    发明申请
    MICROSCOPE WITH A VIEWING DIRECTION PERPENDICULAR TO THE ILLUMINATION DIRECTION 审中-公开
    具有与照明方向相关的观察方向的显微镜

    公开(公告)号：US20140042339A1

    公开(公告)日：2014-02-13

    申请号：US13746597

    申请日：2013-01-22

    Applicant: European Molecular Biology Laboratory (EMBL)

    Inventor： Ernst H.K. Stelzer ,  Sebastian Enders ,  Jan Huisken ,  Steffen Lindek ,  James H. Swoger

    IPC: G02B21/06

    CPC classification number: G02B21/0032 ,  G01N21/4795 ,  G01N21/6458 ,  G02B21/0048 ,  G02B21/0056 ,  G02B21/0076 ,  G02B21/06 ,  G02B21/16 ,  G02B21/26 ,  G02B21/367

    Abstract: A microscope and imaging method in which a layer of the sample is illuminated by a thin strip of light and the sample is viewed perpendicular to the plane of the strip of light. The depth of the strip of light thus essentially determines the depth of focus of the system. To record the image, the object is displaced through the strip of light, which remains fixed in relation to the detector, and fluorescent and/or diffused light is captured by a planar detector. Objects that absorb or diffuse a large amount of light are viewed from several spatial directions. The three-dimensional images, which are captured from each direction can be combined retrospectively to form one image, in which the data is weighted according to its resolution. The resolution of the combined image is then dominated by the lateral resolution of the individual images.

    Abstract translation: 显微镜和成像方法，其中样品的层被薄的光条照射，并且垂直于光条的平面观察样品。 因此，光条的深度基本上决定了系统的焦点深度。 为了记录图像，物体通过相对于检测器保持固定的光条移位，并且荧光和/或漫射光被平面检测器捕获。 从多个空间方向观察吸收或漫射大量光的物体。 从每个方向捕获的三维图像可以追溯地组合以形成一个图像，其中根据其分辨率对数据进行加权。 然后，组合图像的分辨率由单个图像的横向分辨率来支配。

    Computer user interface facilitating acquiring and analyzing of biological specimen traits
    8.
    发明申请
    Computer user interface facilitating acquiring and analyzing of biological specimen traits 审中-公开
    计算机用户界面便于获取和分析生物样本性状

    公开(公告)号：US20040076999A1

    公开(公告)日：2004-04-22

    申请号：US10619227

    申请日：2003-07-14

    Applicant: Baylor College of Medicine ,  European Molecular Biology Laboratory (EMBL) ,  EnVivo Pharmaceuticals

    Inventor： Edward Faeldt ,  Luis Serrano ,  Cayetano Gonzalez ,  Christian Boulin ,  Christopher J. Cummings ,  Juan Botas ,  Huda Zoghbi

    IPC: C12Q001/68 ,  G06F019/00 ,  G01N033/48 ,  G01N033/50

    CPC classification number: G06T7/20 ,  G06T7/0012 ,  Y02A90/24 ,  Y02A90/26

    Abstract: Tools are provided for obtaining and assessing data concerning the physical or behavioral traits of an biological specimen population for the purpose of identifying, treating, or gathering intelligence on the condition of the specimen population. In one aspect, a computer system is provided to assess a condition of a biological specimen by studying the physical traits of a sample that comprises a number of specimens. The condition may comprise a human central nervous system condition. A user interface is provided that comprises a computer screen, an input interface portion, and a processing mechanism. The user interface may further comprise a specimen information input mechanism. The specimen information input mechanism may comprise a specimen type input that allows the user to specify, through the computer screen input, the type of specimen to be studied.

    Abstract translation: 提供工具用于获取和评估有关生物样本人群的身体或行为特征的数据，以便在标本人群的状况下识别，治疗或收集情报。 一方面，提供一种计算机系统，用于通过研究包含多个样本的样品的物理性状来评估生物样品的状况。 该病症可能包括人类中枢神经系统疾病。 提供了一种包括计算机屏幕，输入接口部分和处理机构的用户界面。 用户界面还可以包括标本信息输入机构。 样本信息输入机构可以包括样本类型输入，其允许用户通过计算机屏幕输入来指定要研究的样本的类型。

    Assaying and imaging system identifying traits of biological specimens
    10.
    发明申请
    Assaying and imaging system identifying traits of biological specimens 审中-公开
    鉴定和成像系统识别生物标本的特征

    公开(公告)号：US20040076318A1

    公开(公告)日：2004-04-22

    申请号：US10618869

    申请日：2003-07-14

    Applicant: Baylor College of Medicine ,  European Molecular Biology Laboratory (EMBL) ,  EnVivo Pharmaceuticals

    Inventor： Edward Faeldt ,  Luis Serrano ,  Cayetano Gonzalez ,  Christian Boulin ,  Christopher J. Cummings ,  Juan Botas ,  Huda Zoghbi

    IPC: G06K009/00

    CPC classification number: G06T7/20 ,  G06T7/0012 ,  Y02A90/24 ,  Y02A90/26

    Abstract: A method of system is provided for assaying specimens. In connection with such system or method, plural multi-pixel target images of a field of view are obtained at different corresponding points in time over a given sample period. A background image is obtained using a plural set of the plural target images. For a range of points in time, the background image is removed from the target images to produce corresponding background-removed target images. Analysis is performed using at least a portion of the corresponding background-removed target images to identify visible features of the specimens. A holding structure is provided to hold a set of discrete specimen containers. A positioning mechanism is provided to position a plural subset of the containers to place the moving specimens within the plural subset of the containers within a field of view of the camera.

    Abstract translation: 提供了一种用于测定样品的系统方法。 关于这种系统或方法，在给定的采样周期的不同对应的时间点获得视场的多个多像素目标图像。 使用多组多个目标图像获得背景图像。 对于时间点的范围，从目标图像中去除背景图像，以产生相应的背景去除的目标图像。 使用至少一部分相应的背景去除的目标图像进行分析以识别样本的可见特征。 提供保持结构以保持一组离散的标本容器。 提供了定位机构来定位容器的多个子集，以将移动的样本放置在相机的视野内的容器的多个子集内。

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