公开(公告)号：US12044835B2

公开(公告)日：2024-07-23

申请号：US17750558

申请日：2022-05-23

申请人： The Boeing Company

发明人： Shahriar Khosravani

IPC分类号： G02B21/00 ,  G02B26/08

CPC分类号： G02B21/0024 ,  G02B21/0032 ,  G02B21/0044 ,  G02B21/0048 ,  G02B26/0833

摘要： Methods and apparatus for optical imaging and scanning of holes machined, drilled or otherwise formed in a substrate made of composite or metallic material. The method utilizes an optical instrument for imaging and scanning a hole in combination with an image processor configured (e.g., programmed) to post-process the image data to generate one complete planarized image without conical optical distortion. The optical instrument includes an optical microscope with confocal illumination and a conical mirror axially positioned to produce a full 360-degree sub-image with conical distortion. In the post-processing step, a mathematical transformation in the form of computer-executable code is used to transform the raw conical sub-images to planar sub-images. The planarized sub-images may be stitched together to form a complete planarized image of the hole.

公开(公告)号：US12007542B2

公开(公告)日：2024-06-11

申请号：US17413010

申请日：2019-12-12

申请人： EÖTVÖS LORÁND TUDOMÁNYEGYETEM

发明人： Bálint Szabó

IPC分类号： G02B21/00

CPC分类号： G02B21/0032 ,  G02B21/0048 ,  G02B21/0076

摘要： An assembly for switching optical paths, which assembly includes multiple optical channels for guiding an illuminating light to a specimen and for guiding the light coming from the specimen to an image recording unit. The assembly also includes a plurality of light guiding mirrors and at least one light modifying element in each optical channel for directing the illuminating light and the light coming from the specimen. In each of the multiple optical channels the at least one light modifying element includes a stationary dichroic mirror. Further details regarding the arrangement and rotation of the mirrors, and how the mirrors direct the illuminating light and light coming from the specimen, are defined herein.

公开(公告)号：US20230284939A1

公开(公告)日：2023-09-14

申请号：US18319163

申请日：2023-05-17

申请人： The General Hospital Corporation

发明人： Charles P. Lin ,  Hari Prasad Paudel

IPC分类号： A61B5/145 ,  G02B21/14 ,  G02B21/00 ,  A61B5/1455 ,  G01N15/14 ,  A61B5/00 ,  G02B21/08 ,  G02B26/12 ,  G02B21/36

CPC分类号： A61B5/14535 ,  G02B21/14 ,  G02B21/0056 ,  G02B21/008 ,  G02B21/0068 ,  A61B5/1455 ,  G01N15/1436 ,  G02B21/0048 ,  A61B5/0068 ,  G02B21/002 ,  G02B21/086 ,  G02B26/12 ,  G02B21/365 ,  G01N15/1468 ,  G01N2015/144 ,  A61B2562/0233 ,  G01N2015/1006

摘要： Systems, methods, and apparatus for differential phase contrast microscopy by transobjective differential epi-detection of forward scattered light are provided. In some embodiments, a microscope objective comprises: a housing with mounting threads at a second end; optical components defining an optical axis, comprising: an objective lens mounted at a first end, configured to collect light from a sample placed in a field of view, the plurality of optical components create a pupil plane at a first distance along the optical axis at which rays having the same angle of incidence on the objective lens converge at the same radial distance from the optical axis; a photodetector within the housing offset from the optical axis at a second distance along the optical axis; and another photodetector within the housing at second distance along the optical axis and offset from the optical axis in the opposite direction from the first photodetector.

公开(公告)号：US20230266577A1

公开(公告)日：2023-08-24

申请号：US18172139

申请日：2023-02-21

申请人： PURDUE RESEARCH FOUNDATION

发明人： Meng CUI

IPC分类号： G02B21/00 ,  G02B26/12

CPC分类号： G02B21/0048 ,  G02B26/124 ,  G02B26/125

摘要： High speed laser scanning systems and methods are disclosed for imaging target samples. Embodiments of the laser scanning systems and methods include separating a laser beam into two or more different pathways and pulsing light along the two or more pathways. The different pathways intersect the surface of a moving mirror at different locations and light traveling in a pathway that is being approached by an edge of the moving reflective surface is turned off while light traveling in a different pathway that is farther from the edge of the moving reflective surface is turned on. Embodiments include reflective surfaces that form a rotating polygonal scanner. Further embodiments include recombining the two or more different pathways, focusing the laser light on a test sample, and imaging the light reflected from the test sample.

公开(公告)号：US20230168484A1

公开(公告)日：2023-06-01

申请号：US18162067

申请日：2023-01-31

申请人： Chan Zuckerberg Biohub, Inc.

发明人： Bin Yang ,  Loic Royer

IPC分类号： G02B21/00 ,  G02B26/10 ,  H04N23/56 ,  H04N23/55 ,  H04N23/74 ,  H04N13/282 ,  H04N13/207 ,  G01N21/64

CPC分类号： G02B21/008 ,  G02B21/0076 ,  G02B21/0048 ,  G02B26/101 ,  H04N23/56 ,  H04N23/55 ,  H04N23/74 ,  H04N13/282 ,  H04N13/207 ,  G01N21/6456 ,  H04N13/156

摘要： A method of performing imaging includes operating a light sheet projection module in a first state during a first measurement process and using a first primary objective for illumination of a specimen using a light sheet and detection of a first fluorescent emission. The method also includes operating the light sheet projection module in a second state during a second measurement process and using a second primary objective for illumination of the specimen using the light sheet and detection of a second fluorescent emission.

公开(公告)号：US20180307017A1

公开(公告)日：2018-10-25

申请号：US15959050

申请日：2018-04-20

申请人： California Institute of Technology

发明人： Roarke W. Horstmeyer ,  Guoan Zheng ,  Xiaoze Ou ,  Changhuei Yang

IPC分类号： G02B21/00 ,  G01T1/185 ,  G02B21/36 ,  G02B21/16 ,  G01N23/205 ,  G01T3/00 ,  G02B27/46 ,  G02B27/58

CPC分类号： G02B21/008 ,  G01N23/205 ,  G01T1/185 ,  G01T3/008 ,  G02B21/0032 ,  G02B21/0048 ,  G02B21/0056 ,  G02B21/006 ,  G02B21/16 ,  G02B21/367 ,  G02B27/46 ,  G02B27/58

摘要： Certain aspects pertain to aperture-scanning Fourier ptychographic imaging devices comprising an aperture scanner that can generate an aperture at different locations at an intermediate plane of an optical arrangement, and a detector that can acquire lower resolution intensity images for different aperture locations, and wherein a higher resolution complex image may be constructed by iteratively updating regions in Fourier space with the acquired lower resolution images.

公开(公告)号：US10027855B2

公开(公告)日：2018-07-17

申请号：US13704748

申请日：2011-06-29

申请人： Witold Bula ,  Pavel A. Fomitchov ,  Steve Goodson ,  Erwen Mei ,  Yang Zhang

发明人： Witold Bula ,  Pavel A. Fomitchov ,  Steve Goodson ,  Erwen Mei ,  Yang Zhang

IPC分类号： H04N5/04 ,  G02B21/00 ,  H04N1/113 ,  H04N1/195

CPC分类号： H04N5/04 ,  G02B21/0048 ,  H04N1/113 ,  H04N1/195 ,  H04N2201/04715 ,  H04N2201/04755

摘要： A line confocal microscope system, comprising a scanning unit in the form of a mechanically driven scanning unit with a controllable a scanning trajectory and a two dimensional sensor unit operated in a rolling line shutter mode in synchronization with the scanning unit, wherein the scanning trajectory is set to have an acceleration part outside the field of view of the sensor unit.

公开(公告)号：US10018817B2

公开(公告)日：2018-07-10

申请号：US15061056

申请日：2016-03-04

申请人： Aramco Services Company ,  SAUDI ARABIAN OIL COMPANY ,  TRUSTEES OF BOSTON UNIVERSITY

发明人： Thomas Bifano ,  Shannon L. Eichmann ,  Bennett B. Goldberg ,  Mazen Kanj ,  Hari P. Paudel ,  William Shain

IPC分类号： G01J1/58 ,  G02B21/00 ,  G02B21/02 ,  G01N21/64 ,  G02B27/00 ,  G02B21/36

CPC分类号： G02B21/0028 ,  G01N21/6458 ,  G01N2201/0675 ,  G02B21/002 ,  G02B21/0032 ,  G02B21/0048 ,  G02B21/0076 ,  G02B21/008 ,  G02B21/02 ,  G02B21/367 ,  G02B27/0068

摘要： Embodiments of the invention provide an imaging system and method using adaptive optics and optimization algorithms for imaging through highly scattering media in oil reservoir applications and lab-based petroleum research. Two-/multi-photon fluorescence microscopy is used in conjunction with adaptive optics for enhanced imaging and detection capabilities in scattering reservoir media. Advanced fluorescence techniques are used to allow for super-penetration imaging to compensate for aberrations both in and out of the field of interest, extending the depth at which pore geometry can be imaged within a rock matrix beyond the current capability of confocal microscopy. The placement of a Deformable Mirror or Spatial Light Modulator for this application, in which scattering and index mismatch are dominant aberrations, is in an optical plane that is conjugate to the pupil plane of the objective lens in the imaging system.

公开(公告)号：US20180129031A1

公开(公告)日：2018-05-10

申请号：US15730668

申请日：2017-10-11

申请人： CALIBER IMAGING & DIAGNOSTICS, INC.

发明人： KEITH AARON HADLEY ,  JASON WILLIAM FAULRING ,  PAUL MICHAEL HEMMER ,  JAMES VINCENT MASSARO

IPC分类号： G02B21/26 ,  G02B21/00 ,  G01N33/483

CPC分类号： G02B21/26 ,  G01N33/4833 ,  G02B21/0028 ,  G02B21/0032 ,  G02B21/0048 ,  G02B21/008

摘要： A system, apparatus and method and method for controlling interoperation between a resonant scanner and a movable stage. The movable stage being employed to position a specimen for optical scanning by the resonant scanner. The invention providing high resolution scanning of specimen tissue at a rate of ten times or more faster than other known methods of optically scanning a specimen.

公开(公告)号：US20180120549A1

公开(公告)日：2018-05-03

申请号：US15728726

申请日：2017-10-10

申请人： OLYMPUS CORPORATION

发明人： Susumu HONDA

IPC分类号： G02B21/00 ,  G02B27/28 ,  G02F1/01

CPC分类号： G02B21/0076 ,  G02B21/0032 ,  G02B21/0048 ,  G02B21/0068 ,  G02B27/283 ,  G02F1/0102

摘要： A microscope apparatus includes: an objective lens; an observation optical system that makes the specimen be irradiated with excitation light by the objective lens, and acquires image information of the specimen; a first stimulation optical system that includes a scanning section which scans stimulus light, makes the scanning section scan an irradiation position of the stimulus light and applies an optical stimulus to the specimen; a second stimulation optical system that includes an SLM arranged at a pupil conjugate position of the objective lens and capable of modulating a phase of the stimulus light, selectively switches the irradiation position of the stimulus light by the SLM and applies the optical stimulus to the specimen; and a light path selecting section that selects at least one of a light path of the first stimulation optical system and a light path of the second stimulation optical system.