Invention Application
- Patent Title: Dock Derived Compound against Laminin Receptor (37 LR) and Uses thereof
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Application No.: US16113718Application Date: 2018-08-27
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Publication No.: US20190065669A1Publication Date: 2019-02-28
- Inventor: Marxa L. Figueiredo , Charles Samuel Umbaugh , Herman O. Sintim , Adriana Diaz-Quinones
- Applicant: Purdue Research Foundation
- Applicant Address: US IN West Lafayette
- Assignee: Purdue Research Foundation
- Current Assignee: Purdue Research Foundation
- Current Assignee Address: US IN West Lafayette
- Main IPC: G06F19/16
- IPC: G06F19/16 ; C40B30/02 ; A61K31/497 ; A61P35/00 ; A61P19/02
Abstract:
An in silico screening method generated compounds that are against laminin receptor 37 LR and their anti-cancer functions in prostate cancer cell lines are disclosed herein. A group of derivatives based on the hit compound from the in silico screening are synthesized and tested with improved IC50 value that can have relevant clinical use for prostate cancer or osteoarthritis.
Public/Granted literature
- US10438688B2 Dock derived compound against laminin receptor (37 LR) and uses thereof Public/Granted day:2019-10-08
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