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公开(公告)号:US20190057856A1
公开(公告)日:2019-02-21
申请号:US15769998
申请日:2016-10-21
Applicant: Purdue Research Foundation
Inventor: Robert Graham Cooks , Jason Duncan , Joshua Wiley
Abstract: The invention generally relates to ion traps and methods of use thereof. In certain embodiments, the invention provides a system that includes a mass spectrometer including an ion trap, and a central processing unit (CPU). The CPU has storage that is coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a constant radio frequency (RF) signal to the ion trap, and apply a first alternating current (AC) signal to the ion trap the frequency of which varies as a function of time.
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公开(公告)号:US20200121229A1
公开(公告)日:2020-04-23
申请号:US16720991
申请日:2019-12-19
Applicant: Purdue Research Foundation
Inventor: Robert Graham Cooks , Zheng Ouyang , Chien-hsun Chen , Ziqing Lin , Livia Schiavinato Eberlin
IPC: A61B5/1477 , G01N33/483 , H01J49/34 , H01J49/16 , H01J49/04 , H01J49/00 , A61M25/00 , A61M11/00 , A61B10/00
Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
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公开(公告)号:US20250059419A1
公开(公告)日:2025-02-20
申请号:US18720469
申请日:2022-12-14
Applicant: Purdue Research Foundation
Inventor: Jonathan J. WILKER , Gudrun SCHMIDT , Logan Joseph MILES
Abstract: Underwater adhesive compositions comprising a zein and a tannic acid, alone or further in combination with FeCl3, an inorganic filler, a natural polymer, or any combination thereof; and a method of making them.
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公开(公告)号:US20250055064A1
公开(公告)日:2025-02-13
申请号:US18933069
申请日:2024-10-31
Applicant: Purdue Research Foundation
Inventor: Xiulin Ruan , Amy Marie Marconnet , Tingting Du , Luis Delgado
IPC: H01M10/6551 , H01M10/613 , H01M10/653
Abstract: Variable thermal resistors, systems, and methods suitable for modulating heat transport between a heat source and a heat sink based on a degree of compression of a reversibly-compressible, open-pore graphene foam within the variable thermal resistors. The variable thermal resistor is configured to controllably vary heat transport therethrough by controlling the degree of compression of the graphene foam.
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公开(公告)号:US12220454B2
公开(公告)日:2025-02-11
申请号:US17199972
申请日:2021-03-12
Applicant: Purdue Research Foundation
Inventor: Suresh Kumar Mittal
IPC: A61K39/145 , A61P31/16 , A61P37/04 , A61K39/00
Abstract: Disclosed herein a unique cell line system to generate a novel bovine adenovirus vector that provides more gene insertion capabilities and better immunogenicity for inserted antigens. The unique cell line is used for generating and growing of the new adenovirus vectors for gene delivery or recombinant vaccine production.
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公开(公告)号:US12217559B2
公开(公告)日:2025-02-04
申请号:US17930777
申请日:2022-09-09
Applicant: Purdue Research Foundation
Inventor: Justin Douglas Tarman , Matthew W. Barrett , Nicholas Aaron Catanzarite , Jesse A. Ham , Dominic A. Layne
Abstract: Locking devices, systems, and methods for securing personal property to separate structures. Such a locking device includes a lock body, a cable within the lock body and having a first end accessible from an exterior of the lock body, a spool for extending and retracting the cable out of and into the lock body, a lock pin disposed at the first end of the cable, a cable lock incorporated into the lock body and configured to releasably secure the lock pin to the lock body, and an electronic communication and control unit incorporated into the lock body and configured to communicate with a remote device. The electronic communication and control unit controls the cable lock to secure and release the lock pin relative to the lock body to allow the remote device to wirelessly unlock the first end of the cable from the lock body.
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公开(公告)号:US20250036538A1
公开(公告)日:2025-01-30
申请号:US18782020
申请日:2024-07-23
Applicant: Purdue Research Foundation
Inventor: Sarah Nicole Rodenbeck
IPC: G06F11/30
Abstract: Systems and methods for enabling actionable analysis of support requests are disclosed. Embodiments include systems and methods that ingest support ticket data into an automated workflow (for example, a cron orchestrator), which interacts with one or more databases, one or more APIs, and one or more UIs to supply a user with actionable analysis for, e.g., assisting customers with complex issues. Embodiments may also include one or more ingestion deployments, pre-processing models, pattern-based filtering models, embedding models, message relevancy filtering models, clustering models, anomaly detection models, forecasting models and/or database ingestion models.
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公开(公告)号:US20250034146A1
公开(公告)日:2025-01-30
申请号:US18661871
申请日:2024-05-13
Applicant: Purdue Research Foundation
Inventor: Davin Glenn Piercey , Joseph Robert Yount
IPC: C07D487/04
Abstract: A method of preparing a 1,2,4-triazolo-[4,3-a]pyrazine backbone using an electro-photochemical process comprising coupling a compound comprising a 5-substituted tetrazole moiety to a compound comprising an optionally substituted pyrazine moiety electrochemically and subjecting the resulting compound to photochemical excitation with ultraviolet light.
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公开(公告)号:US20250034094A1
公开(公告)日:2025-01-30
申请号:US18711740
申请日:2022-11-22
Applicant: Purdue Research Foundation , Comell University Center for Technology Licensing at Cornell University (CTL)
Inventor: David H. Thompson , Giulia Murbach De Oliveira , Marcelo M. Nociari
IPC: C07D213/90
Abstract: A process for the preparation of high quality N-retinylidene-N-retinylethanolamine (A2E) using a continuous flow reaction system is described, wherein the process first provides a mixing point for one equivalent of ATR and about ten equivalents of ethanolamine, followed by later introduction of about twelve equivalents of acetic acid into the stream of the continuous reaction flow at about 25° C. using DMSO as the solvent. The products obtained by this process are also described. A rapid method to access the purity of a sample of A2E is described.
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公开(公告)号:US12210167B2
公开(公告)日:2025-01-28
申请号:US18636195
申请日:2024-04-15
Applicant: Purdue Research Foundation
Inventor: Fan Xu , Fang Huang , Donghan Ma
Abstract: A method of in situ point spread function (PSF) retrieval is disclosed which includes encoding 3D location of molecules into PSFs, receiving molecule-generated images containing PSFs, segmenting the images into sub-PSF, initializing template PSFs from a pupil function, determining a statistical measure of a predetermined function between the sub- and template PSFs, associating each of the sub-PSFs with a template PSF, aligning and averaging the sub-PSF, applying a phase retrieval algorithm to the averaged sub-PSFs to update the pupil function, regenerating the template PSFs, repeating until a difference between a new and a prior generation pupil function is below a predetermined threshold, generating in situ PSFs from the last pupil function, and applying a maximum likelihood estimation algorithm based on the in situ PSFs and the sub-PSF to thereby generate lateral and axial locations of molecules.
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