公开(公告)号：US11304637B2

公开(公告)日：2022-04-19

申请号：US17066727

申请日：2020-10-09

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-hsun Chen ,  Ziqing Lin ,  Livia Schiavinato Eberlin

IPC: A61B5/1477 ,  A61B10/00 ,  H01J49/04 ,  A61M11/00 ,  A61M25/00 ,  H01J49/00 ,  H01J49/16 ,  H01J49/34 ,  G01N33/483 ,  A61B5/145 ,  A61B5/15 ,  A61B5/157 ,  G01N1/02

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

公开(公告)号：US10420495B2

公开(公告)日：2019-09-24

申请号：US16248066

申请日：2019-01-15

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-hsun Chen ,  Ziqing Lin ,  Livia Schiavinato Eberlin

IPC: H01J49/00 ,  A61B5/1477 ,  H01J49/34 ,  A61M11/00 ,  A61M25/00 ,  G01N33/483 ,  H01J49/04 ,  H01J49/16 ,  A61B10/00 ,  G01N1/02 ,  A61B5/15 ,  A61B5/145 ,  A61B5/157

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

公开(公告)号：US11903707B2

公开(公告)日：2024-02-20

申请号：US17692613

申请日：2022-03-11

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-hsun Chen ,  Ziqing Lin ,  Livia Schiavinato Eberlin

IPC: A61B5/1477 ,  A61B10/00 ,  H01J49/04 ,  A61M11/00 ,  A61M25/00 ,  H01J49/00 ,  H01J49/16 ,  H01J49/34 ,  G01N33/483 ,  A61B5/145 ,  A61B5/15 ,  A61B5/157 ,  G01N1/02

CPC classification number: A61B5/1477 ,  A61B10/0045 ,  A61M11/00 ,  A61M25/00 ,  G01N33/4833 ,  H01J49/0022 ,  H01J49/0404 ,  H01J49/0445 ,  H01J49/167 ,  H01J49/34 ,  A61B5/145 ,  A61B5/1405 ,  A61B5/157 ,  A61B5/150015 ,  A61B5/150992 ,  A61M2202/0468 ,  G01N2001/028

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

公开(公告)号：US11875983B2

公开(公告)日：2024-01-16

申请号：US17979972

申请日：2022-11-03

Applicant: Purdue Research Foundation

Inventor： Zheng Ouyang ,  Yue Ren ,  Ziqing Lin

IPC: H01J49/16 ,  H01J49/04 ,  C12Q1/6806

CPC classification number: H01J49/167 ,  C12Q1/6806 ,  Y10T436/24 ,  Y10T436/255

Abstract: The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent.

公开(公告)号：US20200121229A1

公开(公告)日：2020-04-23

申请号：US16720991

申请日：2019-12-19

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-hsun Chen ,  Ziqing Lin ,  Livia Schiavinato Eberlin

IPC: A61B5/1477 ,  G01N33/483 ,  H01J49/34 ,  H01J49/16 ,  H01J49/04 ,  H01J49/00 ,  A61M25/00 ,  A61M11/00 ,  A61B10/00

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

公开(公告)号：US10555694B2

公开(公告)日：2020-02-11

申请号：US16539562

申请日：2019-08-13

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-hsun Chen ,  Ziqing Lin ,  Livia Schiavinato Eberlin

IPC: H01J49/00 ,  A61B5/1477 ,  H01J49/34 ,  H01J49/16 ,  H01J49/04 ,  A61M25/00 ,  A61M11/00 ,  A61B10/00 ,  G01N33/483 ,  A61B5/145 ,  A61B5/15 ,  G01N1/02 ,  A61B5/157

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

公开(公告)号：US20210045662A1

公开(公告)日：2021-02-18

申请号：US17066727

申请日：2020-10-09

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-hsun Chen ,  Ziqing Lin ,  Livia Schiavinato Eberlin

IPC: A61B5/1477 ,  A61B10/00 ,  H01J49/04 ,  A61M11/00 ,  A61M25/00 ,  H01J49/00 ,  H01J49/16 ,  H01J49/34 ,  G01N33/483

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

公开(公告)号：US10799165B2

公开(公告)日：2020-10-13

申请号：US16720991

申请日：2019-12-19

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-hsun Chen ,  Ziqing Lin ,  Livia Schiavinato Eberlin

IPC: H01J49/00 ,  A61B5/1477 ,  A61B10/00 ,  H01J49/04 ,  A61M11/00 ,  A61M25/00 ,  H01J49/16 ,  H01J49/34 ,  G01N33/483 ,  A61B5/145 ,  A61B5/15 ,  A61B5/157 ,  G01N1/02

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

公开(公告)号：US20190167164A1

公开(公告)日：2019-06-06

申请号：US16248066

申请日：2019-01-15

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-hsun Chen ,  Ziqing Lin ,  Livia Schiavinato Eberlin

IPC: A61B5/1477 ,  A61B10/00 ,  H01J49/34 ,  A61M11/00 ,  A61M25/00 ,  G01N33/483 ,  H01J49/00 ,  H01J49/04 ,  H01J49/16

CPC classification number: A61B5/1477 ,  A61B5/1405 ,  A61B5/145 ,  A61B5/150015 ,  A61B5/150992 ,  A61B5/157 ,  A61B10/0045 ,  A61M11/00 ,  A61M25/00 ,  A61M2202/0468 ,  G01N33/4833 ,  G01N2001/028 ,  H01J49/0022 ,  H01J49/0404 ,  H01J49/0445 ,  H01J49/167 ,  H01J49/34

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

公开(公告)号：US10213143B2

公开(公告)日：2019-02-26

申请号：US15989706

申请日：2018-05-25

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-Hsun Chen ,  Ziqing Lin ,  Livia Schiavinato Eberlin

IPC: H01J49/00 ,  A61B5/1477 ,  G01N33/483 ,  H01J49/34 ,  A61M11/00 ,  A61M25/00 ,  H01J49/04 ,  H01J49/16 ,  A61B10/00 ,  A61B5/15 ,  G01N1/02 ,  A61B5/157 ,  A61B5/145

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.