公开(公告)号：US12121667B2

公开(公告)日：2024-10-22

申请号：US17674067

申请日：2022-02-17

Applicant: NEBU-TEC MED. PRODUKTE EIKE KERN GMBH

Inventor： Stefan Kern

IPC: A61M15/00 ,  A61M11/00 ,  A61M16/00 ,  A61M16/14

CPC classification number: A61M16/14 ,  A61M11/00 ,  A61M11/005 ,  A61M15/0021 ,  A61M15/0085 ,  A61M15/0086 ,  A61M16/0069 ,  A61M16/024 ,  A61M2016/0018 ,  A61M2016/0027 ,  A61M2016/0039 ,  A61M2205/3365

Abstract: A method for performing an inhalation using a nebulizer includes filling a reservoir with a medication fluid or connecting a medication container to a designated connecting piece; connecting a nebulizer unit to a control unit and a mouthpiece, at least temporarily activating the nebulizer unit; atomizing the medication fluid into a fine particulate aerosol which is emitted into an aerosol chamber formed by the nebulizer unit and the mouthpiece during activation of the nebulizer unit; performing the inhalation, with a user enclosing the mouthpiece with the lips and during inhalation, drawing air from outside into the aerosol chamber, where the air mixes with the aerosol, and then passes further through the mouthpiece as an air stream and into the respiratory tract and, possibly into the user's lung; measuring a pressure within the aerosol chamber and/or a flow rate through the aerosol chamber or the mouthpiece using the control unit; activating the nebulizer unit with each breath on occurrence of at least one activation criterion detected using the control unit; and deactivating the nebulizer unit with fulfilment of at least one stop criterion, wherein from a degree of fulfilment of the at least one activation and/or stop criterion, a weighted average value is formed and the inhalation is started when the weighted average value exceeds a threshold value.

公开(公告)号：US20240342404A1

公开(公告)日：2024-10-17

申请号：US18751627

申请日：2024-06-24

Applicant: Norton (Waterford) Limited

Inventor： Mark Milton-Edwards ,  Guilherme Safioti ,  Lena Granovsky ,  Michael Reich

IPC: A61M15/00 ,  A61B5/00 ,  A61B5/08 ,  A61K31/138 ,  A61M11/00 ,  C07K16/24 ,  C07K16/28 ,  C07K16/42 ,  G16H20/10 ,  G16H20/13 ,  G16H50/30 ,  G16H50/70

CPC classification number: A61M15/009 ,  A61B5/0826 ,  A61B5/4848 ,  A61B5/7275 ,  A61K31/138 ,  A61M15/0001 ,  A61M15/0025 ,  A61M15/003 ,  A61M15/008 ,  A61M15/0091 ,  C07K16/244 ,  C07K16/247 ,  C07K16/2866 ,  C07K16/4291 ,  G16H20/10 ,  G16H20/13 ,  G16H50/30 ,  G16H50/70 ,  A61M11/00 ,  A61M15/0026 ,  A61M2202/064 ,  A61M2205/05 ,  A61M2205/18 ,  A61M2205/3327 ,  A61M2205/3331 ,  A61M2205/3358 ,  A61M2205/3584 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/30 ,  A61M2230/40 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/52

Abstract: Provided is a system (10) for determining a probability of an asthma exacerbation in a subject. The system comprises an inhaler (100) for delivering a rescue medicament to the subject. The inhaler has a use-detection system (12B) configured to determine a rescue inhalation performed by the subject using the first inhaler. A sensor system (12A) is configured to measure a parameter relating to airflow during the rescue inhalation. The system further comprises a processor (14) configured to determine a number of the rescue inhalations during a first time period, and receive the parameter measured for at least some of the rescue inhalations. The processor determines, using a weighted model, the probability of the asthma exacerbation based on the number of rescue inhalations and the parameters. The model is weighted such that the number of rescue inhalations is more significant in the probability determination than the parameters.

公开(公告)号：US20240264144A1

公开(公告)日：2024-08-08

申请号：US18605672

申请日：2024-03-14

Applicant: TransMedics, Inc.

Inventor： Waleed H. HASSANEIN ,  Tamer I. KHAYAL ,  Robert HAVENER ,  Stanley KYI ,  Ihab Abdel FATTAH ,  Hesham SALEH ,  Jon C. TRACHTENBERG

IPC: G01N33/49 ,  A01N1/02 ,  A61M11/00 ,  A61M11/04 ,  A61M16/00 ,  A61M16/10

CPC classification number: G01N33/4925 ,  A01N1/02 ,  A01N1/0226 ,  A01N1/0247 ,  A61M11/042 ,  A61M16/024 ,  A61M11/00 ,  A61M2016/0027 ,  A61M2016/0033 ,  A61M16/0078 ,  A61M16/10 ,  A61M2016/1025 ,  A61M2016/103 ,  A61M2202/0208 ,  A61M2202/0225 ,  A61M2202/025 ,  A61M2202/0468 ,  A61M2205/3368 ,  A61M2230/202 ,  A61M2230/205 ,  A61M2230/432

Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ ex vivo.

公开(公告)号：US12029786B2

公开(公告)日：2024-07-09

申请号：US17170876

申请日：2021-02-08

Applicant: RNAimmune, Inc.

Inventor： Shenggao Tang ,  Dong Shen ,  Chun Lu ,  Ziyang He ,  Jiaxi He ,  Patrick Y. Lu

IPC: A61K39/215 ,  A61K9/00 ,  A61K9/51 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00 ,  A61K39/00 ,  A61M11/00

CPC classification number: A61K39/215 ,  A61K9/0019 ,  A61K9/5123 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/544 ,  A61K2039/55555 ,  A61M11/00 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20071

Abstract: Compositions and methods are provided for potent mRNA vaccines for prevention and treatment of 2019 novel Coronavirus (2019-nCoV) infections. The compositions include a pharmaceutical composition containing one or more mRNA molecules encoding spike protein epitopes, including mutated epitopes, or mRNA cocktails that encode critical viral genes together with pharmaceutically acceptable polymeric nanoparticle carriers and liposomal nanoparticle carriers. Methods for stimulating system immune responses and treatment are provided, including subcutaneous, intraperitoneal and intramuscular injections.

公开(公告)号：US12023434B2

公开(公告)日：2024-07-02

申请号：US17199370

申请日：2021-03-11

Applicant: Pax Labs, Inc.

Inventor： Nicholas Jay Hatton ,  Steven Christensen ,  Esteban Leon Duque ,  Ariel Atkins ,  James Monsees ,  Adam Bowen

IPC: A61M11/00 ,  A24F7/00 ,  A24F40/10 ,  A24F40/40 ,  A24F40/42 ,  A24F40/44 ,  A24F40/46 ,  A24F40/485 ,  A61M11/04 ,  A61M15/00 ,  A61M15/06

CPC classification number: A61M11/00 ,  A24F7/00 ,  A24F40/40 ,  A24F40/42 ,  A24F40/44 ,  A24F40/46 ,  A24F40/485 ,  A61M11/042 ,  A61M11/044 ,  A61M15/06 ,  A24F40/10 ,  A61M15/0021 ,  A61M2205/121 ,  A61M2205/123 ,  A61M2205/8206

Abstract: Vaporizer cartridges and vaporizer apparatuses, and methods for making, using and delivering vapor to a user, that are leak-resistant for use with cannabinoids. In particular, described herein are leak-resistant vaporizer cartridges and apparatuses adapted for use with oil-based vaporizable materials including cannabis oils.

公开(公告)号：US20240164708A1

公开(公告)日：2024-05-23

申请号：US18524346

申请日：2023-11-30

Applicant: Eyenovia, Inc.

Inventor： Bernard L. Ballou, JR. ,  Mark Packer ,  Russell John Mumper ,  Tsontcho Ianchulev

IPC: A61B5/00 ,  A61B3/14 ,  A61B5/11 ,  A61F9/00 ,  A61K8/06 ,  A61K9/00 ,  A61M11/00 ,  A61M11/04 ,  A61M15/00 ,  A61M15/02 ,  B05B17/00 ,  B05B17/06 ,  G16H10/60 ,  G16H15/00 ,  G16H20/10 ,  G16H20/17 ,  G16H30/20 ,  G16H40/63 ,  G16H40/67 ,  G16Z99/00

CPC classification number: A61B5/4839 ,  A61B3/14 ,  A61F9/0008 ,  G16H20/10 ,  A61B5/0059 ,  A61B5/0079 ,  A61B5/1103 ,  A61F9/00 ,  A61F9/0026 ,  A61K8/06 ,  A61K9/0048 ,  A61M11/00 ,  A61M11/005 ,  A61M11/042 ,  A61M15/008 ,  A61M15/0083 ,  A61M15/025 ,  A61M2205/0205 ,  A61M2205/0238 ,  A61M2205/3306 ,  A61M2205/3368 ,  A61M2205/3553 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/36 ,  A61M2205/3673 ,  A61M2205/50 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583 ,  A61M2205/587 ,  A61M2205/8206 ,  A61M2209/086 ,  A61M2210/0612 ,  B05B17/0646 ,  B05B17/0661 ,  B05B17/0676 ,  G16H10/60 ,  G16H15/00 ,  G16H20/17 ,  G16H30/20 ,  G16H40/63 ,  G16H40/67 ,  G16Z99/00

Abstract: The present invention includes and provides a method of delivering a medicament to an eye of a subject in need thereof a solution, the method comprising: (a) providing droplets containing the medicament with a specified average size and average initial ejecting velocity, and (b) delivering the medicament to the eye, where the droplets deliver a percentage of the ejected mass of the droplets to the eye.

公开(公告)号：US11986592B2

公开(公告)日：2024-05-21

申请号：US17320536

申请日：2021-05-14

Applicant: Dynasthetics, LLC

Inventor： Joseph Orr ,  Kyle M. Burk

IPC: A61M16/00 ,  A61M16/06 ,  A61M16/08 ,  A61M16/10 ,  A61M16/20 ,  A62C2/04 ,  A62C3/00 ,  A61M11/00

CPC classification number: A61M16/0087 ,  A61M16/024 ,  A61M16/06 ,  A61M16/0672 ,  A61M16/0816 ,  A61M16/1005 ,  A61M16/202 ,  A62C2/04 ,  A62C3/00 ,  A61M11/00 ,  A61M16/0875 ,  A61M16/204 ,  A61M2205/3334

Abstract: A system and method for reducing the risk of fire in an oxygen delivery system. The system may include an oxygen delivery device with a controller in communication with a flow control valve to control a flow of oxygen through a tubing from an oxygen source to a patient interface. The controller may be programmed to close the flow control valve for a predetermined time period at a predetermined time interval to cause a periodic oxygen pause, the periodic oxygen pause to remove oxygen that may serve as an oxidizer when a fire is present inside at least one of the patient interface and the tubing.

公开(公告)号：US20240123462A1

公开(公告)日：2024-04-18

申请号：US18486169

申请日：2023-10-13

Applicant: HCMed Innovations Co., LTD.

Inventor： CHIA-CHIEN CHANG ,  HSIN-YI PAI ,  CHUN-CHIA JUAN

IPC: B05B17/00 ,  A61M11/00

CPC classification number: B05B17/0646 ,  A61M11/00

Abstract: An atomization module includes a base, an auxiliary fixing member, an atomization member, a piezoelectric element, a conductive member, and a waterproof member. The base includes a support portion and an outer annular portion. The support portion has a first opening, the outer annular portion surrounds the support portion, and the support portion protrudes relative to the outer annular portion. The auxiliary fixing member is disposed on the support portion, and has a second opening. The second opening is opposite to the first opening. The atomization member is disposed between the support portion and the auxiliary fixing member. The piezoelectric element is disposed on the outer annular portion, and the piezoelectric element and the atomization member are disposed on a same side of the base. The conductive member is electrically connected to the piezoelectric element. The waterproof member at least partially covers the piezoelectric element.

公开(公告)号：US20240115136A1

公开(公告)日：2024-04-11

申请号：US18481196

申请日：2023-10-04

Applicant: CITY UNIVERSITY OF HONG KONG

Inventor： Wai Yan CHAN ,  Jianpan HUANG ,  Lok Hin LAW

IPC: A61B5/00 ,  A61B5/055 ,  A61B6/00 ,  A61K9/127 ,  A61K49/04 ,  A61M11/00

CPC classification number: A61B5/0042 ,  A61B5/055 ,  A61B6/481 ,  A61K9/1271 ,  A61K49/0438 ,  A61M11/00

Abstract: Disclosed herein are methods for delivering a drug to the brain of a subject and monitoring the distribution of the drug therein. The method includes steps of: (a) intranasally administering of a first and second liposomes respectively loaded with the drug and a computed tomography (CT) contrast agent therein to the subject; (b) subjecting the brain of the subject of step (a) to a magnetic resonance imaging (MRI) scan; and (c) measuring chemical exchange saturation transfer (CEST) signals during the MRI scan in both olfactory bulb (OB) and frontal lobe (FL) regions at 1.2 ppm, 4.3 ppm, and −3.4 ppm, respectively.

公开(公告)号：US11951249B2

公开(公告)日：2024-04-09

申请号：US16844497

申请日：2020-04-09

Applicant: Pax Labs, Inc.

Inventor： Alexander J. Gould ,  Adam Bowen ,  Ariel Atkins ,  Kevin Lomeli

IPC: A61M15/06 ,  A24F40/20 ,  A24F40/42 ,  A24F40/50 ,  A24F40/60 ,  A61M11/00 ,  A61M11/04 ,  A61M15/00

CPC classification number: A61M15/06 ,  A24F40/42 ,  A24F40/50 ,  A24F40/60 ,  A61M11/00 ,  A61M11/041 ,  A61M11/042 ,  A61M15/0021 ,  A24F40/20 ,  A61M2205/3368

Abstract: An apparatus for vaporizing a concentrate and/or a non-concentrate material is provided. The apparatus can include a housing, a reservoir, a vessel, and a heating element. The reservoir can be coupled to a lid of the apparatus and configured to hold the concentrate. The vessel can be disposed at least partially inside of the housing and can be configured to receive the reservoir when the lid of the apparatus is in a closed position with respect to the housing. The heating element can be configured to generate heat for heating the vessel, thereby vaporizing the concentrate in the reservoir to form an aerosol. Coupling the reservoir to the lid of the apparatus can enable the apparatus to be used for vaporizing the concentrate while decoupling the reservoir from the lid of the apparatus can enable the apparatus to be used for vaporizing the non-concentrate material. Related methods are also provided.