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公开(公告)号：US20190074086A1
公开(公告)日：2019-03-07
申请号：US16113231
申请日：2018-08-27
Applicant: Eyenovia, Inc.
Inventor： Bernard L. Ballou, JR. , Mark Packer , Russell John Mumper , Tsontcho Ianchulev
Abstract: The present invention includes and provides a method of delivering a medicament to an eye of a subject in need thereof a solution, the method comprising: (a) providing droplets containing the medicament with a specified average size and average initial ejecting velocity; and (b) delivering the medicament to the eye, where the droplets deliver a percentage of the ejected mass of the droplets to the eye.
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2.发明申请公开(公告)号：US20220125631A1
公开(公告)日：2022-04-28
申请号：US17434711
申请日：2020-03-02
Applicant: Eyenovia, Inc.
Inventor： Tsontcho Ianchulev , Luke Clauson
IPC: A61F9/00 , A61K31/4178 , A61P27/10 , A61K9/00
Abstract: The present disclosure provides methods and devices for delivering pilocarpine to the eye. In certain aspects, the disclosure provides method for delivering a composition comprising pilocarpine to an eye of a subject in need thereof as a micro-dose stream of droplets. In certain embodiments, the method treats or alleviates one or more symptoms of presbyopia, in particular presbyopia in adults 40 years of age or older, in the subject in need thereof. In certain embodiments, the present disclosure utilizes relatively high concentrations of pilocarpine in the solution to be administered and as a single active agent.
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公开(公告)号：US20210407663A1
公开(公告)日：2021-12-30
申请号：US17319401
申请日：2021-05-13
Applicant: Eyenovia, Inc.
Inventor： Charles Eric Hunter , Bernard L. Ballou, JR. , Jurgen Klaus Vollrath , Arthur H. Tew , Joshua Richard Brown , James Thornhill Leath , Nathan R. Faulks , Bradley G. Johnson , J. Sid Clements , Phillip E. Russell , John H. Hebrank , Tsontcho Ianchulev , Mark Packer , Troy Elliott , Walter M. Fierson , Thomas J. Lindner
IPC: G16H40/63 , A61M15/00 , G16H20/17 , A61F9/00 , A61B5/00 , B05B17/06 , B05B17/00 , A61B5/11 , G16Z99/00 , G16H40/67 , G16H20/10 , G16H30/20 , A61K8/06 , A61K9/00 , A61M11/00
Abstract: A method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use and a device for droplet ejection includes a fluid delivery system capable of delivering a defined volume of the fluid in the form of droplets having properties that afford adequate and repeatable high percentage deposition upon application. The method and device include a housing, a reservoir disposed within the housing for receiving a volume of fluid, an ejector mechanism configured to eject a stream of droplets having an average ejected droplet diameter greater than 15 microns, the stream of droplets having low entrained airflow such that the stream of droplets deposit on the eye of the subject during use.
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公开(公告)号：US20150328151A1
公开(公告)日：2015-11-19
申请号：US14793895
申请日：2015-07-08
Applicant: Eyenovia, Inc.
Inventor： Bernard L. Ballou, JR. , Mark Packer , Russell John Mumper , Tsontcho Ianchulev
IPC: A61K9/08 , A61K31/717 , A61K31/4402 , A61K31/047 , A61K31/4164 , A61K31/4535 , A61K31/695 , A61K33/30 , A61K31/542 , A61K31/165 , A61K31/335 , A61K31/216 , A61K31/4709 , A61K31/245 , A61K31/7036 , A61K31/4409 , A61K31/498 , A61K38/13 , A61K31/496 , A61K31/56 , A61K31/4545 , A61K31/55 , A61K31/382 , A61K31/7052 , A61K31/196 , A61K31/5383 , A61K31/5377 , A61K9/00
CPC classification number: G16H40/63 , A61F9/00 , A61F9/0008 , A61K8/06 , A61K9/0048 , A61K2300/00 , A61M11/00 , A61M2210/0612 , G06F19/321 , G06F19/3418 , G06F19/3456 , G16H10/60 , G16H15/00 , G16H20/10 , G16H30/20 , G16H40/67
Abstract: The present invention includes and provides a method of delivering a medicament to an eye of a subject in need thereof a solution, the method comprising: (a) providing droplets containing the medicament with a specified average size and average initial ejecting velocity; and (b) delivering the medicament to the eye, where the droplets deliver a percentage of the ejected mass of the droplets to the eye.
Abstract translation: 本发明包括并提供将药物递送至有需要的对象的眼睛的方法，所述方法包括：（a）提供含有特定平均尺寸和平均初始喷射速度的药物的液滴; 和（b）将药物递送到眼睛，其中液滴将喷射的液滴质量的百分比传送到眼睛。
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公开(公告)号：US20240164708A1
公开(公告)日：2024-05-23
申请号：US18524346
申请日：2023-11-30
Applicant: Eyenovia, Inc.
Inventor： Bernard L. Ballou, JR. , Mark Packer , Russell John Mumper , Tsontcho Ianchulev
IPC: A61B5/00 , A61B3/14 , A61B5/11 , A61F9/00 , A61K8/06 , A61K9/00 , A61M11/00 , A61M11/04 , A61M15/00 , A61M15/02 , B05B17/00 , B05B17/06 , G16H10/60 , G16H15/00 , G16H20/10 , G16H20/17 , G16H30/20 , G16H40/63 , G16H40/67 , G16Z99/00
CPC classification number: A61B5/4839 , A61B3/14 , A61F9/0008 , G16H20/10 , A61B5/0059 , A61B5/0079 , A61B5/1103 , A61F9/00 , A61F9/0026 , A61K8/06 , A61K9/0048 , A61M11/00 , A61M11/005 , A61M11/042 , A61M15/008 , A61M15/0083 , A61M15/025 , A61M2205/0205 , A61M2205/0238 , A61M2205/3306 , A61M2205/3368 , A61M2205/3553 , A61M2205/3584 , A61M2205/3592 , A61M2205/36 , A61M2205/3673 , A61M2205/50 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/587 , A61M2205/8206 , A61M2209/086 , A61M2210/0612 , B05B17/0646 , B05B17/0661 , B05B17/0676 , G16H10/60 , G16H15/00 , G16H20/17 , G16H30/20 , G16H40/63 , G16H40/67 , G16Z99/00
Abstract: The present invention includes and provides a method of delivering a medicament to an eye of a subject in need thereof a solution, the method comprising: (a) providing droplets containing the medicament with a specified average size and average initial ejecting velocity, and (b) delivering the medicament to the eye, where the droplets deliver a percentage of the ejected mass of the droplets to the eye.
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Patent Agency Ranking
公开(公告)号：US20210295989A1
公开(公告)日：2021-09-23
申请号：US17091607
申请日：2020-11-06
Applicant: Eyenovia, Inc.
Inventor： Bernard L. Ballou, JR. , Mark Packer , Russell John Mumper , Tsontcho Ianchulev
IPC: G16H40/63 , A61M15/00 , G16H20/17 , A61F9/00 , A61B5/00 , B05B17/06 , B05B17/00 , A61B5/11 , G16H40/67 , G16H20/10 , G16H30/20 , A61K8/06 , A61K9/00 , A61M11/00
Abstract: The present invention includes and provides a method of delivering a medicament to an eye of a subject in need thereof a solution, the method comprising: (a) providing droplets containing the medicament with a specified average size and average initial ejecting velocity; and (b) delivering the medicament to the eye, where the droplets deliver a percentage of the ejected mass of the droplets to the eye.
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公开(公告)号：US11011270B2
公开(公告)日：2021-05-18
申请号：US16107716
申请日：2018-08-21
Applicant: Eyenovia, Inc.
Inventor： Charles Eric Hunter , Bernard L. Ballou, Jr. , Jurgen Klaus Vollrath , Arthur H. Tew , Joshua Richard Brown , James Thornhill Leath , Nathan R. Faulks , Bradley G. Johnson , J. Sid Clements , Phillip E. Russell , John H. Hebrank , Tsontcho Ianchulev , Mark Packer , Troy Elliott , Walter M. Fierson , Thomas J. Lindner
IPC: G16H40/63 , A61M15/00 , G16H20/17 , A61F9/00 , G06F19/00 , A61B5/00 , B05B17/06 , B05B17/00 , A61B5/11 , G16H40/67 , G16H20/10 , G16H30/20 , A61K8/06 , A61K9/00 , A61M11/00 , G16H15/00 , G16H10/60 , A61M15/02 , A61M11/04
Abstract: A method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use and a device for droplet ejection includes a fluid delivery system capable of delivering a defined volume of the fluid in the form of droplets having properties that afford adequate and repeatable high percentage deposition upon application. The method and device include a housing, a reservoir disposed within the housing for receiving a volume of fluid, an ejector mechanism configured to eject a stream of droplets having an average ejected droplet diameter greater than 15 microns, the stream of droplets having low entrained airflow such that the stream of droplets deposit on the eye of the subject during use.
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公开(公告)号：US20190053945A1
公开(公告)日：2019-02-21
申请号：US16107716
申请日：2018-08-21
Applicant: Eyenovia, Inc.
Inventor： Charles Eric Hunter , Bernard L. Ballou, JR. , Jurgen Klaus Vollrath , Arthur H. Tew , Joshua Richard Brown , James Thornhill Leath , Nathan R. Faulks , Bradley G. Johnson , J. Sid Clements , Philip E. Russell , John H. Hebrank , Tsontcho Ianchulev , Mark Packer , Troy Elliott , Walter M. Fierson , Thomas J. Lindner
IPC: A61F9/00 , A61B5/00 , G16H20/17 , G16H40/63 , A61M15/00 , G06F19/00 , A61M15/02 , G16H10/60 , G16H15/00
Abstract: A method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use and a device for droplet ejection includes a fluid delivery system capable of delivering a defined volume of the fluid in the form of droplets having properties that afford adequate and repeatable high percentage deposition upon application. The method and device include a housing, a reservoir disposed within the housing for receiving a volume of fluid, an ejector mechanism configured to eject a stream of droplets having an average ejected droplet diameter greater than 15 microns, the stream of droplets having low entrained airflow such that the stream of droplets deposit on the eye of the subject during use.
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公开(公告)号：US11839487B2
公开(公告)日：2023-12-12
申请号：US17849425
申请日：2022-06-24
Applicant: Eyenovia, Inc.
Inventor： Bernard L. Ballou, Jr. , Mark Packer , Russell John Mumper , Tsontcho Ianchulev
IPC: A61B5/00 , A61F9/00 , A61B3/14 , G16H20/10 , G16H15/00 , G16H10/60 , G16H40/63 , A61M15/00 , G16H20/17 , A61M15/02 , B05B17/06 , A61M11/00 , B05B17/00 , A61M11/04 , A61B5/11 , G16Z99/00 , G16H40/67 , G16H30/20 , A61K8/06 , A61K9/00
CPC classification number: A61B5/4839 , A61B3/14 , A61F9/0008 , G16H20/10 , A61B5/0059 , A61B5/0079 , A61B5/1103 , A61F9/00 , A61F9/0026 , A61K8/06 , A61K9/0048 , A61M11/00 , A61M11/005 , A61M11/042 , A61M15/008 , A61M15/0083 , A61M15/025 , A61M2205/0205 , A61M2205/0238 , A61M2205/3306 , A61M2205/3368 , A61M2205/3553 , A61M2205/3584 , A61M2205/3592 , A61M2205/36 , A61M2205/3673 , A61M2205/50 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/587 , A61M2205/8206 , A61M2209/086 , A61M2210/0612 , B05B17/0646 , B05B17/0661 , B05B17/0676 , G16H10/60 , G16H15/00 , G16H20/17 , G16H30/20 , G16H40/63 , G16H40/67 , G16Z99/00
Abstract: The present invention includes and provides a method of delivering a medicament to an eye of a subject in need thereof a solution, the method comprising: (a) providing droplets containing the medicament with a specified average size and average initial ejecting velocity; and (b) delivering the medicament to the eye, where the droplets deliver a percentage of the ejected mass of the droplets to the eye.
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公开(公告)号：US20220395221A1
公开(公告)日：2022-12-15
申请号：US17849425
申请日：2022-06-24
Applicant: Eyenovia, Inc.
Inventor： Bernard L. Ballou, Jr , Mark Packer , Russell John Mumper , Tsontcho Ianchulev
Abstract: The present invention includes and provides a method of delivering a medicament to an eye of a subject in need thereof a solution, the method comprising: (a) providing droplets containing the medicament with a specified average size and average initial ejecting velocity; and (b) delivering the medicament to the eye, where the droplets deliver a percentage of the ejected mass of the droplets to the eye.
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