公开(公告)号：US20240269191A1

公开(公告)日：2024-08-15

申请号：US18569991

申请日：2022-02-01

申请人： PANAGY CO., LTD.

发明人： Shoji KOGA

IPC分类号： A61K35/32 ,  A61P27/10

CPC分类号： A61K35/32 ,  A61P27/10

摘要： An ocular symptom-improving agent which is a composition containing a culture supernatant of dental pulp-derived stem cells or immortalized stem cells thereof and which is used for improving a symptom of myopia, astigmatism, presbyopia, eye fatigue or blurred vision is a novel ocular symptom-improving agent.

公开(公告)号：US20240165089A1

公开(公告)日：2024-05-23

申请号：US18418181

申请日：2024-01-19

申请人： EYE HOSPITAL, WENZHOU MEDICAL UNIVERSITY

发明人： Xiangtian Zhou ,  Sen Zhang ,  Jia Qu ,  Qinyuan Zheng

IPC分类号： A61K31/4375 ,  A61K9/00 ,  A61K47/38 ,  A61P27/10

CPC分类号： A61K31/4375 ,  A61K9/0048 ,  A61K47/38 ,  A61P27/10

摘要： The present application relates to a method for treating myopia with vipocetine, which can effectively prevent myopia and/or control the progression of myopia while being safe and free of obvious side effects, having good prospects for clinical application.

公开(公告)号：US20240103298A1

公开(公告)日：2024-03-28

申请号：US18012983

申请日：2021-12-27

申请人： PEGAVISION CORPORATION

发明人： Yi-Fang HUANG ,  Shih-Siang LIN

IPC分类号： G02C7/04 ,  A61P27/10 ,  G02C7/10

CPC分类号： G02C7/049 ,  A61P27/10 ,  G02C7/10 ,  G02C2202/24

摘要： An optical lens includes an optical zone, and the optical zone includes a relax zone, a distance zone, and a defocus zone. The distance zone surrounds the relax zone. The defocus zone surrounds the distance zone and the relax zone. The diopter of the relax zone reduces along a direction from a center of the optical zone to an edge of the optical zone.

公开(公告)号：US20230414573A1

公开(公告)日：2023-12-28

申请号：US18036666

申请日：2021-11-11

申请人： Cesar Alejandro SÁNCHEZ GALEANA

发明人： Cesar Alejandro SÁNCHEZ GALEANA

IPC分类号： A61K31/4178 ,  A61K9/00 ,  A61K31/4174 ,  A61K31/498 ,  A61K31/728 ,  A61K31/196 ,  A61K45/06 ,  A61P27/10

CPC分类号： A61K31/4178 ,  A61K9/0048 ,  A61K31/4174 ,  A61P27/10 ,  A61K31/728 ,  A61K31/196 ,  A61K45/06 ,  A61K31/498

摘要： An ophthalmic composition for the prevention, control and treatment of presbyopia symptoms comprising a synergistic combination of pilocarpine, brimonidine, oxymetazoline, hyaluronic acid, bromfenac and optionally a vasoconstrictor in a single low concentration dose to improve near vision ability and increase depth of focus is described. In addition, the side effects of pilocarpine administered separately, such as eye redness, headache, and dryness of the eye, are reduced and are better tolerated in patients suffering from presbyopia.

公开(公告)号：US20230414494A1

公开(公告)日：2023-12-28

申请号：US18465918

申请日：2023-09-12

申请人： Lenz Therapeutics, Inc.

发明人： Gerald HORN

IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K47/02 ,  A61K47/26 ,  A61K47/38 ,  A61K31/439 ,  A61P27/10 ,  A61K31/4409 ,  A61K47/32 ,  A61K45/06 ,  A61K47/10 ,  A61K47/34

CPC分类号： A61K9/0048 ,  A61K9/08 ,  A61K47/02 ,  A61K47/26 ,  A61K47/38 ,  A61K31/439 ,  A61P27/10 ,  A61K31/4409 ,  A61K47/32 ,  A61K45/06 ,  A61K47/10 ,  A61K47/34

摘要： Provided herein is an ophthalmological composition and methods for the treatment of presbyopia. In some embodiments, the ophthalmological composition comprises aceclidine and brimonidine.

公开(公告)号：US20230241042A1

公开(公告)日：2023-08-03

申请号：US18131963

申请日：2023-04-07

申请人： GRAND LIFE SCIENCES GROUP (WUHAN) CO., LTD.

发明人： Ling HUANG ,  Xiaohua ZHANG ,  Mo ZHU ,  Wendian XIANG ,  Chao LIU ,  Jing KANG

IPC分类号： A61K31/439 ,  A61K9/00 ,  A61P27/10 ,  A61P27/02

CPC分类号： A61K31/439 ,  A61K9/0048 ,  A61P27/10 ,  A61P27/02

摘要： Provided is a use of a compound represented by Formula (I) or a nitrogen oxide, solvate, metabolite, pharmaceutically acceptable salt, or prodrug thereof in the preparation of medicament.

公开(公告)号：US11648247B1

公开(公告)日：2023-05-16

申请号：US17552654

申请日：2021-12-16

申请人： Lenz Therapeutics, Inc.

发明人： Gerald Horn

IPC分类号： A61K31/498 ,  A61K31/439 ,  A61P27/10 ,  A61K47/10 ,  A61K47/36 ,  A61K47/02 ,  A61K47/40

CPC分类号： A61K31/498 ,  A61K31/439 ,  A61K47/02 ,  A61K47/10 ,  A61K47/36 ,  A61K47/40 ,  A61P27/10

摘要： The present invention is directed to compositions for and methods for the treatment of presbyopia comprising from about 0.3% to about 2.0% w/v aceclidine and from about 0.07% to about 0.15% w/v brimonidine.

公开(公告)号：US11642350B2

公开(公告)日：2023-05-09

申请号：US16495350

申请日：2018-03-22

申请人： Singapore Health Services PTE LTD ,  Santen Pharmaceutical Co., Ltd.

发明人： Tiang Hwee Donald Tan ,  Roger Wilmer Beuerman ,  Seang-Mei Saw ,  Aradhana Upadhyay ,  Masatomo Kato ,  Takaaki Inaba

IPC分类号： A61K31/5386 ,  A61P27/10 ,  A61K9/00

CPC分类号： A61K31/5386 ,  A61K9/0048 ,  A61P27/10

摘要： The present invention relates to an agent for preventing myopia, treating myopia, and/or preventing myopia progression, comprising tiotropium as an active ingredient.

公开(公告)号：US20230062844A1

公开(公告)日：2023-03-02

申请号：US17706225

申请日：2022-03-28

申请人： Seinda Pharmaceutical Guangzhou Corporation

发明人： Hui Ouyang ,  Yong Qiu

IPC分类号： A61K31/46 ,  A61P27/10 ,  A61K9/00 ,  A61K31/24 ,  A61K31/4168 ,  A61K31/417 ,  A61K31/498 ,  A61K31/551

摘要： Compositions and methods useful in slowing, inhibiting, or regressing the progression of myopia, while minimizing pupil dilation and light sensitivity are provided herein. Provided compositions can include a muscarinic receptor antagonist and a miotic agent.

公开(公告)号：US20230032637A1

公开(公告)日：2023-02-02

申请号：US17877564

申请日：2022-07-29

申请人： Ocuphire Pharma, Inc.

发明人： Mina Sooch ,  Alan R. Meyer ,  Konstantinos Charizanis ,  Bernhard Hoffmann ,  William H. Pitlick

IPC分类号： A61K31/417 ,  A61P27/08 ,  A61P27/10 ,  A61K31/4178

摘要： The invention provides methods, compositions, and kits containing an alpha-adrenergic antagonist, such as phentolamine, for use in monotherapy or as part of a combination therapy to treat patients suffering from presbyopia, mydriasis, and/or other ocular disorders.