公开(公告)号：US12023181B2

公开(公告)日：2024-07-02

申请号：US17210585

申请日：2021-03-24

申请人： Drone Delivery Canada Corp.

发明人： Paul Di Benedetto ,  Gregory Colacitti

IPC分类号： A61B50/30 ,  A01N1/02 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/024 ,  A61B5/08 ,  A61B5/145 ,  A61B50/00 ,  A61F17/00 ,  A61M5/00 ,  A61M5/20 ,  A61N1/39

CPC分类号： A61B50/30 ,  A01N1/02 ,  A01N1/0273 ,  A61B5/02055 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0816 ,  A61B5/14542 ,  A61B2050/0067 ,  A61B2050/3008 ,  A61B2562/242 ,  A61F17/00 ,  A61M5/002 ,  A61M5/20 ,  A61N1/3904

摘要： An assembly for forming a portable emergency or medical package has: a main body; and a plurality of modules with fasteners that enable the main body and the modules to be fastened together in different combinations, to form the package. A plurality of compartments for housing medical supplies, and a compartment for communication device, providing real time two-way communication between a user of the package and a communication appliance remote from the package are provided. The communication device is detachable from the remainder of the package.

公开(公告)号：US20230413805A1

公开(公告)日：2023-12-28

申请号：US18241286

申请日：2023-09-01

申请人： TransMedics, Inc.

发明人： Waleed H. HASSANEIN ,  Tamer I. KHAYAL ,  Paul LEZBERG

IPC分类号： A01N1/02 ,  C12M3/00

CPC分类号： A01N1/02 ,  C12M21/08 ,  A01N1/0226 ,  A01N1/0247

摘要： The disclosure, in various embodiments, provides systems, methods, and solutions for perfusing an organ. The present application describes illustrative methods for perfusing an ex-vivo organ in a functioning state under physiological or near physiological conditions, including receiving an ex-vivo organ in an organ care system, the ex-vivo organ coupled to a perfusion circuit, infusing a solution into the system, combining the solution with a perfusion fluid to create a mixed solution, pumping the mixed solution to the ex-vivo organ, and receiving the mixed solution from the ex-vivo organ.

公开(公告)号：US11819523B2

公开(公告)日：2023-11-21

申请号：US17098243

申请日：2020-11-13

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Matthew J. Hamilton ,  Alexander Khoruts ,  Michael J. Sadowsky ,  Christopher M. Staley

IPC分类号： A61K35/74 ,  A01N1/02 ,  A61K9/00 ,  A61P31/04 ,  A61K9/19 ,  A61K31/43 ,  A61K9/16 ,  A61K9/20

CPC分类号： A61K35/74 ,  A01N1/02 ,  A61K9/0053 ,  A61K9/1623 ,  A61K9/1682 ,  A61K9/19 ,  A61K9/2095 ,  A61K31/43 ,  A61P31/04

摘要： The present disclosure provides compositions and methods for treating Clostridium difficile infection (CDI) including primary and recurrent CDI. In particular, the compositions and methods described herein are capable of achieving a CDI clearance rate of at least 80% through a single oral dose of pharmaceutical composition comprising a freeze-dried fecal microbiota preparation.

公开(公告)号：US20230284610A1

公开(公告)日：2023-09-14

申请号：US18119620

申请日：2023-03-09

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V.

发明人： Friedjof TELLKAMP ,  Eike-Christian SCHULZ ,  Hendrik SCHIKORA ,  Pedram MEHRABI ,  Martin KOLLEWE

IPC分类号： A01N1/02 ,  A61B10/00

CPC分类号： A01N1/02 ,  A61B10/0096 ,  A01N1/0242

摘要： The invention relates to a method for vitrifying a biological sample. The method includes positioning a sample holder with the biological sample by a transfer device in a starting position. The sample holder has a base and a pin projecting from the base along a holder axis. Further, the biological sample is attached to the pin distant from the base. The method further comprises adding a liquid to the biological sample in the starting position by a liquid dispenser. Further, the method comprises moving the sample holder with the biological sample by the transfer device along a predetermined transfer path from the starting position to a release position, wherein the biological sample in the release position is arranged in or adjacent to a liquefied gas. It is provided that the transfer path is inclined with respect to the holder axis or runs along a circular arc. Furthermore, the invention relates to a vitrification apparatus which is configured to perform the method.

公开(公告)号：US11752250B2

公开(公告)日：2023-09-12

申请号：US14230108

申请日：2014-03-31

申请人： CytoSorbents Corporation

发明人： Thomas D. Golobish ,  Vincent J. Capponi ,  David R. Clay

IPC分类号： A61M1/36 ,  A61M1/34 ,  A61M1/02 ,  B01J20/28 ,  B01J20/32 ,  A01N1/02 ,  B01J20/26

CPC分类号： A61M1/3679 ,  A01N1/02 ,  A01N1/0215 ,  A61M1/0272 ,  A61M1/34 ,  A61M1/36 ,  B01J20/261 ,  B01J20/267 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/28092 ,  B01J20/3208 ,  B01J20/3246 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3272 ,  B01J20/3282 ,  B01J20/3285 ,  B01J2220/62

摘要： The invention concerns methods of treating blood, blood product, or physiologic fluid to provide at least one of (i) increasing shelf life of the blood, blood product or physiologic fluid, (ii) maintaining freshness of new blood, blood product or physiologic fluid, and (iii) removing undesirable molecules from the blood, blood product or physiologic fluid; said method comprising contacting said blood, blood product or physiologic fluid with a sorbent, said sorbent being primarily in a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of at least one of (1) zwitterionic moieties and (2) oligo(ethylene glycol) moieties attached to the surface of said cross-linked polymeric material.

公开(公告)号：US20230263156A1

公开(公告)日：2023-08-24

申请号：US18310832

申请日：2023-05-02

申请人： TransMedics, Inc.

发明人： Waleed H. HASSANEIN ,  Richard BRINGHAM ,  Giovanni CECERE ,  Tamer I. KHAYAL ,  Ronald TAYLOR ,  Hossam ALGAMIL

IPC分类号： A01N1/02

CPC分类号： A01N1/0242 ,  A01N1/0226 ,  A01N1/02 ,  A01N1/0247

摘要： The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.

公开(公告)号：US11659833B2

公开(公告)日：2023-05-30

申请号：US16326978

申请日：2017-08-22

申请人： BioVerde Inc.

发明人： Chikara Kubota ,  Takaaki Ando ,  Suong-Hyu Hyon ,  Woogi Hyon ,  Shuji Imamura ,  Satoru Gessei

IPC分类号： A01N1/02

CPC分类号： A01N1/0221 ,  A01N1/02 ,  A01N1/0226 ,  A01N1/0231 ,  A01N1/0284

摘要： Provided are a vehicle body assembling method and a vehicle body assembling apparatus which allow a simple configuration in the vicinity of the connecting portion between an upper jig and a lower jig and allow an increase in the efficiency of assembling work (welding work). A vehicle body assembling apparatus is equipped with a jig for supporting vehicle body components in a preassembled position, the jig comprising an upper jig and a lower jig which are connected to each other in at least two places. Each of the connection places is provided with a connecting means for fixing a three-dimensional coordinate position while allowing uniaxial turning. The vehicle body assembling apparatus is also equipped with a conveying means for conveying the upper jig which supports the vehicle body components, and reduces the load applied to the lower jig from the upper jig when connecting the upper jig to the lower jig.

公开(公告)号：US10039278B2

公开(公告)日：2018-08-07

申请号：US15322849

申请日：2015-06-01

申请人： MITSUBISHI PAPER MILLS LIMITED

发明人： Atsushi Matsuzawa ,  Katsumitsu Susaki

IPC分类号： A01N1/02

CPC分类号： A01N1/0252 ,  A01N1/02 ,  A01N1/0221 ,  A01N1/0268 ,  C12M1/00 ,  C12M3/00 ,  C12N5/00

摘要： The present invention aims to provide a device for vitrification cryopreservation enabling easy and reliable vitrification cryopreservation of a cell or tissue. The device for vitrification cryopreservation of a cell or tissue of the present invention includes a support and a vitrification solution absorber including at least an adhesive layer and a vitrification solution absorbing layer in the given order on the support. The device includes a portion with no adhesive layer disposed between the support and a portion of the vitrification solution absorbing layer configured to hold a cell or tissue.

公开(公告)号：US20180153158A1

公开(公告)日：2018-06-07

申请号：US15857953

申请日：2017-12-29

申请人： TransMedics, Inc.

发明人： Waleed H. HASSANEIN ,  Tamer I. KHAYAL ,  Ahmed ELBETANONY ,  Paul LEZBERG ,  Giovanni CECERE ,  Dennis SOUSA ,  Elizabeth HANSEN

IPC分类号： A01N1/02

CPC分类号： A01N1/0247 ,  A01N1/02

摘要： The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.

公开(公告)号：US09982230B2

公开(公告)日：2018-05-29

申请号：US15181195

申请日：2016-06-13

申请人： New York Blood Center, Inc.

发明人： Beth H. Shaz ,  Christopher D. Hillyer

IPC分类号： A61K35/14 ,  C12N5/078 ,  A61M1/02 ,  A01N1/02 ,  A61K35/16 ,  A61K35/18 ,  A61K35/19 ,  A61M1/34

CPC分类号： C12N5/0641 ,  A01N1/02 ,  A01N1/021 ,  A01N1/0226 ,  A61K35/14 ,  A61K35/16 ,  A61K35/18 ,  A61K35/19 ,  A61M1/0272 ,  A61M1/342 ,  A61M1/3496 ,  A61M2202/0429 ,  A61M2202/20 ,  C12N5/0644

摘要： The disclosure provides methods of making a cell-containing product having a uniform amount of cells therein. The method comprises pooling red blood cells from a plurality of blood units, and inactivating any pathogen contained therein. A storage solution added to the cellular component results in a cell-containing product that is essentially pathogen and white blood cell free and has an extended shelf life of about 42 to about 100 days. The cell-containing product is further divided into units which comprise a uniform dose of RBCs per unit.