公开(公告)号：US12123020B2

公开(公告)日：2024-10-22

申请号：US18330167

申请日：2023-06-06

Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA ,  NEW YORK BLOOD CENTER, INC.

Inventor： Stella Chou ,  Connie Westhoff

IPC: A61K35/14 ,  A61K35/17 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  C12N5/078 ,  C12N9/22 ,  C12N15/11 ,  G01N33/68 ,  G01N33/80

CPC classification number: C12N5/0634 ,  A61K35/14 ,  C12N9/22 ,  C12N15/111 ,  G01N33/6854 ,  C12N2310/20 ,  C12N2510/00 ,  G01N33/80

Abstract: Provided herein are engineered red blood cells expressing rare blood antigen group profiles, and methods of making use the same, are described. Also provided are recombinant reagent red blood cells that express or lack the expression of at least one protein (e.g., a blood group antigen) on its surface and uses thereof.

公开(公告)号：US20240301424A1

公开(公告)日：2024-09-12

申请号：US18657145

申请日：2024-05-07

Applicant: Toolgen Incorporated

Inventor： Seok Joong Kim ,  Yoon-Young Kim ,  Ho-Sung Yu ,  In-Young Jung ,  Jung Min Lee

IPC: C12N15/113 ,  A61K35/14 ,  C07K14/705 ,  C12N5/0783 ,  C12N5/0784 ,  C12N9/22 ,  C12N15/10 ,  C12N15/52 ,  C12N15/63 ,  C12N15/85

CPC classification number: C12N15/1132 ,  A61K35/14 ,  C07K14/70503 ,  C07K14/70564 ,  C07K14/70575 ,  C07K14/70578 ,  C07K14/70596 ,  C12N5/0637 ,  C12N5/0638 ,  C12N5/064 ,  C12N5/0646 ,  C12N15/102 ,  C12N15/1138 ,  C12N15/52 ,  C12N15/63 ,  C12N15/85 ,  C12N9/22 ,  C12N2310/20 ,  C12N2320/30 ,  Y02A50/30

Abstract: The present invention relates to an artificially manipulated immune system having an improved immune effect. More particularly, the present invention relates to an immune system having functions artificially altered which comprises artificially manipulated immunoregulatory elements and cells containing the same. Contemplated according to a particular embodiment is an immune system comprising artificially manipulated immunoregulatory genes such as PD-1, CTLA-4, A20, DGKα, DGKζ, FAS, EGR2, PPP2R2D, PSGL-1, KDM6A, and TET2, and/or expression products thereof

公开(公告)号：US20240293360A1

公开(公告)日：2024-09-05

申请号：US18568625

申请日：2022-06-09

Applicant: EpicentRx, Inc.

Inventor： Bryan T. ORONSKY ,  Tony R. REID ,  Christpoher LARSON ,  James KANTER

IPC: A61K31/397 ,  A61K9/14 ,  A61K35/14 ,  A61K47/10 ,  A61P35/00 ,  C07D205/04

CPC classification number: A61K31/397 ,  A61K9/145 ,  A61K35/14 ,  A61K47/10 ,  A61P35/00 ,  C07D205/04

Abstract: The present invention relates to a composition comprising solid crystalline, non-impact or non-detonation sensitive particles comprising 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone (ABDNAZ), methods of preparing the crystalline form, and its use.

公开(公告)号：US11951135B2

公开(公告)日：2024-04-09

申请号：US17255396

申请日：2019-07-22

Applicant: Minovia Therapeutics Ltd.

Inventor： Natalie Yivgi Ohana ,  Uriel Halavee ,  Shmuel Bukshpan ,  Noa Sher ,  Moriya Blumkin

IPC: C12N15/09 ,  A61K35/14 ,  A61K35/15 ,  A61K35/17 ,  A61K35/28 ,  A61K35/33 ,  A61K35/38 ,  A61K35/50 ,  A61K35/51 ,  A61K35/545 ,  A61P21/00

CPC classification number: A61K35/545 ,  A61K35/14 ,  A61K35/15 ,  A61K35/17 ,  A61K35/28 ,  A61K35/33 ,  A61K35/38 ,  A61K35/50 ,  A61K35/51 ,  A61P21/00

Abstract: The present invention provides stem cells enriched with healthy functional mitochondria, pharmaceutical compositions comprising these cells and methods of use thereof for treating muscle diseases, disorders and symptoms thereof where the disease may or may not be associated with acquired mitochondrial dysfunction.

公开(公告)号：US20240108725A1

公开(公告)日：2024-04-04

申请号：US17768769

申请日：2021-03-24

Applicant: OTSUKA MEDICAL DEVICES CO., LTD ,  OTSUKA ELECTRONICS CO., LTD ,  IMRO CO., LTD

Inventor： Kenta KANEDA ,  Hidetaka MAEGAWA

IPC: A61K41/00 ,  A61K35/14 ,  A61P35/02

CPC classification number: A61K41/0061 ,  A61K35/14 ,  A61P35/02

Abstract: The present disclosure includes a system for use in the treatment of cancer, the system comprising



an extracorporeal circulation device comprising a blood circuit and a blood pump to collect and return blood of a subject, and
a light irradiation device to irradiate the blood circuit with light,
wherein a photosensitive substance is administered to the subject prior to blood collection, or added to blood collected from the subject prior to light irradiation,
the blood collected from the subject and irradiated with light is returned to the subject, and
the light has an irradiation energy density of 2.5 to 300 J/cm2.

公开(公告)号：US11944642B2

公开(公告)日：2024-04-02

申请号：US16834952

申请日：2020-03-30

Applicant: MINOVIA THERAPEUTICS LTD.

Inventor： Natalie Yivgi-Ohana ,  Uriel Halavee

IPC: A61K35/12 ,  A61K35/14 ,  A61K35/50 ,  A61K48/00 ,  C12N5/073 ,  A61K47/26

CPC classification number: A61K35/12 ,  A61K35/14 ,  A61K35/50 ,  A61K48/00 ,  C12N5/0605 ,  A61K47/26

Abstract: The present invention relates to mitochondrial compositions and therapeutic methods of using same. The invention discloses compositions of partially purified functional mitochondria and methods of using the compositions to treat conditions which benefit from increased mitochondrial function by administering the compositions to a subject in need thereof.

公开(公告)号：US20240100091A1

公开(公告)日：2024-03-28

申请号：US18275782

申请日：2022-02-06

Applicant: Reddress Ltd.

Inventor： Alon Kushnir

IPC: A61K35/14 ,  A61K33/06 ,  A61P17/02

CPC classification number: A61K35/14 ,  A61K33/06 ,  A61P17/02

Abstract: The present disclosure provides a method and a kit for treating an abnormal hollowed space of a subject, such as a fistula, e.g. an anal fistula or a stoma space. For example, the abnormal hollowed space can be an anal fistula, a stoma opening, or a pilonidal sinus. The method utilizes autologous blood, which is derived from the subject, by introducing it into the abnormal hollowed space and let it clot within the abnormal hollowed space thereby forming a coagulated blood mass therein, namely a blood clot, that enhances the healing process of the abnormal hollowed space. The healing may be a complete or partial closure or reduction in the size or volume of said space; or the formation of healthy tissue within the former abnormal hollowed space.

公开(公告)号：US11903975B2

公开(公告)日：2024-02-20

申请号：US15779754

申请日：2016-11-30

Applicant: FLAGSHIP PIONEERING INNOVATIONS V, INC. ,  The Children's Medical Center Corporation

Inventor： Geoffrey A. von Maltzahn ,  John Miles Milwid ,  Michael Travis Mee ,  Jacob Rosenblum Rubens ,  David Chess ,  Kyle Marvin Trudeau ,  Kiana Mahdaviani ,  Jacob Feala ,  James D. McCully ,  Douglas B. Cowan

IPC: A61K35/35 ,  A61K35/34 ,  A61K35/14 ,  A61K35/19 ,  A61K38/17 ,  A61K35/33 ,  G01N33/15 ,  C12N15/87 ,  A61K35/12 ,  A61P3/00 ,  A61K9/00

CPC classification number: A61K35/35 ,  A61K35/12 ,  A61K35/14 ,  A61K35/19 ,  A61K35/33 ,  A61K35/34 ,  A61K38/1709 ,  A61P3/00 ,  C12N15/87 ,  G01N33/15 ,  A61K9/0029

Abstract: Therapeutic chondrisome and mitoplast compositions and related methods are described.

公开(公告)号：US20240041938A1

公开(公告)日：2024-02-08

申请号：US18366539

申请日：2023-08-07

Applicant: CREATIVE MEDICAL TECHNOLOGIES, INC.

Inventor： Thomas ICHIM ,  Amit PATEL ,  Courtney BARTLETT ,  Timothy WARBINGTON

IPC: A61K35/28 ,  A61K35/545 ,  A61K35/50 ,  A61K35/35 ,  A61K35/30 ,  A61K35/51 ,  A61K35/32 ,  A61K35/14

CPC classification number: A61K35/28 ,  A61K35/545 ,  A61K35/50 ,  A61K35/35 ,  A61K35/30 ,  A61K35/51 ,  A61K35/32 ,  A61K35/14

Abstract: Disclosed are means, methods and compositions of matter useful for prevention of space flight associated bone density loss. In one embodiment, the invention provides cellular populations capable of suppressing osteoclast function and/or stimulating osteoblast activity. The use of mesenchymal stem cell populations alone, or more preferably, selected by expression of CD56 protein are disclosed. Cells may be administered systemically, or locally through the use of various matrices disclosed in this invention.

公开(公告)号：US20230381227A1

公开(公告)日：2023-11-30

申请号：US18231455

申请日：2023-08-08

Applicant: MINOVIA THERAPEUTICS LTD.

Inventor： Natalie YIVGI-OHANA ,  Uriel Halavee ,  Shmuel Bukshpan

IPC: A61K35/14 ,  A61K8/9789 ,  A61P17/14 ,  A61K8/60 ,  A61K8/98 ,  A61K9/00 ,  A61K9/06 ,  A61K35/50 ,  A61Q17/04

CPC classification number: A61K35/14 ,  A61K8/9789 ,  A61P17/14 ,  A61K8/60 ,  A61K8/982 ,  A61K8/983 ,  A61K9/0014 ,  A61K9/06 ,  A61K35/50 ,  A61Q17/04

Abstract: The present invention relates to products and methods for treatment of hair loss. Specifically, the present application relates to compositions and methods for prevention and treatment of hair loss, comprising administration of a composition comprising intact mitochondria, ruptured mitochondria and/or mitochondrial constituents.