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公开(公告)号：US12227734B2
公开(公告)日：2025-02-18
申请号：US17837772
申请日：2022-06-10
Applicant: University of Maryland, Baltimore County
Inventor： Govind Rao , Yordan Kostov , Leah Tolosa Croucher , Kevin Tran , Monohar Pilli , Michael Tolosa , Chandrasekhar Gurramkonda , David Burgenson
IPC: C07K9/00 , A61K35/14 , A61M1/36 , B01D15/08 , B01D15/32 , B01D15/36 , B01D15/38 , C07K1/36 , C12M1/00 , C12M1/40
Abstract: A bioprocessing system for protein manufacturing from human blood is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The parent's own blood can be used as the source of cell extracts for the production of the therapeutic proteins.
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公开(公告)号：US12213994B2
公开(公告)日：2025-02-04
申请号：US18063227
申请日：2022-12-08
Applicant: Organicell Regenerative Medicine, Inc.
Inventor： Maria Ines Mitrani , Michael Bellio , Albert Mitrani
Abstract: Described herein are cell-free therapeutic compositions derived from blood or plasma and uses thereof for the treatment of selected diseases and disorders.
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公开(公告)号：US20240415941A1
公开(公告)日：2024-12-19
申请号：US18818465
申请日：2024-08-28
Applicant: RegenLab USA LLC
Inventor： Antoine Turzi
IPC: A61K38/48 , A61K8/98 , A61K31/728 , A61K35/14 , A61K35/15 , A61K35/16 , A61K35/17 , A61K35/18 , A61K35/19 , A61K38/36 , A61L26/00 , A61M1/02 , A61M5/19 , A61Q19/08
Abstract: The present invention is related to the field of tissue regeneration. It concerns more particularly new processes, tubes and devices for thrombin, platelet concentrate and wound healant preparations, alone or in combination with cell extracts, cell compositions and uses thereof.
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公开(公告)号：US20240374636A1
公开(公告)日：2024-11-14
申请号：US18783156
申请日：2024-07-24
Applicant: Reddress Ltd.
Inventor： Alon KUSHNIR
Abstract: The present disclosure provides a method, a coagulation mold and a kit for preparing a coagulated blood mass having a desired shape and volume. The coagulated blood mass is prepared from whole blood being withdrawn from a subject. The whole blood is mixed with coagulation initiators in order to obtain the coagulated blood mass with optimal parameters. This is obtained, inter alia, by selecting particle size of one of the coagulation initiators such as to yield more rapid dissolving within the blood and/or to yield improved suspension of the particles in the blood when it is still in a liquid form. By controlling theses parameters, an optimal coagulated blood mass is obtained that can be used for treatment of the human body, e.g. for treating skin lesions, internal injuries, such as anal fistula, stoma cavity, damaged tendon, and others.
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公开(公告)号：US12134632B2
公开(公告)日：2024-11-05
申请号：US18153669
申请日：2023-01-12
Applicant: BIOVERATIV THERAPEUTICS INC.
Inventor： Glen Bolton , Keith Selvitelli
Abstract: The present invention is directed to a method of inactivating virus that is present during production of a polypeptide of interest. In particular, the present invention is directed to a method of on-column virus inactivation using a low pH and high salt wash solution that effectively inactivates viruses with minimum recovery loss of the polypeptide.
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Patent Agency Ranking
公开(公告)号：US12090253B2
公开(公告)日：2024-09-17
申请号：US16728138
申请日：2019-12-27
Applicant: VeriGraft AB
Inventor： Suchitra Sumitran-Holgersson , Michael Olausson
IPC: A61L27/50 , A61F2/06 , A61K35/12 , A61K35/14 , A61K35/28 , A61K35/34 , A61K35/44 , A61K35/545 , A61L27/24 , A61L27/36 , A61L27/38 , A61L27/54 , C12N5/071 , C12N5/078
CPC classification number: A61L27/507 , A61K35/14 , A61K35/28 , A61K35/34 , A61K35/44 , A61K35/545 , A61L27/24 , A61L27/3616 , A61L27/3625 , A61L27/3808 , A61L27/3826 , A61L27/3834 , A61L27/3886 , A61L27/54 , C12N5/0641 , C12N5/0691 , C12N5/0692 , A61F2/06 , A61F2/062 , A61F2240/001 , A61K2035/124 , A61L2300/252 , A61L2300/64 , A61L2430/34 , C12N2533/54 , C12N2533/90
Abstract: The present invention relates to methods for recellurization of blood vessels. This method is particularly useful for producing an allogeneic vein, wherein a donor vein is decellularized and then recellularized using whole blood or bone marrow stem cells. The allogeneic veins produced by the methods disclosed herein are particularly advantageous for implantation or transplantation into patients with vascular diseases.
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公开(公告)号：US12090173B2
公开(公告)日：2024-09-17
申请号：US18054364
申请日：2022-11-10
Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Inventor： Robert Sackstein
IPC: A61K35/30 , A61K35/12 , A61K35/14 , A61K35/28 , A61K35/32 , A61K35/33 , A61K35/34 , A61K35/35 , A61K35/37 , A61K35/407 , A61K35/42 , C12N5/00
CPC classification number: A61K35/30 , A61K35/14 , A61K35/28 , A61K35/32 , A61K35/33 , A61K35/34 , A61K35/35 , A61K35/37 , A61K35/407 , A61K35/42 , C12N5/0006 , A61K2035/124 , C12N2501/724
Abstract: Methods of treatment are provided herein, including administration of a population cells modified to enforce expression of an E-selectin and/or an L-selectin ligand, the modified cell population having a cell viability of at least 70% after a treatment to enforce such expression.
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公开(公告)号：US20240238406A1
公开(公告)日：2024-07-18
申请号：US18540621
申请日：2023-12-14
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen , Gary Mansfield
IPC: A61K39/21 , A61K31/7105 , A61K35/12 , A61K35/14 , A61K35/15 , A61K35/17 , A61K39/00 , A61K39/12 , A61K39/39 , A61K45/06 , A61P31/18 , C07K14/715 , C12N5/078 , C12N5/0783 , C12N7/00 , C12N15/11 , C12N15/113 , C12N15/86
CPC classification number: A61K39/21 , A61K31/7105 , A61K35/14 , A61K39/12 , A61K39/39 , A61K45/06 , A61P31/18 , C07K14/7158 , C12N5/0634 , C12N5/0636 , C12N7/00 , C12N15/111 , C12N15/1132 , C12N15/1138 , C12N15/86 , A61K2035/124 , A61K35/15 , A61K35/17 , A61K2039/5156 , A61K2039/545 , A61K2039/55561 , C12N2310/122 , C12N2310/14 , C12N2310/141 , C12N2320/32 , C12N2330/51 , C12N2510/00 , C12N2710/24143 , C12N2740/15021 , C12N2740/15034 , C12N2740/15043 , C12N2740/15052 , C12N2740/16022 , C12N2740/16034 , C12N2740/16043
Abstract: The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.
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公开(公告)号：US20240226403A1
公开(公告)日：2024-07-11
申请号：US18561569
申请日：2022-04-12
Applicant: KANEKA CORPORATION , Broad Bean Science Co., LTD.
Inventor： Yuta FUJITA , Makoto KUROO
CPC classification number: A61M1/3633 , A61K35/14 , A61P7/08 , A61M2202/0413
Abstract: The objective of the present invention is to provide a treatment material for the treatment of a disease of which symptom is alleviated or treated by reducing a blood phosphorus concentration. The treatment material according to the present invention is characterized in comprising a water-insoluble carrier and 1 or more adsorbing groups selected from the group consisting of a phosphate group, a phosphonate group, a phosphinate group, an amino group, a carboxy group and a thiol group, wherein the adsorbing group binds to the water-insoluble carrier through a linker group, the treatment material is used for treating a disease, wherein a symptom of the disease is alleviated or treated by reducing a blood phosphorus concentration, and dialyzed blood is passed through the treatment material to adsorb a calciprotein particle in the dialyzed blood on the adsorbing group, or blood is passed through the treatment material and then dialyzed.
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公开(公告)号：US20240123027A1
公开(公告)日：2024-04-18
申请号：US18360975
申请日：2023-07-28
Applicant: ABIONYX PHARMA SA
Inventor： Jean-Louis DASSEUX
IPC: A61K38/17 , A61K35/14 , A61K45/06 , A61K47/24 , A61P1/16 , A61P3/06 , A61P9/10 , A61P43/00 , C07K14/775 , C07K19/00
CPC classification number: A61K38/1709 , A61K35/14 , A61K45/06 , A61K47/24 , A61P1/16 , A61P3/06 , A61P9/10 , A61P43/00 , C07K14/775 , C07K19/00
Abstract: Apomers comprising apolipoprotein molecules complexed with amphipathic molecules and uses thereof for treating dyslipidemic and liver disorders.
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