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公开(公告)号：US11820999B2
公开(公告)日：2023-11-21
申请号：US16494196
申请日：2018-04-02
Inventor： Tyler Lahusen , Charles David Pauza
CPC classification number: C12N15/86 , A61K35/76 , C12N9/0071 , C12Y114/16001 , A61K48/00 , C12N2310/14 , C12N2310/531 , C12N2740/15021 , C12N2740/15022 , C12N2740/15032 , C12N2740/15042 , C12N2740/15043
Abstract: A lentiviral vector system for expressing a lentiviral particle is disclosed. The lentiviral vector system includes a therapeutic vector. The therapeutic vector comprises a phenylalanine hydroxylase (PAH) sequence for expressing at least one of PAH or a variant thereof, wherein the PAH sequence is truncated.
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公开(公告)号：US20230277579A1
公开(公告)日：2023-09-07
申请号：US18055525
申请日：2022-11-15
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen , Mei-Ling Liou
IPC: A61K31/7105 , A61P35/02 , A61K47/68 , A61K47/69 , A61K31/675 , C12N15/113 , C12N15/86
CPC classification number: A61K31/7105 , A61P35/02 , A61K47/6807 , A61K47/6901 , A61K31/675 , C12N15/1137 , C12N15/86 , C12Y205/0101 , A61K2300/00 , C12N2310/14 , C12N2310/531 , C12N2330/51 , C12N2740/16032 , C12N2740/16043 , C12N2740/16045 , C12N2750/14143 , C12N2810/6072
Abstract: The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
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公开(公告)号：US11612649B2
公开(公告)日：2023-03-28
申请号：US17175278
申请日：2021-02-12
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen , Jeff Galvin
IPC: C12N15/86 , C12N15/113 , C12N7/00 , A61K39/00 , A61K39/12 , A61K39/21 , A61P31/18 , A61K45/06 , C07K14/715 , A61K31/7105 , C12N15/11 , A61K35/14 , A61K39/39 , C12N5/078 , C12N5/0783 , A61K35/17 , A61K35/15 , A61K35/12
Abstract: The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.
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公开(公告)号：US20210047644A1
公开(公告)日：2021-02-18
申请号：US16943800
申请日：2020-07-30
Inventor： Tyler Lahusen , Mei-Ling Liou , Lingzhi Xiao , Haishan Li , Charles David Pauza
IPC: C12N15/113 , C12N15/86 , A61P35/00 , C12N15/62 , C12N15/85
Abstract: A composition for treating cancer is disclosed. The composition includes a lentiviral particle and an aminobisphosphonate drug. The lentiviral particle is capable of infecting a target cell, such as a cancer cell, and includes an envelope protein optimized for targeting such target cell and a viral vector. The viral vector includes a small RNA optimized to target an FDPS mRNA sequence. The aminobisphosphonate drug includes zoledronic acid.
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公开(公告)号：US10888613B2
公开(公告)日：2021-01-12
申请号：US16076655
申请日：2017-01-11
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen
IPC: A61K39/21 , A61K39/12 , C12N15/113 , C12N15/867 , C12N15/86 , A61K39/00
Abstract: The present invention relates generally to immunotherapy for preventing HIV infection in HIV-negative individuals. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.
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公开(公告)号：US10767183B2
公开(公告)日：2020-09-08
申请号：US16083384
申请日：2017-03-09
Inventor： Tyler Lahusen , Mei-Ling Liou , Lingzhi Xiao , Haishan Li , Charles David Pauza
IPC: C12N15/113 , C12N15/86 , A61P35/00 , C12N15/62 , C12N15/85
Abstract: A composition for treating cancer is disclosed. The composition includes a lentiviral particle and an aminobisphosphonate drug. The lentiviral particle is capable of infecting a target cell, such as a cancer cell, and includes an envelope protein optimized for targeting such target cell and a viral vector. The viral vector includes a small RNA optimized to target an FDPS mRNA sequence. The aminobisphosphonate drug includes zoledronic acid.
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公开(公告)号：US20200063161A1
公开(公告)日：2020-02-27
申请号：US16563738
申请日：2019-09-06
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen , Mei-Ling Liou
IPC: C12N15/86 , A61K31/675 , A61K31/7105 , A61K38/16 , C12N5/0783 , C12N15/113
Abstract: The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
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公开(公告)号：US20190264226A1
公开(公告)日：2019-08-29
申请号：US16308373
申请日：2016-12-12
Inventor： Charles David Pauza , Tyler Lahusen
IPC: C12N15/86 , A61K35/76 , C07K16/32 , C07K14/475 , C07K16/10 , C07K14/49 , C07K14/51 , C07K14/435 , C12N15/113
Abstract: A non-integrating viral delivery system is disclosed. The system includes a viral carrier, wherein the viral carrier contains a defective integrase gene; a heterologous viral episomal origin of replication; a sequence encoding at least one initiator protein specific for the heterologous viral episomal origin of replication, wherein expression of the sequence encoding the at least one initiator protein specific for the heterologous viral episomal origin of DNA replication is inducible; and at least one gene, gene product, shRNA, siRNA, miRNA, or other RNA of interest.
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公开(公告)号：US10233464B2
公开(公告)日：2019-03-19
申请号：US16011550
申请日：2018-06-18
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen , Jeff Galvin
IPC: A61K48/00 , A61K9/127 , C07K14/47 , C12N15/85 , C12N15/11 , C12N15/86 , C12N7/00 , A61K39/39 , A61K35/14 , C12N15/113 , C12N5/078 , A61P31/18 , A61K35/12 , A61K39/00 , A61K35/15 , A61K39/12
Abstract: The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.
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公开(公告)号：US20190062786A1
公开(公告)日：2019-02-28
申请号：US16182443
申请日：2018-11-06
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen , Mei-Ling Liou
IPC: C12N15/86 , A61K31/7105 , A61K38/16 , C12N5/0783 , C12N15/113 , A61K31/675 , A61K48/00 , A61K39/00 , C12N5/00
CPC classification number: C12N15/86 , A61K31/675 , A61K31/7105 , A61K38/16 , A61K48/00 , A61K2039/5158 , C12N5/00 , C12N5/0636 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12N2310/531
Abstract: The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
