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    TISSUE BODY FORMATION DEVICE AND TISSUE BODY FORMATION METHOD
    1.
    发明公开
    TISSUE BODY FORMATION DEVICE AND TISSUE BODY FORMATION METHOD 审中-公开

    公开(公告)号：US20240350259A1

    公开(公告)日：2024-10-24

    申请号：US18686816

    申请日：2022-08-26

    申请人： BIOTUBE CO., LTD.

    发明人： Yasuhide NAKAYAMA

    IPC分类号： A61F2/24 ,  A61F2/06

    CPC分类号： A61F2/2415 ,  A61F2/062 ,  A61F2240/001

    摘要： Disclosed is a tissue body formation device for forming a connective tissue body in an environment in which a living tissue material is present. The device includes a partition wall that defines a hollow space for forming the connective tissue body from the living tissue material. An exterior portion of the partition wall that separates the environment from the hollow space includes through-holes that extend between the environment and the hollow space. The through-holes have an opening size of 0.02 mm or greater and 2.5 mm or less. A section of the connective tissue body that includes dense connective tissue is a dense section. A surface of the partition wall that is in contact with the dense section includes non-degradable resin. The non-degradable resin has a compressive strength of 10 MPa or greater and 60 MPa or less and a contact angle with water of 90° or greater.

    BIOMIMETIC VASCULAR NETWORK AND DEVICES USING THE SAME
    6.
    发明申请
    BIOMIMETIC VASCULAR NETWORK AND DEVICES USING THE SAME 审中-公开

    公开(公告)号：US20180256312A1

    公开(公告)日：2018-09-13

    申请号：US15800687

    申请日：2017-11-01

    申请人： The General Hospital Corporation ,  The Charles Stark Draper Laboratory

    发明人： David M. Hoganson ,  Howard I. Pryor ,  Ira Spool ,  Joseph P. Vacanti ,  Jeffrey T. Borenstein

    IPC分类号： A61F2/06 ,  A61F2/04 ,  A61F2/02 ,  G01N33/50

    CPC分类号： A61F2/062 ,  A61F2/022 ,  A61F2/04 ,  A61F2/06 ,  A61F2002/068 ,  G01N33/5008

    摘要： The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.

    Cell or tissue cultivation apparatus and method of cultivation
    9.
    发明授权
    Cell or tissue cultivation apparatus and method of cultivation 有权

    公开(公告)号：US09670450B2

    公开(公告)日：2017-06-06

    申请号：US14642824

    申请日：2015-03-10

    申请人： Purpose Co., Ltd.

    发明人： Setsuo Watanabe

    IPC分类号： C12M1/42 ,  A61F2/06 ,  C12M1/12 ,  C12M3/00 ,  C12M1/00

    CPC分类号： C12M35/04 ,  A61F2/062 ,  C12M21/08 ,  C12M25/02 ,  C12M41/14

    摘要： A cultivation apparatus and a cultivation method of a culture such as a cell or tissue. Provided are an incubator unit for accommodating a culture and a lever that penetrates through the incubator unit and can move in circular arc around a fulcrum as a center, the fulcrum being set at a wall of the incubator unit or in the vicinity thereof, then displacement is imparted to the culture by operating the lever. Bending force can be acted on the culture (cell construct) such as a cell or tissue, so that without any increase or decrease of a culture fluid in the incubator unit, namely, without any increase or decrease of pressure to the culture fluid, displacement required for cultivation can be imparted to the culture in the incubator unit. By curving, continuous compression and extension are generated in a direction of thickness from a concave portion to a convex portion of the curving.