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1.发明授权公开(公告)号：US12115281B2
公开(公告)日：2024-10-15
申请号：US18068168
申请日：2022-12-19
发明人： Joseph P. Vacanti
CPC分类号： A61L27/3808 , A61F2/062 , A61L27/507 , A61L27/52 , C12M21/08 , C12M25/10 , C12M25/14 , C12N5/0671 , C12N2533/50
摘要： A platform for creating engineered tissues includes a vascular tube that defines a vascular diameter and is configured to receive vascular system seed cells, a non-vascular tube that defines a non-vascular tube diameter and is configured to receive organ system seed cells, and a barrier formed between the vascular tube and the non-vascular tube.
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公开(公告)号：US20240228930A9
公开(公告)日：2024-07-11
申请号：US18401976
申请日：2024-01-02
发明人： Masatsugu IGARASHI , Thomas J. Felt
摘要： A cell culturing system includes a cell culturing device and a support device. The cell culturing device cultures cells by allowing a culture medium inside circulation flow paths connected to the bioreactor to flow inside the bioreactor. The cell culturing device is connected to the circulation flow paths and includes a waste liquid flow path in order to discard the liquid flowing through the circulation flow paths, and a waste liquid accommodation unit in which the liquid guided from the waste liquid flow path is accommodated. A sampling unit, in which the culture medium that is guided from the circulation flow paths to the waste liquid flow path is collected, is connected to the waste liquid flow path.
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公开(公告)号：US12012577B1
公开(公告)日：2024-06-18
申请号：US18136953
申请日：2023-04-20
申请人： Mu Mycology
发明人： Edward Dale , Natalie Dale , Nicolaas Vermeulen
IPC分类号： A01G18/60 , A01G18/62 , A01G18/64 , A01G18/69 , C12M1/00 , C12M1/12 , C12M1/16 , C12M1/34 , C12N1/14
CPC分类号： C12M1/16 , A01G18/60 , A01G18/62 , A01G18/64 , A01G18/69 , C12M25/10 , C12M25/14 , C12M29/06 , C12M41/12 , C12N1/14
摘要： A system and method adapted for continuous growth and harvesting of fungal fruiting bodies. The system includes a growth chamber, one or more mycelium feed assemblies, a nutrient reservoir with liquid media, one or more environmental controls to control an environment within the growth chamber and of the liquid media within the nutrient reservoir. One or more mycelium feed assemblies are arranged within the growth chamber. Each of the one or more mycelium feed assemblies includes a nutrient supply member and a mycelium colony which grows around the nutrient supply member, that continuously supplies liquid media to the mycelium colony. The method includes starting one or more mycelium colonies on the nutrient supply member, establishing that a mature colony has formed, and then maintaining the mature mycelium colony by continuous delivery of liquid medium to the mycelium colony, thus allowing for contiguous generation and harvesting of fungal fruiting bodies.
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4.发明公开公开(公告)号：US20240182829A1
公开(公告)日：2024-06-06
申请号：US18441108
申请日：2024-02-14
申请人： Axogen Corporation
CPC分类号： C12M21/08 , C12M23/44 , C12M25/10 , C12M29/10 , C12M45/02 , C12M45/09 , C12M47/04 , B65D21/00
摘要： Tissue-processing containers are disclosed for facilitating multistep processing of tissue. Also disclosed are systems incorporating the tissue-processing containers that include shakers, incubators, controllers, and pumps. Multistep methods are disclosed for processing tissues using the tissue-processing containers. The tissue-processing containers are specially designed to achieve efficiencies in automated tissue processing, exposure of tissues to processing media, and multistep tissue processing protocols. The described tissue-processing containers comprise a cup-like cavity comprising a middle hole covered by a mesh screen, troughs for separate processing steps, and are stackable in a substantially airtight and substantially watertight manner. Tissues for processing using the described tissue-processing containers include nerve tissue. Also described herein is a transport housing for the transport of stacks of tissue-processing containers, and which may directly incubate those containers, or which may be placed inside a separate incubator for incubating the containers.
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公开(公告)号：US20240139378A1
公开(公告)日：2024-05-02
申请号：US18108903
申请日：2023-02-13
发明人： Ming-Sing SI , Josue CHERY , Shuyun WANG
CPC分类号： A61L27/507 , A61L27/225 , A61L27/3808 , A61L27/3834 , A61L27/3839 , A61L27/3895 , A61L27/52 , C12M21/08 , C12M23/16 , C12M25/10 , C12M29/10
摘要： Provided herein is technology relating to engineered tissues and particularly, but not exclusively, to methods, compositions, and systems for engineering a biosynthetic vascular network.
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公开(公告)号：US11932837B2
公开(公告)日：2024-03-19
申请号：US17023229
申请日：2020-09-16
申请人： Axogen Corporation
CPC分类号： C12M21/08 , C12M23/44 , C12M25/10 , C12M29/10 , C12M45/02 , C12M45/09 , C12M47/04 , B65D21/00
摘要： Tissue-processing containers are disclosed for facilitating multistep processing of tissue. Also disclosed are systems incorporating the tissue-processing containers that include shakers, incubators, controllers, and pumps. Multistep methods are disclosed for processing tissues using the tissue-processing containers. The tissue-processing containers are specially designed to achieve efficiencies in automated tissue processing, exposure of tissues to processing media, and multistep tissue processing protocols. The described tissue-processing containers comprise a cup-like cavity comprising a middle hole covered by a mesh screen, troughs for separate processing steps, and are stackable in a substantially airtight and substantially watertight manner. Tissues for processing using the described tissue-processing containers include nerve tissue. Also described herein is a transport housing for the transport of stacks of tissue-processing containers, and which may directly incubate those containers, or which may be placed inside a separate incubator for incubating the containers.
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公开(公告)号：US20230313115A1
公开(公告)日：2023-10-05
申请号：US18206186
申请日：2023-06-06
摘要： A cell culturing system is equipped with a plurality of processing units that perform culturing of cells, a plurality of reactor installation devices in which the plurality of processing units are capable of being respectively installed, a plurality of connection circuits connected respectively to the plurality of processing units, a plurality of circuit control devices which the plurality of connection circuits are capable of being respectively attached to and detached from, and a sensor device. The sensor device is used in common with respect to the plurality of processing units in order to measure components of the culture medium guided into the plurality of processing units. Each of the plurality of processing units includes a plurality of bioreactors.
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公开(公告)号：US20230313103A1
公开(公告)日：2023-10-05
申请号：US18022592
申请日：2021-07-07
申请人： Shimadzu Corporation
发明人： Tsunehiro INOUE , Toyoyuki HASHIMOTO , Yasuko YONEDA , Kenji TAKUBO , Yoichi FUJIYAMA , Tomoki OHKUBO , Eiichi OZEKI , Ryogo TAKAI , Hiroomi GOTO , Sadamu TOMITA
摘要： A cell culture container includes: a container body; a cell culture insert having a tubular portion and an oxygen-permeable membrane; and a lid member. The container body is provided with an opening that communicates with an interior of the container body. The tubular portion includes an upper end and a lower end, and is inserted in the opening such that the lower end is located inside the container body. The lower end side of the tubular portion is closed by the membrane. The upper end side of the tubular portion is closed by the lid member. The lid member includes a lower surface that faces toward an interior of the tubular portion. The lid member is provided with an electrode insertion port and a culture medium outlet port that each communicate with the interior of the tubular portion at the lower surface.
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9.发明公开公开(公告)号：US20230303961A1
公开(公告)日：2023-09-28
申请号：US18179557
申请日：2023-03-07
CPC分类号： C12M41/46 , C12M25/10 , C12M35/00 , G01N21/6428
摘要： An object of the invention is to make it possible to provide a mechanism that applies an external stimulus and to measure structural and electromagnetic changes of a cell due to the external stimulus with high sensitivity by an NV center. There is provided an environment control mechanism configured to change a state of a sample by applying an external stimulus to the sample.
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10.发明授权公开(公告)号：US11746319B2
公开(公告)日：2023-09-05
申请号：US16889632
申请日：2020-06-01
申请人： Terumo BCT, Inc.
发明人： Edward Allan Stanton, IV , Glen Delbert Antwiler , Patrick J. Howley , Michael E. Kinzie , Jon A. Dodd , Casey V. Medina
CPC分类号： C12M41/44 , C12M23/42 , C12M23/44 , C12M25/10 , C12M25/12 , C12M29/16 , C12M29/20 , C12M41/48 , G06F8/38
摘要： Embodiments described herein generally relate to methods and systems for customizing protocols for use with a cell expansion system. Through a user interface, a user may create a custom task for loading, growing and/or harvesting cells. A custom task may comprise one or more steps, in which a user may add or omit steps, as desired. Data may be entered for settings associated with a custom task, in which embodiments provide for such data to be entered each time the custom task is performed. In another embodiment, the settings for a custom task may be configured, in which such settings may be stored and retrieved upon selection of the custom task. Customization and configuration of a custom task may occur using a diagram view of the cell expansion system, in which process settings are associated with graphical user interface elements.
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