公开(公告)号：US20240110141A1

公开(公告)日：2024-04-04

申请号：US18540090

申请日：2023-12-14

Applicant: CORNING INCORPORATED

Inventor： Gregory Roger Martin ,  Allison Jean Tanner

IPC: C12M1/00 ,  C12M1/12 ,  C12M3/00

CPC classification number: C12M23/40 ,  C12M23/44 ,  C12M23/58 ,  C12M29/20 ,  C12M37/04

Abstract: A cell culture apparatus includes a cell culture module including multiple cell culture chambers. A manifold connects the multiple cell culture chambers together along a side of the cell culture module. The manifold includes a side wall base structure connected to the side of the cell culture module and a column structure that is formed as a monolithic part of the side wall base structure. The column structure defines a fluid flow pathway through the manifold and to inlets to the cell culture chambers to allow filling and emptying of the cell culture chambers of liquid medium.

公开(公告)号：US20240026262A1

公开(公告)日：2024-01-25

申请号：US18369233

申请日：2023-09-18

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yaqub HANNA

IPC: C12M3/00 ,  C12M3/04 ,  C12M1/107 ,  C12M1/34 ,  C12M1/36 ,  C12M1/00

CPC classification number: C12M21/08 ,  C12M27/10 ,  C12M23/36 ,  C12M41/34 ,  C12M41/48 ,  C12M29/20

Abstract: Methods and devices for ex-utero mouse embryonic development are provided. Accordingly, there is provided a method of ex-utero culturing a mouse embryo at a zygote stage under conditions that allow developments of the embryo to organogenesis or any developmental stage therein-between. Also provided a fetal incubation system, and methods of using same.

公开(公告)号：US11850589B2

公开(公告)日：2023-12-26

申请号：US17848523

申请日：2022-06-24

Applicant: The Brigham and Women's Hospital, Inc. ,  President and Fellows of Harvard College ,  Vilnius University

Inventor： Joseph Italiano ,  Linas Mazutis ,  Jonathan N. Thon ,  David A. Weitz

IPC: B01L3/00 ,  G01N33/86 ,  C12M1/00 ,  C12M1/12 ,  C12M1/34 ,  C12M3/06 ,  G01N33/49

CPC classification number: B01L3/502753 ,  B01L3/502746 ,  B01L3/502776 ,  C12M23/16 ,  C12M23/20 ,  C12M25/02 ,  C12M29/04 ,  C12M29/10 ,  C12M29/20 ,  C12M41/36 ,  C12M41/40 ,  G01N33/86 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2400/086 ,  G01N33/491 ,  G01N2800/222 ,  Y10T436/25375

Abstract: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.

公开(公告)号：US20230383228A1

公开(公告)日：2023-11-30

申请号：US18202602

申请日：2023-05-26

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Stephen E. FEINBERG ,  James Brian WASHINGTON ,  Roger W. MULDER ,  Allen SAMUELS ,  Cynthia L. MARCELO

IPC: C12M1/42 ,  C12M1/00 ,  C12N5/071

CPC classification number: C12M35/04 ,  C12M23/38 ,  C12M29/20 ,  C12N5/0629

Abstract: An apparatus (e.g., for cell culture for in vitro growth of tissues and/or organs) includes a base, a plate on the base, and a removable barrier component on the plate. The removable barrier component is configured to at least partially define a first region. The removable barrier component includes a bottom surface and a top surface. The bottom surface configured to be in contact with the plate. The top surface is opposite the bottom surface. The press is configured to engage the top surface of the removable barrier component to apply a predetermined pressure to the removable barrier component. The removable barrier component is between the press and the plate. A joint between the plate and the removable barrier component may be substantially impermeable to live cells. The apparatus may further include a removable cover that engages the base to enclose the plate, the removable barrier component, and the press.

公开(公告)号：US20230279331A1

公开(公告)日：2023-09-07

申请号：US18005777

申请日：2021-07-29

Applicant: KYOTO SEISAKUSHO CO., LTD.

Inventor： Akira HIGUCHI

IPC: C12M1/34 ,  C12M1/00

CPC classification number: C12M41/34 ,  C12M29/04 ,  C12M41/12 ,  C12M41/44 ,  C12M29/16 ,  C12M29/26 ,  C12M29/20

Abstract: A culture device includes a culture vessel that contains a culture solution for culturing cells, a gas supply device that supplies a gas to the culture vessel, and a humidification device that humidifies the gas flowing from the gas supply device to the culture vessel. The humidification device includes a hollow fiber membrane filter that includes a hollow fiber membrane through which the gas from the gas supply device passes and a casing that accommodates the hollow fiber membrane, a water supply device that fills the casing of the hollow fiber membrane filter with water, and a first heater that heats the hollow fiber membrane filter.

公开(公告)号：US10011813B2

公开(公告)日：2018-07-03

申请号：US15294704

申请日：2016-10-15

Applicant: California Institute of Technology

Inventor： Silvan Scheller ,  Victoria J. Orphan ,  Hang Yu

IPC: H01M8/04 ,  C12M1/00 ,  C12M1/12 ,  H01M4/92 ,  H01M8/06 ,  H01M8/1009 ,  H01M8/1039 ,  H01M8/1018

CPC classification number: C12M43/08 ,  C12M25/02 ,  C12M29/00 ,  C12M29/04 ,  C12M29/20 ,  C12M29/26 ,  H01M4/921 ,  H01M4/925 ,  H01M8/06 ,  H01M8/1009 ,  H01M8/1039 ,  H01M2008/1095

Abstract: The disclosure provides devices and methods to produce electrical energy from microorganisms capable of metabolizing methane.

公开(公告)号：US09932555B2

公开(公告)日：2018-04-03

申请号：US15044718

申请日：2016-02-16

Applicant: PANASONIC HEALTHCARE HOLDINGS CO., LTD.

Inventor： Tomoyoshi Tokumaru ,  Akira Higuchi

IPC: C12M1/00 ,  C12M3/00 ,  C12M1/12 ,  B01L1/02

CPC classification number: C12M41/14 ,  B01L1/025 ,  C12M23/44 ,  C12M29/00 ,  C12M29/20 ,  C12M37/00

Abstract: The present invention includes a conveyor body which partitions a plurality of storage chambers, a connection opening connected to an external device, and a conveying chamber that connects the plurality of storage chambers to the connection opening, a plurality of incubators detachably stored in the plurality of incubators, a conveyor device that conveys one of the plurality of incubators from the storage chamber to the connection opening, and an environment control device that individually controls an interior environment of the plurality of incubators by supplying and discharging gas to and from each incubator.

公开(公告)号：US20180080570A1

公开(公告)日：2018-03-22

申请号：US15826007

申请日：2017-11-29

Applicant: VANDERBILT UNIVERSITY

Inventor： Frank E. Block, III ,  Philip C. Samson ,  Erik M. Werner ,  Dmitry A. Markov ,  Ronald S. Reiserer ,  Jennifer R. Mckenzie ,  David E. Cliffel ,  William J. Matloff ,  Frank E. Block, JR. ,  Joseph R. Scherrer ,  W. Hunter Tidwell ,  John P. Wikswo

IPC: F16K11/16 ,  F04B43/12 ,  C12M3/00 ,  C12M3/06 ,  C12M1/00 ,  B01L3/00

CPC classification number: F16K11/163 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/028 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2200/18 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0644 ,  B01L2400/0655 ,  C12M21/08 ,  C12M23/16 ,  C12M23/44 ,  C12M23/52 ,  C12M29/00 ,  C12M29/02 ,  C12M29/10 ,  C12M29/20 ,  F04B19/006 ,  F04B43/12 ,  F04B43/1269 ,  F04B43/1292 ,  F16K99/0023

Abstract: A rotary planar peristaltic micropump (RPPM) includes an actuator having a shaft engaged with a motor such that activation of the motor causes the shaft to rotate, and a bearing assembly engaged with the shaft. The bearing assembly has a bearing cage defining a plurality of spaced-apart openings thereon, and a plurality of rolling-members accommodated in the plurality of spaced-apart openings of the bearing cage, such that when the shaft rotates, the plurality of rolling-members of the bearing assembly rolls along a circular path. The RPPM also includes a fluidic path in fluidic communication with first and second ports. The fluidic path is positioned under the actuator and coincident with the circular path, such that when the shaft of the actuator rotates, the plurality of rolling-members of the bearing assembly rolls along the fluidic path to cause a fluid to transfer between the first and second ports.

公开(公告)号：US20180066221A1

公开(公告)日：2018-03-08

申请号：US15693763

申请日：2017-09-01

Applicant: TOKYO ELECTRON LIMITED

Inventor： Toshifumi KITAHARA ,  Kunitada HATABAYASHI ,  Kenichi KAGAWA ,  Yusuke YODA

IPC: C12M1/00 ,  C12M1/34 ,  C12M3/00

CPC classification number: C12M29/20 ,  C12M23/02 ,  C12M23/34 ,  C12M23/40 ,  C12M23/48 ,  C12M29/00 ,  C12M29/26 ,  C12M33/04 ,  C12M33/14 ,  C12M41/12 ,  C12M41/24 ,  C12M41/26 ,  C12M41/34 ,  C12M41/44 ,  C12M47/02

Abstract: A buffer tank for storing a culture medium for cell culture, includes: a tank main body including a cylindrical inner surface extending in a vertical direction, an inverted conical storage bottom surface formed below the cylindrical inner surface, and a storage space defined by the cylindrical inner surface and the inverted conical storage bottom surface and configured to store the culture medium an injection portion configured to inject the culture medium from the inverted conical storage bottom surface of the tank main body into the storage space; and a discharge portion configured to discharge the culture medium stored in the storage space, wherein the injection portion is configured to inject the culture medium toward a central axis line of the cylindrical inner surface of the tank main body and obliquely upward with respect to the central axis line.

公开(公告)号：US20180021778A1

公开(公告)日：2018-01-25

申请号：US15547756

申请日：2015-01-30

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Jeremy Sells ,  Chantelle E. Domingue ,  Robert Moline ,  Manish Giri

IPC: B01L3/00

CPC classification number: B01L3/502723 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2400/0439 ,  B01L2400/0442 ,  C12M23/16 ,  C12M29/20 ,  C12M41/48 ,  G01N33/48707

Abstract: Vented microfluidic reservoirs can include a housing and a vent coupled to the housing to vent air associated with a fluid sample communicated into the housing to an environment surrounding a microfluidic device coupled to the housing.