公开(公告)号：US20240326060A1

公开(公告)日：2024-10-03

申请号：US18741404

申请日：2024-06-12

申请人： BIOTIX, INC.

发明人： Scott E. Curry ,  Arta Motadel ,  Peter Paul Blaszcak

IPC分类号： B01L9/00 ,  B01L3/02

CPC分类号： B01L9/543 ,  B01L3/0275 ,  B01L2200/028 ,  B01L2200/12 ,  B01L2200/141 ,  B01L2300/0829

摘要： Provided in part herein are static-defeating apparatus for use in multipipettor systems. Multiple pipette tips can be retained by a static-defeating sheet of material. A multipipettor, having multiple pipettes or nozzles, can engage the pipette tips retained by the sheet. After use, the multipipettor can eject the pipette tips, which sometimes are ejected as a single unit due to the pipette tips being retained by the sheet. In certain embodiments, an apparatus includes a snap plate having one or more holes, and a base rack for ease of mounting.

公开(公告)号：US12097490B2

公开(公告)日：2024-09-24

申请号：US17595925

申请日：2021-05-26

申请人： DNABOY CO., LTD.

发明人： Muntak Son

IPC分类号： B01L3/02 ,  G01N35/00 ,  G01N35/10

CPC分类号： B01L3/0237 ,  B01L3/0275 ,  G01N35/00623 ,  G01N35/1009 ,  B01L2200/023 ,  B01L2200/028 ,  B01L2200/147 ,  B01L2300/18

摘要： This application relates to a sample analyzing apparatus. In one aspect, the apparatus includes a base, a connector arranged at an end of the base, and a temperature controlling member mounted on the base and configured to adjust a temperature of the connector. The apparatus may also include a controller configured to adjust heat generation of the temperature controlling member to adjust a bonding force of a pipette tip attached to a surface of the connector.

公开(公告)号：US20240299937A1

公开(公告)日：2024-09-12

申请号：US18283733

申请日：2022-03-23

申请人： SANCHIP SOCIETA' A RESPONSABILTRA' LIMITATA

发明人： Denise Pezzuoli ,  Marco Cozzolino

IPC分类号： B01L3/00 ,  G01N21/85

CPC分类号： B01L3/502715 ,  G01N21/85 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/0487

摘要： A modular lab-on-a-chip device for the analysis of a fluid including at least a base module, an end module and one or more analysis modules is described. Each module includes a respective first conduit and a respective second conduit. The first conduits define at least partially a first portion and the second conduits define at least partially a second portion of a fluidic channel. The end module includes a connecting conduit connecting the first portion and the second portion of the fluidic conduit to each other; and each analysis module includes a respective analysis conduit in fluidic connection with the respective first conduit and a sensor unit configured to determine at least one characteristic of the fluid and/or components present in the fluid when the fluid is present, in use, in the analysis conduit.

公开(公告)号：US12053774B2

公开(公告)日：2024-08-06

申请号：US17185177

申请日：2021-02-25

申请人： The General Hospital Corporation

发明人： Robert Granier ,  Ramin Haghgooie ,  Ken Kotz ,  Anne C. Petrofsky ,  Ronald G. Tompkins

IPC分类号： G01N1/00 ,  B01L3/00 ,  G01N15/01 ,  G01N15/10 ,  G01N15/12 ,  G01N15/14 ,  G01N15/1434 ,  G01N21/01 ,  G01N21/359 ,  G01N21/53 ,  G01N21/64 ,  G01N21/78 ,  G01N35/00

CPC分类号： B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  G01N15/1434 ,  G01N21/01 ,  G01N21/359 ,  G01N21/532 ,  G01N21/6486 ,  G01N21/78 ,  G01N35/00029 ,  G01N35/00871 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0689 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0832 ,  B01L2300/0861 ,  B01L2400/0487 ,  G01N15/01 ,  G01N2015/1006 ,  G01N15/12 ,  G01N15/1459 ,  G01N2021/6493 ,  G01N2035/00158 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00881 ,  G01N2201/024 ,  G01N2201/06113 ,  G01N2201/062

摘要： A modular analytic system includes a base, at least one fluid sample processing module configured to be removably attached to the base, at least one fluid sample analysis module configured to be removably attached to the base, a fluid actuation module positioned on the base, a fluidic network comprising multiple fluidic channels, in which the fluid actuation module is arranged to control transport of a fluid sample between the at least one sample processing module and the at least one sample analysis module through the fluidic network, and an electronic processor, in which the electronic processor is configured to control operation of the fluid actuation module and receive measurement data from the at least one fluid sample analysis module.

公开(公告)号：US12017215B2

公开(公告)日：2024-06-25

申请号：US16486736

申请日：2018-02-27

申请人： Cytiva Sweden AB

发明人： Tuomo Valtteri Frigard ,  Robert Magnusson ,  Mats Lundkvist ,  Karl Axel Jakob Liderfelt ,  Helena Nordvarg ,  Andreas Torbjorn Lundin ,  Peter Arne Reffner

IPC分类号： B01L3/00 ,  B01D15/10 ,  B01D61/14

CPC分类号： B01L3/502715 ,  B01D15/10 ,  B01D61/145 ,  B01L3/502738 ,  B01L3/502761 ,  B01D2311/2626 ,  B01D2315/16 ,  B01L2200/028 ,  B01L2200/0647 ,  B01L2300/0627 ,  B01L2300/0809 ,  B01L2300/0864 ,  B01L2400/06

摘要： Disclosed is a modular bio-processing unit (100) comprising: a housing (110) having one or more internal fluid paths (101), the housing having at least one inlet and at least one outlet (5,10,15,20,25,30,35,40,45,50,55,60,65,70), each in fluid communication with the fluid path or one or more of the fluid paths; one or more sensor elements (120,150,170,190) operatively associated with the or each path, said sensor(s) elements including elements of one or more of: a flow sensor, a flow rate sensor, a conductivity sensor, a pressure sensor, a pH sensor, and a light absorbance sensor such as a UV spectroscopic concentration sensor; one or more fluid flow inducing components (140) operatively associated with the or each fluid path; and plural valves (180) for preventing or reducing flow in the or each path, the housing, inlet(s), outlet(s), flow inducing component(s) and valve(s) being arranged to operate together as a bio-processing unit within or substantially within the housing.

公开(公告)号：US12006528B2

公开(公告)日：2024-06-11

申请号：US17554537

申请日：2021-12-17

申请人： Debut Biotechnology, Inc.

发明人： Joshua Britton ,  Nicholas Brideau

IPC分类号： C12P9/00 ,  B01L3/00 ,  C12P7/42

CPC分类号： C12P9/00 ,  B01L3/00 ,  C12P7/42 ,  B01L2200/028 ,  B01L2200/0631 ,  B01L2200/0689 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/048 ,  B01L2300/0663 ,  B01L2300/0832 ,  B01L2300/163 ,  B01L2300/1894

摘要： Geranyl pyrophosphate (GPP) is a key intermediate molecule in the bioproduction of thousands of natural products. Currently, natural products are either cultivated from plants, synthesized via complex chemical synthesis strategies, or through cell-based factories also known as biofoundries. However, in order to replicate the process in a cell free environment, numerous enzymes and cofactors must be utilized making this approach costly and unviable. In order to make this process viable, a new approach was needed that uses fewer enzymes and co-factors. As described herein, the present invention demonstrates that it is possible to create GPP from glycerol through a short and concise biosynthetic pathway outside of the cell.

公开(公告)号：US11986830B2

公开(公告)日：2024-05-21

申请号：US17795461

申请日：2021-01-27

申请人： Research Foundation of the City University of New York

发明人： Michael Zions

IPC分类号： B01L9/06

CPC分类号： B01L9/06 ,  B01L2200/028 ,  B01L2200/18 ,  B01L2300/0803

摘要： A device for storage and transport of biological samples. Multiple trays are assembled into a stack with sample tubes constrained between adjacent trays. The surface of each tray has radial grooves sized to hold the sample tubes. Each tray is secured to an adjacent tray with a bolt or snap-fit connector.

公开(公告)号：US11976272B2

公开(公告)日：2024-05-07

申请号：US17070877

申请日：2020-10-14

申请人： Translate Bio, Inc.

发明人： Jonathan Abysalh ,  Daniel Crawford ,  Frank DeRosa ,  Shrirang Karve ,  Anusha Dias ,  Michael Heartlein

IPC分类号： C12N15/10 ,  B01L3/00 ,  C12Q1/6806

CPC分类号： C12N15/1017 ,  B01L3/502753 ,  C12Q1/6806 ,  B01L2200/028 ,  B01L2200/16 ,  B01L2300/0681 ,  B01L2400/0409 ,  C12Q2523/113 ,  C12Q2523/308 ,  C12Y201/03003

摘要： The present invention relates, in part, to methods for large-scale purification of mRNA. The method includes, at least, steps of forming an mRNA slurry, stirring the slurry, and vacuum or pressure filtering the slurry.

公开(公告)号：US20240123444A1

公开(公告)日：2024-04-18

申请号：US18395585

申请日：2023-12-24

申请人： Leslie Don Roberts

发明人： Leslie Don Roberts

IPC分类号： B01L3/00 ,  G01N35/00 ,  G01N35/10

CPC分类号： B01L3/502715 ,  B01L3/502 ,  G01N35/0092 ,  G01N35/10 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/0672 ,  B01L2300/0832 ,  B01L2300/0861 ,  B01L2300/087 ,  B01L2400/0415 ,  B01L2400/0481 ,  B01L2400/0683 ,  B01L2400/082 ,  G01N35/00 ,  G01N2035/00326 ,  G01N2035/0094 ,  G01N35/1079

摘要： A modular system for constructing a variety of self-contained analytical cartridges enabled to perform a number of symmetrical or asymmetrical tests on a single sample source within a single device. Said cartridges are embodied as a readily reversible assemblage of two or more modules that are, in turn, operable to perform one or more tasks of an analytical test as discrete articles-of-manufacture.

公开(公告)号：US11953382B2

公开(公告)日：2024-04-09

申请号：US16988656

申请日：2020-08-09

申请人： STRATEC SE

发明人： Manuel Künz ,  Daniel Ahr ,  Martin Trump ,  Rüdiger Retzlaff

IPC分类号： G01K1/02 ,  B01L7/00 ,  B01L9/00 ,  G01N35/00

CPC分类号： G01K1/026 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/147 ,  B01L2200/148 ,  G01N2035/00366

摘要： A system comprising a device or the device itself for measuring temperatures, comprising a sensor array plate, comprising on a first surface at least one temperature sensor arranged on at least one tongue that is surrounded by a cut-out leaving a bridge to the sensor array plate, wherein the at least one sensor has on both sides' spacer and a second surface opposite the first surface for connection to at least one operating plate of a thermocycler; and a pressure plate, comprising fins at the side for connection to the sensor array plate that align with the spacer of the sensor array plate when a pressure plate is arranged onto a sensor array plate.