公开(公告)号：US20240344107A1

公开(公告)日：2024-10-17

申请号：US18606784

申请日：2024-03-15

申请人： SHIMADZU CORPORATION ,  Hyogo Medical University ,  Kyoto University

发明人： Hiroshi IWATA ,  Hiroomi GOTO ,  Shojiro KIKUCHI ,  Yuichi OGAWA

IPC分类号： C12Q1/18 ,  C12M1/00 ,  C12M1/12 ,  C12M1/34

CPC分类号： C12Q1/18 ,  C12M25/04 ,  C12M29/04 ,  C12M29/06 ,  C12M41/36

摘要： The bacteria detection device includes a reservoir which stores a bacterial solution containing bacteria, a sensor which is provided on a bottom of the reservoir and configured to detect the bacteria in the bacterial solution stored in the reservoir, and a filter which is placed on a liquid surface of the bacterial solution stored in the reservoir to permeate the bacterial solution. The filter increases the concentration of the bacteria in the bacterial solution present in a detection region of the sensor by permeating the bacterial solution.

公开(公告)号：US20240342730A1

公开(公告)日：2024-10-17

申请号：US18682315

申请日：2022-06-28

申请人： BTA International GmbH

发明人： Hans KÜBLER

IPC分类号： B03B9/06 ,  B03B5/34 ,  C12M1/00 ,  C12M1/107

CPC分类号： B03B9/06 ,  B03B5/34 ,  C12M23/36 ,  C12M29/06 ,  C12M47/12

摘要： Important variables which influence the efficiency of a hydrodynamic separation of dense materials using a hydrocyclone are the dynamic viscosity at the inflow of the hydrocyclone and the number of passes through the hydrocyclone. According to the invention, the method and the device allow a control of the viscosity in the hydrocyclone as well as the number of passes through the hydrocyclone when separating dense materials from a slurry in conjunction with an anaerobic fermentation of the constituents of the slurry which can be fermented. By fermenting the constituents of the slurry which can be fermented, the content of a fermentation reactor has a lower viscosity than the slurry being fed. The viscosity in the inflow of the hydrocyclone is set by means of a controlled return flow from a fermentation reactor, and the number of passes is set by a controlled return flow from the outflow of the hydrocyclone. The slurry is pumped into a return flow from the fermentation reactor. The viscosity in the inflow of the hydrocyclone is controlled by the throughput of the return pump on the basis of the content of solids of the slurry. The number of passes through the hydrocyclone is controlled via the ratio of the feed of the hydrocyclone to the feed of the fermentation reactor from which dense materials are removed. Because the process of diluting the slurry with the content of the fermentation reactor does not have an influence on the hydraulic dwell time in the fermentation reactor, the fermentation reactor can be designed for a smaller accumulation of slurry.

公开(公告)号：US20240331887A1

公开(公告)日：2024-10-03

申请号：US18619120

申请日：2024-03-27

申请人： The Fourth Research and Design Engineering Institute of China National Nuclear Corporation

发明人： Juan Sun ,  Yifu An ,  Yang Gao ,  Guoxi Lian ,  Xuyang Wu ,  Haoyan Zhang

IPC分类号： G21F9/18 ,  C12M1/00

CPC分类号： G21F9/18 ,  B09B3/30 ,  B09B3/60 ,  C02F3/00 ,  C02F9/00 ,  C12M29/06 ,  C12M41/14 ,  C02F2103/16 ,  C02F2201/002 ,  C02F2203/002 ,  C02F2203/006

摘要： A device for treating uranium tailings with microorganism is provided and includes a treatment container, a spray water distribution assembly, a microbial incubator and a first pump. The water is transported from the microbial incubator to the spray water distribution assembly through the first pump, allowing the microorganisms to enter the interior of the uranium tailings in the treatment container. After treatment is completed, the water is collected by the water collection cylinder and sent back to the microbial incubator for recovery, so as to reduce the waste of microorganisms. The even distribution of horizontal spray pipes can evenly spray water containing microorganisms on the uranium tailings in the treatment container, which makes the distribution of microorganisms in the uranium tailings more uniform and can prevent inadequate treatment and improve the treatment efficiency of microorganisms on uranium tailings.

公开(公告)号：US20240309307A1

公开(公告)日：2024-09-19

申请号：US18272643

申请日：2022-02-03

申请人： Unibio Tech Science A/S

发明人： Ebbe Busch LARSEN

IPC分类号： C12M1/00

CPC分类号： C12M29/06 ,  C12M29/18 ,  C12M29/20

摘要： A fermentor system for cultivation of microorganisms dependent on gas supply for growth includes an inlet pipe feeding growth medium and gas connected with one or more adjustable inlet pump members allowing a given velocity of growth medium and gas through the inlet pipe; a fermentor tank having a cylindrical volume, the fermentor tank including liquid media with a microorganism to be cultivated and a plurality of upper feeding nozzles that receive and distribute growth medium and gas from the inlet pipe into the fermentor tank; an inner cylindrical outlet pipe, extending from the bottom to the top of the fermentor tank, and being encircled by the plurality of upper feeding nozzles at the top of the fermentor tank; and a transport pipe transporting liquid media from the outlet pipe to a dewatering separator, thereby obtaining concentrated living microorganism material for further processing and liquid separated from concentrated living microorganism material.

公开(公告)号：US20240287455A1

公开(公告)日：2024-08-29

申请号：US18415134

申请日：2024-01-17

申请人： ADVA Biotechnology Ltd.

发明人： Ohad Karnieli ,  Rami Massri ,  Mahmoud Abuelhija ,  Batel Tayar ,  Noam Bercovich ,  Helena Feldman

IPC分类号： C12N5/0783 ,  C12M1/00 ,  C12M1/34 ,  C12M1/36

CPC分类号： C12N5/0636 ,  C12M29/06 ,  C12M41/30 ,  C12M41/48

摘要： A bioreactor chamber for growing a cell culture in a liquid medium includes a controller, sensors coupled to the bioreactor chamber, control devices for varying a gas flow and/or a fluid flow in the bioreactor chamber. The plurality of sensors is configured to measure a plurality of sensor parameters in the liquid medium. Sensor data from each of the sensors is received at predefined time intervals. A desired cell growth configuration and the sensor data from each of the sensors are inputted into a cell culture control machine learning model. Performing, based on output data from the cell culture control machine learning model, transmitting a control circuitry command to a control device to control at least one of: a display of a cell culture parameter prediction, a gas flow, a liquid flow of a nutrient fluid, or a removal of waste products from the liquid medium.

公开(公告)号：US20240279580A1

公开(公告)日：2024-08-22

申请号：US18651331

申请日：2024-04-30

申请人： Life Technologies Corporation

发明人： Clinton C. Staheli ,  Nephi D. Jones ,  Michael E. Goodwin

IPC分类号： C12M1/00 ,  B01D5/00 ,  B01D47/05 ,  B01F23/231 ,  B01F23/233 ,  B01F23/237 ,  B01F27/2121 ,  B01F27/88 ,  B01F27/90 ,  B01F27/91 ,  B01F35/10 ,  B01F35/51 ,  B01F35/513 ,  B01F35/90 ,  B01F35/92 ,  B01F101/44 ,  C12M1/02 ,  C12M1/06 ,  C12M1/12 ,  C12N1/10 ,  C12N1/12 ,  C12N1/14 ,  C12N1/20 ,  C12N5/00 ,  C12N5/04 ,  C12N5/10 ,  F28B1/02 ,  F28D21/00 ,  F28F3/12 ,  F28F21/06

CPC分类号： C12M23/14 ,  B01D5/0072 ,  B01D47/05 ,  B01F23/23125 ,  B01F23/233 ,  B01F27/2121 ,  B01F27/88 ,  B01F27/90 ,  B01F27/91 ,  B01F35/146 ,  B01F35/51 ,  B01F35/513 ,  B01F35/92 ,  C12M23/26 ,  C12M23/34 ,  C12M27/02 ,  C12M29/00 ,  C12M29/06 ,  C12M29/24 ,  C12M37/00 ,  C12M41/14 ,  C12M41/18 ,  C12N1/10 ,  C12N1/12 ,  C12N1/14 ,  C12N1/20 ,  C12N5/00 ,  C12N5/04 ,  F28B1/02 ,  F28F3/12 ,  F28F21/06 ,  F28F21/065 ,  B01F23/231151 ,  B01F23/231262 ,  B01F23/23362 ,  B01F23/23761 ,  B01F23/237611 ,  B01F23/237612 ,  B01F23/23762 ,  B01F23/23765 ,  B01F2035/98 ,  B01F2101/44 ,  C12N5/10 ,  F28D2021/0063 ,  F28F2255/02

摘要： A bag assembly for use with a heat exchanger includes a flexible bag having of one or more sheets of polymeric material, the bag having a first end that bounds a first compartment and an opposing second end that bounds a second compartment, a support structure being disposed between the first compartment and the second compartment so that the first compartment is separated and isolated from the second compartment. A first inlet port, a first outlet port, and a first drain port are coupled with the flexible bag so as to communicate with the first compartment. A second inlet port, a second outlet port, and a second drain port are coupled with the flexible bag so as to communicate with the second compartment.

公开(公告)号：US20240209306A1

公开(公告)日：2024-06-27

申请号：US18287287

申请日：2022-12-21

申请人： POW Genetic Solutions, Inc.

发明人： Shannon HALL ,  Ouwei WANG ,  Brian LEE ,  Charles EMRICH

IPC分类号： C12M1/36 ,  C12M1/00 ,  C12M1/34 ,  C12N1/20

CPC分类号： C12M41/48 ,  C12M27/20 ,  C12M29/06 ,  C12M41/12 ,  C12M41/26 ,  C12M41/32 ,  C12M41/34 ,  C12N1/20

摘要： Methods and systems for iteratively improving culture condition for at least one culture output in a culture process. The methods comprise: a) providing a continuous culture of cells in a bioreactor, wherein the cells are cultured under culture conditions that comprise a set of culture parameters. and wherein the culture of cells produces at least one culture output at a first measure: b) while maintaining the cells in continuous culture, iteratively testing different culture conditions by: (i) selecting a new culture condition comprising a new set of culture parameters predicted to improve the measure of the culture output: (ii) perturbing the cells with the new culture conditions: and (iii) determining a new measure of the culture output: wherein testing is iterated to produce a plurality of improvements in the measure of culture output. The iterative process can be performed by an automated artificial intelligence.

公开(公告)号：US12018242B2

公开(公告)日：2024-06-25

申请号：US16956888

申请日：2018-12-21

申请人： Evologic Technologies GmbH

发明人： Markus Brillmann ,  Paul Krautwaschl ,  Wieland Reichelt ,  Christoph Herwig

IPC分类号： C12M1/33 ,  C12M1/00 ,  C12M1/06 ,  C12M1/12 ,  C12M1/26 ,  C12M1/34 ,  C12N5/04

CPC分类号： C12M45/02 ,  C12M25/16 ,  C12M27/02 ,  C12M29/06 ,  C12M33/00 ,  C12M41/00 ,  C12M41/26 ,  C12M41/32 ,  C12N5/04

摘要： The present invention relates to bioreactors for root organ cultures that enable large parts of the inoculation or biomass transfer, cultivation and harvest of the cultures to be performed outside of an aseptic environment. The present invention further relates to methods of producing and aseptically harvesting roots, and methods of producing root cultures using the aforementioned bioreactors alone or as part of an apparatus further comprising an inoculation vessel or at least one further bioreactor.

公开(公告)号：US20240174963A1

公开(公告)日：2024-05-30

申请号：US18525422

申请日：2023-11-30

申请人： Ark Biotech Inc.

发明人： Zheng Huang ,  Kai Hoeffner ,  Orianna Elysse Kane

IPC分类号： C12M1/00 ,  C12M1/34

CPC分类号： C12M29/24 ,  C12M29/06 ,  C12M41/26 ,  C12M41/34

摘要： A bioreactor includes one or more sensors, a plurality of spargers, a plurality of vertical circulation loops, and a controller coupled to the plurality of spargers and the one or more sensors. The controller is configured to determine that a reading associated with the bioreactor is not at a setpoint, adjust a sparging rate associated with at least one of the plurality of spargers responsive to gas sparging or a liquid additive being introduced to the bioreactor, wherein the sparging rate associated with the at least one of the plurality of spargers is adjusted from a first sparging rate to a second sparging rate, and in response to the reading associated with the bioreactor being consistent and at the setpoint, modify the sparging rate associated with the at least one of the plurality of spargers from the second sparging rate to the first sparging rate.

公开(公告)号：US20240110144A1

公开(公告)日：2024-04-04

申请号：US18263359

申请日：2022-02-01

申请人： Avectas Limited

发明人： Michael Maguire ,  Shirley O'Dea

IPC分类号： C12M1/26 ,  C12M1/00 ,  C12M1/12 ,  C12M1/36 ,  C12M1/42 ,  C12M3/06

CPC分类号： C12M33/04 ,  C12M25/02 ,  C12M27/16 ,  C12M29/06 ,  C12M35/04 ,  C12M41/48

摘要： The current subject matter provides a cell engineering platform for vector-free and/or viral delivery of payload/cargo compounds and compositions into cells. The platform achieves delivery to cells quickly and in an easy to use manner. Related apparatus, systems, techniques, articles and compositions are also described.