公开(公告)号：US20250041401A1

公开(公告)日：2025-02-06

申请号：US18775289

申请日：2024-07-17

Applicant: Gilead Sciences, Inc.

Inventor： Brian Moldt ,  Craig S. Pace

IPC: A61K39/21 ,  A61K31/4745 ,  A61K31/519 ,  A61P31/18 ,  C07K16/10 ,  C12Q1/70

Abstract: Provided are methods for identifying patient populations infected with HIV that can be targeted by antibodies that bind to HIV gp120 V3 glycan region.

公开(公告)号：US12194088B2

公开(公告)日：2025-01-14

申请号：US18158940

申请日：2023-01-24

Applicant: Emory University ,  Indian Institute of Science

Inventor： Rama Rao Amara ,  Andrew Jones ,  Raghavan Varadarajan

IPC: A61K39/12 ,  A61K39/21 ,  C07K14/155 ,  C07K14/16 ,  C12N7/00 ,  A61K39/00

Abstract: This disclosure relates to methods of promoting immune responses against HIV and compositions related thereto. In certain embodiments, this disclosure relates to methods of vaccinating for HIV comprising administering to the subject a priming composition followed by a boosting composition. In certain embodiments, the priming composition comprises a recombinant virus such as recombinant MVA that encodes an Env protein of HIV or segment thereof. In certain embodiments, the boosting composition comprises a trimeric cyclically permuted gp120 chimeric protein reported herein or DNA encoding the same.

公开(公告)号：US12145968B2

公开(公告)日：2024-11-19

申请号：US17937719

申请日：2022-10-03

Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services

Inventor： Peter Kwong ,  Marie Pancera ,  Tongqing Zhou ,  Ivelin Georgiev ,  Michael Gordon Joyce ,  Priyamvada Acharya ,  Jason Gorman ,  Yongping Yang ,  Guillaume Stewart-Jones ,  Rita Chen ,  Gwo-Yu Chuang ,  John Mascola ,  Baoshan Zhang ,  Cheng Cheng ,  Mallika Sastry ,  Aliaksandr Druz

IPC: C07K14/435 ,  A61K39/12 ,  A61K39/21 ,  C07K14/005 ,  C07K16/10 ,  G01N33/569 ,  A61K39/00

Abstract: HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

公开(公告)号：US20240358825A1

公开(公告)日：2024-10-31

申请号：US18406869

申请日：2024-01-08

Applicant: Zoetis Services LLC

Inventor： Paul Joseph Dominowski ,  Ramasamy Mannar Mannan ,  Richard Lee Krebs ,  James Richard Thompson ,  Tedd Alan Childers ,  Mary Kathryn Olsen ,  Robert John Yancey, Jr. ,  Risini Dhammika Weeratna ,  Shucheng Zhang ,  Cedo Martin Bagi

IPC: A61K39/39 ,  A61K39/00 ,  A61K39/002 ,  A61K39/012 ,  A61K39/02 ,  A61K39/108 ,  A61K39/12 ,  A61K39/145 ,  A61K39/15 ,  A61K39/21 ,  A61K39/215 ,  A61P37/02

CPC classification number: A61K39/39 ,  A61K39/0011 ,  A61K39/002 ,  A61K39/012 ,  A61K39/0208 ,  A61K39/0241 ,  A61K39/0258 ,  A61K39/12 ,  A61K39/145 ,  A61K39/15 ,  A61K39/21 ,  A61K39/215 ,  A61P37/02 ,  A61K2039/521 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/54 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577 ,  C12N2720/12334 ,  C12N2720/12351 ,  C12N2740/13034 ,  C12N2740/13051 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2770/20034 ,  C12N2770/20051 ,  C12N2770/24334 ,  C12N2770/24351 ,  Y02A50/30

Abstract: This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.

公开(公告)号：US12076392B2

公开(公告)日：2024-09-03

申请号：US17698205

申请日：2022-03-18

Applicant: Intervet Inc.

Inventor： Ian Tarpey

IPC: C12N7/00 ,  A61K39/21 ,  A61P31/14 ,  C12N15/11 ,  C12N15/33 ,  C12N15/48 ,  C12N15/86 ,  A61K39/00

CPC classification number: A61K39/21 ,  A61P31/14 ,  C12N7/00 ,  C12N15/86 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/70 ,  C12N2740/13034 ,  C12N2740/13071 ,  C12N2770/36143

Abstract: The present invention provides a vaccine for feline leukemia virus and methods of making and using the vaccine alone, or in combinations with other protective agents.

公开(公告)号：US12070495B2

公开(公告)日：2024-08-27

申请号：US17439198

申请日：2020-03-13

Applicant: ModernaTX, Inc. ,  The United States of America, as represented by the Department of Health and Human Services

Inventor： Paolo Lusso ,  Peng Zhang ,  Elisabeth Narayanan ,  Sayda Mahgoub Elbashir

IPC: A61K39/21 ,  A61K39/39 ,  A61K39/00

CPC classification number: A61K39/21 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/55516 ,  A61K2039/6018

Abstract: Provided herein are methods and compositions for inducing in a subject abroad neutralizing antibody response to human immunodeficiency virus (HIV) infection.

公开(公告)号：US20240269265A1

公开(公告)日：2024-08-15

申请号：US18567621

申请日：2022-06-09

Applicant: CHIMERON BIO CORPORATION

Inventor： Jolly Mazumdar Chendrimada ,  Thimmaiah Ponnappa Chendrimada

IPC: A61K39/215 ,  A61K39/00 ,  A61K39/145 ,  A61K39/205 ,  A61K39/21 ,  A61P31/14 ,  C12N7/00

CPC classification number: A61K39/215 ,  A61K39/145 ,  A61K39/205 ,  A61K39/21 ,  A61P31/14 ,  C12N7/00 ,  A61K2039/5258 ,  A61K2039/575 ,  C12N2770/20023 ,  C12N2770/20034 ,  C12N2770/20052 ,  C12N2770/20071

Abstract: Provided herein are peptide VLP vaccines that deliver at least one immunogenic antigen to a subject and induce a protective immune response in the subject. Additionally, provided are related methods and compositions.

公开(公告)号：US12053520B2

公开(公告)日：2024-08-06

申请号：US17587817

申请日：2022-01-28

Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services

Inventor： Xuejun Chen ,  Jeffrey Boyington ,  Hongying Duan Holdsworth ,  Cheng Cheng ,  John R. Mascola

IPC: A61K39/21 ,  C07K14/005 ,  C07K14/16 ,  C12N7/00 ,  A61K39/00

CPC classification number: A61K39/21 ,  C07K14/005 ,  C07K14/162 ,  C12N7/00 ,  C12Y205/01078 ,  A61K2039/5258 ,  A61K2039/55555 ,  C07K2319/00 ,  C12N2740/16023 ,  C12N2740/16043 ,  C12N2740/16111 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16171

Abstract: Embodiments of immunogens based on the outer domain of HIV-1 gp120 and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to prime an immune response to gp120 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.

公开(公告)号：US12053519B2

公开(公告)日：2024-08-06

申请号：US17277694

申请日：2019-09-23

Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services

Inventor： Peter Kwong ,  Li Ou ,  John Mascola ,  Baoshan Zhang ,  Kai Xu ,  Wing-Pui Kong ,  Yaroslav Tsybovsky ,  Cara W. Chao ,  Jeffrey Boyington ,  Yiran Wang

IPC: A61K39/21 ,  A61K9/16 ,  A61K39/00 ,  A61K39/12 ,  A61K47/64 ,  A61K47/69 ,  A61P31/18

CPC classification number: A61K39/21 ,  A61K9/1658 ,  A61K47/64 ,  A61K47/644 ,  A61K47/646 ,  A61K47/6925 ,  A61P31/18 ,  A61K2039/6031 ,  A61K2039/6037 ,  A61K2039/6068 ,  A61K2039/6075 ,  A61K2039/6081 ,  A61K2039/645

Abstract: Embodiments of immunogenic conjugates including the HIV-1 Env fusion peptide and methods of their use and production are disclosed. In several embodiments, the immunogenic conjugates can be used to generate an immune response to HIV-1 Env in a subject, for example, to treat or prevent an HIV-1 infection in the subject.

公开(公告)号：US20240238407A1

公开(公告)日：2024-07-18

申请号：US18562059

申请日：2022-05-18

Applicant: NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION ,  UNIVERSITY OF THE RYUKYUS ,  DAIICHI SANKYO COMPANY, LIMITED

Inventor： Ken ISHII ,  Takuya FUKUSHIMA ,  Yuetsu TANAKA ,  Fumihiko TAKESHITA ,  Makoto KOIZUMI ,  Takako NIWA ,  Shoko NOGUSA ,  Nao JONAI ,  Yoshikuni ONODERA

IPC: A61K39/21 ,  A61K9/51 ,  A61P31/14 ,  A61P37/04 ,  A61K39/00

CPC classification number: A61K39/21 ,  A61K9/5123 ,  A61P31/14 ,  A61P37/04 ,  A61K2039/6018

Abstract: Provided is a vaccine for preventing and/or treating infection with human T-cell leukemia virus type 1 (HTLV-1).
A lipid particle encapsulating a nucleic acid expressing a gp46 antigen or a Tax antigen of human T-cell leukemia virus type 1 (HTLV-1), wherein the lipid comprises a cationic lipid represented by general formula (Ia):




or a pharmaceutically acceptable salt thereof,
wherein
R1 and R2 each independently represent a C1-C3 alkyl group;
L1 represents a C17-C19 alkenyl group optionally having one or more C2-C4 alkanoyloxy groups;
L2 represents a C10-C19 alkyl group optionally having one or more C2-C4 alkanoyloxy groups, or a C10-C19 alkenyl group optionally having one or more C2-C4 alkanoyloxy groups; and
p is 3 or 4.