公开(公告)号：US11969465B2

公开(公告)日：2024-04-30

申请号：US17692333

申请日：2022-03-11

申请人： Alpha-O Peptides AG ,  Emergent Travel Health Inc.

发明人： Rima McLeod ,  Kamal El Bissati ,  Ying Zhou ,  Jeff Alexander ,  Steve Reed ,  Peter Burkhard ,  Mariane Melo ,  Darrel Irvine ,  Ron Weiss ,  Yuan Zhang

IPC分类号： A61K39/002 ,  A61K9/00 ,  A61K39/00 ,  A61K39/012 ,  A61P33/02

CPC分类号： A61K39/002 ,  A61K9/0009 ,  A61K9/0019 ,  A61K39/012 ,  A61P33/02 ,  A61K2039/55566 ,  A61K2039/57 ,  A61K2039/70 ,  C07K2319/00

摘要： Disclosed herein are polynucleotides encoding multi-epitope polypeptides and assemblies thereof, and their use for treating or limiting Toxoplasma gondii infection.

公开(公告)号：US11692164B2

公开(公告)日：2023-07-04

申请号：US17367231

申请日：2021-07-02

申请人： Huvepharma Inc.

发明人： Mary Ann Pfannenstiel ,  Jennifer Albrecht ,  Glen M. Wilkinson

IPC分类号： C12N1/10 ,  C12N1/04 ,  A61K39/012 ,  A61K39/00 ,  A61K35/68

CPC分类号： C12N1/10 ,  A61K39/012 ,  C12N1/04 ,  A61K35/68 ,  A61K2039/51

摘要： Compositions are provided that contain sporulated coccidial oocysts, wherein the compositions are free of antibiotics and comprise formalin at a concentration sufficient to inhibit microbial growth for at least 12 months while maintaining oocyst viability. Methods of preparing such compositions are also provided.

公开(公告)号：US20190216911A1

公开(公告)日：2019-07-18

申请号：US16245773

申请日：2019-01-11

申请人： The United States of America, as represented by the Secretary of Agriculture ,  Board of Trustees Southern Illinois University

发明人： MARK C. JENKINS ,  VJOLLCA KONJUFCA

IPC分类号： A61K39/012 ,  A61P33/10

CPC分类号： A61K39/012 ,  A61K2039/542 ,  A61K2039/543 ,  A61K2039/552 ,  A61K2039/60 ,  A61P33/10

摘要： Provided herein are immunogenic compositions containing recombinant proteins capable of presenting all, or antigenic portions of, the Eimeria maxima, Eimeria tenella, and Eimeria acervulina IMP1 protein in developing active immunity to, and control of, coccidiosis. Also provided are methodologies of using the immunogenic compositions for administration to poultry and other animals in the control of coccidiosis. Nanoparticle-conjugated rIMP1 immunogenic compositions and methods of making and using them are provided.

公开(公告)号：US20180177855A1

公开(公告)日：2018-06-28

申请号：US15902669

申请日：2018-02-22

申请人： CEVA ANIMAL HEALTH INC.

发明人： Eng-Hong Lee

IPC分类号： A61K39/012 ,  A61K45/06 ,  A01K45/00 ,  A61D1/02 ,  A61D7/00 ,  A61K47/36 ,  A01K39/01 ,  A61K39/002 ,  A61K9/06 ,  A61K39/00

CPC分类号： A61K39/012 ,  A01K39/01 ,  A01K45/00 ,  A01K45/002 ,  A01K45/007 ,  A61D1/025 ,  A61D7/00 ,  A61K9/0053 ,  A61K9/0095 ,  A61K9/06 ,  A61K39/002 ,  A61K45/06 ,  A61K47/36 ,  A61K2039/52 ,  A61K2039/54 ,  A61K2039/542 ,  A61K2039/552 ,  A61K2039/70 ,  Y02A50/481

摘要： The present invention is directed to a method of treating poultry hatchlings in a hatchling tray. The method comprises of providing a soft gel form capable of being dispensed through a spray nozzle, providing a spray dispensing apparatus, the apparatus being capable of delivering a predetermined volume of the gel as a plurality of small beadlets through a plurality of nozzles, placing the hatchling tray containing the hatchlings beneath the nozzles of the dispensing apparatus, dispensing the predetermined volume of the soft gel containing the therapeutic agent as small beadlets into the hatchling tray and allowing the hatchlings to consume the beadlets. The present invention is also directed to a dispensing apparatus for dispensing a therapeutic agent in a soft gel into a hatchling tray of poultry hatchlings.

公开(公告)号：US20180021424A1

公开(公告)日：2018-01-25

申请号：US15213627

申请日：2016-07-19

申请人： Zoetis Services LLC

发明人： Paul Joseph Dominowski ,  Duncan Mwangi ,  Sharath K. Rai ,  Dennis L. Foss ,  Traci K. Godbee ,  Laurel Mary Sly ,  Suman Mahan ,  Shaunak Vora

IPC分类号： A61K39/12 ,  A61K39/39 ,  A61K39/145 ,  C12N7/00 ,  A61K39/002 ,  C12N15/117 ,  A61K39/265

CPC分类号： A61K39/12 ,  A61K39/012 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/16734 ,  C12N2710/16771 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2770/24034 ,  C12N2770/24334 ,  C12N2770/24371

摘要： The invention provides a liposomal adjuvant composition comprising an external membrane and an internal compartment, the external membrane comprising: a quaternary ammonium compound; a sterol; a phospholipid; and a glycolipid. Vaccine compositions comprising the liposomal adjuvant of the instant invention are also provided.

公开(公告)号：US20170304434A1

公开(公告)日：2017-10-26

申请号：US15494920

申请日：2017-04-26

申请人： Zoetis Services LLC

发明人： Paul Joseph Dominowski ,  Ramasamy Mannar Mannan ,  Richard Lee Krebs ,  James Richard Thompson ,  Tedd Alan Childers ,  Mary Kathryn Olsen ,  Robert John Yancey, Jr. ,  Risini Dhammika Weeratna ,  Shucheng Zhang ,  Cedo Martin Bagi

IPC分类号： A61K39/39 ,  A61K39/012 ,  A61K39/02 ,  A61K39/108 ,  A61K39/00 ,  A61K39/145 ,  A61K39/15 ,  A61K39/21 ,  A61K39/215 ,  A61K39/12 ,  A61K39/002

CPC分类号： A61K39/39 ,  A61K39/0011 ,  A61K39/002 ,  A61K39/012 ,  A61K39/0208 ,  A61K39/0241 ,  A61K39/0258 ,  A61K39/12 ,  A61K39/145 ,  A61K39/15 ,  A61K39/21 ,  A61K39/215 ,  A61K2039/521 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/54 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577 ,  C12N2720/12334 ,  C12N2720/12351 ,  C12N2740/13034 ,  C12N2740/13051 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2770/20034 ,  C12N2770/20051 ,  C12N2770/24334 ,  C12N2770/24351 ,  Y02A50/474

摘要： This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.

公开(公告)号：US09662385B2

公开(公告)日：2017-05-30

申请号：US14013299

申请日：2013-08-29

申请人： Zoetis Services LLC

发明人： Paul Joseph Dominowski ,  Ramasamy Mannar Mannan ,  Richard Lee Krebs ,  James Richard Thompson ,  Tedd Alan Childers ,  Mary Kathryn Olsen ,  Robert John Yancey, Jr. ,  Risini Dhammika Weeratna ,  Shucheng Zhang ,  Cedo Martin Bagi

IPC分类号： A61K45/00 ,  A61K39/39 ,  A61K39/00 ,  A61K39/012 ,  A61K39/02 ,  A61K39/108 ,  A61K39/12 ,  A61K39/145 ,  A61K39/15 ,  A61K39/21 ,  A61K39/215 ,  A61K39/002

CPC分类号： A61K39/39 ,  A61K39/0011 ,  A61K39/002 ,  A61K39/012 ,  A61K39/0208 ,  A61K39/0241 ,  A61K39/0258 ,  A61K39/12 ,  A61K39/145 ,  A61K39/15 ,  A61K39/21 ,  A61K39/215 ,  A61K2039/521 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/54 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577 ,  C12N2720/12334 ,  C12N2720/12351 ,  C12N2740/13034 ,  C12N2740/13051 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2770/20034 ,  C12N2770/20051 ,  C12N2770/24334 ,  C12N2770/24351 ,  Y02A50/474

摘要： This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.

公开(公告)号：US09089551B2

公开(公告)日：2015-07-28

申请号：US14097660

申请日：2013-12-05

申请人： SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC

发明人： Laurent Dupuis ,  Francois Bertrand ,  Sebastien Deville

IPC分类号： A61K39/012 ,  A61K39/39 ,  C07K14/455 ,  A61K39/00

CPC分类号： A61K39/39 ,  A61K39/012 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/57

摘要： A vaccine adjuvant which, based on the 100% mass thereof, includes between 10% and 95% of a mineral oil containing: between 0.05 mass-% and 10 mass-% hydrocarbon chains having less than 16 carbon atoms, and between 0.05 mass-% and 5 mass-% hydrocarbon chains having more than 28 carbon atoms. In addition, the adjuvant has a P/N ratio, corresponding to the ratio of the mass quantity of the paraffinic hydrocarbon chains to the mass quantity of the naphthenic hydrocarbon chains, of between 2.5 and 3, the adjuvant being intended for the production of a vaccine composition to prevent coccidiosis.

摘要翻译： 基于其100％质量的疫苗佐剂包含10％至95％的矿物油，其含有0.05质量％至10质量％的碳原子数小于16的烃链和0.05质量％ 具有大于28个碳原子的％和5质量％烃链。 此外，佐剂对应于石蜡烃链的质量与环烷烃链的质量之比的P / N比在2.5和3之间，所述佐剂用于生产 疫苗组合物以预防球虫病。

公开(公告)号：US20150165008A1

公开(公告)日：2015-06-18

申请号：US14418984

申请日：2013-08-02

申请人： VITAMFERO ,  INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE ,  UNIVERSITE FRANCOIS RABELAIS DE TOURS

发明人： Audrey Gnahoui-David ,  Fabrice Laurent ,  Marie-Noelle Mevelec ,  Edouard Seche

IPC分类号： A61K39/012 ,  A61K39/002

CPC分类号： A61K39/002 ,  A61K39/012 ,  A61K39/39 ,  A61K2039/522 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/57 ,  A61K2039/572 ,  A61K2039/575 ,  A61K2039/58 ,  Y02A50/489

摘要： Strains of Sarcocystidae selected from Toxoplasma spp or Neospora spp isolated from their natural environment and having an immunostimulant effect, for the use thereof in the prevention or the treatment, in a mammal, of a pathology associated with an apicomplexan of the family Cryptosporidiidae.

摘要翻译： 从其天然环境中分离的具有免疫刺激作用的选自弓形虫属或新孢子虫属的螨科的菌株，用于在哺乳动物中预防或治疗与隐孢子虫科的复合物有关的病理学的用途。

公开(公告)号：US08794185B2

公开(公告)日：2014-08-05

申请号：US11793047

申请日：2005-04-14

申请人： Eng-Hong Lee

发明人： Eng-Hong Lee

IPC分类号： A01K39/00 ,  A01K45/00 ,  A61D1/02 ,  A61D7/00

CPC分类号： A61K39/012 ,  A01K39/01 ,  A01K45/00 ,  A01K45/002 ,  A01K45/007 ,  A61D1/025 ,  A61D7/00 ,  A61K9/06 ,  A61K39/002 ,  A61K45/06 ,  A61K47/36 ,  A61K2039/52 ,  A61K2039/54 ,  A61K2039/542 ,  A61K2039/552 ,  A61K2039/70

摘要： The present invention is directed to a method of treating poultry hatchlings in a hatchling tray. The method comprises of providing a soft gel form capable of being dispensed through a spray nozzle, providing a spray dispensing apparatus, the apparatus being capable of delivering a predetermined volume of the gel as a plurality of small beadlets through a plurality of nozzles, placing the hatchling tray containing the hatchlings beneath the nozzles of the dispensing apparatus, dispensing the predetermined volume of the soft gel containing the therapeutic agent as small beadlets into the hatchling tray and allowing the hatchlings to consume the beadlets. The pre sent invention is also directed to a dispensing apparatus for dispensing a therapeutic agent in a soft gel into a hatchling tray of poultry hatchlings.

摘要翻译： 本发明涉及一种在孵化盘中处理家禽幼体的方法。 该方法包括提供能够通过喷嘴分配的软凝胶形式，提供喷雾分配装置，该装置能够通过多个喷嘴将预定体积的凝胶作为多个小珠粒递送， 将分配装置的喷嘴下面的小型幼稚园的幼体托盘分配给小型小珠的预定体积的含有作为小珠粒的治疗剂的软凝胶，并允许幼体消耗小珠。 本发明还涉及一种用于将软凝胶中的治疗剂分配到家禽幼体的孵化盘中的分配装置。