公开(公告)号：US12102677B2

公开(公告)日：2024-10-01

申请号：US16877292

申请日：2020-05-18

Applicant: Gilead Sciences, Inc.

Inventor： Brian Moldt ,  Craig S. Pace

IPC: A61K39/21 ,  A61K31/4745 ,  A61K31/519 ,  A61P31/18 ,  C07K16/10 ,  C12Q1/70

CPC classification number: A61K39/21 ,  A61K31/4745 ,  A61K31/519 ,  A61P31/18 ,  C07K16/1063 ,  C12Q1/703 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: Provided are methods for identifying patient populations infected with HIV that can be targeted by antibodies that bind to HIV gp120 V3 glycan region.

公开(公告)号：US20230056252A1

公开(公告)日：2023-02-23

申请号：US17409260

申请日：2021-08-23

Applicant: Gilead Sciences, Inc.

Inventor： Manuel Baca ,  Wade S. Blair ,  Brian A. Carr ,  Sheila B. Clancy ,  Joshua Goldsmith ,  Magdeleine S. Hung ,  Manu Kanwar ,  Brian Moldt ,  Mark Nagel ,  Craig S. Pace ,  YenRu Pan ,  Heather T. Stephenson ,  Nathan D. Thomsen

IPC: C07K16/10 ,  C07K16/28 ,  A61P31/18

Abstract: Provided are multi-specific antigen binding molecules, including bispecific antibodies, that bind to CD3 and an HIV antigen, including HIV envelope protein gp120. Also provided are methods of using such antigen binding molecules to treat or prevent HIV infection.

公开(公告)号：US20250041401A1

公开(公告)日：2025-02-06

申请号：US18775289

申请日：2024-07-17

Applicant: Gilead Sciences, Inc.

Inventor： Brian Moldt ,  Craig S. Pace

IPC: A61K39/21 ,  A61K31/4745 ,  A61K31/519 ,  A61P31/18 ,  C07K16/10 ,  C12Q1/70

Abstract: Provided are methods for identifying patient populations infected with HIV that can be targeted by antibodies that bind to HIV gp120 V3 glycan region.

公开(公告)号：US20200368347A1

公开(公告)日：2020-11-26

申请号：US16877292

申请日：2020-05-18

Applicant: Gilead Sciences, Inc.

Inventor： Brian Moldt ,  Craig S. Pace

IPC: A61K39/21 ,  A61K31/519 ,  A61K31/4745 ,  C12Q1/70 ,  C07K16/10 ,  A61P31/18

Abstract: Provided are methods for identifying patient populations infected with HIV that can be targeted by antibodies that bind to HIV gp120 V3 glycan region.

公开(公告)号：US20250059261A1

公开(公告)日：2025-02-20

申请号：US18771566

申请日：2024-07-12

Applicant: Gilead Sciences, Inc.

Inventor： Manuel Baca ,  Wade S. Blair ,  Brian A. Carr ,  Sheila B. Clancy ,  Joshua Goldsmith ,  Magdeleine S. Hung ,  Manu Kanwar ,  Brian Moldt ,  Mark Nagel ,  Craig S. Pace ,  YenRu Pan ,  Heather T. Stephenson ,  Nathan D. Thomsen

IPC: C07K16/10 ,  A61K39/00 ,  A61P31/18 ,  C07K16/28

Abstract: Provided are multi-specific antigen binding molecules, including bispecific antibodies, that bind to CD3 and an HIV antigen, including HIV envelope protein gp120. Also provided are methods of using such antigen binding molecules to treat or prevent HIV infection.

公开(公告)号：US20220144923A1

公开(公告)日：2022-05-12

申请号：US17522648

申请日：2021-11-09

Applicant: Gilead Sciences, Inc.

Inventor： Stephen R. Martin ,  Brian Moldt ,  Aiyappa Parvangada

IPC: C07K16/10 ,  A61P31/18

Abstract: Provided are methods for identifying patient populations infected with HIV that can be targeted by antibodies that bind to HIV gp120 CD4 binding site (CD4bs) region.