公开(公告)号：US20240117017A1

公开(公告)日：2024-04-11

申请号：US18468515

申请日：2023-09-15

Applicant: Gilead Sciences, Inc.

Inventor： Xinan Liu ,  Azure T. Makadzange ,  Stephen R. Martin ,  Hesham Shehata ,  Evguenia Svarovskaia

IPC: C07K16/10 ,  A61K9/14 ,  A61K45/06 ,  C07K16/28 ,  C12N15/10

CPC classification number: C07K16/1045 ,  A61K9/14 ,  A61K45/06 ,  C07K16/2818 ,  C07K16/2827 ,  C12N15/1082

Abstract: Provided are HIV-1 fusion polypeptides, polynucleotides encoding such fusion polypeptides, vectors expressing such fusion polypeptides for use in eliciting an immune response against HIV-1; pharmaceutical and immunogenic compositions and kits comprising such fusion polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HIV-1. Further provided are methods for design of antiviral vaccines, including vaccines to elicit an immune response against HIV-1.

公开(公告)号：US20250049908A1

公开(公告)日：2025-02-13

申请号：US18743701

申请日：2024-06-14

Applicant: Gilead Sciences, Inc.

Inventor： Jiani Li ,  Xinan Liu ,  Azure T. Makadzange ,  Stephen R. Martin ,  Sarah Schmidt ,  Hesham Shehata ,  Felix Stemeseder ,  Evguenia Svarovskaia ,  Archana V. Boopathy

IPC: A61K39/12 ,  A61K39/00 ,  A61P31/18 ,  C07K14/005 ,  C07K16/10 ,  C07K16/28 ,  C12N15/10 ,  C12N15/86

Abstract: Provided are HIV-1 fusion polypeptides, polynucleotides encoding such fusion polypeptides, vectors expressing such fusion polypeptides for use in eliciting an immune response against HIV-1; pharmaceutical and immunogenic compositions and kits comprising such fusion polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HIV-1. Further provided are methods for design of antiviral vaccines, including vaccines to elicit an immune response against HIV-1.

公开(公告)号：US12053517B2

公开(公告)日：2024-08-06

申请号：US17574465

申请日：2022-01-12

Applicant: Gilead Sciences, Inc.

Inventor： Jiani Li ,  Xinan Liu ,  Azure T. Makadzange ,  Stephen R. Martin ,  Hesham Shehata ,  Evguenia Svarovskaia

IPC: A61K39/12 ,  A61P31/18 ,  C07K14/005 ,  C07K16/10 ,  C07K16/28 ,  C12N15/10 ,  C12N15/86 ,  A61K39/00

CPC classification number: A61K39/12 ,  A61P31/18 ,  C07K14/005 ,  C07K16/1045 ,  C07K16/2818 ,  C07K16/2827 ,  C12N15/1082 ,  C12N15/86 ,  A61K2039/53 ,  A61K2039/70 ,  C12N2710/10343 ,  C12N2710/16143 ,  C12N2740/15034 ,  C12N2740/16022 ,  C12N2740/16034 ,  C12N2740/16134 ,  C12N2740/16234 ,  C12N2760/10043

Abstract: Provided are HIV-1 fusion polypeptides, polynucleotides encoding such fusion polypeptides, vectors expressing such fusion polypeptides for use in eliciting an immune response against HIV-1; pharmaceutical and immunogenic compositions and kits comprising such fusion polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HIV-1. Further provided are methods for design of antiviral vaccines, including vaccines to elicit an immune response against HIV-1.

公开(公告)号：US11795210B2

公开(公告)日：2023-10-24

申请号：US16928571

申请日：2020-07-14

Applicant: Gilead Sciences, Inc.

Inventor： Xinan Liu ,  Azure T. Makadzange ,  Stephen R. Martin ,  Hesham Shehata ,  Evguenia Svarovskaia

IPC: C07K16/10 ,  C07K16/28 ,  C12N15/10 ,  A61K9/14 ,  A61K45/06

CPC classification number: C07K16/1045 ,  A61K9/14 ,  A61K45/06 ,  C07K16/2818 ,  C07K16/2827 ,  C12N15/1082

Abstract: Provided are HIV-1 fusion polypeptides, polynucleotides encoding such fusion polypeptides, vectors expressing such fusion polypeptides for use in eliciting an immune response against HIV-1; pharmaceutical and immunogenic compositions and kits comprising such fusion polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HIV-1. Further provided are methods for design of antiviral vaccines, including vaccines to elicit an immune response against HIV-1.

公开(公告)号：US20220218813A1

公开(公告)日：2022-07-14

申请号：US17574465

申请日：2022-01-12

Applicant: Gilead Sciences, Inc.

Inventor： Jiani Li ,  Xinan Liu ,  Azure T. Makadzange ,  Stephen R. Martin ,  Sarah Schmidt ,  Hesham Shehata ,  Felix Stemeseder ,  Evguenia Svarovskaia ,  Archana V. Boopathy

IPC: A61K39/12 ,  A61P31/18 ,  C07K14/005 ,  C07K16/10 ,  C07K16/28 ,  C12N15/10 ,  C12N15/86

Abstract: Provided are HIV-1 fusion polypeptides, polynucleotides encoding such fusion polypeptides, vectors expressing such fusion polypeptides for use in eliciting an immune response against HIV-1; pharmaceutical and immunogenic compositions and kits comprising such fusion polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HIV-1. Further provided are methods for design of antiviral vaccines, including vaccines to elicit an immune response against HIV-1.

公开(公告)号：US20210017255A1

公开(公告)日：2021-01-21

申请号：US16928571

申请日：2020-07-14

Applicant: Gilead Sciences, Inc.

Inventor： Xinan Liu ,  Azure T. Makadzange ,  Stephen R. Martin ,  Hesham Shehata ,  Evguenia Svarovskaia

IPC: C07K16/10 ,  C07K16/28 ,  A61K9/14 ,  C12N15/10 ,  A61K45/06

Abstract: Provided are HIV-1 fusion polypeptides, polynucleotides encoding such fusion polypeptides, vectors expressing such fusion polypeptides for use in eliciting an immune response against HIV-1; pharmaceutical and immunogenic compositions and kits comprising such fusion polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HIV-1. Further provided are methods for design of antiviral vaccines, including vaccines to elicit an immune response against HIV-1.

公开(公告)号：US20220144923A1

公开(公告)日：2022-05-12

申请号：US17522648

申请日：2021-11-09

Applicant: Gilead Sciences, Inc.

Inventor： Stephen R. Martin ,  Brian Moldt ,  Aiyappa Parvangada

IPC: C07K16/10 ,  A61P31/18

Abstract: Provided are methods for identifying patient populations infected with HIV that can be targeted by antibodies that bind to HIV gp120 CD4 binding site (CD4bs) region.