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公开(公告)号：US20210009718A1
公开(公告)日：2021-01-14
申请号：US16909521
申请日：2020-06-23
发明人： Alexandre Ambrogelly , Manuel Baca , Brian A. Carr , Hon Man Hamlet Chu , Magdeleine S. Hung , Manu Kanwar , Michelle R. Kuhne , Douglas S. Rehder , Matthew R. Schenauer , Nicholas S. Wilson
摘要： Provided are FLT3L-Fc fusion proteins, polynucleotides encoding such fusion proteins, expression cassettes, vectors, cells and kits comprising such fusion proteins, and methods of using.
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公开(公告)号：US20220089698A1
公开(公告)日：2022-03-24
申请号：US17496250
申请日：2021-10-07
发明人： Mini Balakrishnan , Brian A. Carr , Magdeleine S. Hung , Manu Kanwar , Craig S. Pace , Doug Rehder , Matthew Robert Schenauer , Loredana Serafini , Heather Theresa Stephenson , Nathan D. Thomsen , Helen Yu , Xue Zhang
摘要： Antibodies that bind to HIV gp120 and neutralize HIV are disclosed. Also disclosed are methods of using such antibodies alone or in combination with other therapeutic agents to treat or prevent HIV infection.
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公开(公告)号：US11124582B2
公开(公告)日：2021-09-21
申请号：US16951458
申请日：2020-11-18
发明人： Alexandre Ambrogelly , Manuel Baca , Brian A. Carr , Hon Man Hamlet Chu , Magdeleine S. Hung , Manu Kanwar , Michelle R. Kuhne , Douglas S. Rehder , Matthew R. Schenauer , Nicholas S. Wilson
摘要： Provided are FLT3L-Fc fusion proteins, polynucleotides encoding such fusion proteins, expression cassettes, vectors, cells and kits comprising such fusion proteins, and methods of using.
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公开(公告)号：US20240269235A1
公开(公告)日：2024-08-15
申请号：US18540652
申请日：2023-12-14
发明人： Manuel Baca , Sarah A. Gilmore , Magdeleine S. Hung , Hassan Javanbakht , Manu Kanwar , Shahzada Khan , Prasenjit K. Mukherjee , Mark R. Nagel , Giuseppe Papalia , Danny W. Tam , Majlinda K. Thomas
CPC分类号： A61K38/2013 , A61K39/3955 , A61P31/20 , A61P35/00 , C07K14/55 , A61K38/00 , C07K2319/30
摘要： Provided are serum half-life extended-IL-2 variant (IL-2v) heterodimers having reduced binding to the IL2Rα (CD25) subunit. In particular, Fc-IL-2v heterodimers are provided and methods for making and using, e.g. for enhancing an immune response, e.g. in the prevention and treatment of viral infections and cancer.
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公开(公告)号：US20230056252A1
公开(公告)日：2023-02-23
申请号：US17409260
申请日：2021-08-23
发明人： Manuel Baca , Wade S. Blair , Brian A. Carr , Sheila B. Clancy , Joshua Goldsmith , Magdeleine S. Hung , Manu Kanwar , Brian Moldt , Mark Nagel , Craig S. Pace , YenRu Pan , Heather T. Stephenson , Nathan D. Thomsen
摘要： Provided are multi-specific antigen binding molecules, including bispecific antibodies, that bind to CD3 and an HIV antigen, including HIV envelope protein gp120. Also provided are methods of using such antigen binding molecules to treat or prevent HIV infection.
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公开(公告)号：US20200223907A1
公开(公告)日：2020-07-16
申请号：US16460094
申请日：2019-07-02
发明人： Mini Balakrishnan , Brian A. Carr , Magdeleine S. Hung , Manu Kanwar , Craig S. Pace , Doug Rehder , Matthew Robert Schenauer , Loredana Serafini , Heather Theresa Stephenson , Nathan D. Thomsen , Helen Yu , Xue Zhang
摘要： Antibodies that bind to HIV gp120 and neutralize HIV are disclosed. Also disclosed are methods of using such antibodies alone or in combination with other therapeutic agents to treat or prevent HIV infection.
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公开(公告)号：US11987617B2
公开(公告)日：2024-05-21
申请号：US18365869
申请日：2023-08-04
发明人： Mini Balakrishnan , Brian A. Carr , Magdeleine S. Hung , Manu Kanwar , Doug Rehder , Matthew Robert Schenauer , Loredana Serafini , Nathan D. Thomsen
CPC分类号： C07K16/1063 , A61P31/18 , A61K45/06 , C07K2317/21 , C07K2317/31 , C07K2317/41 , C07K2317/52 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/732 , C07K2317/76
摘要： Antibodies that bind to HIV gp120 and neutralize HIV are disclosed. Also disclosed are methods of using such antibodies alone or in combination with other therapeutic agents to treat or prevent HIV infection.
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公开(公告)号：US20240034774A1
公开(公告)日：2024-02-01
申请号：US18365869
申请日：2023-08-04
发明人： Mini Balakrishnan , Brian A. Carr , Magdeleine S. Hung , Manu Kanwar , Craig S. Pace , Doug Rehder , Matthew Robert Schenauer , Loredana Serafini , Heather Theresa Stephenson , Nathan D. Thomsen , Helen Yu , Xue Zhang
CPC分类号： C07K16/1063 , A61P31/18 , A61K45/06
摘要： Antibodies that bind to HIV gp120 and neutralize HIV are disclosed. Also disclosed are methods of using such antibodies alone or in combination with other therapeutic agents to treat or prevent HIV infection.
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公开(公告)号：US20220125884A1
公开(公告)日：2022-04-28
申请号：US17506483
申请日：2021-10-20
发明人： Manuel Baca , Sarah A. Gilmore , Magdeleine S. Hung , Hassan Javanbakht , Manu Kanwar , Shahzada Khan , Prasenjit K. Mukherjee , Mark R. Nagel , Giuseppe Papalia , Danny W. Tam , Majlinda K. Thomas
IPC分类号： A61K38/20 , C07K14/55 , A61P31/20 , A61P35/00 , A61K39/395
摘要： Provided are serum half-life extended-IL-2 variant (IL-2v) heterodimers having reduced binding to the IL2Rα (CD25) subunit. In particular, Fc-IL-2v heterodimers are provided and methods for making and using, e.g. for enhancing an immune response, e.g. in the prevention and treatment of viral infections and cancer.
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公开(公告)号：US20210070887A1
公开(公告)日：2021-03-11
申请号：US16951458
申请日：2020-11-18
发明人： Alexandre Ambrogelly , Manuel Baca , Brian A. Carr , Hon Man Hamlet Chu , Magdeleine S. Hung , Manu Kanwar , Michelle R. Kuhne , Douglas S. Rehder , Matthew R. Schenauer , Nicholas S. Wilson
摘要： Provided are FLT3L-Fc fusion proteins, polynucleotides encoding such fusion proteins, expression cassettes, vectors, cells and kits comprising such fusion proteins, and methods of using.
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