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公开(公告)号：US20200223907A1
公开(公告)日：2020-07-16
申请号：US16460094
申请日：2019-07-02
发明人： Mini Balakrishnan , Brian A. Carr , Magdeleine S. Hung , Manu Kanwar , Craig S. Pace , Doug Rehder , Matthew Robert Schenauer , Loredana Serafini , Heather Theresa Stephenson , Nathan D. Thomsen , Helen Yu , Xue Zhang
摘要： Antibodies that bind to HIV gp120 and neutralize HIV are disclosed. Also disclosed are methods of using such antibodies alone or in combination with other therapeutic agents to treat or prevent HIV infection.
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公开(公告)号：US11897862B2
公开(公告)日：2024-02-13
申请号：US18297316
申请日：2023-04-07
发明人： Gayatri Balan , Peter A. Blomgren , Chen Chen , Julian A. Codelli , Zhimin Du , Musong Kim , Dorothée Saddier Axe , Gregg M. Schwarzwalder , Rhiannon Thomas-Tran , Michael T. Tudesco , Chandrasekar Venkataramani , William J. Watkins , Brian M. Weist , Suet C. Yeung , Helen Yu
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07B2200/05 , C07D401/04 , C07B2200/05
摘要： The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.
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公开(公告)号：US10059697B2
公开(公告)日：2018-08-28
申请号：US15280801
申请日：2016-09-29
发明人： Tomas Cihlar , Michael Graupe , Yunfeng Eric Hu , Jeffrey Patrick Murry , Derek Dean Sloan , George Stepan , Helen Yu
IPC分类号： C07D405/12 , A61K31/4196 , A61K31/69 , A61K38/06 , A61K38/07 , A61K45/06
CPC分类号： C07D405/12 , A61K31/4196 , A61K31/69 , A61K38/06 , A61K38/07 , A61K45/06 , C07D249/10
摘要： Provided are compounds, compositions, combinations, kits, uses, and methods for treating HIV in a human being using such compounds or combinations with proteasome inhibitors.
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公开(公告)号：US20230295111A1
公开(公告)日：2023-09-21
申请号：US18297316
申请日：2023-04-07
发明人： Gayatri Balan , Peter A. Blomgren , Chen Chen , Julian A. Codelli , Zhimin Du , Musong Kim , Dorothée Saddier Axe , Gregg M. Schwarzwalder , Rhiannon Thomas-Tran , Michael T. Tudesco , Chandrasekar Venkataramani , William J. Watkins , Brian M. Weist , Suet C. Yeung , Helen Yu
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07B2200/05
摘要： The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.
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公开(公告)号：US20220089698A1
公开(公告)日：2022-03-24
申请号：US17496250
申请日：2021-10-07
发明人： Mini Balakrishnan , Brian A. Carr , Magdeleine S. Hung , Manu Kanwar , Craig S. Pace , Doug Rehder , Matthew Robert Schenauer , Loredana Serafini , Heather Theresa Stephenson , Nathan D. Thomsen , Helen Yu , Xue Zhang
摘要： Antibodies that bind to HIV gp120 and neutralize HIV are disclosed. Also disclosed are methods of using such antibodies alone or in combination with other therapeutic agents to treat or prevent HIV infection.
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公开(公告)号：US20170114048A1
公开(公告)日：2017-04-27
申请号：US15280801
申请日：2016-09-29
发明人： Tomas Cihlar , Michael Graupe , Yunfeng Eric Hu , Jeffrey Patrick Murry , Derek Dean Sloan , George Stepan , Helen Yu
IPC分类号： C07D405/12 , A61K38/06 , A61K31/4196 , A61K38/07 , A61K45/06 , A61K31/69
CPC分类号： C07D405/12 , A61K31/4196 , A61K31/69 , A61K38/06 , A61K38/07 , A61K45/06 , C07D249/10
摘要： Provided are compounds, compositions, combinations, kits, uses, and methods for treating HIV in a human being using such compounds or combinations with proteasome inhibitors.
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公开(公告)号：US20240034774A1
公开(公告)日：2024-02-01
申请号：US18365869
申请日：2023-08-04
发明人： Mini Balakrishnan , Brian A. Carr , Magdeleine S. Hung , Manu Kanwar , Craig S. Pace , Doug Rehder , Matthew Robert Schenauer , Loredana Serafini , Heather Theresa Stephenson , Nathan D. Thomsen , Helen Yu , Xue Zhang
CPC分类号： C07K16/1063 , A61P31/18 , A61K45/06
摘要： Antibodies that bind to HIV gp120 and neutralize HIV are disclosed. Also disclosed are methods of using such antibodies alone or in combination with other therapeutic agents to treat or prevent HIV infection.
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公开(公告)号：US20230373950A1
公开(公告)日：2023-11-23
申请号：US18184335
申请日：2023-03-15
发明人： Gayatri Balan , Peter A. Blomgren , Chen Chen , Julian A. Codelli , Zhimin Du , Musong Kim , Dorothée Saddier Axe , Gregg M. Schwarzwalder , Rhiannon Thomas-Tran , Michael T. Tudesco , Chandrasekar Venkataramani , William J. Watkins , Brian M. Weist , Suet C. Yeung , Helen Yu
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07B2200/05
摘要： The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.
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公开(公告)号：US11168130B2
公开(公告)日：2021-11-09
申请号：US16460094
申请日：2019-07-02
发明人： Mini Balakrishnan , Brian A. Carr , Craig S. Pace , Doug Rehder , Matthew Robert Schenauer , Loredana Serafini , Heather Theresa Stephenson , Nathan D. Thomsen , Helen Yu , Xue Zhang
摘要： Antibodies that bind to HIV gp120 and neutralize HIV are disclosed. Also disclosed are methods of using such antibodies alone or in combination with other therapeutic agents to treat or prevent HIV infection.
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