公开(公告)号：US20250032473A1

公开(公告)日：2025-01-30

申请号：US18740078

申请日：2024-06-11

Applicant: Gilead Sciences, Inc.

Inventor： Peter A. Blomgren ,  Taryn Campbell ,  Jayaraman Chandrasekhar ,  Christopher T. Clark ,  Julian A. Codelli ,  Kevin S. Currie ,  Jeffrey E. Kropf ,  Yasamin Moazami ,  Nicole Nava ,  Leena Patel ,  Stephane Perreault ,  Jason K. Perry ,  Kassandra F. Sedillo ,  Natalie Seeger ,  Kirk L. Stevens ,  Jennifer Anne Treiberg ,  Suet C. Yeung ,  Zhongdong Zhao

IPC: A61K31/47 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/501 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5355 ,  A61K31/541 ,  A61K45/06 ,  C07D215/14 ,  C07D215/18 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D475/02 ,  C07D487/04 ,  C07D491/04 ,  C07D491/06 ,  C07D491/08 ,  C07D498/10 ,  C07D513/04

Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.

公开(公告)号：US12053462B2

公开(公告)日：2024-08-06

申请号：US17379175

申请日：2021-07-19

Applicant: Gilead Sciences, Inc.

Inventor： Peter A. Blomgren ,  Taryn Campbell ,  Jayaraman Chandrasekhar ,  Christopher T. Clark ,  Julian A. Codelli ,  Kevin S. Currie ,  Jeffrey E. Kropf ,  Yasamin Moazami ,  Nicole Nava ,  Leena Patel ,  Stephane Perreault ,  Jason K. Perry ,  Kassandra F. Sedillo ,  Natalie Seeger ,  Kirk L. Stevens ,  Jennifer Anne Treiberg ,  Suet C. Yeung ,  Zhongdong Zhao

IPC: C07D215/02 ,  A61K31/4375 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/501 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5355 ,  A61K31/541 ,  A61K45/06 ,  C07D215/14 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D215/18 ,  C07D401/04 ,  C07D413/04 ,  C07D417/14 ,  C07D475/02 ,  C07D491/04 ,  C07D491/06 ,  C07D491/08 ,  C07D498/10 ,  C07D513/04

CPC classification number: A61K31/47 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/501 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5355 ,  A61K31/541 ,  A61K45/06 ,  C07D215/14 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D215/18 ,  C07D401/04 ,  C07D413/04 ,  C07D417/14 ,  C07D475/02 ,  C07D491/04 ,  C07D491/06 ,  C07D491/08 ,  C07D498/10 ,  C07D513/04

Abstract: The present disclosure provides a compound of Formula (I):




or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.

公开(公告)号：US11174256B2

公开(公告)日：2021-11-16

申请号：US16667532

申请日：2019-10-29

Applicant: Gilead Sciences, Inc.

Inventor： Peter A. Blomgren ,  Taryn Campbell ,  Jayaraman Chandrasekhar ,  Christopher T. Clark ,  Julian A. Codelli ,  Kevin S. Currie ,  Jeffrey E. Kropf ,  Yasamin Moazami ,  Nicole Nava ,  Leena Patel ,  Stephane Perreault ,  Jason K. Perry ,  Kassandra F. Sedillo ,  Natalie Seeger ,  Kirk L. Stevens ,  Jennifer Anne Treiberg ,  Suet C. Yeung ,  Zhongdong Zhao

IPC: C07D471/04 ,  A61K31/437 ,  A61K31/541

Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.

公开(公告)号：US20200165248A1

公开(公告)日：2020-05-28

申请号：US16667532

申请日：2019-10-29

Applicant: Gilead Sciences, Inc.

Inventor： Peter A. Blomgren ,  Taryn Campbell ,  Jayaraman Chandrasekhar ,  Christopher T. Clark ,  Julian A. Codelli ,  Kevin S. Currie ,  Jeffrey E. Kropf ,  Yasamin Moazami ,  Nicole Nava ,  Leena Patel ,  Stephane Perreault ,  Jason K. Perry ,  Kassandra F. Sedillo ,  Natalie Seeger ,  Kirk L. Stevens ,  Jennifer Anne Treiberg ,  Suet C. Yeung ,  Zhongdong Zhao

IPC: C07D471/04 ,  A61K31/541

Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.

公开(公告)号：US20240182476A1

公开(公告)日：2024-06-06

申请号：US18450646

申请日：2023-08-16

Applicant: GILEAD SCIENCES, INC. ,  CARNA BIOSCIENCES, INC.

Inventor： Masaaki Sawa ,  Mai Arai ,  Ryoko Nakai ,  Hirokazu Matsumoto ,  Catherine Pugh ,  Eric Hu ,  Juan Guerrero ,  Jesse Jacobsen ,  Jonathan William Medley ,  Jie Xu ,  Latesh Lad ,  Leena Patel ,  Michael Graupe ,  Qingming Zhu ,  Stephen Holmbo ,  Tetsuya Kobayashi ,  Will Watkins ,  Yasamin Moazami ,  Suet C. Yeung ,  Julian A. Codelli ,  Heath A. Weaver

IPC: C07D487/04 ,  A61K31/395 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/55 ,  A61K31/553 ,  A61K31/695 ,  A61K31/704 ,  A61K31/7068 ,  A61K35/15 ,  A61K35/17 ,  A61K39/395 ,  A61K45/06 ,  C07D519/00 ,  C07F7/18

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/55 ,  A61K31/553 ,  A61K31/5545 ,  A61K31/695 ,  A61K31/704 ,  A61K31/7068 ,  A61K35/15 ,  A61K35/17 ,  A61K39/3955 ,  A61K45/06 ,  C07D519/00 ,  C07F7/1804

Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

公开(公告)号：US11999733B2

公开(公告)日：2024-06-04

申请号：US17844921

申请日：2022-06-21

Applicant: Gilead Sciences, Inc.

Inventor： Julian A. Codelli ,  Jonathan William Medley

IPC: C07D471/14 ,  A61P31/18 ,  A61P31/20 ,  A61P35/00 ,  A61P35/04 ,  C07D471/04 ,  C07D519/00

CPC classification number: C07D471/14 ,  C07D471/04 ,  C07D519/00

Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

公开(公告)号：US20230295111A1

公开(公告)日：2023-09-21

申请号：US18297316

申请日：2023-04-07

Applicant: Gilead Sciences, Inc.

Inventor： Gayatri Balan ,  Peter A. Blomgren ,  Chen Chen ,  Julian A. Codelli ,  Zhimin Du ,  Musong Kim ,  Dorothée Saddier Axe ,  Gregg M. Schwarzwalder ,  Rhiannon Thomas-Tran ,  Michael T. Tudesco ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Brian M. Weist ,  Suet C. Yeung ,  Helen Yu

IPC: C07D401/04

CPC classification number: C07D401/04 ,  C07B2200/05

Abstract: The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.

公开(公告)号：US20230046340A1

公开(公告)日：2023-02-16

申请号：US17844921

申请日：2022-06-21

Applicant: Gilead Sciences, Inc.

Inventor： Julian A. Codelli ,  Jonathan William Medley

IPC: C07D471/14 ,  C07D471/04 ,  C07D519/00

Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

公开(公告)号：US20230013585A1

公开(公告)日：2023-01-19

申请号：US17331900

申请日：2021-05-27

Applicant: Gilead Sciences, Inc.

Inventor： Gayatri Balan ,  Mark J. Bartlett ,  Jayaraman Chandrasekhar ,  Julian A. Codelli ,  John H. Conway ,  Jennifer L. Cosman ,  Rao V. Kalla ,  Musong Kim ,  Seung H. Lee ,  Jennifer R. Lo ,  Jennifer A. Loyer-Drew ,  Scott A. Mitchell ,  Thao D. Perry ,  Gary B. Phillips ,  Patrick J. Salvo ,  Joshua J. Van Veldhuizen ,  Suet C. Yeung ,  Jeff Zablocki

IPC: A61K31/4545 ,  A61K31/444 ,  A61K31/5386 ,  C07D471/04 ,  C07D519/00

Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

公开(公告)号：US20220213091A1

公开(公告)日：2022-07-07

申请号：US17522628

申请日：2021-11-09

Applicant: Gilead Sciences, Inc.

Inventor： Gayatri Balan ,  Mark J. Bartlett ,  Jayaraman Chandrasekhar ,  Julian A. Codelli ,  John H. Conway ,  Jennifer L. Cosman ,  Rao V. Kalla ,  Zachary A. Kasun ,  Musong Kim ,  Seung H. Lee ,  Jennifer R. Lo ,  Jennifer A. Loyer-Drew ,  Scott A. Mitchell ,  Thao D. Perry ,  Gary B. Phillips ,  Patrick J. Salvo ,  Sundaramoorthi Swaminathan ,  Joshua J. Van Veldhuizen ,  Suet C. Yeung ,  Jeff Zablocki

IPC: C07D471/04 ,  C07D519/00

Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.